MADOPAR 50MG/12.5MG HARD CAPSULES
Active substance: LEVODOPA
View full screen / Print PDF » Download PDF ⇩
Transcript
Genisys-No. Printing Colour: Format: Folding Format: Type Size Drawing Norm make-up code
10142875 Pantone Black 148x594 mm
11 pt NP9344 GB 11.08.10 97.4.3524
Good To Print MMBFMM8W MMBFMM8Z
Version
Date
Signature
1
29.10.12
Heck
Patient Information Leaet
Madopar Madopar Madopar
50 mg/12.5 mg 100 mg/25 mg 200 mg/50 mg
Hard Capsules
Levodopa and benserazide (as hydrochloride)
Please read all of this leaet carefully before you start taking this medicine. Keep this leaet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them even if their symptoms are the same as yours. If any of the side effects become serious or troublesome, or if you notice any side effects not listed in this leaet, please tell your doctor or pharmacist. In this leaet: 1. What Madopar is and what it is used for 2. Before you take Madopar 3. How to take Madopar 4. Possible side effects 5. How to store Madopar 6. Further information
prescription and herbal medicines. This is because Madopar can affect the way some medicines work. Also some other medicines can affect the way Madopar works. Do not take Madopar if you have taken a medicine for depression called a nonselective monoamine oxidase inhibitor (MAOI) in the last 14 days. These medicines include isocarboxazid and phenelzine. If this applies to you, do not take Madopar and ask your doctor or pharmacist for advice. In particular, tell your doctor or pharmacist if you are taking the following medicines: Other medicines for Parkinsons disease, such as amantadine, anticholinergics called orphenadrine and benzhexol, dopamine agonists called pergolide and ropinirole and a COMT inhibitor called entacaprone. Ferrous sulphate (used to treat low levels of iron in the blood). Antacids (used for stomach acid if you have indigestion). Metoclopramide (used to treat problems with digestion). Phenothiazines - such as chlorpromazine, promazine and prochloroperazine (used to treat mental illness). Thioxanthenes - such as upentixol and zuclopenthixol (used to treat mental illness). Butyrophenones - such as haloperidol and benperidol (used to treat mental illness). Diazepam (used to treat anxiety and insomnia). Tetrabenazine (used to help problems controlling your muscle movement). Papaverine (used to improve blood ow around the body). Treatment for high blood pressure (hypertension), in particular reserpine. Sympathomimetics such as epinephrine, norepinephrine and isoproterenol (used to treat problems with your heart or asthma). Amphetamines - medicines used for attention decit disorder, feeling sleepy during the day (narcolepsy) or to help control appetite and weight gain. Operations If you are going to have an operation, tell the doctor that you are taking Madopar. This is because you may need to stop taking it before you have a general anaesthetic. Tests If you need to have tests on your blood or urine, tell the doctor or nurse that you are taking Madopar. This is because the medicine may affect the results of some tests. Pregnancy and breast-feeding Do not take Madopar if you are pregnant, trying to get pregnant or breast-feeding. This is because Madopar may affect your baby. It is important for women to use contraception while taking the medicine. If you get pregnant while taking Madopar, talk to your doctor straight away. Driving and using machines Talk to your doctor about driving and using machines or tools, when you take Madopar. This is because one of the medicines in Madopar, levodopa, can make you feel very sleepy. This can happen very quickly, even during the day. You must not drive or use machines if this happens to you. If you are in any doubt about whether you can do a particular activity, talk to your doctor.
1. What Madopar is and what it is used for
Madopar capsules contain two medicines called levodopa and benserazide. They are used to treat Parkinsons disease. People with Parkinsons disease do not have enough dopamine in certain parts of their brains. This can result in slow movements, stiff muscles and tremor. Madopar works like this: In your body the levodopa is changed into dopamine. Dopamine is the active medicine that is needed in your brain to help Parkinsons disease. The benserazide allows more of the levodopa you take to get into your brain, before it is changed into dopamine.
