MADOPAR CR 125 CAPSULES

Active substance: LEVODOPA

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PACKAGE LEAFLET: INFORMATION FOR THE USER
MADOPAR® CR ‘125’ CAPSULES
MODOPAR® CR ‘125’ CAPSULES
( levodopa and benserazide (as hydrochloride) )
This product is available in the above names but will be referred to
as Madopar CR throughout this leaflet.
Please read all of this leaflet carefully before you start taking
this medicine.
 Keep this leaflet. You may need to read it again
 If you have any further questions, ask your doctor or pharmacist.
 This medicine has been prescribed for you. Do not pass it on to
others. It may harm them even if their symptoms are the same
as yours.
 If any of the side effects become serious or troublesome, or if
you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.
In this leaflet:
1. What Madopar CR is and what it is used for
2. Before you take Madopar CR
3. How to take Madopar CR
4. Possible side effects
5. How to store Madopar CR
6. Further information
1.

What Madopar CR is and what it is used for

Madopar CR capsules contain two medicines called levodopa and
benserazide. They are used to treat Parkinson’s disease.
People with Parkinson’s disease do not have enough dopamine in
certain parts of their brains. This can result in slow movements, stiff
muscles and tremor.
Madopar CR works like this:
 In your body the levodopa is changed into dopamine.
Dopamine is the active medicine that is needed in your brain to
help Parkinson’s disease.
 The benserazide allows more of the levodopa you take to get
into your brain, before it is changed into dopamine.
The capsules are designed to release the medicines into your body
slowly. This is why they are called ‘CR’ which stands for ‘controlled
release’.
2.

Before you take Madopar CR

Do not take Madopar CR if:
 You are allergic (hypersensitive) to levodopa, benserazide or
any of the other ingredients of Madopar CR (listed in Section 6:
Further information).
 You have a problem with the pressure in your eyes called
‘narrow-angle glaucoma’.
 You have serious problems with your kidneys, liver or heart.
 You have a serious problem with your hormones, such as an
overactive thyroid gland.
 You have a severe mental problem which may make you
distressed and anxious, or may make you lose contact with
reality and become unable to think and judge clearly.
 You have depression and have taken a medicine called a
‘non-selective monoamine oxidase inhibitor’ (MAOI) in the last
14 days. These medicines include isocarboxazid and
phenelzine. See the section on ‘Taking other medicines’.
 You are pregnant or trying to become pregnant. See the section
on ‘Pregnancy and breast-feeding’.
 You are under 25 years of age. This is because your bones may
not have finished developing.
 You have ever had skin cancer.
Do not take Madopar CR if any of the above applies to you. If you
are not sure, talk to your doctor or pharmacist before you take
Madopar CR.
Take special care with Madopar CR
Check with your doctor or pharmacist before you take Madopar CR
if:
 You have a problem with the pressure in your eyes called
‘wide-angle glaucoma’.
 You have problems with your hormones, kidneys, lungs or liver.
 You have diabetes (high blood sugar).
 You have heart problems, particularly an uneven heart beat
(arrhythmia) or you have had a heart attack.
 You have any mental illness, such as depression.
 You have a ‘peptic ulcer’, an ulcer in your stomach, or in the
tube leading from it (‘duodenal ulcer’).
 You have something called ‘osteomalacia’ which causes
problems with the strength of your bones.
If any of the above apply to you, or if you are not sure, talk to your
doctor or pharmacist before you take Madopar CR.
Tell your doctor if you or your family/carer notices you are
developing urges or cravings to behave in ways that are unusual for
you or you cannot resist the impulse, drive or temptation to carry out
certain activities that could harm yourself or others.

