EVOREL SEQUI

Active substance: NORETHISTERONE ACETATE MICRONISED

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Cover Front - outside

PACKAGE LEAFLET:
INFORMATION FOR THE USER

Evorel® Sequi
Estradiol hemihydrate,
norethisterone acetate
Evorel is a registered trademark

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Cover Front - inside

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Read all of this leaflet carefully
before you start using this medicine.

• Keep this leaflet. You may need to read it again
• If you have any further questions, ask your
doctor or pharmacist
• This medicine has been prescribed for you.
Do not pass it on to others. It may harm them,
even if their symptoms are the same as yours
• If you get side effects and they become
serious or if you notice any side effects not
listed in this leaflet, please tell your doctor or
pharmacist

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In this leaflet
1 What Evorel Sequi is and what it is
used for

5

2 Before you use Evorel Sequi

10

3 Safety of HRT

20

4 How to use Evorel Sequi

32

5 Possible side effects

45

6 How to store Evorel Sequi

50

7 Further information

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1 What Evorel Sequi is
and what it is used for
The name of your medicine is Evorel Sequi.
It belongs to a group of medicines called
hormone replacement therapy (HRT).
Evorel Sequi contains two medicines:
• An oestrogen (estradiol)
• A progestogen (norethisterone)
They are both female hormones.
Evorel Sequi comes in a ‘memory pack’. This can
be used to help you remember when to change
your patches. Each pack contains eight patches:
• Four ‘Evorel 50’ patches marked CE50
(containing estradiol only)
• Four ‘Evorel Conti’ patches marked CEN1
(containing estradiol and norethisterone)
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The hormones are spread evenly in each patch.
They pass slowly into your body through the skin.

What Evorel Sequi is used for

Evorel Sequi is used:
• For the symptoms of the menopause
(see ‘What is the menopause?’ on the next
page). It is only used in women who still have
a womb. It is suitable for women who have had
the menopause (postmenopausal) or who are
around the time of the menopause
(perimenopausal)
• To prevent osteoporosis (fragile bones) in
women who have had the menopause and
are most likely to have bone problems.
Evorel Sequi is only used if other medicines
for osteoporosis have been tried first and
they have not worked
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What is the menopause?

Women produce oestrogen hormones from
their ovaries throughout their adult life.
These hormones are important in sexual
development and control of the menstrual cycle.
The menopause happens when the level of
hormones produced by the ovaries goes down.
This is a gradual process. During this time,
the levels of oestrogen can go up and down.
This can cause:
• Hot flushes, night sweats or mood swings
• Vaginal problems such as dryness or itching
• Uncomfortable or painful sexual intercourse
You may get the same symptoms if you have
had your ovaries taken out in an operation.

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How Evorel Sequi works

Evorel Sequi is known as ‘continuous
sequential’ HRT. This is because two
hormones are used one after another:
• Estradiol is used by itself for two weeks
• Then estradiol and norethisterone are used
together for the next two weeks
Evorel Sequi patches replace the oestrogen
that is normally released by the ovaries.
However, taking an oestrogen hormone
regularly may cause the lining of your womb
to build up and get thicker.
• This means it is necessary to add
a progestogen hormone to the oestrogen
• This helps shed the lining of the womb and
stop any problems happening. Evorel Conti
patches used during weeks 3 and 4 contain
this progestogen
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The shedding of the lining of the womb will
probably give a ‘withdrawal bleed’. This will be
like having a period each month. The withdrawal
bleed will start during week 4, before you finish
an Evorel Sequi pack.
Evorel Sequi is not a contraceptive.

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2 Before you use Evorel
Sequi
Do not use Evorel Sequi if:

• You are allergic to anything in the patches
(listed in section 7 below)
• You have (or have ever had) or think you may
have breast cancer
• You have (or are suspected of having) or ever
had a cancer that is made worse by oestrogens
(such as endometrial cancer)
• You have a thickening of the lining of the
womb which has not been treated
• You have vaginal bleeding you cannot explain
• You have ever had blood clots in a vein
(thrombosis) or a blood clot that has travelled
to your lung (pulmonary embolism)
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Do not use Evorel Sequi if:

• You have problems with your blood which
increases the likelihood of developing a blood
clot (thrombosis);
(such as protein C, protein S or antithrombin
deficiency)
• You have ever had blocked arteries (arterial
thrombo-embolic disease) that gave you
angina or a heart attack or a stroke
• You have ( or have ever had) a liver disease
and your liver function tests have not returned
to normal
• You have a blood problem called ‘porphyria’

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Do not use this medicine if any of the above
applies to you. If you are not sure, talk to your
doctor or pharmacist before using Evorel Sequi.
Stop using Evorel Sequi at once if any of the
above appears for the first time and talk to your
doctor immediately.
Evorel Sequi should not be used by children.

