QUININE SULPHATE TABLETS BP 200MG

Active substance: QUININE SULPHATE

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Quinine Sulphate 200mg tablets
Read all of this leaflet carefully before you
start taking this medicine.
• Keep this leaflet. You may need to read it
again.
• If you have any further questions, ask your
doctor or pharmacist.
• This medicine has been prescribed for you.
Do not pass it on to others. It may harm
them, even if their symptoms are the same
as yours.

Index
1 What Quinine sulphate tablets are
and what they are used for
2 Before you take
3 How to take
4 Possible side effects
5 How to store
6 Further information

1 What Quinine sulphate tablets are
and what they are used for

Quinine sulphate belongs to a group of medicines
called anti-protozoal agents and they are used to
treat:
• malaria
• and prevent night cramps in adults and the
elderly when sleep is regularly disrupted

2 Before you take

Do not take Quinine sulphate tablets and
tell your doctor if you have:

• an allergy (hypersensitivity) to quinine (including
that in tonic waters or other beverages),
quinoline or any of the other ingredients (see
section 6)
• blood in your urine
• ringing in your ears
• suffer from muscle weakness (myasthenia
gravis)
• problems with your eyes or difficulty seeing

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Check with your doctor or pharmacist
before taking Quinine sulphate tablets if you:
• have irregular heart beats or other heart
disease
• have had malaria for a long time
• suffer from severe glucose-6-phosphate
dehydrogenase deficiency (G6PD), this can cause
episodes of anaemia after eating certain foods
such as fava beans (favism) or certain drugs
including drugs to prevent malaria and dapsone
You should not take more than the prescribed dose
as a condition called ‘cinchonism’ may occur even
with normal doses. Please see section 4 ‘Possible
side effects’ for symptoms of cinchonism and tell
your doctor if you experience any of them.

Taking other medicines

Please tell your doctor or pharmacist if you
are taking or have recently taken any other
medicines, including medicines obtained without a
prescription. Especially:
• anticoagulants (to stop your blood from clotting)
• cardiac glycosides (for your heart such as digoxin)
• chloroquine, mefloquine, artemether with
lumefantrine or primaquine (also to treat
malaria)
• cimetidine (to treat stomach ulcers or acid reflux
and indigestion)
• amantadine (to treat Parkinsons Disease or some
viral infections)
• ciclosporin (to prevent transplant rejection)
• flecainide, quinidine or amiodarone (to treat
irregular heart beats)
• terfenadine (for allergic reactions)
• pimozide or thioridazine (to treat some mental
disorders)
• moxifloxacin rifampicin or antifungals (to treat
infections)
• medicines to treat diabetes
• suxamethonium (muscle relaxant)
• HIV medicines
• barbiturates, carbamazepine or phenytoin (used
in epilepsy)

Pregnancy and breast-feeding

You should not take Quinine sulphate tablets if
you are pregnant, planning to become pregnant
or breast-feeding unless advised to by your doctor.
Quinine sulphate tablets should not be used for
night cramps during pregnancy.
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Quinine sulphate tablets may affect your vision.
Make sure you are not affected before you drive or
operate machinery.

3 How to take

Always take Quinine sulphate tablets exactly as
your doctor has told you. If you are not sure, check
with your doctor or pharmacist.
Swallow the tablets with water.
Doses:
• Malaria (you may be given another medicine for
malaria with or after this course of quinine):
Adults (including elderly) and children over 12
years - 600mg every eight hours for 5-7 days
Children under 12 years - 10mg per kg of body
weight every eight hours for 7 days
If you have kidney or liver disease you may be
given a different dose.
• Night cramps:
Adults (including elderly) - 200mg at bedtime.
It may take up to 4 weeks before you notice any
reduction in the frequency of leg cramps.

If you take more than you should

If you (or someone else) swallow a lot of tablets
at the same time, or you think a child may
have swallowed any, contact your nearest
hospital casualty department or tell your
doctor immediately. Symptoms include loss of
consciousness, difficulty breathing, changes in
heart beat, fits, ‘ringing’ in the ears, loss of hearing,
headache, feeling or being sick and changes in
vision.

If you forget to take the tablets

Do not take a double dose to make up for a
forgotten dose. If you forget to take a dose take it
as soon as you remember it and then take the next
dose at the right time.

4 Possible side effects

Like all medicines, Quinine sulphate tablets can
cause side effects, although not everybody gets
them.
Contact your doctor at once if the following
effects occur:
• allergic reactions –itchy skin rash, swelling of
the lips, face, throat or tongue, flushing, fever,
asthma or sensitivity to light
• cinchonism –abdominal pain, diarrhoea,
disturbed vision (blurred vision, changes
in colour perception or field of vision, total
blindness), headache, feeling or being sick,
ringing in the ears or impaired hearing, rashes,
loss of consciousness, fits, shock due to heart
problems, irregular heart beats, death. If these
occur while taking Quinine sulphate tablets for
leg cramps, treatment should be stopped and a
doctor contacted straight away.

•  hanges to blood cells, if you notice that you
c
are bruising or bleeding easily, have frequent
nose bleeds, or you have more sore throats and
infections than usual tell your doctor who may
want to give you a blood test.
Tell your doctor if you notice any of the
following side effects or notice any other effects
not listed:
• diarrhoea, feeling or being sick, abdominal pain,
low blood sugar.
• muscle weakness, excitement, agitation,
‘spinning’ sensation’, confusion, loss of
consciousness, coma, death.
•  eadache, changes in vision, ‘ringing’ in the ears,
h
loss of hearing.
• swollen, itchy, flaky, red or raised patches of skin,
rashes, sensitivity to light.
• aggrevation of Myasthenia gravis.
• kidney damage, water retention, slowed heart
rate, changes in heart rhythm and the way the
heart beats, eczema, miscarriages (at very high
concentrations), difficulty breathing.
If you notice any side effects, they get worse, or if
you notice any not listed, please tell your doctor or
pharmacist.

5 How to store

Keep out of the reach and sight of children.
Store below 25°C in a dry place
Do not use Quinine sulphate tablets after the
expiry date stated on the label/carton/bottle. The
expiry date refers to the last day of that month.
Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer
required. These measures will help to protect the
environment.

6 Further information

What Quinine sulphate tablets contain

• The active substance (the ingredient that makes
the tablet work) is 200mg quinine sulphate.
• The other ingredients are sodium lauryl sulphate,
povidone, microcrystalline cellulose (E460),
croscarmellose sodium, magnesium stearate,
hydrogenated vegetable oil.
• The coating contains hydroxypropylmethyl
cellulose, hydroxypropyl cellulose, medium chain
triglycerides, macrogol 3350, titanium dioxide
(E171).

What Quinine sulphate tablets look like
and contents of the pack
Quinine sulphate tablets are white, circular,
film-coated tablets.
Pack sizes are 28 tablets
Marketing Authorisation Holder and Manufacturer
Actavis, Barnstaple, EX32 8NS, UK
Date of last revision: May 2010

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Actavis, Barnstaple, EX32 8NS, UK

Pharmacode
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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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