MORPHINE ORAL SOLUTION 10MG/5ML

Active substance: MORPHINE SULPHATE

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D01095

Morphine Oral Solution 10mg / 5ml
Morphine Sulphate BP
Read all this leaflet carefully before you use Morphine Oral
Solution
• Keep this leaflet. You may need to read it again
• If you have any further questions, please ask your doctor
or pharmacist
• This medicine has been prescribed for you personally. Do
not pass it on to others, it may harm them even if their
symptoms are the same as yours
• If any of the side effects become serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor or pharmacist

In this leaflet:
1. What Morphine Oral Solution is and what it is used for
2. Before you take Morphine Oral Solution
3. How to take Morphine Oral Solution
4. Possible side effects
5. Storing Morphine Oral Solution
6. Further information

1. What Morphine Oral Solution is and what it is
used for
Morphine is an alkaloid with powerful pain relieving properties.
This medicine is used for the relief of severe pain.

2. Before you take Morphine Oral Solution
You should not take Morphine Oral Solution if:
• you are allergic (hypersensitive) to Morphine or any of the
ingredients of this medicine (listed in section 6 & ‘Important
information about some of the ingredients, column 2).
• you are having an asthma attack, shallow breathing and
other breathing difficulties
• you are suffering from severe headaches. This could be a sign
of raised pressure inside your skull
• you have suffered a head injury
• you suffer from alcoholism
• you have fits (convulsions)
• you have any liver problems
• you have paralytic ileus (loss of intestinal movement)
• you are taking or have in the last two weeks taken
medication to treat depression such as Monoamine-Oxidase
Inhibitors (MAOI's) (see 'Taking other medicines')
• you have something called 'phaeochromocytoma'. This is a
rare tumour which is not malignant
• the person taking this medicine is in a deep and prolonged
unconscious state (coma)
Take special care with Morphine Oral Solution
Tell your doctor if:
• You have a particular lung problem that causes shortness of
breath called emphysema
• you have any prostate problems
• you have an under-active adrenal gland (adrenocortical
insufficiency)
• you have asthma
• you have long term (chronic) liver or kidney problems
• you have an under-active thyroid gland or swelling of your
skin (myxoedema)
• you have had an operation in the last 24 hours
• you are extremely overweight
• your spine is unusually curved (kyphoscoliosis)
• you have shock (circulatory failure)
• you suffer from bowel problems

Taking other medicines:
Please tell your doctor if you are taking or have recently taken
any other medicines, including those obtained without
prescription.
Morphine Oral Solution must not be used with drugs used to
treat severe depression, such as phenelzine or moclobemide, or if
you are within 2 weeks of discontinuing them.
These drugs are known as Monoamine Oxidase Inhibitors
(MAOI’s),
Other medicines which may interact with Morphine Oral Solution
include:
• medicines to help you sleep, make you feel less anxious or
calm you down such as tranquilisers, anaesthetics, hypnotics,
sedatives, antipsychotics, tricyclic antidepressants
(clomipramine) and alcohol
• CNS depressants (drugs that act on the brain to cause
drowsiness)
• medicines for controlling heart rhythm such as esmolol and
mexiletine
• medicines to treat stomach ulcers, indigestion or heartburn
such as cimetidine
• medicines for feeling sick (nausea) and being sick (vomiting)
such as domperidone and metoclopramide
• medicines to treat HIV infections such as ritonavir
• medicines used to treat fungal infections such as
voriconazole
• medicines to treat epilepsy and long lasting pain caused by
damage to the nerves such as gabapentin
Pregnancy and breast-feeding:
Morphine Oral Solution should not be used during pregnancy
(especially during the first three months) as Morphine is known
to cross the placenta.
This medicine should also not be used whilst breast-feeding as
Morphine is known to be present in breast milk and it may cause
respiratory problems in newborn babies.
If you take this medicine for a long time whilst pregnant, it may
mean that the baby will be born showing signs of withdrawal.
Stomach upset and risk of inflammation of the lungs in mother
when giving birth.
Effects on the ability to drive and use machinery:
This medicine can affect your ability to drive and operate
machinery. This effect is even more enhanced, when used in
combination with alcohol or CNS depressants (medicines for
sleeping disorders and anxiety). Do not drive or operate
machinery if you feel drowsy or cannot think clearly.
Important information about some of the ingredients:
• If you have been told by your doctor that you have an
intolerance to some sugars (sucrose), contact your doctor
before taking this medicinal product
• sodium propyl hydroxybenzoate (E217) and sodium methyl
hydroxybenzoate (E219) may cause an allergic reaction which
could be delayed. Although rare, you may have difficulty
breathing.
• Morphine Oral Solution contains alcohol which may be
harmful to those suffering from alcoholism.
Continued overleaf

DEVELOPMENT ARTWORK
Component Code: D01095
Paper size: 170 x 220mm
Version Control Date

By

Version A Created 09/11/09 AC
Version B

10/11/09 AC

Version C

15/12/09 HM

Version D
Version E
Version F
Version G
Version H
Version I
Version J
Version K
Version L
Version M
Version N
Grand Fromage Creative Ltd
60 Churchill Square, Kings Hill
West Malling, Kent ME19 4YU
t:+44 (0)1732 54 34 94
f:+44 (0)1732 54 34 04
e:studio@grand-fromage.co.uk