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Medical check-ups

Before taking HRT, your doctor should ask
about you and your family’s medical history.
Your doctor may decide to examine your
breasts or your tummy and may do an internal
examination. They will only do this if it is
necessary for you or if you have any special
concerns.
Once you have started on HRT, see your doctor
for regular check-ups (at least once a year).
At these check-ups, your doctor may discuss
the benefits and risks of continuing to take HRT.

Make sure that you:

• Go for regular breast screening and cervical
smear tests
• Regularly check your breasts for any changes
such as dimpling of the skin, changes in the
nipple or any lumps you can see or feel

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Take special care with Evorel Sequi

Tell your doctor if you have ever had any of the
following. You may need t to have checks more
often.
• Vaginal bleeding which you could not explain
• A problem caused by growth of the womb lining:
• Inside the womb (fibroids)
• Outside the womb (endometriosis)
• Thickening of the lining of the womb
(endometrial hyperplasia)
• Increased risk of blood clots (see ‘Blood clots’
in section 3 below)
• A family history of increased risk of cancers
related to oestrogens (see ‘Breast cancer’
in section 3 below)
• High blood pressure (hypertension).
Your doctor may tell you to stop using
Evorel Sequi if your blood pressure goes up
• Diabetes
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• Gallstones
• Migraine or severe headaches
• Systemic Lupus Erythematosus (SLE).
This is an allergic condition that causes
joint pain, skin rashes and fever
• Epilepsy
• Asthma
• A disease affecting the eardrum and hearing
(otosclerosis)
• Liver, heart or kidney problems
• High levels of triglycerides (a type of fat) in
your blood as you may have a higher risk of
pancreatitis (inflammation of the pancreas, which
causes severe pain in the abdomen and back)
• Any breast problems
• History of sudden swelling of the face or
throat, which may cause difficulty in
swallowing or breathing, rapid swelling of
the hands and feet and stomach cramps
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You may still be able to use Evorel Sequi, but you
should discuss this with your doctor first. Also tell
your doctor if these illnesses return or get worse
while you are using Evorel Sequi.
If you have had a premature menopause the risk
of using HRT may be different. Talk to your
doctor about the risks.
Other conditions:
• If you have brown patches on your face or
body (chloasma) or have a history of them,
you may need to keep out of the sun or away
from sunbeds (these patches may not
completely disappear again)

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Taking other medicines

Please tell your doctor or pharmacist if you
are taking or have recently taken any other
medicines. This includes medicines that you
buy without a prescription or herbal medicines.
In particular, tell your doctor or pharmacist
if you are taking any of the following:
• Medicines for epilepsy such as phenobarbital,
phenytoin or carbamazepine
• Certain medicines for infections such as
rifampicin, rifabutin, nevirapine, efavirenz,
ritonavir or nelfinavir
• Bosentan - for high blood pressure in the
blood vessels of the lungs
• St. John’s Wort - for depression
Taking these medicines with Evorel Sequi can
stop it from working as well. Because of this you
may get some bleeding like a period, when you
are not expecting it.

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In particular, tell your doctor or pharmacist
if you are taking any of the following:
• A medicine for epilepsy called lamotrigine.
Using Evorel Sequi with lamotrigine could
affect control of your epilepsy

Operations or tests

Tell your doctor if you are going to have surgery.
You may need to stop taking HRT about 4 to
6 weeks before the operation to reduce the risk
of a blood clot. Your doctor will tell you when you
can start taking HRT again.
If you visit a hospital or your family doctor for
a blood or urine test, tell them that you are
taking Evorel Sequi. This is because this
medicine may affect the results of the tests.

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Pregnancy and breast-feeding

Do not use this medicine if you are pregnant,
think you may be pregnant or might become
pregnant. This is because it may affect the baby.
If you become pregnant, contact your doctor
straight away and remove the patch.
Do not use this medicine if you are
breast-feeding.
Ask your doctor or pharmacist for advice before
taking any medicine if you are pregnant or
breast-feeding.