These behaviours are called impulse control disorders and can
include addictive gambling, excessive eating or spending, an
abnormally high sex drive or a an increase in sexual thoughts or
feelings. Your doctor may need to review your treatments.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines. This includes medicines that
you buy without a prescription and herbal medicines. This is
because Madopar CR can affect the way some medicines work.
Also some other medicines can affect the way Madopar CR works.
Do not take Madopar CR if you have taken a medicine for
depression called a ‘non-selective monoamine oxidase
inhibitor’ (MAOI) in the last 14 days.
These medicines include isocarboxazid and phenelzine. If this
applies to you, do not take Madopar CR and ask your doctor or
pharmacist for advice.
In particular, tell your doctor or pharmacist if you are taking the
following medicines:
 Other medicines for Parkinson’s disease, such as amantadine,
‘anticholinergics’ called orphenadrine and benzhexol, ‘dopamine
agonists’ called pergolide and ropinirole and a ‘COMT inhibitor’
called entacaprone.
 Ferrous sulphate (used to treat low levels of iron in the blood).
 Antacids (used for stomach acid if you have indigestion).
 Metoclopramide (used to treat problems with digestion).
 Phenothiazines - such as chlorpromazine, promazine and
prochloroperazine (used to treat mental illness).
 Thioxanthenes - such as flupentixol and zuclopenthixol (used to
treat mental illness).
 Butyrophenones - such as haloperidol and benperidol (used to
treat mental illness).
 Diazepam (used to treat anxiety and insomnia).
 Tetrabenazine (used to help problems controlling your muscle
movement).
 Papaverine (used to improve blood flow around the body).
 Treatment for high blood pressure (hypertension), in particular
reserpine.
 ‘Sympathomimetics’ – such as epinephrine, norepinephrine and
isoproterenol (used to treat problems with your heart or asthma).
 Amphetamines - medicines used for attention deficit disorder,
feeling sleepy during the day (narcolepsy) or to help control
appetite and weight gain.
Madopar CR contains soyabean. If you are allergic to peanut or
soya, do not use this medicinal product.
Operations
If you are going to have an operation, tell the doctor that you are
taking Madopar CR. This is because you may need to stop taking it
before you have a general anaesthetic.
Tests
If you need to have tests on your blood or urine, tell the doctor or
nurse that you are taking Madopar CR. This is because the
medicine may affect the results of some tests.
Pregnancy and breast-feeding
Do not take Madopar CR if you are pregnant, trying to get pregnant
or breast-feeding. This is because Madopar CR may affect your
baby. It is important for women to use contraception while taking the
medicine.
If you get pregnant while taking Madopar CR, talk to your doctor
straight away.
Driving and using machines
Talk to your doctor about driving and using machines or tools, when
you take Madopar CR. This is because one of the medicines in
Madopar CR, levodopa, can make you feel very sleepy. This can
happen very quickly, even during the day.
You must not drive or use machines if this happens to you. If you
are in any doubt about whether you can do a particular activity, talk
to your doctor.
3.

How to take Madopar CR

Always take Madopar CR exactly as your doctor has told you. You
should check with your doctor if you are not sure. How much you
take and when you take it is different for different people.
 Swallow the capsules whole with a little water (do not crush or
chew them).
 Take them with or without food.
Patients NOT already treated with levodopa:
 The usual starting dose is 1 capsule (100 mg levodopa), three
times a day with meals.
 The starting dose should not be more than 6 capsules (600 mg
levodopa) a day.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you.
 Some people may also need to take another medicine for
Parkinson’s disease with their first morning dose of Madopar
CR. This is because Madopar CR releases the medicines slowly
into the body.

Patients already treated with levodopa:
 Your doctor will start by giving you one Madopar CR capsule to
replace each 100 mg of levodopa you have been taking.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you. This may take up to 4 weeks.
 At the start of treatment your condition may become worse, until
the right dose is found for you. Your doctor may want to
supervise you closely during this time.
If you forget to take Madopar CR
 If you forget to take a dose, skip the missed dose. Then take the
next dose when it is due.
 Do not take a double dose (two doses at the same time) to make
up for a forgotten dose.
Stopping Madopar CR
You must not stop taking your capsules without talking to your
doctor first. This is because if you stop taking the capsules suddenly
it can cause something called ‘neuroleptic malignant-like
syndrome’ (NMLS). Early signs include increased shaking, sudden
high body temperature and muscle problems including stiffness and
trouble with balance and keeping upright (postural instability)
especially if seen with sweating, paleness and fast heart beat.
NMLS can be life threatening.
If the above apply to you, talk to a doctor or go to a hospital straight
away.
If you take more Madopar CR than you should
If you take more Madopar CR than you should, talk to a doctor or go
to a hospital straight away. Take the medicine pack with you. The
following effects may happen if you have taken more capsules than
you should: changes in your heart beat, confusion, difficulty
sleeping, feeling or being sick and unusual movements of different
parts of the body that you cannot control.
If someone else takes your Madopar CR capsules by mistake, they
should talk to a doctor or go to a hospital straight away.
If you have any further questions on the use of this medicine, ask
your doctor or pharmacist.
4.

