MADOPAR 100 MG/25MG HARD CAPSULES

Active substance: LEVODOPA

View full screen / Print PDF » Download PDF ⇩

Transcript
PACKAGE LEAFLET: INFORMATION FOR THE USER
Madopar® 100 mg/25 mg Hard Capsules
(levodopa/benserazide hydrochloride)
This product is available in the above name but will be referred to as
Madopar throughout the remainder of this leaflet.
This product is available in other strengths which may be referred to
throughout this leaflet.
Please read all of this leaflet carefully before you start taking
this medicine.
 Keep this leaflet. You may need to read it again.
 If you have any further questions, ask your doctor or pharmacist.
 This medicine has been prescribed for you. Do not pass it on to
others. It may harm them even if their symptoms are the same as
yours.
 If any of the side effects become serious or troublesome, or if you
notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
In this leaflet:
1. What Madopar is and what it is used for
2. Before you take Madopar
3. How to take Madopar
4. Possible side effects
5. How to store Madopar
6. Further information
1.

What Madopar is and what it is used for

Madopar capsules contain two medicines called levodopa and
benserazide. They are used to treat Parkinson’s disease.
People with Parkinson’s disease do not have enough dopamine in
certain parts of their brains. This can result in slow movements, stiff
muscles and tremor.
Madopar works like this:
 In your body the levodopa is changed into dopamine. Dopamine
is the active medicine that is needed in your brain to help
Parkinson’s disease.
 The benserazide allows more of the levodopa you take to get
into your brain, before it is changed into dopamine.
2.

Before you take Madopar

Do not take Madopar if:
 You are allergic (hypersensitive) to levodopa, benserazide or any
of the other ingredients of Madopar (listed in Section 6: Further
information).
 You have a problem with the pressure in your eyes called ‘narrow
-angle glaucoma’.
 You have serious problems with your kidneys, liver or heart.
 You have a serious problem with your hormones, such as an
overactive thyroid gland.
 You have a severe mental problem which may make you
distressed and anxious, or may make you lose contact with
reality and become unable to think and judge clearly.
 You have depression and have taken a medicine called a ‘nonselective monoamine oxidase inhibitor’ (MAOI) in the last 14
days. These medicines include isocarboxazid and phenelzine.
See the section on ‘Taking other medicines’.
 You are pregnant or trying to become pregnant. See the section
on ‘Pregnancy and breast-feeding’.
 You are under 25 years of age. This is because your bones may
not have finished developing.
 You have ever had skin cancer.
Do not take Madopar if any of the above applies to you. If you are not
sure, talk to your doctor or pharmacist before you take Madopar.
Take special care with Madopar
Check with your doctor or pharmacist before you take Madopar if:
 You have a problem with the pressure in your eyes called ‘wideangle glaucoma’.
 You have problems with your hormones, kidneys, lungs or liver.
 You have diabetes (high blood sugar).
 You have heart problems, particularly an uneven heart beat
(arrhythmia) or you have had a heart attack.
 You have any mental illness, such as depression.
 You have a ‘peptic ulcer’, an ulcer in your stomach, or in the tube
leading from it (‘duodenal ulcer’).
 You have something called ‘osteomalacia’ which causes
problems with the strength of your bones.

