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S609 LEAFLET Deponit 20131121


Taking other medicines

(glyceryl trinitrate)
Read all of this leaflet carefully before you start using this

This medicine has been prescribed for you. Do not pass it on to
others. It may harm them, even if their symptoms are the same
as yours

Medicines which are used to treat angina, heart failure, or an
irregular heartbeat. A blood condition (methaemoglobinaemia)
can occur when other nitrate treatments are given at the same
time. This can result in breathing problems, anxiety, loss of
consciousness and heart attack.

Medicines which reduce blood pressure (e.g. beta-blockers,
calcium channel blockers, vasodilators, ACE inhibitors)

Diuretics (water tablets)

Tricyclic antidepressants (used to treat depression)

Neuroleptics (used to treat anxiety)

Dihydroergotamine (used to treat migraine)

Aspirin or other non-steroidal anti-inflammatory drugs (used to
treat pain)

Any other medicine, including medicines obtained without a

If you have further questions, please ask your doctor or

Tell your doctor if you are taking any of the following

Keep this leaflet. You may need to read it again

 In this leaflet Deponit 10mg/24h Patches will be called Deponit.
In this leaflet:
1. What Deponit is for
2. Before you use Deponit
3. How to use Deponit
4. Possible side effects
5. How to store Deponit
6. Further information.

Do not take Deponit with medicines for failure to achieve
an erection such as Viagra. Using Deponit with these
medicines could cause a severe drop in blood pressure
and could lead to collapse and unconsciousness, and may
be fatal

If any of the above applies to you, do not take Deponit. Talk to your

Deponit belongs to a group of medicines called ‘nitrates’. These are
used to widen your blood vessels and reduce the workload of your
Deponit is used to prevent angina pectoris. Angina attacks feel like
a tight pain in your chest, neck or arm and are a sign that your heart
is not getting enough oxygen for the amount of work it is doing.

Using Deponit with food and drink
Do not drink alcohol whilst using Deponit as it can cause your blood
pressure to drop. This may make you may feel dizzy or faint.
Pregnancy and breast-feeding
If you are pregnant, trying to become pregnant or breast feeding,
ask your doctor for advice before using Deponit.

Do not use Deponit if:

Driving and using machines

You are allergic to glyceryl trinitrate or to any of the other
ingredients in Deponit (See section 6)

Deponit may make you feel dizzy, tired or have blurred vision. If this
happens to you, do not drive a vehicle or operate machinery.

You are taking medicines for failure to achieve an erection such
as Viagra. Using Deponit with these medicines could cause a
severe drop in blood pressure and could lead to collapse and
unconsciousness, and may be fatal


You suffer from low blood pressure


You suffer from low blood volume

You suffer from anaemia (low iron levels in your blood)

You have an eye disease called glaucoma

Your doctor will choose the dose that is right for you. Your
dose will be shown clearly on the label that your pharmacist
puts on your medicine. If it does not, or you are not sure, ask
your doctor or pharmacist.

You have a heart valve disorder

Deponit is not suitable for children.

You suffer from inflammation of the heart lining

Adults and the Elderly

You suffer from increased fluid around the heart (cardiac

You suffer from a heart condition called hypertrophic obstructive

You have ever had a serious head injury, cerebral haemorrhage
(bleeding in the brain) or a disease which is accompanied by
increased pressure on the brain

Always use Deponit exactly as your doctor has advised.

Normally one patch per day is enough

Your doctor may increase this to two patches depending on
how you respond to the medicine

Each morning put on a new patch

Remove the patch before you go to bed

You must have 8 to 12 hours each day without a patch on. This
will prevent you from becoming tolerant to the medicine. If you
do this it will ensure the treatment remains effective.

You have an acute angina attack. Your doctor will give you a
different medicine such as a GTN spray for this.

If any of the above applies to you talk to your doctor.
Check with your doctor before using Deponit if:

When applying the patch you should always:

Place the new patch on a different area of skin

Allow several days to pass before applying a fresh patch to
the same area of skin.

You have an underactive thyroid gland

You have any diseases of the lungs, liver or kidneys

You have recently had a heart attack or you suffer from heart

Things to remember:

Do not stretch the skin when putting a patch on

You suffer from hypoxaemia (insufficient oxygen in your blood)

Do not put the patch on a cut or reddened area of skin

You have hypothermia (very low body temperature)

Do not pull the patch off the skin and then stick it back on again.

You are malnourished (severe lack of food).