2. Before you take Madopar
Do not take Madopar if: You are allergic (hypersensitive) to levodopa, benserazide or any of the other ingredients of Madopar (listed in Section 6: Further information). You have a problem with the pressure in your eyes called narrow-angle glaucoma. You have serious problems with your kidneys, liver or heart. You have a serious problem with your hormones, such as an overactive thyroid gland. You have a severe mental problem which may make you distressed and anxious, or may make you lose contact with reality and become unable to think and judge clearly. You have depression and have taken a medicine called a non-selective monoamine oxidase inhibitor (MAOI) in the last 14 days. These medicines include isocarboxazid and phenelzine. See the section on Taking other medicines. You are pregnant or trying to become pregnant. See the section on Pregnancy and breast-feeding. You are under 25 years of age. This is because your bones may not have nished developing. You have ever had skin cancer. Do not take Madopar if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before you take Madopar. Take special care with Madopar Check with your doctor or pharmacist before you take Madopar if: You have a problem with the pressure in your eyes called wide-angle glaucoma. You have problems with your hormones, kidneys, lungs or liver. You have diabetes (high blood sugar). You have heart problems, particularly an uneven heart beat (arrhythmia) or you have had a heart attack. You have any mental illness, such as depression. You have a peptic ulcer, an ulcer in your stomach, or in the tube leading from it (duodenal ulcer). You have something called osteomalacia which causes problems with the strength of your bones. Tell your doctor if you or your family/ carer notices you are developing urges or cravings to behave in ways that are unusual for you or you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. These behaviours are called impulse control disorders and can include addictive gambling, excessive eating or spending, an abnormally high sex drive or an increase in sexual thoughts or feelings. Your doctor may need to review your treatments. If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before you take Madopar. Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines that you buy without a
1
3. How to take Madopar
Always take Madopar exactly as your doctor has told you. You should check with your doctor if you are not sure. How much you take and when you take it is different for different people. Swallow the capsules whole with a little water (do not crush or chew them). Take them with or just after food. Patients NOT already treated with levodopa: The usual starting dose is one 50 mg/12.5 mg capsule (50 mg levodopa), three or four times a day. Your doctor will then increase your dose every 2 to 3 days until they nd the right dose for you. Patients already treated with levodopa: Your starting dose of Madopar will be one less 100 mg/25 mg capsule than the number of levodopa 500 mg capsules or tablets you take each day. For example if you take four levodopa tablets (2000 mg levodopa) each day, your doctor will start by giving you three Madopar 100 mg/25 mg capsules daily. After one week your doctor may then start to increase your dose every 2 to 3 days until they nd the right dose for you.
Please turn over
10142875 GB 1210.1079
10142875_NP 9344.indd 1
31.10.2012 09:52:55
Checked and approved
Date
148x297 mm
Signature
KAU-Nr.
1324
Genisys-No. Printing Colour: Format: Folding Format: Type Size Drawing Norm make-up code
10142875 Pantone Black 148x594 mm
11 pt NP9344 GB 11.08.10 97.4.3524
Good To Print MMBFMM8W MMBFMM8Z
Version
Date
Signature
1
29.10.12
Heck
Patients already treated with a combined levodopa/decarboxylase inhibitor: The usual starting dose is one 50 mg/12.5 mg capsule (50 mg levodopa), three or four times a day. Your doctor will then increase your dose every 2 to 3 days until they nd the right dose for you. If you forget to take Madopar If you forget to take a dose, skip the missed dose. Then take the next dose when it is due. Do not take a double dose (two doses at the same time) to make up for a forgotten dose. Stopping Madopar You must not stop taking your capsules without talking to your doctor rst. This is because if you stop taking the capsules suddenly it can cause something called neuroleptic malignant-like syndrome (NMLS). Early signs include increased shaking, sudden high body temperature and muscle problems including stiffness and trouble with balance and keeping upright (postural instability) especially if seen with sweating, paleness and fast heart beat. NMLS can be life threatening. If the above apply to you, talk to a doctor or go to a hospital straight away. If you take more Madopar than you should If you take more Madopar than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you. The following effects may happen if you have taken more capsules than you should: changes in your heart beat, confusion, difculty sleeping, feeling or being sick and unusual movements of different parts of the body that you cannot control. If someone else takes your Madopar capsules by mistake, they should talk to a doctor or go to a hospital straight away. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Others: Unusual movements of different parts of your body which you cannot control. This may affect your hands, feet, face or tongue. Your doctor may change your dose of Madopar to help with these effects. Changes to how things taste or a loss of taste. Redness of the face or neck. Sweating. Your urine (water) may become slightly red. This is not a cause for concern. It is caused by your body getting rid of the medicine. If any of the side effects become serious or troublesome, or if you notice any side effects not listed in this leaet, please tell your doctor or pharmacist.