Tell your doctor if you or your family/carer notices you are developing
urges or cravings to behave in ways that are unusual for you or you
cannot resist the impulse, drive or temptation to carry out certain
activities that could harm yourself or others. These behaviours are
called impulse control disorders and can include addictive gambling,
excessive eating or spending, an abnormally high sex drive or an
increase in sexual thoughts or feelings. Your doctor may need to
review your treatments.
If any of the above apply to you, or if you are not sure, talk to your
doctor or pharmacist before you take Madopar.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines. This includes medicines that you
buy without a prescription and herbal medicines. This is because
Madopar can affect the way some medicines work. Also some other
medicines can affect the way Madopar works.
Do not take Madopar if you have taken a medicine for depression
called a ‘non-selective monoamine oxidase inhibitor’ (MAOI) in the
last 14 days. These medicines include isocarboxazid and phenelzine.
If this applies to you, do not take Madopar and ask your doctor or
pharmacist for advice.
In particular, tell your doctor or pharmacist if you are taking the
following medicines:
 Other medicines for Parkinson’s disease, such as amantadine,
‘anticholinergics’ called orphenadrine and benzhexol, ‘dopamine
agonists’ called pergolide and ropinirole and a ‘COMT inhibitor’
called entacaprone.
 Ferrous sulphate (used to treat low levels of iron in the blood).
 Antacids (used for stomach acid if you have indigestion).
 Metoclopramide (used to treat problems with digestion).
 Phenothiazines - such as chlorpromazine, promazine and
prochloroperazine (used to treat mental illness).
 Thioxanthenes - such as flupentixol and zuclopenthixol (used to
treat mental illness).
 Butyrophenones - such as haloperidol and benperidol (used to
treat mental illness).
 Diazepam (used to treat anxiety and insomnia).
 Tetrabenazine (used to help problems controlling your muscle
movement).
 Papaverine (used to improve blood flow around the body).
 Treatment for high blood pressure (hypertension), in particular
reserpine.
 ‘Sympathomimetics’ – such as epinephrine, norepinephrine and
isoproterenol (used to treat problems with your heart or asthma).
 Amphetamines - medicines used for attention deficit disorder,
feeling sleepy during the day (narcolepsy) or to help control
appetite and weight gain.
Operations
If you are going to have an operation, tell the doctor that you are
taking Madopar. This is because you may need to stop taking it
before you have a general anaesthetic.
Tests
If you need to have tests on your blood or urine, tell the doctor or
nurse that you are taking Madopar. This is because the medicine
may affect the results of some tests.
Pregnancy and breast-feeding
Do not take Madopar if you are pregnant, trying to get pregnant or
breast-feeding. This is because Madopar may affect your baby. It is
important for women to use contraception while taking the medicine.
If you get pregnant while taking Madopar, talk to your doctor straight
away.
Driving and using machines
Talk to your doctor about driving and using machines or tools, when
you take Madopar. This is because one of the medicines in Madopar,
levodopa, can make you feel very sleepy. This can happen very
quickly, even during the day. You must not drive or use machines if
this happens to you. If you are in any doubt about whether you can
do a particular activity, talk to your doctor.
3.

How to take Madopar

Always take Madopar exactly as your doctor has told you. You
should check with your doctor if you are not sure. How much you
take and when you take it is different for different people.
 Swallow the capsules whole with a little water (do not crush or
chew them).
 Take them with or just after food.

Patients NOT already treated with levodopa:
 The usual starting dose is one 50 mg/12.5 mg capsule (50 mg
levodopa), three or four times a day.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you.

Blood:
 Low numbers of red blood cells (anaemia). The signs include
feeling tired, pale skin, palpitations (a fluttering sensation in your
heart) and being short of breath.
 Changes to your liver or blood - shown in a blood test.

Patients already treated with levodopa:
 Your starting dose of Madopar will be one less 100 mg/25 mg
capsule than the number of levodopa 500 mg capsules or tablets
you take each day. For example if you take four levodopa tablets
(2000 mg levodopa) each day, your doctor will start by giving you
three Madopar 100 mg/25 mg capsules daily.
 After one week your doctor may then start to increase your dose
every 2 to 3 days until they find the right dose for you.

Mental problems:
 Feeling excited, anxious, agitated, depressed, aggressive or
disorientated (the feeling of being lost).
 Believing things which are not true, hallucinations (seeing and
possibly hearing things that are not really there) or losing contact
with reality.
 Feeling sleepy, sometimes during the daytime.
 Falling asleep suddenly.
 Having difficulty sleeping.

Patients already treated with a combined levodopa/
decarboxylase inhibitor:
 The usual starting dose is one 50 mg/12.5 mg capsule (50 mg
levodopa), three or four times a day.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you.
If you forget to take Madopar
 If you forget to take a dose, skip the missed dose. Then take the
next dose when it is due.
 Do not take a double dose (two doses at the same time) to make
up for a forgotten dose.
Stopping Madopar
You must not stop taking your capsules without talking to your
doctor first. This is because if you stop taking the capsules suddenly
it can cause something called ‘neuroleptic malignant-like
syndrome’ (NMLS). Early signs include increased shaking, sudden
high body temperature and muscle problems including stiffness and
trouble with balance and keeping upright (postural instability)
especially if seen with sweating, paleness and fast heart beat. NMLS
can be life threatening.
If the above apply to you, talk to a doctor or go to a hospital straight
away.
If you take more Madopar than you should
If you take more Madopar than you should, talk to a doctor or go to a
hospital straight away. Take the medicine pack with you. The
following effects may happen if you have taken more capsules than
you should: changes in your heart beat, confusion, difficulty sleeping,
feeling or being sick and unusual movements of different parts of the
body that you cannot control.
If someone else takes your Madopar capsules by mistake, they
should talk to a doctor or go to a hospital straight away.
If you have any further questions on the use of this medicine, ask
your doctor or pharmacist.
4.

