MAXTREX TABLETS 2.5MG

Active substance: METHOTREXATE

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Package leaflet: Information for the user

Maxtrex

®

2.5mg Tablets

methotrexate
Read all of this leaflet carefully before you
start taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor
or pharmacist.
• This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
• If any of the side effects get serious, or if you notice
any side effects not listed in this leaflet, please tell
your doctor or pharmacist.

In this leaflet:
1. What Maxtrex Tablets are and what they are
used for
2. Before you take Maxtrex Tablets
3. How to take Maxtrex Tablets
4. Possible side effects
5. How to store Maxtrex Tablets
6. Further information

1. What Maxtrex Tablets are
and what they are used for
Maxtrex Tablets contain the active ingredient methotrexate. Methotrexate is referred to as a cytotoxic medicine. It is most commonly used to kill cells in tumours.
Maxtrex Tablets can be used to treat rheumatoid arthritis. It is usually used for patients who have tried
other treatments but their illness has not improved. In
the treatment of rheumatoid arthritis, methotrexate is
thought to stop or reduce inflammation by altering the
body’s defences.
Maxtrex Tablets can also be used to treat severe, uncontrolled psoriasis. It is usually used for patients who
have tried other treatments but their condition has not
improved.
Methotrexate helps patients with psoriasis by killing
the cells in the skin, which are growing too quickly.
It is these fast growing cells, which cause the raised
patches of skin in psoriasis.
Maxtrex is used to treat a wide range of tumours, in
particular:
• acute leukaemias,
• Non-Hodgkin’s lymphoma,
• soft tissue and bone sarcomas,
• solid tumours like breast, lung, head and neck,
bladder, cervical, ovarian and testicular cancer.
Maxtrex can be given alone or in combination with
other medicines.
You should consult your doctor if you are unsure why
you have been given Maxtrex 2.5mg Tablets.

2. Before you take Maxtrex
Tablets
Do not take Maxtrex Tablets if you:
• are allergic (hypersensitive) to methotrexate, or any
of the other ingredients of Maxtrex 2.5mg Tablets,
refer to Section 6.
• are pregnant, trying to become pregnant or breastfeeding. Methotrexate may harm your baby (see
section on Pregnancy). You and your partner should
avoid conception (becoming pregnant or fathering
children) for at least three months after your treatment with methotrexate has stopped.
• have severe liver problems, including fibrosis, cirrhosis and recent or active hepatitis.
• have severe kidney problems, including conditions
requiring kidney dialysis.
• have any serious blood problems including severe
anaemia and clotting problems.
• have a medical condition or are receiving medication which lowers your resistance to infection.
• are taking antibiotics which prevent the production
of folic acid (vitamin B9) such as co-trimoxazole,
which are used to treat bacterial infections.
• have an active infectious disease (e.g. fever, chills,
joint pain).

Take special care with Maxtrex Tablets
Medicines are not always suitable for everyone. Tell
your doctor before you take Maxtrex Tablets if you suffer from or have suffered in the past from any of the
following conditions;
• have any mild or moderate kidney disease,
• have any blood disorders or anaemia,
• have diarrhoea,
• have gastro-intestinal (digestive) problems,
• have or have ever suffered from mental illness,
• received or you are receiving radiotherapy (x-ray
treatment),
• have received any vaccinations recently or you are
due to have any, as methotrexate can reduce their
effect,

• have any symptoms or signs of infection,
• have excess fluid, between the lungs and chest
wall or abdominal swelling (ascites).

Regular Check–ups
Whilst being treated with this medicine your doctor
will want to monitor your progress on a weekly basis until your therapy is stable. Thereafter, you will
be monitored every 2 to 3 months, whilst taking the
medicine.
These checks may include taking blood and urine
samples to check your blood cells and to make sure
that your liver and kidneys are working properly. It is
important that you do not miss any blood tests.
There may also be a chest x-ray and a physical examination to check for swelling of your lymph nodes
(glands in your neck, armpits and groin). Any unusual
swellings should also be reported to your doctor.