5. How to store Madopar
Store Madopar capsules in their bottle, with the lid closed to protect the capsules from moisture. Do not store Madopar capsules above 25C. Keep out of the reach and sight of children. Do not use Madopar after the expiry date printed on the pack. Do not throw away any left over capsules. Instead, return them to your pharmacist so that they can be disposed of carefully. Only keep them if your doctor tells you to.
6. Further information
What Madopar contains There are two active substances in Madopar hard capsules, and there are three different strengths of capsules available. Each Madopar 50 mg/12.5 mg Hard Capsule contains 50 mg levodopa and 12.5 mg benserazide as the hydrochloride. Each Madopar 100 mg/25 mg Hard Capsule contains 100 mg levodopa and 25 mg benserazide as the hydrochloride. Each Madopar 200 mg/50 mg Hard Capsule contains 200 mg levodopa and 50 mg benserazide as the hydrochloride. Other ingredients in the capsules are Microcrystalline cellulose (E460), povidone K90 (E1201), talc (E553b), magnesium stearate (E572), gelatin, indigo carmine (E132), titanium dioxide (E171), iron oxide (E172), black iron oxide (E172). Madopar 50 mg/12.5 mg Hard Capsules also contain mannitol (E421). What Madopar capsules look like and contents of the pack Madopar 50 mg/12.5 mg Hard Capsules are grey in colour at one end and pale blue at the other, with Roche printed in black ink on both ends. Madopar 100 mg/25 mg Hard Capsules are pale pink in colour at one end and pale blue at the other, with Roche printed in black ink on both ends. Madopar 200 mg/50 mg Hard Capsules are brown in colour at one end and pale blue at the other, with Roche printed in black ink on both ends. Madopar capsules are supplied in amber coloured glass bottles containing 100 capsules. Marketing Authorisation Holder and Manufacturer Roche Products Limited 6 Falcon Way Shire Park Welwyn Garden City, AL7 1TW United Kingdom This leaet was last revised in October 2012
4. Possible side effects
Like all medicines Madopar can cause side effects, although not everyone will get them. See your doctor as soon as possible if you get the following side effects: Allergic reactions. The signs include a rash and feeling itchy. Heart beat that is uneven or is faster or slower than normal. Bleeding in your stomach or intestines. You may see blood in your stools (they may look black and tarry) or blood when you are sick (this may look like coffee grounds). Low numbers of all types of white blood cells. The signs include infections of your mouth, gums, throat and lungs. Reduced numbers of red blood cells, white blood cells and platelets in your blood. This may make you feel tired, get infections more easily, or bruise more easily. Low numbers of platelets in your blood. The signs include bruising easily and nose bleeds. Other possible side effects: Stomach and gut: Loss of appetite, feeling sick or being sick or diarrhoea, particularly at the start of your treatment. To help with this, your doctor may tell you to take Madopar with some food or drink or increase your dose more slowly. Heart and circulation: Feeling dizzy when you stand up. This usually gets better if your dose is lowered. Blood: Low numbers of red blood cells (anaemia). The signs include feeling tired, pale skin, palpitations (a uttering sensation in your heart) and being short of breath. Changes to your liver or blood - shown in a blood test. Mental problems: Feeling excited, anxious, agitated, depressed, aggressive or disorientated (the feeling of being lost). Believing things which are not true, hallucinations (seeing and possibly hearing things that are not really there) or losing contact with reality. Feeling sleepy, sometimes during the daytime. Falling asleep suddenly. Having difculty sleeping. Impulse Control Disorders: You may experience an inability to resist the impulse to perform an action that could be harmful, which may include: Strong impulse to gamble excessively despite serious personal or family consequences. Altered or increased sexual interest and behaviour of signicant concern to you or to others, for example an increased sexual drive. Uncontrollable excessive shopping or spending Binge eating (eating large amounts of food in a short time period) or compulsive eating (eating more food than normal and more than is needed to satisfy your hunger). Tell your doctor if you experience any of these behaviours; they will discuss ways of managing or reducing the 2 symptoms
10142875_NP 9344.indd 2
10142875 GB 1210.1079
31.10.2012 09:52:56
Checked and approved
Date
148x297 mm
Signature
KAU-Nr.