Possible side effects

Like all medicines Madopar can cause side effects, although not
everyone will get them.
See your doctor as soon as possible if you get the following
side effects:
 Allergic reactions. The signs include a rash and feeling itchy.
 Heart beat that is uneven or is faster or slower than normal.
 Bleeding in your stomach or intestines. You may see blood in
your stools (they may look black and tarry) or blood when you are
sick (this may look like coffee grounds).
 Low numbers of all types of white blood cells. The signs include
infections of your mouth, gums, throat and lungs.
 Reduced numbers of red blood cells, white blood cells and
platelets in your blood. This may make you feel tired, get
infections more easily, or bruise more easily.
 Low numbers of platelets in your blood. The signs include
bruising easily and nose bleeds.
Other possible side effects:
Stomach and gut:
 Loss of appetite, feeling sick or being sick or diarrhoea,
particularly at the start of your treatment. To help with this, your
doctor may tell you to take Madopar with some food or drink or
increase your dose more slowly.
Heart and circulation:
 Feeling dizzy when you stand up. This usually gets better if your
dose is lowered.

Impulse Control Disorders:
You may experience an inability to resist the impulse to perform an
action that could be harmful, which may include:
 Strong impulse to gamble excessively despite serious personal
or family consequences.
 Altered or increased sexual interest and behaviour of significant
concern to you or to others, for example an increased sexual
drive.
 Uncontrollable excessive shopping or spending
 Binge eating (eating large amounts of food in a short time period)
or compulsive eating (eating more food than normal and more
than is needed to satisfy your hunger).
Tell your doctor if you experience any of these behaviours; they
will discuss ways of managing or reducing the symptoms
Others:
 Unusual movements of different parts of your body which you
cannot control. This may affect your hands, feet, face or tongue.
Your doctor may change your dose of Madopar to help with these
effects.
 Changes to how things taste or a loss of taste.
 Redness of the face or neck.
 Sweating.
 Your urine (water) may become slightly red. This is not a cause
for concern. It is caused by your body getting rid of the medicine.
If any of the side effects become serious or troublesome, or if you
notice any side effects not listed in this leaflet, please tell your doctor
or pharmacist.
5.

How to store Madopar




KEEP OUT OF THE SIGHT AND REACH OF CHILDREN
Store in the original package. Keep bottle tightly closed to protect
from moisture. Do not store above 25ºC.
 Do not use Madopar after the expiry date printed on the pack.
 If you notice the capsules become discoloured or show any signs
of deterioration, you should seek the advice of your pharmacist.
 Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment.
6.

Further information

What Madopar contains
Each capsule contains 100 mg levodopa and 25 mg
benserazide as the hydrochloride.
 Other ingredients in the capsules are povidone K90, talc,
magnesium stearate, microcrystalline cellulose, gelatin, titanium
dioxide (E171), red iron oxide (E172), indigotine (E132). The
black printing ink contains shellac, potassium hydroxide and
black iron oxide (E172).


What Madopar looks like and contents of the pack
Your capsules have a pale pink body and a pale blue cap, imprinted
with the name ‘Roche’ in black ink on both sides. Madopar is
supplied in amber coloured glass bottles containing 30 or 60 (2x30)
capsules. A desiccant is integrated into the child resistant cap.
Manufacturer
Manufactured by Roche S.p.A., officina di Segrate, Via Morelli 2,
Italy. Procured from within the EU. Repackaged by the Product
Licence holder: G Pharma Ltd, Salford M50 2PU.
POM

PL 16369/1499
Leaflet revision:24th January 2013
'Madopar' is a registered trademark of Roche.