Driving or using machines

There is no information about whether Evorel
Sequi affects your ability to drive or use
machines. See how this medicine affects you
before you drive or use any tools or machines.
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3 Safety of HRT
As well as benefits, HRT has some risks.
Consider the following when deciding to take
or continue HRT.

Heart disease

HRT is not recommended for women who
have had heart disease recently. If you have
ever had heart disease, talk to your doctor to
see if you should be taking HRT.
HRT will not help to prevent heart disease.
Studies of HRT (containing oestrogen and
progestogen) have shown that women may be
slightly more likely to get heart disease.

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If you get a pain in your chest that spreads
to your arm and neck:
• See a doctor as soon as possible
• Do not use any more HRT until your doctor
says you can
This pain may be a sign of heart disease.

Stroke

Research suggests that HRT slightly increases
the risk of having a stroke. Other things that can
increase the risk of stroke include:
• Getting older
• High blood pressure
• Smoking
• Drinking too much alcohol
• An irregular heartbeat
If you are worried about any of these things or
if you have had a stroke in the past, talk to your
doctor to see if you should take HRT.
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How likely is a stroke?
Looking at women in their 50s, on average,
over 5 years:
• In women not taking HRT - 3 in 1000 would
be expected to have a stroke
• In women taking HRT - 4 in 1000 would be
expected to have a stroke
Looking at women in their 60s, on average,
over 5 years:
• In women not taking HRT - 11 in 1000 would
be expected to have a stroke
• In women taking HRT - 15 in 1000 would be
expected to have a stroke

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If you get migraine-type headaches which you
cannot explain:
• See a doctor as soon as possible
• Do not use any more HRT until your doctor
says you can
These headaches may be an early warning sign
of a stroke.

Blood clots

HRT is not recommended for women who
have ever had a blood clot.
HRT may increase the risk of blood clots in the
veins (also called deep vein thrombosis or
DVT), especially during the first year of taking it.
These blood clots are not always serious.
However, if a clot travels to the lungs, it can cause
chest pain, breathlessness, collapse or even
death. This is called pulmonary embolism or PE.
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You are more likely to get a blood clot if:
• You are very overweight (BMI > 30 kg/m²)
• You have had a blood clot before
• Any of your close family have had blood clots
• You have had one or more miscarriages
• You have any blood clotting problem that
needs treatment with a medicine such as
warfarin
• You are off your feet for a long time because
of major surgery, injury or illness
• You are going on a long journey and will not
be moving about for some time
• You have a rare illness called SLE
(Systemic Lupus Erythematosus)
• You have cancer
If any of these things apply to you, talk to your
doctor to see if you should take HRT.

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How likely is a blood clot?
Looking at women in their 50s, on average,
over 5 years:
• In women not taking HRT - 3 in 1000 would
be expected to get a blood clot
• In women taking HRT - 7 in 1000 would be
expected to get a blood clot
Looking at women in their 60s, on average,
over 5 years:
• In women not taking HRT - 8 in 1000 would
be expected to get a blood clot
• In women taking HRT - 17 in 1000 would be
expected to get a blood clot
If you get painful swelling in your leg, sudden
chest pain or have difficulty breathing:
• See a doctor as soon as possible
• Do not use any more HRT until your doctor
says you can
These may be signs of a blood clot.

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Breast cancer

Women who have breast cancer or have had
breast cancer in the past should not take HRT.
Taking HRT slightly increases the risk of breast
cancer. The risk is also slightly increased if you
have a later menopause.
• Postmenopausal women taking oestrogen-only
HRT for 5 years - the risk is about the same as
for a woman of the same age who is still having
periods over that time and not taking HRT
• Women taking oestrogen plus progestogen
HRT - the risk is higher than for oestrogen-only
HRT. However, oestrogen plus progestogen
HRT is beneficial for the endometrium
(see ‘Endometrial cancer’)
For all kinds of HRT, the extra risk of breast cancer
goes up the longer you take it. However, it returns
to normal within about 5 years after stopping HRT.
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Your risk of breast cancer is also higher if:
• You have a close relative (mother, sister or
grandmother) who has had breast cancer
• You are very overweight
How likely is breast cancer?
Looking at women aged 50, on average, over
the next 15 years:
• In women not taking HRT - 32 in 1000 will
get breast cancer
• In women taking oestrogen-only HRT
at age 50 and take it for 5 years, between
33 and 34 in 1000 will get breast cancer
• In women taking oestrogen-only HRT for
10 years - 37 in 1000 will get breast cancer
• In women taking oestrogen plus
progestogen HRT at age 50 and take it for
5 years - 38 in 1000 will get breast cancer
• In women taking oestrogen plus progestogen
HRT for 10 years - 51 in 1000 will get breast
cancer
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If you notice any changes in your breast,
such as:
• Dimpling of the skin
• Changes in the nipple
• Any lumps you can see or feel
Make an appointment to see your doctor
as soon as possible.