1324
10142875 Pantone Black 148x594 mm
11 pt NP9344 GB 11.08.10 97.4.3524
Good To Print MMBFMM8W MMBFMM8Z
Version
Date
Signature
1
29.10.12
Heck
Patient Information Leaet
Madopar Madopar Madopar
50 mg/12.5 mg 100 mg/25 mg 200 mg/50 mg
Hard Capsules
Levodopa and benserazide (as hydrochloride)
Please read all of this leaet carefully before you start taking this medicine. Keep this leaet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them even if their symptoms are the same as yours. If any of the side effects become serious or troublesome, or if you notice any side effects not listed in this leaet, please tell your doctor or pharmacist. In this leaet: 1. What Madopar is and what it is used for 2. Before you take Madopar 3. How to take Madopar 4. Possible side effects 5. How to store Madopar 6. Further information
prescription and herbal medicines. This is because Madopar can affect the way some medicines work. Also some other medicines can affect the way Madopar works. Do not take Madopar if you have taken a medicine for depression called a nonselective monoamine oxidase inhibitor (MAOI) in the last 14 days. These medicines include isocarboxazid and phenelzine. If this applies to you, do not take Madopar and ask your doctor or pharmacist for advice. In particular, tell your doctor or pharmacist if you are taking the following medicines: Other medicines for Parkinsons disease, such as amantadine, anticholinergics called orphenadrine and benzhexol, dopamine agonists called pergolide and ropinirole and a COMT inhibitor called entacaprone. Ferrous sulphate (used to treat low levels of iron in the blood). Antacids (used for stomach acid if you have indigestion). Metoclopramide (used to treat problems with digestion). Phenothiazines - such as chlorpromazine, promazine and prochloroperazine (used to treat mental illness). Thioxanthenes - such as upentixol and zuclopenthixol (used to treat mental illness). Butyrophenones - such as haloperidol and benperidol (used to treat mental illness). Diazepam (used to treat anxiety and insomnia). Tetrabenazine (used to help problems controlling your muscle movement). Papaverine (used to improve blood ow around the body). Treatment for high blood pressure (hypertension), in particular reserpine. Sympathomimetics such as epinephrine, norepinephrine and isoproterenol (used to treat problems with your heart or asthma). Amphetamines - medicines used for attention decit disorder, feeling sleepy during the day (narcolepsy) or to help control appetite and weight gain. Operations If you are going to have an operation, tell the doctor that you are taking Madopar. This is because you may need to stop taking it before you have a general anaesthetic. Tests If you need to have tests on your blood or urine, tell the doctor or nurse that you are taking Madopar. This is because the medicine may affect the results of some tests. Pregnancy and breast-feeding Do not take Madopar if you are pregnant, trying to get pregnant or breast-feeding. This is because Madopar may affect your baby. It is important for women to use contraception while taking the medicine. If you get pregnant while taking Madopar, talk to your doctor straight away. Driving and using machines Talk to your doctor about driving and using machines or tools, when you take Madopar. This is because one of the medicines in Madopar, levodopa, can make you feel very sleepy. This can happen very quickly, even during the day. You must not drive or use machines if this happens to you. If you are in any doubt about whether you can do a particular activity, talk to your doctor.
1. What Madopar is and what it is used for
Madopar capsules contain two medicines called levodopa and benserazide. They are used to treat Parkinsons disease. People with Parkinsons disease do not have enough dopamine in certain parts of their brains. This can result in slow movements, stiff muscles and tremor. Madopar works like this: In your body the levodopa is changed into dopamine. Dopamine is the active medicine that is needed in your brain to help Parkinsons disease. The benserazide allows more of the levodopa you take to get into your brain, before it is changed into dopamine.