PACKAGE LEAFLET: INFORMATION FOR THE USER
Madopar® 100 mg/25 mg Hard Capsules
(levodopa/benserazide hydrochloride)
This product is available in the above name but will be referred to as
Madopar throughout the remainder of this leaflet.
This product is available in other strengths which may be referred to
throughout this leaflet.
Please read all of this leaflet carefully before you start taking
this medicine.
 Keep this leaflet. You may need to read it again.
 If you have any further questions, ask your doctor or pharmacist.
 This medicine has been prescribed for you. Do not pass it on to
others. It may harm them even if their symptoms are the same as
yours.
 If any of the side effects become serious or troublesome, or if you
notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
In this leaflet:
1. What Madopar is and what it is used for
2. Before you take Madopar
3. How to take Madopar
4. Possible side effects
5. How to store Madopar
6. Further information
1.

What Madopar is and what it is used for

Madopar capsules contain two medicines called levodopa and
benserazide. They are used to treat Parkinson’s disease.
People with Parkinson’s disease do not have enough dopamine in
certain parts of their brains. This can result in slow movements, stiff
muscles and tremor.
Madopar works like this:
 In your body the levodopa is changed into dopamine. Dopamine
is the active medicine that is needed in your brain to help
Parkinson’s disease.
 The benserazide allows more of the levodopa you take to get
into your brain, before it is changed into dopamine.
2.

Before you take Madopar

Do not take Madopar if:
 You are allergic (hypersensitive) to levodopa, benserazide or any
of the other ingredients of Madopar (listed in Section 6: Further
information).
 You have a problem with the pressure in your eyes called ‘narrow
-angle glaucoma’.
 You have serious problems with your kidneys, liver or heart.
 You have a serious problem with your hormones, such as an
overactive thyroid gland.
 You have a severe mental problem which may make you
distressed and anxious, or may make you lose contact with
reality and become unable to think and judge clearly.
 You have depression and have taken a medicine called a ‘nonselective monoamine oxidase inhibitor’ (MAOI) in the last 14
days. These medicines include isocarboxazid and phenelzine.
See the section on ‘Taking other medicines’.
 You are pregnant or trying to become pregnant. See the section
on ‘Pregnancy and breast-feeding’.
 You are under 25 years of age. This is because your bones may
not have finished developing.
 You have ever had skin cancer.
Do not take Madopar if any of the above applies to you. If you are not
sure, talk to your doctor or pharmacist before you take Madopar.
Take special care with Madopar
Check with your doctor or pharmacist before you take Madopar if:
 You have a problem with the pressure in your eyes called ‘wideangle glaucoma’.
 You have problems with your hormones, kidneys, lungs or liver.
 You have diabetes (high blood sugar).
 You have heart problems, particularly an uneven heart beat
(arrhythmia) or you have had a heart attack.
 You have any mental illness, such as depression.
 You have a ‘peptic ulcer’, an ulcer in your stomach, or in the tube
leading from it (‘duodenal ulcer’).
 You have something called ‘osteomalacia’ which causes
problems with the strength of your bones.

