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Active substance: CALCIPOTRIOL

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Dovonex® Ointment

In this leaflet:
1. What Dovonex® is and what it is used for
2. Before you use Dovonex®
3. How to use Dovonex®
4. Possible side effects
5. How to store Dovonex®
6. Further information

Dovonex® belongs to a group of medicines called
anti-psoriatics. It is a type of vitamin D.
Vitamin D controls how the cells in your skin grow.
If the cells in your skin grow too much you may get psoriasis.
Psoriasis is a condition where your skin develops raised red
patches and silver coloured scaly patches. The scaly patches
are dead cells that would normally fall off your skin without
you noticing.
Dovonex® works by reducing the amount of cells your skin
makes. This means your skin symptoms will reduce too.
These diagrams explain how your skin may improve when you
use this medicine.
Patch of


Your skin before treatment.

After about two weeks you
may see a change in your
skin. The scaly or flaky
patches usually clear up first.
They will feel smoother.

The redness of the skin will
start to clear up next. It may
clear up in the centre first.

Dovonex® is used to treat:
• Plaque psoriasis (psoriasis vulgaris).

Do not use Dovonex®
• If you are allergic (hypersensitive) to calcipotriol or any
of the other ingredients in your medicine. You can find a list
of these ingredients in section 6 of this leaflet.
• If you have been told by a doctor that you have high or low
levels of a substance called calcium in your body (calcium
metabolism disorders).
• If you have severe kidney problems.
• If you have severe liver problems.
Take special care with Dovonex®
Before you use Dovonex® tell your doctor:
• If you are already having ultraviolet (UV) light treatment.
You must discuss with your doctor about having light
treatment and using Dovonex® at the same time.
• If you know you have a type of psoriasis called generalised
pustular psoriasis. Ask your doctor if you are unsure.

• If you know you have a type of psoriasis called erythrodermic
exfoliative psoriasis. Ask your doctor if you are unsure.
Do not use Dovonex® on your face.
Your doctor may tell you to limit your exposure to natural or
artificial sunlight while you are using this medicine.
You may get too much calcium in your blood when you use
this medicine. Please read section 4 of this leaflet so that you
can spot any signs this may be happening to you. Your doctor
may need to change your dose.
You are not likely to get too much calcium in your blood if you
use the dose prescribed for you. You can find the dose that
you should use in section 3 of this leaflet. You are more likely
to get too much calcium in your blood if you use more than
the recommended dose each week.
Taking other medicines
Please tell your doctor or pharmacist if you are taking, or
have recently taken any other medicines. This includes any
medicines which you have bought without a prescription.
You must tell your doctor or pharmacist if you are taking any
of the following medicines:
• Any other medicines to treat psoriasis.
Pregnancy and breast-feeding
Please ask your doctor or pharmacist for advice before using
• If you are pregnant, or think you are pregnant.
• If you are breast-feeding.
Tell your doctor if you become pregnant while using this
If your doctor has agreed that you can breast-feed, do not
apply Dovonex® to the breast area.
Driving and using machines
Usually your medicine may have very little effect on your ability
to drive or use machines. Check with your doctor if you feel any
side effect that may stop you from driving or using machines.
Important information about some of the ingredients of
Dovonex® contains:
• Propylene glycol. It may irritate your skin.
Please ask your doctor if you are worried about any of the
ingredients in this medicine.

Always use Dovonex® exactly as your doctor has told you.
You should check with your doctor or pharmacist if you are
not sure.
How to put on Dovonex®
This medicine is only for using on your skin or the skin of a
child. Do not swallow it. Do not put it inside your body.
Never put this medicine on your face or the face of your child
as it may cause irritation.
Do not mix Dovonex® with any other medicines.
Remove the cap. Check the seal is not broken before you first
use the ointment. If you have a 30 gram tube, you will need to
break the seal by using the point in the back of the cap.
Always wash your hands before using Dovonex®.
Put your medicine on the skin which has the psoriasis. You
can squeeze your medicine on to your skin directly. You can
squeeze it on to your finger first if you wish. Put your medicine
on thickly. Then rub it in gently to cover the psoriasis.


Please read all of this leaflet carefully before you start using this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if theirm symptoms
are the same as yours.
• If any of the side effects become serious, or you notice any side effects not listed in this leaflet please tell your
doctor or pharmacist.
• In this leaflet Dovonex® Ointment will be called Dovonex®.