Endometrial cancer (cancer of the
lining of the womb)

HRT is not recommended for women who
have ever had cancer of the lining of the womb.
Taking oestrogen-only HRT for a long time
can increase the risk of cancer of the lining
of the womb (the endometrium). Taking
a progestogen as well as the oestrogen
helps to lower the extra risk.
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If you still have your womb, your doctor will
usually prescribe a progestogen as well as
oestrogen. These may be prescribed separately
or as a combined HRT product.
If you have had your womb removed
(a hysterectomy), your doctor will discuss with
you whether you can safely take oestrogen
without a progestogen.
If you have had your womb removed
because of endometriosis, any endometrium
left in your body may be at risk of cancer.
This means your doctor may prescribe HRT that
includes a progestogen as well as an oestrogen.
Your product, Evorel Sequi, contains a progestogen.
Evorel Sequi is only used in women who still
have a womb (see Section 1 ‘What Evorel Sequi
is used for’).
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How likely is endometrial cancer?
Looking at women aged 50 who still have
a womb, on average, over the next 15 years:
• In women not taking HRT - 5 in 1000 will
get endometrial cancer
• In women taking oestrogen-only HRT, the
number will be 2 to 12 times higher, depending
on the dose and how long you take it for
The addition of a progestogen to oestrogen-only
HRT substantially reduces the risk of
endometrial cancer.
If you get breakthrough bleeding or spotting,
it is usually nothing to worry about, especially
during the first few months of taking HRT.
But if the bleeding or spotting:
• Carries on for more than the first few months
• Starts after you have been on HRT for a while
• Carries on even after you’ve stopped taking HRT
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Make an appointment to see your doctor as
soon as possible.
It could be a sign that your endometrium has
become thicker.

Ovarian cancer

Ovarian cancer (cancer of the ovaries) is rare,
but it is serious. It can be difficult to diagnose.
This is because there are often no obvious
signs of the disease. Some studies have
suggested that taking HRT for more than
5 years may increase the risk of ovarian cancer.

Dementia

Evorel Sequi and medicines like it will not stop
memory loss (dementia). Women who start using
medicines like Evorel Sequi after the age of 65
may have a small increase in the risk of dementia.
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4 How to use Evorel Sequi
Always use Evorel Sequi exactly as your doctor
has told you. You should check with your doctor
or pharmacist if you are not sure. Your doctor will
aim to reduce your symptoms with the lowest
possible dose for the shortest amount of time.

When to start using Evorel Sequi

You may put an Evorel 50 patch on at any
time if:
• You have not used HRT before your menopause
and no longer have menstrual periods
• Your menstrual cycles are not regular and you
are not pregnant
• You are changing from HRT that does not give
you a withdrawal bleed
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Put an Evorel 50 patch on within 5 days
of the start of bleeding if:
• You are not currently using HRT and still
having regular periods
Put an Evorel 50 patch on at the end of
a treatment cycle or one week after you
finish using another HRT product if:
• You are changing from an HRT medicine
that gives you a withdrawal bleed
If you are using another type of HRT:
• The day you start will depend on the type
of HRT you have been using
Talk to your doctor if you are not sure which
type of HRT you are using.

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Using the patches

The patches need to be changed twice a week.
You must use the patches in the right order.
Weeks 1 and 2
Use the four Evorel 50 patches one at a time.
Weeks 3 and 4
Use the four Evorel Conti patches one at a time.
As soon as you remove your fourth Evorel 50
patch, replace it with the first Evorel Conti patch.
Start a new pack of Evorel Sequi as soon as you
finish one. Do not leave a break between packs.