Tell your doctor if you or your family/carer notices you are developing
urges or cravings to behave in ways that are unusual for you or you
cannot resist the impulse, drive or temptation to carry out certain
activities that could harm yourself or others. These behaviours are
called impulse control disorders and can include addictive gambling,
excessive eating or spending, an abnormally high sex drive or an
increase in sexual thoughts or feelings. Your doctor may need to
review your treatments.
If any of the above apply to you, or if you are not sure, talk to your
doctor or pharmacist before you take Madopar.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines. This includes medicines that you
buy without a prescription and herbal medicines. This is because
Madopar can affect the way some medicines work. Also some other
medicines can affect the way Madopar works.
Do not take Madopar if you have taken a medicine for depression
called a ‘non-selective monoamine oxidase inhibitor’ (MAOI) in the
last 14 days. These medicines include isocarboxazid and phenelzine.
If this applies to you, do not take Madopar and ask your doctor or
pharmacist for advice.
In particular, tell your doctor or pharmacist if you are taking the
following medicines:
 Other medicines for Parkinson’s disease, such as amantadine,
‘anticholinergics’ called orphenadrine and benzhexol, ‘dopamine
agonists’ called pergolide and ropinirole and a ‘COMT inhibitor’
called entacaprone.
 Ferrous sulphate (used to treat low levels of iron in the blood).
 Antacids (used for stomach acid if you have indigestion).
 Metoclopramide (used to treat problems with digestion).
 Phenothiazines - such as chlorpromazine, promazine and
prochloroperazine (used to treat mental illness).
 Thioxanthenes - such as flupentixol and zuclopenthixol (used to
treat mental illness).
 Butyrophenones - such as haloperidol and benperidol (used to
treat mental illness).
 Diazepam (used to treat anxiety and insomnia).
 Tetrabenazine (used to help problems controlling your muscle
movement).
 Papaverine (used to improve blood flow around the body).
 Treatment for high blood pressure (hypertension), in particular
reserpine.
 ‘Sympathomimetics’ – such as epinephrine, norepinephrine and
isoproterenol (used to treat problems with your heart or asthma).
 Amphetamines - medicines used for attention deficit disorder,
feeling sleepy during the day (narcolepsy) or to help control
appetite and weight gain.
Operations
If you are going to have an operation, tell the doctor that you are
taking Madopar. This is because you may need to stop taking it
before you have a general anaesthetic.
Tests
If you need to have tests on your blood or urine, tell the doctor or
nurse that you are taking Madopar. This is because the medicine
may affect the results of some tests.
Pregnancy and breast-feeding
Do not take Madopar if you are pregnant, trying to get pregnant or
breast-feeding. This is because Madopar may affect your baby. It is
important for women to use contraception while taking the medicine.
If you get pregnant while taking Madopar, talk to your doctor straight
away.
Driving and using machines
Talk to your doctor about driving and using machines or tools, when
you take Madopar. This is because one of the medicines in Madopar,
levodopa, can make you feel very sleepy. This can happen very
quickly, even during the day. You must not drive or use machines if
this happens to you. If you are in any doubt about whether you can
do a particular activity, talk to your doctor.
3.

How to take Madopar

Always take Madopar exactly as your doctor has told you. You
should check with your doctor if you are not sure. How much you
take and when you take it is different for different people.
 Swallow the capsules whole with a little water (do not crush or
chew them).
 Take them with or just after food.

Patients NOT already treated with levodopa:
 The usual starting dose is one 50 mg/12.5 mg capsule (50 mg
levodopa), three or four times a day.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you.

Blood:
 Low numbers of red blood cells (anaemia). The signs include
feeling tired, pale skin, palpitations (a fluttering sensation in your
heart) and being short of breath.
 Changes to your liver or blood - shown in a blood test.

Patients already treated with levodopa:
 Your starting dose of Madopar will be one less 100 mg/25 mg
capsule than the number of levodopa 500 mg capsules or tablets
you take each day. For example if you take four levodopa tablets
(2000 mg levodopa) each day, your doctor will start by giving you
three Madopar 100 mg/25 mg capsules daily.
 After one week your doctor may then start to increase your dose
every 2 to 3 days until they find the right dose for you.

Mental problems:
 Feeling excited, anxious, agitated, depressed, aggressive or
disorientated (the feeling of being lost).
 Believing things which are not true, hallucinations (seeing and
possibly hearing things that are not really there) or losing contact
with reality.
 Feeling sleepy, sometimes during the daytime.
 Falling asleep suddenly.
 Having difficulty sleeping.

Patients already treated with a combined levodopa/
decarboxylase inhibitor:
 The usual starting dose is one 50 mg/12.5 mg capsule (50 mg
levodopa), three or four times a day.
 Your doctor will then increase your dose every 2 to 3 days until
they find the right dose for you.
If you forget to take Madopar
 If you forget to take a dose, skip the missed dose. Then take the
next dose when it is due.
 Do not take a double dose (two doses at the same time) to make
up for a forgotten dose.
Stopping Madopar
You must not stop taking your capsules without talking to your
doctor first. This is because if you stop taking the capsules suddenly
it can cause something called ‘neuroleptic malignant-like
syndrome’ (NMLS). Early signs include increased shaking, sudden
high body temperature and muscle problems including stiffness and
trouble with balance and keeping upright (postural instability)
especially if seen with sweating, paleness and fast heart beat. NMLS
can be life threatening.
If the above apply to you, talk to a doctor or go to a hospital straight
away.
If you take more Madopar than you should
If you take more Madopar than you should, talk to a doctor or go to a
hospital straight away. Take the medicine pack with you. The
following effects may happen if you have taken more capsules than
you should: changes in your heart beat, confusion, difficulty sleeping,
feeling or being sick and unusual movements of different parts of the
body that you cannot control.
If someone else takes your Madopar capsules by mistake, they
should talk to a doctor or go to a hospital straight away.
If you have any further questions on the use of this medicine, ask
your doctor or pharmacist.
4.