Possible side effects

Like all medicines Madopar CR can cause side effects, although not
everyone will get them.
See your doctor as soon as possible if you get the following
side effects:
 Allergic reactions. The signs include a rash and feeling itchy.
 Heart beat that is uneven or is faster or slower than normal.
 Bleeding in your stomach or intestines. You may see blood in
your stools (they may look black and tarry) or blood when you
are sick (this may look like coffee grounds).
 Low numbers of all types of white blood cells. The signs include
infections of your mouth, gums, throat and lungs.
 Reduced numbers of red blood cells, white blood cells and
platelets in your blood. This may make you feel tired, get
infections more easily, or bruise more easily.
 Low numbers of platelets in your blood. The signs include
bruising easily and nose bleeds.
Other possible side effects:
Stomach and gut:
 Loss of appetite, feeling sick or being sick or diarrhoea,
particularly at the start of your treatment. To help with this, your
doctor may tell you to take Madopar CR with some food or drink
or increase your dose more slowly.
Heart and circulation:
 Feeling dizzy when you stand up. This usually gets better if your
dose is lowered.
Blood:
 Low numbers of red blood cells (anaemia). The signs include
feeling tired, pale skin, palpitations (a fluttering sensation in your
heart) and being short of breath.
 Changes to your liver or blood - shown in a blood test.
Mental problems:
 Feeling excited, anxious, agitated, depressed, aggressive or
disorientated (the feeling of being lost).
 Believing things which are not true, hallucinations (seeing and
possibly hearing things that are not really there) or losing contact
with reality.
 Feeling sleepy, sometimes during the daytime.
 Falling asleep suddenly.
 Having difficulty sleeping.

Impulse Control Disorders:
You may experience an inability to resist the impulse to perform an
action that could be harmful, which may include:
· Strong impulse to gamble excessively despite serious personal or
family consequences.
· Altered or increased sexual interest and behaviour of significant
concern to you or to others, for example an increased sexual drive.
· Uncontrollable excessive shopping or spending
· Binge eating (eating large amounts of food in a short time period)
or compulsive eating (eating more food than normal and more than
is needed to satisfy your hunger).
Tell your doctor if you experience any of these behaviours;
they will discuss ways of managing or reducing the symptoms
Others:
Unusual movements of different parts of your body which you
cannot control. This may affect your hands, feet, face or tongue.
Your doctor may change your dose of Madopar CR to help with
these effects.
 Changes to how things taste or a loss of taste.
 Redness of the face or neck.
 Sweating.
 Your urine (water) may become slightly red. This is not a cause
for concern. It is caused by your body getting rid of the medicine.


If any of the side effects become serious or troublesome, or if you
notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
You may experience the following side effects:
 inability to resist the impulse to perform an action that could be
harmful, which may include:
 Strong impulse to gamble excessively despite serious
personal or family consequences.
 Altered or increased sexual interest and behaviour of
significant concern to you or to others, for example, an
increased sexual drive.
 uncontrollable excessive shopping or spending
 binge eating (eating large amounts of food in a short time
period) or compulsive eating (eating more food than
normal and more than is needed to satisfy your hunger)
Tell your doctor if you experience any of these behaviours;
they will discuss ways of managing or reducing the symptoms
5.

How to store Madopar CR





Do not store above 25ºC. Protect from moisture.
Keep out of the sight and reach of children.
Do not use Madopar CR after the expiry date printed on the
pack.
 Do not throw away any left over capsules. Instead, return them
to your pharmacist so that they can be disposed of carefully.
Only keep them if your doctor tells you to.
If you notice the capsules become discoloured or show any signs of
deterioration, you should seek the advice of your pharmacist.
6.

Further information

What Madopar CR contains
 This medication contains the active ingredients levodopa
(100mg) and benserazide (25mg) (as the hydrochloride).
 The inactive ingredients contained in these capsules are
hydroxypropylmethylcellulose, hydrogenated castor oil (Sterotex
K), calcium hydrogen phosphate, mannitol, povidone, talc,
magnesium stearate, gelatin, indigo carmine (E132), titanium
dioxide (E171), yellow iron oxide (E172) and red printing ink.
What Madopar CR looks like and contents of the pack
Your capsules are dark green and light blue controlled release
capsules, marked ‘ROCHE’ in red.
Madopar CR is available in a plastic container containing 60
capsules.
This product is manufactured by:
ROCHE 30, cours de I’Ile Seguin 92100 Boulogne-Billancourt,
France. Procured within the EU. Parallel Import Product Licence
holder: G Pharma Ltd, Unit 4, Dakota Avenue, Dakota Park,
Salford M50 2PU.
PL 16369/0317

POM

Madopar CR ‘125’ Capsules
Modopar CR ‘125’ Capsules
19/05/2014
‘MADOPAR’ is a registered trademark of Roche.

