PROPRANOLOL HYDROCHLORIDE 50MG/5ML ORAL SOLUTION

Active substance: PROPRANOLOL HYDROCHLORIDE

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Patient Information Leaflet



Rare (affects less than 1 in 1000 people)
heart failure getting worse (signs include being breathless or swollen ankles), feeling dizzy or
light-headed when standing quickly
n dizziness and fainting, worsening of breathing (called ‘heart block’)
n poor circulation getting worse. This can lead to cramp-like pains in the lower leg
n bruising more easily or purplish marks on the skin.
n

SYPROL® 50mg/5ml Oral Solution
propranolol hydrochloride

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Tell your doctor if you get any of these side effects:
Common (affects less than 1 in 10 people)
n feeling cold, numbness and spasm in the fingers and toes
n nightmares, tiredness or difficulty sleeping.


Uncommon (affects less than 1 in 100 people)
feeling or being sick
stomach ache
diarrhoea.



Rare (affects less than 1 in 1000 people)
feeling confused or dizzy
changes in your mood
memory loss
mental illness where a person loses touch with reality (psychoses)
strange sounds and visions (hallucinations)
thinning of the hair
skin rash, worsening of skin problem called ‘psoriasis’
dry eyes, changes in your sight
tingling sensation (pins and needles) particularly in the hands.

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Syprol Oral Solution can be used for:
n high blood pressure
n symptoms of chest pain (angina)
n protection against further heart attacks - if you have already had one
n thickened heart muscle – also called ‘hypertrophic cardiomyopathy’
n problems affecting the beat of your heart (arrhythmias, tachycardia).

Keep out of the reach and sight of children.
Do not store above 25°C. Do not refrigerate or freeze.
Take back to the pharmacy 3 months after you first open it.
Do not use after the expiry date (month, year) stated on the label and carton.
If it is out of date or you no longer want it, take it back to the pharmacy.
Do not use Syprol Oral Solution if you notice anything wrong with the medicine.
Talk to your pharmacist.

6. Further information
What Syprol Oral Solution contains
The active ingredient is propranolol hydrochloride. The other ingredients are citric acid, methyl and
propyl parahydroxybenzoate (E218 and E216), propylene glycol (E1520), liquid maltitol (E965),
orange/tangerine flavour (including ethanol (0.12%v/v) and butylhydroxyanisole (E320)), colouring
E110 and purified water.
What Syprol Oral Solution looks like and contents of the pack
A bright orange liquid which smells of orange/tangerine.
It comes in a brown glass bottle holding 150ml of solution.
Marketing Authorisation Holder and Manufacturer
Rosemont Pharmaceuticals Ltd, Yorkdale Industrial Park, Braithwaite Street,
Leeds, LS11 9XE, UK.
This leaflet was last revised in 12/2012

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Syprol Oral Solution contains propranolol hydrochloride. This belongs to a group of medicines
called beta-blockers.

5. How to store Syprol Oral Solution







In this leaflet
1. What is Syprol Oral Solution and what it is used for
2. Before you take Syprol Oral Solution
3. How to take Syprol Oral Solution
4. Possible side effects
5. How to store Syprol Oral Solution
6. Further information

1. What is Syprol Oral Solution and what it is used for

If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.

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Read all of this leaflet carefully before you start taking this medicine.
Keep this leaflet. You may need to read it again.
If you have further questions, ask your doctor or your pharmacist.
This medicine has been prescribed only for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
n If any of the side effects listed below become serious, or if
you notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.
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Very rare (affects less than 1 in 10,000 people)
n muscle weakness and a disease of the muscles (called ‘myasthenia gravis’)
getting worse
n low blood sugar (hypoglycaemia) in children or elderly
who do not have diabetes (signs include weakness,
headache, feeling hungry, visual disturbances and mood
changes). Hypoglycaemia may lead to fits (seizures).