2. Before you take Madopar
Do not take Madopar if: You are allergic (hypersensitive) to levodopa, benserazide or any of the other ingredients of Madopar (listed in Section 6: Further information). You have a problem with the pressure in your eyes called narrow-angle glaucoma. You have serious problems with your kidneys, liver or heart. You have a serious problem with your hormones, such as an overactive thyroid gland. You have a severe mental problem which may make you distressed and anxious, or may make you lose contact with reality and become unable to think and judge clearly. You have depression and have taken a medicine called a non-selective monoamine oxidase inhibitor (MAOI) in the last 14 days. These medicines include isocarboxazid and phenelzine. See the section on Taking other medicines. You are pregnant or trying to become pregnant. See the section on Pregnancy and breast-feeding. You are under 25 years of age. This is because your bones may not have nished developing. You have ever had skin cancer. Do not take Madopar if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before you take Madopar. Take special care with Madopar Check with your doctor or pharmacist before you take Madopar if: You have a problem with the pressure in your eyes called wide-angle glaucoma. You have problems with your hormones, kidneys, lungs or liver. You have diabetes (high blood sugar). You have heart problems, particularly an uneven heart beat (arrhythmia) or you have had a heart attack. You have any mental illness, such as depression. You have a peptic ulcer, an ulcer in your stomach, or in the tube leading from it (duodenal ulcer). You have something called osteomalacia which causes problems with the strength of your bones. Tell your doctor if you or your family/ carer notices you are developing urges or cravings to behave in ways that are unusual for you or you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. These behaviours are called impulse control disorders and can include addictive gambling, excessive eating or spending, an abnormally high sex drive or an increase in sexual thoughts or feelings. Your doctor may need to review your treatments. If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before you take Madopar. Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines that you buy without a
1
3. How to take Madopar
Always take Madopar exactly as your doctor has told you. You should check with your doctor if you are not sure. How much you take and when you take it is different for different people. Swallow the capsules whole with a little water (do not crush or chew them). Take them with or just after food. Patients NOT already treated with levodopa: The usual starting dose is one 50 mg/12.5 mg capsule (50 mg levodopa), three or four times a day. Your doctor will then increase your dose every 2 to 3 days until they nd the right dose for you. Patients already treated with levodopa: Your starting dose of Madopar will be one less 100 mg/25 mg capsule than the number of levodopa 500 mg capsules or tablets you take each day. For example if you take four levodopa tablets (2000 mg levodopa) each day, your doctor will start by giving you three Madopar 100 mg/25 mg capsules daily. After one week your doctor may then start to increase your dose every 2 to 3 days until they nd the right dose for you.
Please turn over
10142875 GB 1210.1079
10142875_NP 9344.indd 1
31.10.2012 09:52:55
Checked and approved
Date
148x297 mm
Signature
KAU-Nr.
1324
Genisys-No. Printing Colour: Format: Folding Format: Type Size Drawing Norm make-up code
10142875 Pantone Black 148x594 mm
11 pt NP9344 GB 11.08.10 97.4.3524
Good To Print MMBFMM8W MMBFMM8Z
Version
Date
Signature
1
29.10.12
Heck
Patients already treated with a combined levodopa/decarboxylase inhibitor: The usual starting dose is one 50 mg/12.5 mg capsule (50 mg levodopa), three or four times a day. Your doctor will then increase your dose every 2 to 3 days until they nd the right dose for you. If you forget to take Madopar If you forget to take a dose, skip the missed dose. Then take the next dose when it is due. Do not take a double dose (two doses at the same time) to make up for a forgotten dose. Stopping Madopar You must not stop taking your capsules without talking to your doctor rst. This is because if you stop taking the capsules suddenly it can cause something called neuroleptic malignant-like syndrome (NMLS). Early signs include increased shaking, sudden high body temperature and muscle problems including stiffness and trouble with balance and keeping upright (postural instability) especially if seen with sweating, paleness and fast heart beat. NMLS can be life threatening. If the above apply to you, talk to a doctor or go to a hospital straight away. If you take more Madopar than you should If you take more Madopar than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you. The following effects may happen if you have taken more capsules than you should: changes in your heart beat, confusion, difculty sleeping, feeling or being sick and unusual movements of different parts of the body that you cannot control. If someone else takes your Madopar capsules by mistake, they should talk to a doctor or go to a hospital straight away. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Others: Unusual movements of different parts of your body which you cannot control. This may affect your hands, feet, face or tongue. Your doctor may change your dose of Madopar to help with these effects. Changes to how things taste or a loss of taste. Redness of the face or neck. Sweating. Your urine (water) may become slightly red. This is not a cause for concern. It is caused by your body getting rid of the medicine. If any of the side effects become serious or troublesome, or if you notice any side effects not listed in this leaet, please tell your doctor or pharmacist.