PACKAGE LEAFLET: INFORMATION FOR THE USER
MADOPAR® CR ‘125’ CAPSULES
MODOPAR® CR ‘125’ CAPSULES
( levodopa and benserazide (as hydrochloride) )
This product is available in the above names but will be referred to
as Madopar CR throughout this leaflet.
Please read all of this leaflet carefully before you start taking
this medicine.
 Keep this leaflet. You may need to read it again
 If you have any further questions, ask your doctor or pharmacist.
 This medicine has been prescribed for you. Do not pass it on to
others. It may harm them even if their symptoms are the same
as yours.
 If any of the side effects become serious or troublesome, or if
you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.
In this leaflet:
1. What Madopar CR is and what it is used for
2. Before you take Madopar CR
3. How to take Madopar CR
4. Possible side effects
5. How to store Madopar CR
6. Further information
1.

What Madopar CR is and what it is used for

Madopar CR capsules contain two medicines called levodopa and
benserazide. They are used to treat Parkinson’s disease.
People with Parkinson’s disease do not have enough dopamine in
certain parts of their brains. This can result in slow movements, stiff
muscles and tremor.
Madopar CR works like this:
 In your body the levodopa is changed into dopamine.
Dopamine is the active medicine that is needed in your brain to
help Parkinson’s disease.
 The benserazide allows more of the levodopa you take to get
into your brain, before it is changed into dopamine.
The capsules are designed to release the medicines into your body
slowly. This is why they are called ‘CR’ which stands for ‘controlled
release’.
2.

Before you take Madopar CR

Do not take Madopar CR if:
 You are allergic (hypersensitive) to levodopa, benserazide or
any of the other ingredients of Madopar CR (listed in Section 6:
Further information).
 You have a problem with the pressure in your eyes called
‘narrow-angle glaucoma’.
 You have serious problems with your kidneys, liver or heart.
 You have a serious problem with your hormones, such as an
overactive thyroid gland.
 You have a severe mental problem which may make you
distressed and anxious, or may make you lose contact with
reality and become unable to think and judge clearly.
 You have depression and have taken a medicine called a
‘non-selective monoamine oxidase inhibitor’ (MAOI) in the last
14 days. These medicines include isocarboxazid and
phenelzine. See the section on ‘Taking other medicines’.
 You are pregnant or trying to become pregnant. See the section
on ‘Pregnancy and breast-feeding’.
 You are under 25 years of age. This is because your bones may
not have finished developing.
 You have ever had skin cancer.
Do not take Madopar CR if any of the above applies to you. If you
are not sure, talk to your doctor or pharmacist before you take
Madopar CR.
Take special care with Madopar CR
Check with your doctor or pharmacist before you take Madopar CR
if:
 You have a problem with the pressure in your eyes called
‘wide-angle glaucoma’.
 You have problems with your hormones, kidneys, lungs or liver.
 You have diabetes (high blood sugar).
 You have heart problems, particularly an uneven heart beat
(arrhythmia) or you have had a heart attack.
 You have any mental illness, such as depression.
 You have a ‘peptic ulcer’, an ulcer in your stomach, or in the
tube leading from it (‘duodenal ulcer’).
 You have something called ‘osteomalacia’ which causes
problems with the strength of your bones.
If any of the above apply to you, or if you are not sure, talk to your
doctor or pharmacist before you take Madopar CR.
Tell your doctor if you or your family/carer notices you are
developing urges or cravings to behave in ways that are unusual for
you or you cannot resist the impulse, drive or temptation to carry out
certain activities that could harm yourself or others.

