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Active substance(s): NEFOPAM HYDROCHLORIDE

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Ref: 0907/140514/1/F


Acupan 30mg Tablets / Nefopam Hydrochloride 30mg Tablets
(nefopam hydrochloride)
Patient Information Leaflet
Please read all of this leaflet carefully before you start taking this
medicine. If you have any futher questions or are not sure about anything,
please ask your doctor or your pharmacist. If any of the side effects get
serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others as it
may harm them, even if their symptoms are the same as yours. Ensure you
keep this leaflet because you may need to read it again.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently
taken any other medicines, including those obtained without prescription and
medicines listed below:
* Monoamine oxidase inhibitors (known as MAOIs) for depression. You
must tell your doctor if you are taking this medicine.
* Tricyclic antidepressants for depression
* Anticholinergics
* Sympathomimetics

Your medicine is called Acupan 30mg Tablets but will be referred to as
Acupan throughout this leaflet.

Tell your doctor or dentist if you are taking any of these medicines.

In this leaflet:
1 What Acupan is and what it is used for
2 Before you take Acupan
3 How to take Acupan
4 Possible side effects

Pregnancy and breast-feeding
Acupan should not be taken during pregnancy or while breast-feeding.
Ask your doctor or pharmacist for advice before taking any medicine. Please
contact your doctor if you become pregnant during your treatment.
Driving and using machines
Acupan can cause drowsiness. Do not drive or operate heavy machinery
unless you know how Acupan affects you.

5 How to store Acupan
6 Further information

What Acupan is and what it is used for

Acupan belongs to a group of medicines called analgesics, commonly known
as pain killers or pain relievers.
The active substance, nefopam hydrochloride, interrupts the pain messages
being sent to your brain, and it also acts in your brain to stop pain messages
being felt. This means that Acupan does not stop the pain from happening,
but you will not be able to feel the pain as much.
Acupan is used to relieve of acute and chronic pain (for example pain after
an operation, dental pain, joint or muscle pain, after an injury, or pain caused
by cancer). Acupan should not be used to treat the pain from a heart attack.


Before you take Acupan

Do not take Acupan if:
* you are a child under 12 years old
* you have ever had an allergic reaction to nefopam hydrochloride or any of
the ingredients resulting in a skin rash, swelling of the face or difficulty in
breathing (see section 6. Further Information)
* you are taking monoamine oxidase inhibitors (MAOIs) to treat your
* you have, or have ever had, epilepsy (fits).
Take special care with Acupan
If the answer to any of the following is ‘yes’, you must tell your doctor
– your doctor may decide to alter your treatment.
- Are you pregnant or breast feeding?
- Do you have severe problems with your liver or kidneys?
- Do you have, or have you had in the past difficulty passing urine?
- Are you taking other medicines?

How to take Acupan

Dosage for adults:
Always take Acupan exactly as your doctor has told you.
The usual initial dose is two tablets taken three times a day. Your doctor may
increase this dose up to a maximum of three tablets taken three times a day
according to your needs.
Ask your doctor or pharmacist if:
* you are not sure how many tablets to take or when to take them
* you think the effect is too strong or too weak
Swallow your tablets with water.
Dosage for children:
Over 12 years - as per adults (see above).
Under 12 years - Acupan 30mg Tablets should not be taken by children
under 12.
Dosage for elderly patients:
In elderly patients the doctor may reduce the number of tablets that are
Dosage for patients with kidney and/or liver problems:
Your doctor may adjust the dose of Acupan depending upon your condition.
If you take more Acupan than you should
If you accidentally take more tablets than your prescribed dose, tell your
doctor or pharmacist immediately and if necessary contact your nearest
hospital casualty department. Remember to take the pack and any remaining
medicines with you.
If you forget to take Acupan
If you forget to take Acupan, take it as soon as you remember. Do not take
more than one dose at the same time to make up for the forgotten dose.

Ref: 0907/140514/1/B


Acupan 30mg Tablets / Nefopam Hydrochloride 30mg Tablets
(nefopam hydrochloride)
Patient Information Leaflet (continued)
If you stop taking Acupan
Do not stop taking Acupan without first checking with your doctor.
If you have any further questions on the use of this product, ask your doctor
or pharmacist.


Possible side effects

Like all medicines Acupan can cause side effects, although not everybody
gets them.
Please stop taking this medicine and contact your doctor as soon as
possible if you experience the following rare reactions:
* swelling of the skin and soft tissue around the eyes, nose and throat
(angioedema), or allergic reactions (anaphylaxis).
Side-effects which may occur most frequently include:
* feeling sick
* feeling light-headed, dizzy or nervous, or fainting
* a decrease in blood pressure
* numbness or tingling in the extremities
* a dry mouth
* having difficulty passing urine
* convulsions, tremor
* confusion
* hallucinations (seeing things that aren’t there).
Other side-effects which may occur less frequently include:
* being sick
* abdominal pain or diarrhoea
* blurred vision
* drowsiness
* sweating
* trouble sleeping
* headaches
* awareness of your heartbeat (palpitations), or a fast heartbeat
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card Scheme at
By reporting side effects, you can help provide more information on the
safety of this medicine.


How to store Acupan

Do not use this medicine after the date shown on the carton label or blister
strip. If your doctor tells you to stop taking this medicine, return any unused
tablets to your pharmacist for safe disposal. Only keep this medicine if your
doctor tells you to. If your tablets become discoloured or show any other
signs of deterioration, consult your pharmacist (chemist) who will tell you
what to do.

Do not store above 30°C.
Keep out of the sight and reach of children.
Remember this medicine is for you. It can only be prescribed to you by a
doctor. Never give you medicine to other people. It may harm them, even if
their symptoms are the same as yours. This leaflet does not tell you
everything about your medicine. If you have any questions or are not sure
about anything to do with this
medicine, ask a doctor or pharmacist (chemist). He/she will have additional
information and will be able to advise you.


Further information

What this medicine contains:
Each tablet contains 30mg of Nefopam Hydrochloride as the active
ingredient. Acupan also contains the following inactive ingredients: dibasic
calcium phosphate dihydrate, microcrystalline cellulose, pregelatinised maize
starch, magnesium stearate, hydrogenated vegetable oil, colloidal silicon
dioxide, hydroxypropyl methylcellulose 2910 and titanium dioxide.
What this medicine looks like and contents of the pack
Acupan are white, round, film-coated tablets, marked ‘APN’ on one side and
plain on the reverse. They come in blister packs of 30 and 90 tablets.
Manufacturer and Licence Holder
This medicine is manufactured by 3M Health Care Limited, Derby Road,
Loughborough, Leicestershire, LE11 1EP and is procured from within the EU
and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18,
Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.


PL 15184/0907

Acupan 30mg Tablets

Acupan is a registered trademark of Meda AB.
Revision date: 14/05/14

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.