DDAVP 4 MICROGRAMS/ML INJECTION

Active substance: DESMOPRESSIN

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DDAVP 4 micrograms/ml Injection
(Desmopressin acetate)

PATIENT INFORMATION
Read all of this leaflet carefully before you
start using this medicine.
• Keep this leaflet, you may need to read it again
• If you have further questions, please ask your
doctor or pharmacist
• This medicine has been prescribed for you
personally and you should not pass it on to
others. It may harm them even if their
symptoms are the same as yours.
• If any of the side effects gets serious, or if you
notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
Important things that you need to know:
• DDAVP Injection is used
- to diagnose and treat cranial diabetes
insipidus
- to test kidney function
- during surgery or following trauma in
patients with mild to moderate haemophilia
(blood condition) or von Willebrand’s
disease (blood clotting condition)
- to treat headache prior to and resulting
from a lumbar puncture
- to test for fibrinolytic response
• You should avoid drinking large amounts of fluid
while you are being treated with
DDAVP Injection.
• If you experience unusually bad or prolonged
headache, confusion, unexplained weight gain,
ankle swelling, nausea or vomiting stop using
DDAVP Injection.

In this leaflet:
1. What DDAVP Injection is and what it is used for
2. Before DDAVP Injection is given
3. How DDAVP Injection will be given
4. Possible side effects
5. Storing DDAVP Injection
6. Further information

1. What DDAVP Injection is and
what it is used for
DDAVP Injection is a clear, colourless solution.
It contains Desmopressin acetate, an antidiuretic
(reduces urine production).
It is used:
• to diagnose and treat cranial diabetes insipidus
(a condition which causes extreme thirst and the
continuous production of large volumes of dilute
urine). IMPORTANT: This should not be confused
with diabetes mellitus (sugar diabetes)
• as a test to check if the kidneys are functioning
properly (renal function test).
• during surgery or following trauma in patients
with mild to moderate haemophilia (blood
condition) or von Willebrand’s disease (blood
clotting condition) to increase blood clotting
factors (Note: DDAVP Injection is not suitable
for every patient or for the treatment of all
types of haemophilia or von Willebrand’s
disease).
• to treat headache prior to or resulting from a
lumbar puncture (a procedure to obtain a sample
of fluid from the spine for laboratory examination
in the investigation of disorders of the nervous
system)
• to test for fibrinolytic response (a test to measure
the capacity of the body to dissolve blood clots
once they have formed)

2. Before DDAVP Injection is given
DDAVP Injection will not be given if you:
• are allergic to any of the ingredients listed in
section 6 of this leaflet
• drink unusually large quantities of fluids,
including alcohol
DDAVP Injection will not be given for the
treatment of lumbar puncture headache
or for a renal function test or to test
your fibrinolytic response if you:
• have high blood pressure or heart problems
• are taking diuretics (water tablets)
DDAVP Injection will not be given to
increase blood clotting factors if you:
• suffer from angina
• suffer from moderate to severe von Willebrand’s
disease
Please consult your doctor before
DDAVP Injection is given if you:
• have an illness causing fluid and/or
electrolyte imbalance e.g. vomiting,
diarrhoea, infections or fever
• have a medical condition that could be made
worse by fluid and/or electrolyte disturbance
(conditions where your blood sodium levels
are too low or you are likely to build up too
much water in your body, e.g. Hyponatremia
• suffer from serious heart or kidney disease
Renal function testing in children below 1 years
old should only be performed under carefully
supervised conditions in hospital.
Taking/using other medicines:
Please inform your doctor or pharmacist if you:
• are taking or have recently taken or used any
other medicines - even those not prescribed
• are on medication for depression or epilepsy
• are taking a medicine for pain and/or
inflammation containing non-steroidal
anti-inflammatory drugs (also known as
NSAIDs) e.g. indomethacin or ibuprofen
Taking DDAVP Injection with food or drinks:
• you should avoid drinking large amount of
fluid while you are being treated with
DDAVP Injection as this could lead to build up
of water which dilutes the salt in the body.
This is a serious problem and may lead to
convulsions. You should only drink enough
fluid to satisfy your thirst.
• when used for diagnostic purpose (fibrinolytic
response, kidney function, or cranial diabetes
insipidus), limit fluid intake to no more than
500ml, from 1 hour before until 8 hours after
the dose
Pregnancy:
If you are pregnant or planning a pregnancy,
please inform your doctor before you use
DDAVP Injection as blood pressure monitoring
is recommended due to the increased risk of
pre-eclampsia (a condition in pregnant women
that can cause serious complications).
Symptoms of pre-eclampsia include high
blood pressure, oedema (swelling due to the
build up of fluid) and proteinuria (protein in
the urine).
Breast-feeding:
If you are breast-feeding ask your doctor or
pharmacist for advice before using
DDAVP Injection.