Taking other medicines
Some medicines can affect the way Maxtrex Tablets
works, or Maxtrex Tablets can reduce the effectiveness of other medicines taken at the same time. These
include:
• vaccinations
• aspirin, ibuprofen, indometacin (NSAID’s, non-steroidal anti-inflammatory drugs) which are used for
pain or inflammation.
• antibiotics (used to treat bacterial infections e.g.
chloramphenicol, penicillin, sulphonamides, cotrimoxazole, trimethoprim and tetracyclines),
• thiazides (a group of diuretics used for the treatment of fluid retention e.g. bendroflumethiazide),
• hypoglycaemics (used for lowering blood sugar levels e.g. metformin),
• p-aminobenzoic acid, acitretin (used to treat psoriasis or skin disorders),
• diphenylhydantoins, phenytoin (used to treat epilepsy),
• probenicid, sulfinapyrazone (used to treat gout),
• vitamin preparations containing folic acid or similar
products,
• nitrous oxide (a gas used in general anaesthesia).
Please tell your doctor or pharmacist if you are taking
or have recently taken any other medicines, including
medicines obtained without a prescription.

Taking Maxtrex Tablets with food and drink
Alcohol should be avoided while receiving methotrexate.

Pregnancy and Breast-feeding
If you think you might be pregnant, or are planning to
get pregnant, tell your doctor before you take Maxtrex
Tablets.
Methotrexate can cause birth defects, harm unborn
babies or cause miscarriages and so it is very important that it is not given to pregnant patients or patients planning to become pregnant. It may also affect
women’s periods; they may become less frequent or
stop completely. Methotrexate can affect sperm and
egg production with the potential to cause birth defects. You and your partner should avoid conception
(becoming pregnant or fathering children) for at least
three months after your treatment with methotrexate
has stopped.
You should not take Maxtrex Tablets if you are breastfeeding.
Ask your doctor or pharmacist for advice before taking
any medicine.

Driving and using machines
Maxtrex Tablets may cause some side effects which
could affect your ability to drive or use machinery for
example drowsiness, loss of co-ordination or blurred
vision. If you experience these symptoms, do not drive
or use any tools or machinery. The full list of side effects are listed in Section 4.

Important information about some of the
ingredients of Maxtrex Tablets
Maxtrex Tablets contains lactose, a type of sugar. If
you have been told that you have an intolerance to
some sugars, contact your doctor before taking this
medicinal product.

3. How to take Maxtrex
Tablets
Always take Maxtrex Tablets exactly as your doctor
has instructed you. You should check with your doctor
or pharmacist if you are unsure. The usual dose is:

Dosage for rheumatoid arthritis:
Adults
You will usually take your tablets once a week on the
same day each week. The dose will normally be between 7.5 and 20mg. However, this may be changed
depending upon your response to treatment.
You will find more about MAXTREX on the back of
this leaflet.
Elderly
Elderly patients may need smaller doses of methotrexate.
110814-9

Children
Not recommended for use in children.

Dosage for psoriasis:
Adults
For severe psoriasis, the usual dose is 10 to 25mg
by mouth, once a week on the same day each week.
This should be adjusted according to your response to
treatment and side effects.
Elderly
No dosage adjustment required.
Children:
Not recommended for use in children.

Dosage for treatment of cancer:
Adults, the Elderly and Children
• Your doctor should give you a test dose of 5 to10mg
by injection one week before starting treatment.
• The doctor will calculate the dosage required from
your body surface area (m2), and the dose expressed as mg/m2.
• Maxtrex Tablets are usually given as single doses,
not exceeding 30mg/m2, for up to five days.
• A rest period of at least two weeks is advised between treatments, to allow recovery from any side
effects.
• Doses in excess of 100mg are usually given by injection by your doctor or physician.
• Doses of more than 70mg/m2 should not be administered without leucovorin rescue (folinic acid rescue) or blood levels of methotrexate being checked
24 to 48 hours after taking your medicine.
• These doses may be reduced if you are receiving
other medication. Your doctor will decide the correct dose for you, if you want more information you
should ask your doctor.
If you have the impression that the effect of Maxtrex
Tablets is too strong or too weak, talk to your doctor
or pharmacist.
Always take Maxtrex Tablets exactly as your doctor
has told you. You should check with your doctor or
pharmacist if you are still not sure.

If you take more Maxtrex Tablets than you
should
If you accidentally take too many Maxtrex Tablets contact your doctor at once or go to the nearest hospital
casualty department. Always take the labelled medicine package with you, whether there are any Maxtrex
Tablets left or not. Inappropriate intake resulting in
overdose can sometimes lead to death.

If you forget to take Maxtrex Tablets
If you forget to take a dose, take it as soon as you
remember if this is within two days. However, if you
have missed a dose by more than two days, please
contact your doctor for advice. Do not take a double
dose to make up for a missed dose.

