INDERAL LA CAPSULES 160MG

Active substance: PROPRANOLOL HYDROCHLORIDE

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Inderal® LA Capsules 160mg
Half Inderal® LA 80 Capsules
(propranolol hydrochloride)
Your medicine is known by either of the above names, but will be referred to
as Inderal throughout this:
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others.
It may harm them, even if their symptoms are the same as yours.
• If any of the side effects get serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.

In this leaflet:
1) What Inderal is and what it is used for
2) Before you take Inderal
3) How to take Inderal
4) Possible side effects
5) How to store Inderal
6) Further information

1) What Inderal is and what it is used for
Inderal contains a medicine called propranolol hydrochloride. This belongs
to a group of medicines called beta-blockers.
Inderal is used for many conditions including:
• High blood pressure (hypertension).
• Chest pain (angina).
• Preventing migraines.
• Essential tremor (shaking with an unknown cause).
• Anxiety.
• Some thyroid problems (such as thyrotoxicosis which is caused by an
overactive thyroid gland).
• Bleeding in the food pipe (oesophagus) caused by high blood pressure in
the liver.
It works by the effects it has on the heart and circulation and also on other
parts of the body.

2) Before you take Inderal
Do not take Inderal if:
• You have ever had asthma or wheezing. If this applies to you talk to
your doctor or pharmacist.
• You are allergic (hypersensitive) to propranolol hydrochloride or any of
the other ingredients in Inderal (see section 6: Further information).
• You have ever had any of the following heart problems:
• heart failure which is not under control (this usually makes you
breathless and causes your ankles to swell)
• second- or third-degree heart block (a condition which may be treated
by a pacemaker)
• very slow or very uneven heart beats, very low blood pressure or very
poor circulation
• a type of chest pain (angina) called Prinzmetal's angina.
• You have a tumour called phaeochromocytoma that is not being treated.
This is usually near your kidney and can cause high blood pressure.
• You have been told that you have higher than normal levels of acid in
your blood (metabolic acidosis).
• You have been fasting recently.
Do not take Inderal if any of the above apply to you. If you are not sure, talk
to your doctor or pharmacist before taking Inderal.
Take special care with Inderal
Check with your doctor or pharmacist before taking Inderal if:
• You have ever had an allergic reaction, for example to insect stings.
• You have poor blood circulation or controlled heart failure.
• You have first-degree heart block.
• You have sharp chest pain which is not caused by exercise (unstable
angina).
• You have problems with your kidneys. You may need to have some
check-ups during your treatment.
• You have problems with your liver (such as cirrhosis of the liver). You
may need to have some check-ups during your treatment.
• You have diabetes. Your medicine may change how you respond to
having low blood sugar (hypoglycaemia). You may feel your heart beating
faster.
• You have thyrotoxicosis (a condition caused by an overactive thyroid
gland). Your medicine may hide the symptoms of thyrotoxicosis.

If you are not sure if any of the above apply to you, talk to your doctor or
pharmacist before taking Inderal.
Taking other medicines
Please tell your doctor or pharmacist if you are taking, or have recently
taken, any other medicines. This includes medicines that you buy without a
prescription and herbal medicines. This is because Inderal can affect the
way some other medicines work and some medicines can have an effect on
Inderal.
In particular, tell your doctor if you are taking any of the following medicines:
• Clonidine (for high blood pressure or migraine). If you are taking clonidine
and Inderal together, do not stop taking clonidine unless your doctor tells
you to do so. If you have to stop taking clonidine, your doctor will give you
careful instructions about how to do it.
• Verapamil, diltiazem, nifedipine, nisoldipine, nicardipine, isradipine or
lacidipine (for high blood pressure or chest pain).
• Disopyramide, lidocaine, quinidine, amiodarone or propafenone (for an
uneven heart beat).
• Digoxin (for heart problems).
• Warfarin (to thin the blood).
• Adrenaline, also known as epinephrine (a medicine that stimulates the
heart).
• Ibuprofen or indometacin (for pain and inflammation).
• Ergotamine or dihydroergotamine (for migraine).
• Chlorpromazine or thioridazine (for mental illness).
• Cimetidine (for stomach problems).
• Rifampicin (for tuberculosis).
• Theophylline (for asthma).
• Insulin.
Operations
If you go into hospital to have an operation, tell the anaesthetist or medical
staff that you are taking Inderal. This is because you can get low blood
pressure (hypotension) if you are given certain anaesthetics while you are
taking Inderal.
Taking Inderal with food and drink
If you frequently drink a lot of alcohol, talk to your doctor before having this
medicine. This is because alcohol can affect how the medicine works.
Pregnancy and breast-feeding
Talk to your doctor before taking this medicine if you are pregnant, might
become pregnant or are breast-feeding.
Driving and using machines
• Your medicine is not likely to affect you being able to drive or use any
tools or machines. However, it is best to wait to see how your medicine
affects you before trying these activities.
• If you feel dizzy or tired when taking this medicine, do not drive or use any
tools or machines.
Important information about some of the ingredients of Inderal
Inderal Capsules contain microcrystalline cellulose and titanium dioxide.
These may cause a problem in a very small number of people who are
sensitive to them.