These behaviours are called impulse control disorders and can
include addictive gambling, excessive eating or spending, an
abnormally high sex drive or a an increase in sexual thoughts or
feelings. Your doctor may need to review your treatments.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines. This includes medicines that
you buy without a prescription and herbal medicines. This is
because Madopar CR can affect the way some medicines work.
Also some other medicines can affect the way Madopar CR works.
Do not take Madopar CR if you have taken a medicine for
depression called a ‘non-selective monoamine oxidase
inhibitor’ (MAOI) in the last 14 days.
These medicines include isocarboxazid and phenelzine. If this
applies to you, do not take Madopar CR and ask your doctor or
pharmacist for advice.
In particular, tell your doctor or pharmacist if you are taking the
following medicines:
 Other medicines for Parkinson’s disease, such as amantadine,
‘anticholinergics’ called orphenadrine and benzhexol, ‘dopamine
agonists’ called pergolide and ropinirole and a ‘COMT inhibitor’
called entacaprone.
 Ferrous sulphate (used to treat low levels of iron in the blood).
 Antacids (used for stomach acid if you have indigestion).
 Metoclopramide (used to treat problems with digestion).
 Phenothiazines - such as chlorpromazine, promazine and
prochloroperazine (used to treat mental illness).
 Thioxanthenes - such as flupentixol and zuclopenthixol (used to
treat mental illness).
 Butyrophenones - such as haloperidol and benperidol (used to
treat mental illness).
 Diazepam (used to treat anxiety and insomnia).
 Tetrabenazine (used to help problems controlling your muscle
movement).
 Papaverine (used to improve blood flow around the body).
 Treatment for high blood pressure (hypertension), in particular
reserpine.
 ‘Sympathomimetics’ – such as epinephrine, norepinephrine and
isoproterenol (used to treat problems with your heart or asthma).
 Amphetamines - medicines used for attention deficit disorder,
feeling sleepy during the day (narcolepsy) or to help control
appetite and weight gain.
Operations
If you are going to have an operation, tell the doctor that you are
taking Madopar CR. This is because you may need to stop taking it
before you have a general anaesthetic.
Tests
If you need to have tests on your blood or urine, tell the doctor or
nurse that you are taking Madopar CR. This is because the
medicine may affect the results of some tests.
Pregnancy and breast-feeding
Do not take Madopar CR if you are pregnant, trying to get pregnant
or breast-feeding. This is because Madopar CR may affect your
baby. It is important for women to use contraception while taking the
medicine.
If you get pregnant while taking Madopar CR, talk to your doctor
straight away.

Patients already treated with levodopa:
 Your doctor will start by giving you one Madopar CR capsule to
replace each 100 mg of levodopa you have been taking.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you. This may take up to 4 weeks.
 At the start of treatment your condition may become worse, until
the right dose is found for you. Your doctor may want to
supervise you closely during this time.
If you forget to take Madopar CR
 If you forget to take a dose, skip the missed dose. Then take the
next dose when it is due.
 Do not take a double dose (two doses at the same time) to make
up for a forgotten dose.
Stopping Madopar CR
You must not stop taking your capsules without talking to your
doctor first. This is because if you stop taking the capsules suddenly
it can cause something called ‘neuroleptic malignant-like
syndrome’ (NMLS). Early signs include increased shaking, sudden
high body temperature and muscle problems including stiffness and
trouble with balance and keeping upright (postural instability)
especially if seen with sweating, paleness and fast heart beat.
NMLS can be life threatening.
If the above apply to you, talk to a doctor or go to a hospital straight
away.
If you take more Madopar CR than you should
If you take more Madopar CR than you should, talk to a doctor or go
to a hospital straight away. Take the medicine pack with you. The
following effects may happen if you have taken more capsules than
you should: changes in your heart beat, confusion, difficulty
sleeping, feeling or being sick and unusual movements of different
parts of the body that you cannot control.
If someone else takes your Madopar CR capsules by mistake, they
should talk to a doctor or go to a hospital straight away.
If you have any further questions on the use of this medicine, ask
your doctor or pharmacist.
4.

Possible side effects

Like all medicines Madopar CR can cause side effects, although not
everyone will get them.
See your doctor as soon as possible if you get the following
side effects:
 Allergic reactions. The signs include a rash and feeling itchy.
 Heart beat that is uneven or is faster or slower than normal.
 Bleeding in your stomach or intestines. You may see blood in
your stools (they may look black and tarry) or blood when you
are sick (this may look like coffee grounds).
 Low numbers of all types of white blood cells. The signs include
infections of your mouth, gums, throat and lungs.
 Reduced numbers of red blood cells, white blood cells and
platelets in your blood. This may make you feel tired, get
infections more easily, or bruise more easily.
 Low numbers of platelets in your blood. The signs include
bruising easily and nose bleeds.
Other possible side effects:

Driving and using machines
Talk to your doctor about driving and using machines or tools, when
you take Madopar CR. This is because one of the medicines in
Madopar CR, levodopa, can make you feel very sleepy. This can
happen very quickly, even during the day.
You must not drive or use machines if this happens to you. If you
are in any doubt about whether you can do a particular activity, talk
to your doctor.
3.