If you stop taking Maxtrex Tablets
Do not stop taking Maxtrex Tablets unless your doctor
tells you to. Should you need to stop taking Maxtrex
Tablets, your doctor will have decided which is the
best method for you.
If you have any further questions on how to take this
product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, Maxtrex Tablets can cause side effects, although not everybody gets them.
Tell your doctor immediately if you experience any
of the following symptoms after taking this medicine.
Although they are very rare, these symptoms can be
serious.
• Severe skin rash that causes blistering, (this
can affect the mouth and tongue). These may be
signs of a condition known as Stevens Johnson
Syndrome. Your doctor will stop your treatment in
these cases.
• Persistent cough, pain or difficulty breathing or
become breathless; methotrexate can cause inflammation of the lungs.
• Skin rash and fever with swollen glands, particularly in the first two months of treatment, as these
may be signs of a hypersensitivity reaction.
• Sore throat, fever, chills or achiness; methotrexate can make you more likely to catch infections.
• Severe allergic reaction (anaphylactic reaction)
– although very rare you may experience a sudden itchy skin rash (hives), swelling of the hands,
feet, ankles, face, lips, mouth or throat (which
may cause difficulty in swallowing or breathing),
wheeze, and you may feel you are going to faint.
If this happens you should seek medical attention
immediately.

Other side effects that may occur are:






Drowsiness
Convulsions
Loss of coordination
Confusion
Liver damage (seen as yellowing of the skin and
whites of the eye)
• Kidney damage

• Low levels of white and red blood cells and cells
that clot blood
• Infection, reduced resistance to infection
• Abnormal red blood cell function
• May encourage the development of diabetes
• Inability to move
• Inability to move in one half of the body
• Dizziness
• Headaches, Blurred vision
• Loss of ability to speak or understand speech
• Slow thought process
• Mood alteration
• Black or tarry stools
• Skin ulcers and erosions of inflamed areas, in psoriasis patients
• Damaged skin becomes inflamed on re-exposure
to radiation and sunlight
• Reduced ability to become pregnant and reduced
ability to father children
• Blood in the urine
• Raised liver enzymes
• Weakening or softening of bones
• Unusual sensations in the head
• Anorexia (eating disorders)
• Loss of interest in, or inability to have sex
• Stomach pains and soreness of the mouth, throat
and lips
• Inflamed blood vessels
• Feeling sick, being sick and/or diarrhoea
• Irritation or swelling of the vaginal tissues
• Vaginal ulcers
• Pain or difficulty in passing urine
• The need to pass urine more often than usual
• Joint and muscle pain
• Chills and fever
• Changes in skin colouration
• Hair loss
• Red spots on the skin, skin lesions, acne, boils
• Flaking skin, redness
• Itchiness and rash
• Sensitivity to light
• Eye irritation
• Tiredness
• General feeling of illness
• Other metabolic changes
If any of the side effects gets serious, or if you notice
any side effects not listed in this leaflet, please tell
your doctor or pharmacist.

5. How to store Maxtrex
Tablets
Keep out of the reach and sight of children. Keep the
blister in the outer carton in order to protect from light.
Do not use Maxtrex Tablets after the expiry date which
is stamped on the carton and label. The expiry date
refers to the last day of that month.
Medicines should not be disposed of via wastewater
or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Further Information
What Maxtrex Tablets contains
Each tablet contains 2.5mg of the active ingredient
methotrexate.
The other ingredients are maize starch, lactose,
pregelatinised starch, polysorbate 80, microcrystalline
cellulose, magnesium stearate and purified water.

What Maxtrex Tablets looks like and
contents of the pack
Maxtrex 2.5mg Tablets are yellow, round in shape and
have ‘M2.5’ written on one side of the tablets.
Maxtrex Tablets are available in plastic bottles containing 100 tablets.
Maxtrex tablets are also available in packs containing
2 blisters with 12 tablets in each blister.

Marketing Authorisation Holder
Pharmacia Limited
Ramsgate Road
Sandwich
Kent, CT13 9NJ
United Kingdom

Manufacturer
Orion Corporation
Farmos,
PO Box 425,
SF 20101,
Turku
Finland

Company Contact address:
If you have any comments on the way this leaflet is
written, please contact Medical Information at Pfizer
Limited in Walton Oaks, Tadworth, Surrey, Tel :01304
616161.
This leaflet was last updated April 2012
MX 6_0

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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