5. How to store Madopar
Store Madopar capsules in their bottle, with the lid closed to protect the capsules from moisture. Do not store Madopar capsules above 25C. Keep out of the reach and sight of children. Do not use Madopar after the expiry date printed on the pack. Do not throw away any left over capsules. Instead, return them to your pharmacist so that they can be disposed of carefully. Only keep them if your doctor tells you to.
6. Further information
What Madopar contains There are two active substances in Madopar hard capsules, and there are three different strengths of capsules available. Each Madopar 50 mg/12.5 mg Hard Capsule contains 50 mg levodopa and 12.5 mg benserazide as the hydrochloride. Each Madopar 100 mg/25 mg Hard Capsule contains 100 mg levodopa and 25 mg benserazide as the hydrochloride. Each Madopar 200 mg/50 mg Hard Capsule contains 200 mg levodopa and 50 mg benserazide as the hydrochloride. Other ingredients in the capsules are Microcrystalline cellulose (E460), povidone K90 (E1201), talc (E553b), magnesium stearate (E572), gelatin, indigo carmine (E132), titanium dioxide (E171), iron oxide (E172), black iron oxide (E172). Madopar 50 mg/12.5 mg Hard Capsules also contain mannitol (E421). What Madopar capsules look like and contents of the pack Madopar 50 mg/12.5 mg Hard Capsules are grey in colour at one end and pale blue at the other, with Roche printed in black ink on both ends. Madopar 100 mg/25 mg Hard Capsules are pale pink in colour at one end and pale blue at the other, with Roche printed in black ink on both ends. Madopar 200 mg/50 mg Hard Capsules are brown in colour at one end and pale blue at the other, with Roche printed in black ink on both ends. Madopar capsules are supplied in amber coloured glass bottles containing 100 capsules. Marketing Authorisation Holder and Manufacturer Roche Products Limited 6 Falcon Way Shire Park Welwyn Garden City, AL7 1TW United Kingdom This leaet was last revised in October 2012
4. Possible side effects
Like all medicines Madopar can cause side effects, although not everyone will get them. See your doctor as soon as possible if you get the following side effects: Allergic reactions. The signs include a rash and feeling itchy. Heart beat that is uneven or is faster or slower than normal. Bleeding in your stomach or intestines. You may see blood in your stools (they may look black and tarry) or blood when you are sick (this may look like coffee grounds). Low numbers of all types of white blood cells. The signs include infections of your mouth, gums, throat and lungs. Reduced numbers of red blood cells, white blood cells and platelets in your blood. This may make you feel tired, get infections more easily, or bruise more easily. Low numbers of platelets in your blood. The signs include bruising easily and nose bleeds. Other possible side effects: Stomach and gut: Loss of appetite, feeling sick or being sick or diarrhoea, particularly at the start of your treatment. To help with this, your doctor may tell you to take Madopar with some food or drink or increase your dose more slowly. Heart and circulation: Feeling dizzy when you stand up. This usually gets better if your dose is lowered. Blood: Low numbers of red blood cells (anaemia). The signs include feeling tired, pale skin, palpitations (a uttering sensation in your heart) and being short of breath. Changes to your liver or blood - shown in a blood test. Mental problems: Feeling excited, anxious, agitated, depressed, aggressive or disorientated (the feeling of being lost). Believing things which are not true, hallucinations (seeing and possibly hearing things that are not really there) or losing contact with reality. Feeling sleepy, sometimes during the daytime. Falling asleep suddenly. Having difculty sleeping. Impulse Control Disorders: You may experience an inability to resist the impulse to perform an action that could be harmful, which may include: Strong impulse to gamble excessively despite serious personal or family consequences. Altered or increased sexual interest and behaviour of signicant concern to you or to others, for example an increased sexual drive. Uncontrollable excessive shopping or spending Binge eating (eating large amounts of food in a short time period) or compulsive eating (eating more food than normal and more than is needed to satisfy your hunger). Tell your doctor if you experience any of these behaviours; they will discuss ways of managing or reducing the 2 symptoms
10142875_NP 9344.indd 2
10142875 GB 1210.1079
31.10.2012 09:52:56
Checked and approved
Date
148x297 mm
Signature
KAU-Nr.
1324
Source: Medicines and Healthcare Products Regulatory Agency
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