100mm Measurement Verification Bar

PATIENT LEAFLET: INFORMATION FOR THE USER

This medicine is for oral use
Adults:

Usual dose is one or two 5ml spoonfuls
(10 – 20mg) every 4 hours

Elderly and infirm patients: A reduced dose is recommended
Children: Under 1 year: not recommended
1 to 5 years: maximum of half a 5ml spoonful (5mg)
every 4 hours
6 to 12 years: maximum of one 5ml spoonful
(5-10mg) every 4 hours
If you forget to take Morphine Oral Solution
If you have missed a dose take it as soon as you remember unless
it is nearly time for your next dose. Then continue your normal
dose times. Do not take a double dose.
If you take more Morphine Oral Solution than you should:
If you take too much of your medicine seek immediate medical
advice from your doctor or your nearest hospital.
Symptoms of an overdose include sudden or unexpected
difficulty in breathing, pin-point pupils (the black circle in the
centre of your eyes (pupil) getting smaller) or a drop in blood
pressure. In the case of infants and children they may suffer fits
(convulsions).
In more severe cases, very high doses could cause your blood
circulation to slow down and cause unconsciousness for a long
time, o even death.
If you stop taking Morphine Oral Solution
You should not stop taking Morphine Oral Solution until advised
to do so by your doctor. If you stop treatment too suddenly you
may experience symptoms of withdrawal such as stomach pains,
feeling sick and feeling anxious. Your doctor will advise you how
to stop your treatment with Morphine Oral Solution.

4. Possible side effects
Like all medicines, Morphine Oral Solution can cause side effects
but not everyone gets them.
Repeated use of morphine can result in tolerance and
addiction
Serious side effects:
If any of the following symptoms occur contact your doctor or
nearest accident and emergency department immediately.
Symptoms of respiratory depression:
- breathing difficulties (weak, shallow breathing)
Symptoms of a serious allergic reaction:
• sudden wheeziness and tightness of chest
• swelling of eyelids, face or lips
• skin lumps or hives
• skin rash (red spots), itchiness, fever
• collapse
Other side effects that may occur include:
• confusion
• restlessness
• changes in mood
• drowsiness
• constipation
• dry mouth
• feeling sick (nausea)
• being sick (vomiting)
• facial flushing
















sweating
a fast heartbeat (tachycardia)
a slow heartbeat (bradycardia)
a fast and uneven heartbeat (palpitations)
reduced blood pressure
difficulty passing urine
lower abdomen spasms
the black circle in the centre of your eyes (pupil) getting
smaller (pin-point pupils)
a feeling of dizziness or spinning (vertigo)
seeing or hearing things that are not there (hallucinations)
tense muscles
lowered sex drive
lower body temperature (hypothermia)
severe headache. This could be a sign of raised pressure
inside your skull

DEVELOPMENT ARTWORK
Component Code: D01095
Paper size: 170 x 220mm
Version Control Date

By

Version A Created 09/11/09 AC

If any of the side effects get serious, or if you notice any side
effects not listed in this leaflet, please tell your doctor or
pharmacist.

Version B

10/11/09 AC

Version C

15/12/09 HM

5. Storing Morphine Oral Solution

Version D

Keep all medicines out of the reach and sight of children.

Version E

Do not use this product after the expiry date which is stated on
the carton. The expiry date refers to the last day of that month.
Keep container in the outer carton. Use within 90 days of first
opening.

Version F
Version G
Version H

Do not store above 25°C

Version I

Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment.

Version J
Version K
Version L

6. Further Information

Version M

What Morphine Oral Solution contains:
Active ingredient: Morphine Sulphate Ph Eur 10mg in each 5ml
of solution.
Other ingredients: sugar (sucrose), alcohol, disodium edetate,
sodium propyl hydroxybenzoate (E217), sodium methyl
hydroxybenzoate (E219), raspberry flavour, purified water and
may include hydrochloric acid.
Each 5ml dose of this solution contains 0.4ml of alcohol and
2.25g of sugar.

Version N
Grand Fromage Creative Ltd
60 Churchill Square, Kings Hill
West Malling, Kent ME19 4YU
t:+44 (0)1732 54 34 94
f:+44 (0)1732 54 34 04
e:studio@grand-fromage.co.uk

What Morphine Oral Solution looks like and contents of the
pack:
The clear, colourless solution is supplied in amber glass bottles
containing 100ml, 250ml, 300ml or 500ml.
Marketing Authorisation Holder and Manufacturer:
Martindale Pharmaceuticals Ltd. Bampton Road, Romford, Essex,
RM3 8UG, UK
Product Licence No.: PL 00156/0036
Date of approval: 11/2009
© Martindale Pharmaceuticals

100mm Measurement Verification Bar

Your doctor will decide on the dose and duration of your
therapy. Always follow the instructions of your doctor and
pharmacist. If you are changing from other types of morphine
medication your doctor may have to change your dose.

D01095

3. How to take Morphine Oral Solution

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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