How and where to apply the patch

Uncommon side effects (affects less than 1 in 100 people)

Collapse sometimes with a slow heart beat and fainting

Very low blood pressure (severe hypotension) where you are
being sick, feeling sick, are restless, have a pale skin and sweat
a great deal. This may lead to a worsening of the chest pain
you often get with angina

Temporary low oxygen level in the blood (temporary
hypoxaemia). For people with heart disease this may lead to
low oxygen level in the tissue surrounding the heart (myocardial

A slight reddening, slight itching or burning sensation on the
skin where you have applied the patch. This usually disappears
after the patch has been removed.

Allergic skin rash, which may be severe

Flushing of the face

Choose a smooth area of skin to apply the patch. The area
should be hairless, to ensure good contact of the patch with the
skin. The chest, upper abdomen, upper arm, shoulder or thigh
is suitable.

Your hands and the skin where you will apply the patch should
be clean and dry. Do not use powder or moisturiser.

Tear open the wrapper across the top, take out the patch and
hold it with the writing facing away from you.

Feeling sick

Being sick

Fold the patch along the S-shaped cut so the sides of the
backing come apart.

Very red skin with scaling and thickened itchy skin (exfoliative

Hold the patch on one side and peel off the backing on the
other side to expose the sticky patch. Place the sticky side of
the patch directly onto the skin.


Peel off the remainder of the backing and press down firmly
with the palm of your hand.

If you use more Deponit than you should
If you accidentally use more Deponit than you should, remove the
patches straight away and immediately go to your doctor or the
nearest hospital casualty department.
If you use more Deponit than you should, you may have a fall in
blood pressure. This may make you feel dizzy, weak and lightheaded on standing. You may also be pale, sweat a lot, have a
weak pulse, rapid heart beats (tachycardia), flushed skin,
headache, feel sick or be sick. In severe cases of overdose you
may get an increase of the pressure of the fluid around the brain.
If you forget to use Deponit

If any of the side effects gets serious, lasts for more than a few
days or if you notice any side effects not mentioned in this leaflet,
please tell your doctor.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet. You
can also report side effects directly via the Yellow Card Scheme at:
By reporting side effects, you can help provide more information on
the safety of this medicine.


Do not store above 25°C. Store in the original package.

Do not use after the expiry date printed on the carton or patch

If you forget to change your patch: Take the old one off and put
a new one on as soon as you remember, then carry on as

Medicines should not be disposed of via wastewater or
household waste. Return all unused medicine to your

If you forget to apply a patch: Put a new one on as soon as
possible, then carry on as before.

If the medicine becomes discoloured or shows any other signs
of deterioration, you should seek the advice of your pharmacist
who will tell you what to do.

Do not take a double dose to make up for a missed dose.
If you stop using Deponit


Do not stop using Deponit even if you feel better. If you stop taking
your medicine your condition may get worse. Keep using Deponit
until your doctor tells you to stop.

What Deponit contains

If your doctor thinks you should stop taking Deponit your dose will
gradually be reduced.
Like all medicines, Deponit can cause side effects, although not
everybody gets them.
Stop using Deponit and seek immediate medical help if you
have an allergic reaction. This includes any of the following

Sudden wheeziness

Difficulties in breathing

Swelling of your eyelids, face or lips

Rash or itching especially those covering your whole body.

Very common side effects (affects more than 1 in 10 people)

Headaches at the start of treatment. These usually disappear
after a few days of continuing to use the patches.

Common side effects (affects less than 1 in 10 people)

Low blood pressure (hypotension) and lightheadedness upon
standing which you may notice as dizziness, drowsiness, rapid
heart beat (reflex tachycardia) and a feeling of weakness at the
start of treatment or when the dosage is increased.

Each patch contains 37.4mg of glyceryl trinitrate and is
designed to release 10mg of glyceryl trinitrate in 24 hours.

Deponit also contains the following inactive ingredients:
acrylate/ vinyl acetate copolymer, polypropylene, polyethylene.

What Deponit looks like and contents of the pack
The patch is a self-adhesive transdermal patch.
Deponit is available as packs of 15 or 28 patches.
Product Licence holder
Procured from within the EU and repackaged by the Product
Licence holder: S&M Medical Ltd, Chemilines House,
Alperton Lane, Wembley, HA0 1DX.
This product is manufactured by

UCB Pharma GmbH, Monheim, Germany.

Aesica Pharmaceuticals GmbH, Alfred-Nobel-Strasse 10,
Monheim, Germany.


PL No: 19488/0609

Leaflet revision date: 21 November 2013
Deponit is a registered trade mark of Schwarz Pharma AG,
S609 LEAFLET Deponit 20131121

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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