Possible side effects

Like all medicines Madopar can cause side effects, although not
everyone will get them.
See your doctor as soon as possible if you get the following
side effects:
 Allergic reactions. The signs include a rash and feeling itchy.
 Heart beat that is uneven or is faster or slower than normal.
 Bleeding in your stomach or intestines. You may see blood in
your stools (they may look black and tarry) or blood when you are
sick (this may look like coffee grounds).
 Low numbers of all types of white blood cells. The signs include
infections of your mouth, gums, throat and lungs.
 Reduced numbers of red blood cells, white blood cells and
platelets in your blood. This may make you feel tired, get
infections more easily, or bruise more easily.
 Low numbers of platelets in your blood. The signs include
bruising easily and nose bleeds.
Other possible side effects:
Stomach and gut:
 Loss of appetite, feeling sick or being sick or diarrhoea,
particularly at the start of your treatment. To help with this, your
doctor may tell you to take Madopar with some food or drink or
increase your dose more slowly.
Heart and circulation:
 Feeling dizzy when you stand up. This usually gets better if your
dose is lowered.

Impulse Control Disorders:
You may experience an inability to resist the impulse to perform an
action that could be harmful, which may include:
 Strong impulse to gamble excessively despite serious personal
or family consequences.
 Altered or increased sexual interest and behaviour of significant
concern to you or to others, for example an increased sexual
drive.
 Uncontrollable excessive shopping or spending
 Binge eating (eating large amounts of food in a short time period)
or compulsive eating (eating more food than normal and more
than is needed to satisfy your hunger).
Tell your doctor if you experience any of these behaviours; they
will discuss ways of managing or reducing the symptoms
Others:
 Unusual movements of different parts of your body which you
cannot control. This may affect your hands, feet, face or tongue.
Your doctor may change your dose of Madopar to help with these
effects.
 Changes to how things taste or a loss of taste.
 Redness of the face or neck.
 Sweating.
 Your urine (water) may become slightly red. This is not a cause
for concern. It is caused by your body getting rid of the medicine.
If any of the side effects become serious or troublesome, or if you
notice any side effects not listed in this leaflet, please tell your doctor
or pharmacist.
5.

How to store Madopar




KEEP OUT OF THE SIGHT AND REACH OF CHILDREN
Store in the original package. Keep bottle tightly closed to protect
from moisture. Do not store above 25ºC.
 Do not use Madopar after the expiry date printed on the pack.
 If you notice the capsules become discoloured or show any signs
of deterioration, you should seek the advice of your pharmacist.
 Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment.
6.

Further information

What Madopar contains
Each capsule contains 100 mg levodopa and 25 mg
benserazide as the hydrochloride.
 Other ingredients in the capsules are povidone K90, talc,
magnesium stearate, microcrystalline cellulose, gelatin, titanium
dioxide (E171), red iron oxide (E172), indigotine (E132). The
black printing ink contains shellac, potassium hydroxide and
black iron oxide (E172).


What Madopar looks like and contents of the pack
Your capsules have a pale pink body and a pale blue cap, imprinted
with the name ‘Roche’ in black ink on both sides. Madopar is
supplied in amber coloured glass bottles containing 30 or 60 (2x30)
capsules. A desiccant is integrated into the child resistant cap.
Manufacturer
Manufactured by Roche S.p.A., officina di Segrate, Via Morelli 2,
Italy. Procured from within the EU. Repackaged by the Product
Licence holder: G Pharma Ltd, Salford M50 2PU.
POM

PL 16369/1499
Leaflet revision:24th January 2013
'Madopar' is a registered trademark of Roche.

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Hide
(web3)