QUININE BISULPHATE TABLETS 300MG

Active substance: QUININE BISULPHATE

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PATIENT INFORMATION LEAFLET
KEEP THIS LEAFLET AND READ IT BEFORE YOU TAKE YOUR MEDICINE
Quinine Bisulphate Tablets 300mg
YOUR MEDICINE
Your tablets are called Quinine Bisuslphate Tablets 300mg. Each tablet contains
300mg of the active ingredient Quinine Bisulphate. Each tablet also contains
microcrystaline cellulose, fumed silicon dioxide, guar gum, magnesium stearate,
hydroxypropylmethylcellulose, ethylcellulose, titanium dioxide, diethyl phthalate,
dichloromethane, methanol, petroleum spirit and beeswax.
Quinine Bisulphate Tablets are round, white film-coated tablets marked QBS over
300 on one side and R on the reverse and are available in containers of 16, 21, 28, 30,
50, 56, 60, 84, 90 and 100 tablets.
WHO MAKES IT?
The product licence is held by
Mercury Pharmaceuticals Ltd, No. 1 Croydon, 12-16 Addiscombe Road, Croydon
CR0 0XT, UK
and the product is manufactured by
DDSA Pharmaceuticals Ltd., Chatfield Road, Off
York Road, London SW11 3SE.
WHAT IS IT FOR?
Quinine Bisulphate tablets belong to a group of medicines known as the antimalarials,
and are used in the treatment of malaria resistant to the medicine chloroquine. Quinine
Bisulphate Tablets are also used in the prevention of night cramps.
WARNING:
Before taking this medicine, tell your doctor if you have had any unusual or allergic reactions
to Quinine Bisulphate, or to any of the other ingredients.
Also tell your doctor or pharmacist if you are allergic to any other substances such as
foods, preservatives or dyes.
Because the presence of other medical problems may affect the use of Quinine Bisulphate,
make sure to tell your doctor if you have had any of the following:
* Optic neuritis (inflammation of the main nerve of the eye).
* Haemoglobinuria (a pink/red discolouration of the urine)
* Asthma
* Atrial fibrillation (rapid, irregular heart beats)
* Myaesthenia gravis (a type of muscle weakness).
* Glucose-6-phosphate dehydrogenase deficiency (an enzyme
deficiency)
It is important to tell your doctor if you are pregnant, or likely to become pregnant.
High doses of quinine can adversely affect the foetus and may cause miscarriage in
pregnant women.
SPECIAL WARNINGS
If you develop any new medical problems while using this medicine, check with your doctor
or pharmacist. Although you can take these tablets with other medicines, it is important to tell

your doctor or pharmacist about all the medicines that you are taking, whether or not they
were prescribed by your doctor or bought without a prescription from the pharmacy or
elsewhere.
It is important for your doctor or pharmacist to know if you are taking any of the following:
* Digoxin
* Cimetidine
* Anticoagulants (blood thinners)
* Flecainide
Because visual disturbances may occur when taking Quinine Bisulphate, ability to
drive or use machines may be impaired. It is not advisable, therefore, to drive or operate
machinery.
USE IN PREGNANCY AND BREASTFEEDING
Quinine Bisulphate may be used in pregnancy for the treatment of malaria and during
breastfeeding. Although quinine is excreted in breast milk, the amounts are too small
to affect the infant.
TAKING YOUR MEDICINE
Take this medicine by mouth and only in the doses prescribed by your doctor. Your
pharmacist can also help if you are not sure. Do not take more of the product than the doctor
recommends and do not take it more often or for a longer time that your doctor advises. Do
not stop the treatment without talking to your doctor first. You may feel well but the tablets
are helping to prevent another attack of your disease.
Dosages:
In the treatment of chloroquine-resistant malaria:
Adults and the elderly: 600mg (2 tablets) at 8 hourly intervals for 7 days.
Children: 10mg per kg bodyweight at 8 hourly intervals for 7 days.
In the treatment of night cramps
Adults and elderly: 300mg at night.
Children: Not recommended.
If you forget to take your medicine, just carry on with the next dose as normal. Do
not take an extra dose to make up for the missed dose. If you are not sure, ask your
doctor or pharmacist for advice.
If you feel that this medicine is not working as well after you have taken it for a short
time (1-2 weeks) do not increase the dose, instead check with your doctor.
WHAT TO DO IN CASE OF OVERDOSE
If you think you have taken an overdose of this medicine, you must obtain emergency
help at once. Contact your doctor or go to the Accident & Emergency Department of
your nearest hospital at once. Take with you any remaining tablets in the original
container so that the medicine can be identified.
The symptoms of overdose include fits, nausea, vomiting, ringing in the ears,
deafness, headache, low blood pressure, visual disturbances, loss of consciousness,
coma, respiratory problems and heart problems. Doses of 2-8g have resulted in death
in some adult patients. High doses of quinine can also adversely affect the foetus may
cause miscarriage in pregnant women.
SIDE EFFECTS

Quinine may cause “cinchonism” which generally occurs in overdose, but may rarely also
occur at normal doses. Early symptoms are tinnitus (ringing in the ears), impaired hearing
and vision, headache and nausea. More severe symptoms include vomiting, severe eyesight
problems, including blindness, and effects on the heart and brain.
In people who are allergic to quinine small doses may cause reactions including rash, fever,
face swelling and asthma.
If you feel unwell whilst taking tablets for night cramps, stop taking the medicine and
talk to your doctor.
Quinine Bisulphate can reduce the number of certain types of blood cells. If you get a sore
throat or high temperature, or become gradually more tired and pale, or notice bruises or nose
bleeds, stop taking quinine and contact your doctor. Kidney function may be impaired.
STORING YOUR MEDICINE
You must keep the medicine in a safe place where children cannot get it. Your medicine
could harm them. Keep your medicine in a dry place and store below 25°C. Keep the tablets
in the closed container in which they were given to you.
If your doctor tells you to stop the treatment, return any remaining tablets to the pharmacist.
Only keep the medicine if the doctor tells you to. Do not use this medicine after the expiry
date shown on the label.
REMEMBER
This medicine is only for you. Never give it to someone else, even if their symptoms are the
same as yours. This leaflet does not contain the complete information about your medicine. If
you have any questions or are not sure about anything, ask your doctor or pharmacist who
have access to additional information.
Revised on: March 2012

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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