SPC update 4.4/5/8

It can also be used for:
severe headaches (migraine)
shaking (tremors)
stress (anxiety)
an overactive thyroid gland – also called ‘thyrotoxicosis’
bleeding in the food pipe (oesophagus). This happens when the blood pressure is high in your liver
n high blood pressure caused by a tumour on the adrenal gland. This is called 'phaeochromocytoma'.
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2. Before you take Syprol Oral Solution
Do not take Syprol Oral Solution if:
n you are allergic (hypersensitive) to propranolol or any of the other ingredients in this liquid
(see section 6: Further information)
An allergic reaction can include a rash, itching or shortness of breath
n you have ever had asthma or wheezing
n you have heart problems such as heart failure which is not under control, heart block, slow or
uneven heart beats, low blood pressure or very poor circulation
n you have not been eating (fasting) for a long period of time or if your blood has become too
acidic (metabolic acidosis)
n you have high blood pressure caused by a tumour on the adrenal gland which has not been
treated. This is called 'phaeochromocytoma'
n you have or sometimes get low blood sugar ('hypoglycaemia'). This can happen if you are not
eating well, have long-term liver disease or have diabetes
n you have chest pain that happens when you are resting rather than during exercise (called
'prinzmetals angina').
Do not take Syprol Oral Solution if any of the above apply to you. If you are not sure, talk to your
doctor before taking Syprol Oral Solution.
Continued overleaf

Rosemont Pharmaceuticals Ltd. Printed Packaging Origination and Approval
Product:

Syprol 50mg/5ml Oral Solution
Propranolol Hydrochloride

Date:

Strength:

50mg/5ml

Proof Number:

New Item Code:

SPC update 4.4/5/8

Page:

Previous Item Code:

P0565

New Pharmacode:

Design Icon:

-

Sugar-Free

YES

Cutter Ref:

-

Pack Size

150ml

Dimensions:

210 x 300mm (folded 150 x 30mm)

Number of 
colours used:

ONE

Black

10.12.12
THREE
1 of: 2

86
Barcode:

Keyline

Tick
applicable
box

Pregnancy and Breast-feeding
Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant or
are breast-feeding.
Take special care with Syprol Oral Solution
Before you take Syprol Oral Solution tell your doctor if:
n you have heart failure which is being treated
n circulation problems or other heart problems (such as angina or heart attacks)
n you have liver problems (such as cirrhosis) or kidney problems
n you have allergic reactions to things like insect bites
n you have diabetes. This is because Syprol may interfere
with your body’s reaction to low blood sugar
n you have an overactive thyroid gland – also called
'thyrotoxicosis'.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines,
including medicines obtained without a prescription.
In particular tell your doctor or pharmacist if you are taking any of the following medicines:
n medicines for diabetes
n medicines used to treat anxiety and depression as well as more serious mental health problems
such as chlorpromazine, thioridazine, fluvoxamine, imipramine or MAOIs such as phenelzine and
diazepam
n medicines for uneven heart beats such as disopyramide, quinidine, propafenone, lidocaine,
flecainide and amiodarone
n medicines for chest pain (angina) or high blood pressure such as verapamil, nifedipine,
diltiazem, nisoldipine, nicardipine, isradipine, lacidipine
medicines used to treat high blood pressure such as hydralazine, captopril (ACE inhibitors),
furosemide and other water tablets (diuretics), losartan and candesartan, diazoxide, doxazosin,
guanethidine, moxisylyte, moxonidine, nitrates (such as glyceryl trinitrate and isosorbide
dinitrate) and methyldopa
n medicines for stimulating the heart such as adrenaline and dobutamine
n medicines for pain and inflammation including arthritis such as ibuprofen or indomethacin
n steroids used to reduce swelling such as prednisolone and dexamethasone
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medicines used to treat myasthenia gravis such as neostigmine
medicines used to relax muscles such as baclofen and tizanidine
medicines to help you sleep or to treat epilepsy known as barbiturates such as phenobarbital
medicines used to treat parkinsons disease such as levodopa
ergotamine, dihydroergotamine and rizatriptan - used for migraine

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digoxin and warfarin - used for heart failure
cimetidine - used for too much stomach acid
rifampicin - used for tuberculosis
theophylline - used for asthma
mefloquine - used to prevent malaria

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aldesleukin - used for kidney cancer
alprostadil - used to help men get or keep an erection or to test for erection problems
oestrogens - used in hormone replacement therapy (HRT)
clonidine - used for high blood pressure and migraine. You must not stop taking clonidine
unless your doctor tells you to. If you have to stop taking it, your doctor will tell you how to do it.