How to take Madopar CR

Always take Madopar CR exactly as your doctor has told you. You
should check with your doctor if you are not sure. How much you
take and when you take it is different for different people.
 Swallow the capsules whole with a little water (do not crush or
chew them).
 Take them with or without food.
Patients NOT already treated with levodopa:
 The usual starting dose is 1 capsule (100 mg levodopa), three
times a day with meals.
 The starting dose should not be more than 6 capsules (600 mg
levodopa) a day.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you.
 Some people may also need to take another medicine for
Parkinson’s disease with their first morning dose of Madopar
CR. This is because Madopar CR releases the medicines slowly
into the body.

Stomach and gut:
 Loss of appetite, feeling sick or being sick or diarrhoea,
particularly at the start of your treatment. To help with this, your
doctor may tell you to take Madopar CR with some food or drink
or increase your dose more slowly.
Heart and circulation:
 Feeling dizzy when you stand up. This usually gets better if your
dose is lowered.
Blood:
 Low numbers of red blood cells (anaemia). The signs include
feeling tired, pale skin, palpitations (a fluttering sensation in your
heart) and being short of breath.
 Changes to your liver or blood - shown in a blood test.
Mental problems:
 Feeling excited, anxious, agitated, depressed, aggressive or
disorientated (the feeling of being lost).
 Believing things which are not true, hallucinations (seeing and
possibly hearing things that are not really there) or losing contact
with reality.
 Feeling sleepy, sometimes during the daytime.
 Falling asleep suddenly.
 Having difficulty sleeping.

Impulse Control Disorders:
You may experience an inability to resist the impulse to perform an
action that could be harmful, which may include:
· Strong impulse to gamble excessively despite serious personal or
family consequences.
· Altered or increased sexual interest and behaviour of significant
concern to you or to others, for example an increased sexual drive.
· Uncontrollable excessive shopping or spending
· Binge eating (eating large amounts of food in a short time period)
or compulsive eating (eating more food than normal and more than
is needed to satisfy your hunger).
Tell your doctor if you experience any of these behaviours;
they will discuss ways of managing or reducing the symptoms
Others:
 Unusual movements of different parts of your body which you
cannot control. This may affect your hands, feet, face or tongue.
Your doctor may change your dose of Madopar CR to help with
these effects.
 Changes to how things taste or a loss of taste.
 Redness of the face or neck.
 Sweating.
 Your urine (water) may become slightly red. This is not a cause
for concern. It is caused by your body getting rid of the medicine.
If any of the side effects become serious or troublesome, or if you
notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
You may experience the following side effects:
 inability to resist the impulse to perform an action that could be
harmful, which may include:
 Strong impulse to gamble excessively despite serious
personal or family consequences.
 Altered or increased sexual interest and behaviour of
significant concern to you or to others, for example, an
increased sexual drive.
 uncontrollable excessive shopping or spending
 binge eating (eating large amounts of food in a short time
period) or compulsive eating (eating more food than
normal and more than is needed to satisfy your hunger)
Tell your doctor if you experience any of these behaviours;
they will discuss ways of managing or reducing the symptoms
5.

How to store Madopar CR





Do not store above 25ºC. Protect from moisture.
Keep out of the sight and reach of children.
Do not use Madopar CR after the expiry date printed on the
pack.
 Do not throw away any left over capsules. Instead, return them
to your pharmacist so that they can be disposed of carefully.
Only keep them if your doctor tells you to.
If you notice the capsules become discoloured or show any signs of
deterioration, you should seek the advice of your pharmacist.
6.

Further information

What Madopar CR contains
 This medication contains the active ingredients levodopa
(100mg) and benserazide (25mg) (as the hydrochloride).
 The inactive ingredients contained in these capsules are
hydroxypropylmethylcellulose, hydrogenated castor oil (Sterotex
K), calcium hydrogen phosphate, mannitol, povidone, talc,
magnesium stearate, gelatin, indigo carmine (E132), titanium
dioxide (E171), yellow iron oxide (E172) and red printing ink.
What Madopar CR looks like and contents of the pack
Your capsules are dark green and light blue controlled release
capsules, marked ‘ROCHE’ in red.
Madopar CR is available in a plastic container containing 60
capsules.
This product is manufactured by:
ROCHE 30, cours de I’Ile Seguin 92100 Boulogne-Billancourt,
France. Procured within the EU. Parallel Import Product Licence
holder: G Pharma Ltd, Unit 4, Dakota Avenue, Dakota Park,
Salford M50 2PU.
PL 16369/0317

POM

Madopar CR ‘125’ Capsules
Modopar CR ‘125’ Capsules
19/05/2014
‘MADOPAR’ is a registered trademark of Roche.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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