3) How to take Inderal
Always take Inderal exactly as your doctor has told you. You should check
with your doctor or pharmacist if you are not sure.
• Your doctor will tell you how many capsules to take each day and when to
take them. Read the label on the carton to remind you what the doctor
said.
• Swallow your Inderal capsules with a drink of water. Swallow whole. Do
not chew.
Adults
• High blood pressure (hypertension): the usual dose is 160 mg a day.
Your doctor may decide to increase this dose.
• Chest pain (angina): the usual dose is 80 mg to 240 mg a day.
• To prevent migraine: the usual dose is 80 mg to 240 mg a day.
• Essential tremor: the usual dose is 80 mg to 240 mg a day.
• Anxiety: the usual dose is 80 mg to 160 mg a day.
• Thyroid conditions (such as thyrotoxicosis): the usual dose is 80 mg
to 240 mg a day.
• Bleeding in the food pipe (oesophagus) caused by high blood
pressure in the liver: the usual dose is 80 mg to 320 mg a day.

Elderly people
If you are an elderly person, your doctor may decide to start you on a lower
dose.
Children
Your medicine must not be given to children.
If you take more Inderal than you should
If you take more Inderal than prescribed by your doctor, talk to a doctor or
go to a hospital straight away. Take the medicine pack with you so that the
capsules can be identified.
If you forget to take Inderal
If you forget to take a dose, take it as soon as you remember. However, if it
is almost time for the next dose, skip the missed dose. Do not take a double
dose to make up for a forgotten dose.
If you stop taking Inderal
Do not stop taking Inderal without talking to your doctor. In some cases, you
may need to stop taking it gradually.

4) Possible side effects
Like all medicines, Inderal can cause side effects, although not everybody
gets them. The following side effects may happen with this medicine:
Common (affects less than 1 in 10 people)
• You may notice that your pulse rate becomes slower while you are taking
the capsules. This is normal, but if you are concerned please tell your
doctor about it.
• Cold hands and feet.
• Numbness and spasm in your fingers which is followed by warmth and
pain (Raynaud's disease).
• Disturbed sleep or nightmares.
• Feeling tired.
Uncommon (affects less than 1 in 100 people)
• Diarrhoea.
• Feeling sick (nausea).
• Being sick (vomiting).
Rare (affects less than 1 in 1,000 people)
• Heart block (which may cause an abnormal heart beat, dizziness,
tiredness or fainting).
• Dizziness, particularly on standing up.
• Thinning of your hair.
• Mood changes.
• Feeling confused.
• Memory loss.
• Changes in personality (psychoses).
• Hallucinations.
• Tingling of your hands.
• Disturbances of vision.
• Dry eyes.
• Skin rash.
• Reduced numbers of platelets in your blood which may make you bruise
more easily.
• Purplish marks on your skin.
Very rare (affects less than 1 in 10,000 people)
• Severe muscle weakness (myasthenia gravis).
• Changes to some of the cells or other parts of your blood. Your doctor
may take blood samples every so often to check whether Inderal has had
any effect on your blood.
• Low levels of sugar in the blood (hypoglycaemia). This can happen in
people with or without diabetes. This includes elderly people, people on
artificial kidneys (haemodialysis) or people taking medicines for diabetes.
It may also happen if you are fasting or in people with a long-term liver
disease.
Conditions that may get worse
If you have any of the following conditions, they may get worse when you
start to take your medicine. This happens rarely affecting less than 1 in
1,000 people.
• Psoriasis (a skin condition).
• Being short of breath or having swollen ankles (if you have heart failure).
• Asthma or breathing problems.
• Poor circulation.
Do not be concerned by this list of side effects. You may not get any of
them. If any of the side effects get serious, or if you notice any side effects
not listed in this leaflet, please tell your doctor or pharmacist.

5) How to store Inderal





Keep all medicines out of the sight and reach of children.
Do not use after the expiry date printed on the carton label or blister strip.
Do not store above 25°C. Protect from light and moisture.
If the capsules become discoloured or show any other signs of
deterioration, you should seek the advice of your pharmacist who will tell
you what to do.
• Medicines should not be disposed of via wastewater or household waste.
Ask your pharmacist how to dispose of medicines no longer required.
These measures will help to protect the environment.

6) Further information
What Inderal contains:
• Each capsule contains either 80mg or 160mg of the active ingredient
propranolol hydrochloride in a modified release form.
• Inderal LA Capsules also contain the following inactive ingredients:
erythrosine (E127), ethylcellulose, gelatin, iron oxide (E172),
microcrystalline
cellulose,
titanium
dioxide
(E171)
and
methylhydroxypropylcellulose. 160mg capsules also contain glycerol
What Inderal looks like and contents of the pack
80mg capsules: The hard gelatin capsules consist of a clear pink body and
opaque, lavender cap, marked 'INDERAL LA-80' in black and contain
granules.
160mg capsules: The hard gelatin capsules consist of a clear pink body and
opaque, purple cap, marked 'INDERAL LA' in white and contain granules.
Inderal Capsules are available as calendar blister packs of 28 capsules.
PL 10383/0322
PL 10383/0323

160mg Capsules
80mg Capsules

POM

Who makes and repackages your medicine?
Your medicine is manufactured by AstraZeneca Produtos Farmaceuticos
Lda., Rua Humberto Maderia, 7 Valejas, 2745-663 Barcarena, Portugal.
Procured from within the EU and repackaged by Product Licence Holder:
Primecrown Ltd, 4/5 Northolt Trading Estate, Belvue Road, Northolt,
Middlesex, UB5 5QS.
Leaflet date: 27.02.2013
®

Inderal is a registered trademark of AstraZeneca UK Ltd.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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