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Changing your patches

• You must change the patches twice a week to
give your body a steady supply of hormones.
There is enough hormone in each patch to last
for several days
• Change your patch on the same two days
every week. This will mean that one patch is
on for three days and the next patch for four
days
• For example, if you apply your first patch on
a Monday, change it on Thursday and again
on the following Monday. You can work out
your two days from the following table,
starting from the first day of use:

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If you put your
first patch on:

Change on:

Change
again on:

Monday

Thursday

& Monday

Tuesday

Friday

& Tuesday

Wednesday

Saturday

& Wednesday

Thursday

Sunday

& Thursday

Friday

Monday

& Friday

Saturday

Tuesday

& Saturday

Sunday

Wednesday & Sunday

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To help you remember your two “patch change"
days, mark them here or on the pack. They are
written on the pack like this:

Where to apply the patch

Stick the patch onto a hairless area of skin
below the waist. Most women prefer to wear the
patch on the thigh or bottom.
• Do not apply on or near the breasts
• Do not put it on top of cuts, spots or anywhere
the skin is irritated
• Do not use cream, moisturiser or talc before
applying the patch
• Do not apply the patch on the same area of
skin twice in a row
• It can be worn under loose areas of clothing
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• Do not wear a patch under elasticated areas
or a tight waistband
• Apply the patch to clean, dry, cool skin as
soon as you open the protective pouch

Putting a patch on

Do not use a patch if its protective pouch is
already open.
Step 1: Open and Peel
• Using the notches as a guide,
tear along two edges of the
pouch. Remove the patch
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• With the protective backing
facing you, bend and peel off
half the backing. Don’t touch
the sticky side - it may not
stick properly if you do
Step 2: Apply and Press
• Apply the open half of the
patch to your skin
• Remove the remaining
backing and press down the
rest of the patch
• Press the patch with the palm
of your hand to make sure it
is firmly stuck

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Removing a patch

• Peel an edge of the patch
smoothly away from the skin
• Fold the patch in half, so that
the sticky side sticks to itself
• Put it in with the household
rubbish, safely out of the
reach of children and pets
• Do not flush used patches down the toilet
When you remove the patch some glue may
remain on your skin. It will disappear with time
or you can use baby oil to remove it.

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If a patch falls off

Apply a new patch of the same type. If you have
just had a bath or shower, wait until your skin
cools before applying the new patch.
It is always useful to keep a spare pack that you
can use to replace patches that have fallen off.
Talk to your doctor if you need more patches.

If you forget to change the patch

Change it as soon as you remember and then
keep to your original ‘patch change’ days.
You may get some bleeding and spotting like
a period during this time.

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If you use more Evorel Sequi than
you should

It is unlikely that you will have too much of the
hormones in Evorel Sequi. The most common
symptoms of having too much oestrogen or
progestogen in your body are:
• Tender breasts
• Feeling sick (nausea) or being sick
• Unexpected vaginal bleeding
• Stomach pain or bloating
Removing the patch can reverse the effects
of too much oestrogen and/or progestogen.
Talk to your doctor or pharmacist before using
any more patches.

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Contraception while using Evorel
Sequi

The levels of hormone from the patches are too
low to act as a contraceptive. Use non-hormonal
contraceptive methods (such as a condom,
diaphragm or coil) until your periods have
completely stopped.

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Everyday activities

• You can have a bath or shower as normal.
Do not scrub too hard as this can loosen the
edges of the patch
• You can go swimming. The patch will not be
affected
• You can exercise and play sports. However,
do not wear the patch under tight clothing or
waist bands
• You can sunbathe. However, keep the patch
covered, out of direct sunlight
If you have any further questions on the use
of this product, ask your doctor or pharmacist.

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5 Possible side effects
Like all medicines, Evorel Sequi can cause side
effects, although not everybody gets them.
Take off the patch and tell your doctor
straight away if you notice or suspect
any of the following. You may need urgent
medical treatment.
• Blood clots (thrombosis) or stroke
(frequency not known)
• Yellowing of the skin or whites of the eyes
(jaundice) or other liver problems
• Migraine-type headaches for the first time
or more frequent (affects less than 1 in
10 people)

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• An increase in blood pressure (affects less
than 1 in 10 people)
• Breast or ovarian cancer, endometrial cancer
or hyperplasia (long, heavy or irregular vaginal
bleeding)
• Widespread rash with peeling skin and
blistering in the mouth, eyes and genitals
(Stevens-Johnson syndrome) (frequency not
known)
• Convulsions or fits (frequency not known)
Tell your doctor if you notice any of the
following side effects while using Evorel Sequi:
Very common (affects more than 1 in 10 people)
• Irritated, itchy red skin where the patch is
applied