Like all medicines, Dovonex® can cause side effects,
although not everybody gets them.
Important side effects to look out for:
You must get urgent medical help if you have any of the
following symptoms. You may be having an allergic reaction:
• You have difficulty breathing
• Your face including around your eyes swell
• Your skin develops a severe rash.
You should tell your doctor straight away if you spot any of
the following signs which may be due to too much calcium
in your blood:
• You need to pass water (urine) more often
• You feel thirsty
• You have a dry mouth or a metallic taste in your mouth
• You feel weak or have pain in your muscles or bones
• You have a headache
• You feel sick or have constipation.
Other possible side effects:
The possible side effects in the following section of this
leaflet are usually mild.
Very common side effects (probably affect more than
1 in 10 people)
• Skin irritation.

Common side effects (probably affect up to 1 in 10 people)
• Rash
• Burning or stinging feeling
• Dry skin
• Itching skin
• Redness
• Itchy rash and skin inflammation in the area where the
medicine is used.
Uncommon side effects (probably affect less than 1 in 100
• Worsening of your psoriasis
• Red, itchy, scaly rash. Blisters may form.
These may weep or become crusty (eczema).
Side effects where the number of people affected is not known
• Itchy raised rash (hives)
• Temporary changes in your skin colour
• Temporary increased sensitivity to sunlight.
If any of the side effects become serious or you notice any side
effects not listed in this leaflet, tell your doctor or pharmacist.

• Keep out of the reach and the sight of children.
• Do not use Dovonex® after the expiry date on the carton.
The expiry date is the last day of that month.
• Do not keep the tube for more than 6 months after you first
open it. Write the date you first opened the tube in the
space provided on the carton.
• Do not store above 25°C.
Medicines should not be thrown away in waste water or in
household waste. Please ask your pharmacist how to throw
away any medicine you do not need anymore. If you do this
you will help protect the environment.

What Dovonex® contains
• The active ingredient is calcipotriol. Dovonex® contains
50 micrograms of calcipotriol in each gram of ointment.
• The other ingredients are disodium edetate, disodium
phosphate dihydrate, DL-α-tocopherol, liquid paraffin,
macrogol (2) stearyl ether, propylene glycol, purified water
and white soft paraffin.
You can find important information about some of the
ingredients in your medicine near the end of section 2 of
this leaflet.
What Dovonex® looks like and contents of the pack
Dovonex® is an off white to yellowish white translucent
Dovonex® comes in tubes of 30 grams.
Marketing Authorisation Holder and Manufacturer
Marketing Authorisation Holder:
LEO Laboratories
Limited, Hurley, Berkshire SL6 6RJ, UK.
LEO Laboratories Limited, Dublin 12, Ireland.
This leaflet was last revised in Ocotober 2013.
More about psoriasis
You can get psoriasis anywhere on your body.
Psoriasis is not infectious so you do not need to worry about
other people catching it from you.
We still do not know what causes psoriasis but you can inherit
it. Other things can make psoriasis worse such as stress.
For further information about psoriasis, you can contact:
The Psoriasis Association
If you have any questions about your treatment, ask your
doctor or pharmacist.
®Registered Trade Mark



Always wash your hands after using Dovonex®. This will stop
any medicine accidentally spreading to other parts of your
body. Do not worry if you accidentally get any ointment on
your normal skin, but wash it off if it spreads too far.
Unless you are using the ointment to treat your hands, always
wash your hands after using Dovonex®.
You should try to keep your skin well moisturised particularly
after a bath or shower. If you use a moisturiser wait for it to
soak in before you use your medicine.
How much Dovonex® to use
Your doctor will tell you how much Dovonex® to use, or give
to your child.
For the best results you should use Dovonex® twice each day.
If you are an adult, your doctor may suggest you use the
medicine once a day. If you use it twice a day, use it in the
morning and in the evening. To remind you to use your
medicine it may help to use it when you do another regular
action, such as brushing your teeth.
Your dose will depend on how bad your psoriasis is. Your
doctor will prescribe the dose that is right for you.
Use the medicine once or twice each day. Follow the advice
of your doctor.
Do not use more than 100 grams each week.
The dose will depend on how bad the psoriasis is. Your doctor
will prescribe the dose that is right for your child.
• Children over 12 years old:
Use the medicine twice each day.
Do not use more than 75 grams each week.
• Children between 6 and 12 years old:
Use the medicine twice each day.
Do not use more than 50 grams each week.
• Children under 6 years old:
Always refer to your doctor for advice.
If you use more Dovonex® than you should
Tell your doctor straight away.
You may get too much calcium in your blood. Please read
section 4 of this leaflet so you can spot any signs that this
may be happening to you.
If you forget to use Dovonex®
If you forget to use your medicine, use it as soon as you
remember. Then next use your medicine at the usual time.
If you have any further questions about taking this medicine,
please ask your doctor or pharmacist.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.