Driving and using machines
Syprol is not likely to affect you being able to drive or use any tools or machines. However,
sometimes you may feel dizzy or tired while taking Syprol. If this happens, do not drive or use any
tools or machines and tell your doctor.
Important information about what is in Syprol Oral Solution
This medicine contains:
n Methyl and propyl parahydroxybenzoates. These may
cause an allergic reaction (the allergy may happen some
time after starting the medicine)
n Liquid maltitol. If your doctor has told you that you cannot
tolerate some sugars, see your doctor before taking this
medicine
n A colour, sunset yellow E110. Some people are allergic to these colours.

3. How to take Syprol Oral Solution
Taking this medicine
Take this medicine as your doctor or pharmacist has told you. Look on the label and ask the doctor
or pharmacist if you are not sure.
n This medicine contains 50mg of propranolol in each 5ml
n Take this medicine by mouth
n Do not stop taking this medicine unless your doctor tells you to stop.
Adults
The usual doses range from 30mg - 320mg daily depending on what condition you are taking the
medicine for.
Children
Your doctor will decide on the amount of Syprol to give to your child based on their weight.
Elderly
Your doctor will decide how much Syprol Oral Solution to give you. They may start you on a lower
dose.
If you take more Syprol Oral Solution than you should
Talk to your doctor or go to a hospital straight away.
If you forget to take Syprol Oral Solution
Do not take a double dose to make up for forgotten doses. Take your next dose as soon as you
remember. Then go on as before.
If you stop taking Syprol Oral Solution
Keep taking this medicine until your doctor tells you to stop. You may have to stop taking this
medicine gradually. Your doctor will help you do this.

Operations and Tests
Tell your doctor, dentist or nurse you are taking Syprol Oral Solution if:
n you are going to have an operation or an anaesthetic. This is because you can get low blood
pressure (hypotension) if you are given certain anaesthetics while you are taking Syprol Oral
Solution
n you are going to have any blood or urine tests.
Taking Syprol Oral Solution with food and drink
Do not drink alcohol while taking Syprol Oral Solution. This is because alcohol can change the way
the Syprol works.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, Syprol Oral Solution can cause side effects although not everybody gets them.
If you get any of the following side effects, see a doctor straight away:
n any kind of skin rash, flaking skin, boils or sore lips and mouth. You could also notice sudden
wheezing, fluttering or tightness of the chest or collapse.
This may mean you are having an allergic reaction to Syprol Oral Solution
n if you develop asthma or breathing problems.
If you get any of the following side effects, stop taking Syprol Oral Solution and see your doctor as
soon as possible:
Common (affects less than 1 in 10 people)
n slow heart beats.
Continued overleaf

SPC update 4.4/5/8

Rosemont Pharmaceuticals Ltd. Printed Packaging Origination and Approval
Product:

Syprol 50mg/5ml Oral Solution
Propranolol Hydrochloride

Date:

Strength:

50mg/5ml

Proof Number:

New Item Code:

SPC update 4.4/5/8

Page:

Previous Item Code:

P0565

New Pharmacode:

Design Icon:

-

Sugar-Free

YES

Cutter Ref:

-

Pack Size

150ml

Dimensions:

210 x 300mm (folded 150 x 30mm)

Number of 
colours used:

ONE

Black

24.07.12
THREE
2 of: 2

86
Barcode:

Keyline

Tick
applicable
box

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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