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Common (affects less than 1 in 10 people)
• Feeling depressed or nervous
• Inappropriate signs of emotion
• Being unable to sleep
• Headache
• Itchy skin or red rash
• Feeling sick (nausea), or having stomach pain
wind or other stomach upsets
• Diarrhoea
• Pain including pain in the back, muscles, joints
• Breast pain
• Feeling generally unwell
• Weight gain
• Heavy vaginal bleeding, painful periods
• Water retention or build-up of fluid under the
skin (oedema)

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Uncommon (affects less than 1 in 100 people)
• Concentration problems
• Feeling dizzy
• More or less interest in sex than usual
• Allergic reaction (hypersensitivity)
• A fungal infection called thrush
• Feeling tired
• Being aware of your heartbeat (palpitations)
• Numb or tingling hands or feet, less skin
sensitivity
• Breast lumps (non-cancerous)
• Fuller breasts
• Irregular vaginal bleeding
• Thickening of the lining of the womb

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Frequency not known
• Mood swings
• Bloated feeling
• Gallstones
• Swelling of the hands and feet
(peripheral oedema)
• Puffy skin where the patch is applied
If any of the side effects gets serious, or if you
notice any other side effects not listed in this
leaflet, please tell your doctor or pharmacist.

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6 How to store Evorel
Sequi
Keep out of the reach and sight of children.
It should be stored at room temperature
(at or below 25°C).
Do not use Evorel Sequi after the expiry date
which is stated on the label. The expiry date
refers to the last day of that month.
Do not use a patch if its protective pouch is
open.

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7 Further information
The active substances in Evorel Sequi are
estradiol hemihydrate and norethisterone acetate.
Each Evorel 50 patch contains 3.2 mg of
estradiol hemihydrate. Each Evorel 50 patch
delivers 50 micrograms of estradiol a day.
Each Evorel Conti patch contains 3.2 mg of
estradiol hemihydrate and 11.2 mg of
norethisterone acetate. Each Evorel Conti patch
delivers 50 micrograms of estradiol and
170 micrograms of norethisterone a day.
The other ingredients are Duro-Tak 387-2287
(this makes the patches sticky), guar gum and
Hostaphan MN19 (backing film).

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What Evorel Sequi looks like and
contents of the pack

Evorel Sequi comes in a memory pack
containing four Evorel 50 patches (marked
CE50) and four Evorel Conti patches (marked
CEN1).
Both types of patch are square with rounded
corners. They are clear with a sticky backing
that can be stuck to the skin. Each patch comes
in a protective sealed pouch and has a surface
area of 16 sq cm.
The product licence is held by:
JANSSEN-CILAG LTD, 50-100 Holmers
Farm Way, High Wycombe, Buckinghamshire
HP12 4EG, UK

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Evorel Sequi is made by:
Janssen Pharmaceutica NV, Turnhoutseweg 30,
B-2340 Beerse, Belgium
OR
McGregor Cory Ltd, Middleton Close, Banbury,
Oxfordshire OX16 4RS, UK

For information in large
print, tape, CD or Braille,
telephone 0800 7318450.
This leaflet was last approved in APRIL 2013

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BLANK PAGE

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Cover Back - inside

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Cover Back - outside

© J-C 2011
GB - AW_74123

AW_74123.pdf - Page 56 of 57 - June 7, 2012 - 09:40:53

JANSSEN-CILAG

Graphic Services
Tel. Inge Vermeiren: +32 14606915 - E-mail: ivermei1@its.jnj.com
Tel. François Vermeylen: +32 14606865 - E-mail: fvermeyl@its.jnj.com
BOOKLET EVOREL SEQUI

Market: GB

Article Number : AW_74123
Format Name : B/BO/004/V1 (72x72)

Mat. ID Code: NA
Operator: EPE

Pointsize : 8 pt
File Name : AW_74123.indd (CS4 - PC)
L
Black

A

B

Date: 1. 30-11-2011
2. 01-12-2011
3. 06-12-2011
4. 09-12-2011
5. 13-12-2011
6. 16-03-2012
7. 11-05-2012 (BEP)
8. 07-06-2012

AW_74123.pdf - Page 57 of 57 - June 7, 2012 - 09:40:53

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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