3. How DDAVP Injection will be given

4. Possible side effects

Depending on the condition that you are being
treated for, the doctor will administer the
appropriate dose by injection either just under the
skin (subcutaneous), into a muscle (intramuscular)
or directly into one of your veins (intravenous).

Like all medicines, DDAVP Injection can cause
side effects.

Diagnosis of diabetes insipidus:
The usual dose for adults and children is 2
micrograms given by injection either just under the
skin (subcutaneous) or into a muscle (intramuscular).
Treatment of diabetes insipidus:
By injection either just under the skin
(subcutaneous), into a muscle (intramuscular) or
directly into one of your veins (intravenous).
Adults: The usual dose is 1 to 4 micrograms daily
Children and infants: Doses from 0.4 micrograms
may be used.
Renal function test:
A single dose of 2 micrograms is given to adults
and children by injection either just under the skin
(subcutaneous) or into a muscle (intramuscular).
During surgery or following trauma in patients
with mild to moderate haemophilia and von
Willebrand’s disease to increase blood clotting
factors:
The dose for adults, children and infants is 0.4
micrograms per kilogram body weight, administered
by intravenous infusion (by drip) over a period of 20
minutes. This dose should be given before surgery
or following trauma. Further doses may be
administered at 12 hourly intervals.
To treat headache prior to or resulting from a
lumbar puncture:
The dose for adults is 4 micrograms by injection
either just under the skin (subcutaneous) or into a
muscle (intramuscular). This dose can be given prior
to lumbar puncture to prevent headache or after
lumbar puncture when headache occurs.
This dose may be repeated 24 hours later.
Fibrinolytic response test:
The dose for adults and children is 0.4 micrograms
per kilogram body weight, administered by injection
directly into one of your veins (intravenous) over a
period of 20 minutes.
If you are given more of DDAVP Injection than
you should:
As this medicine will be given to you whilst you are
in hospital it is unlikely that you will be given too
much, however, avoid drinking any more fluid and
seek medical advice if you have any concerns.

STOP USING DDAVP INJECTION
if you experience:
• allergic reactions including; itching, skin
rashes, swelling of the face, lips or throat,
difficulty in breathing, wheeziness, chest
tightness or coughing
• unusually bad or prolonged headaches
• confusion
• unexplained weight gain
• ankle swelling
• nausea or vomiting
If you experience any of the above side effects,
you should contact your doctor or go to the
nearest casualty department immediately.
Low level of sodium in your blood can leads to fits.

This is more likely to happen if you drink large
amounts of fluid receiving this medication.

Most people using DDAVP Injection find it
causes them no problems. However, common
side effects can include:
• headache
• stomach pain
Very rare cases of emotional disorders including
aggression in children have also been reported.
If you experience one or more of these side
effects or any other undesirable effects, please
inform your doctor or pharmacist.

5. Storing DDAVP Injection
DDAVP Injection should be stored in a refrigerator
at 2°C to 8°C. Keep container in the outer carton.
Use by date: Do NOT use DDAVP Injection past
the expiry date on the packaging. The expiry
date refers to the last day of that month.
This product should only be given by a doctor or
qualified nurse and will be safely disposed of by
them.

6. Further information
Your medicine is called DDAVP Injection.
• it is supplied in clear glass ampoules and each
ampoule contains 1ml of a clear, sterile
colourless solution.
• each 1ml of the solution contains 4 micrograms
of the active ingredient Desmopressin acetate
dissolved in water for injection.
• other ingredients in DDAVP Injection are
sodium chloride and hydrochloric acid.
Marketing Authorisation Holder:
Ferring Pharmaceuticals Ltd.,
The Courtyard, Waterside Drive,
Langley, Berkshire, SL3 6EZ (UK).
Manufacturer:
Ferring GmbH, Whittland 11, D-24109 Kiel,
Germany.
DDAVP 4 micrograms/ml Injection PL 03194/0002
This leaflet was last revised in March 2013.
DDAVP is a registered trademark.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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