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CosmoCol Plain
Powder for oral solution

Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
This medicine is available without prescription. However, you still need to take
CosmoCol Plain carefully to get the best results from it.
- Keep this leaflet. You may need to read it again.
- Ask your pharmacist if you need more information or advice.
- You must contact a doctor if your symptoms worsen or do not improve after
14 days.
- If you get any side effects talk to your doctor or pharmacist . This includes
any possible side effects not listed in this leaflet.
What is in this leaflet:
1. What CosmoCol Plain is and what it is used for
2. What you need to know before you take CosmoCol Plain
3. How to take CosmoCol Plain
4. Possible side effects
5. How to store CosmoCol Plain
6. Contents of the pack and other information
1. What CosmoCol Plain is and what it is used for
CosmoCol Plain is a laxative used for the treatment of long term (chronic)
constipation and faecal impaction (persistent constipation, where a large
volume of stools cause a blockage of the rectum and / or colon). It is not
recommended for children below 12 years of age. Macrogol 3350 makes
your faeces softer and easier to pass, giving you relief from constipation.
The electrolytes (salts) help to maintain your body’s normal levels of sodium,
potassium and water while you are being treated for constipation.
2. What you need to know before you take CosmoCol Plain
Do not take CosmoCol Plain
- if you are allergic (hypersensitive) to macrogol 3350, sodium chloride,
sodium hydrogen carbonate, potassium chloride, or any of the other
ingredients in CosmoCol Plain
- if you have a perforated gut (bowel) wall
- if you have a blockage in your intestine (gut obstruction, ileus)
- if you have severe inflammatory bowel disease such as ulcerative colitis,
Crohn’s disease or toxic megacolon
If any of these applies to you, please talk to your doctor or pharmacist for
further advice.
Other medicines and CosmoCol Plain
Some medicines, e.g. anti-epileptics, may not work as effectively during use
with CosmoCol Plain.
Please tell your doctor or pharmacist if you are taking, or have recently taken,
any other medicines, including medicines obtained without a prescription.
CosmoCol Plain with food and drink
CosmoCol Plain can be taken at any time with or without food or drink
Pregnancy and breast-feeding
If you are pregnant or breast-feeding talk to your doctor before taking
CosmoCol Plain.
Driving and using machines
CosmoCol Plain has no effect on the ability to drive or use machinery.
Important information about some of the ingredients of CosmoCol Plain
CosmoCol Plain contains 0.63 mmol (25 mg) of potassium per sachet. This
should be taken into consideration if you take more than one sachet daily and
you have reduced kidney function, or if you are on a controlled potassium diet.
CosmoCol Plain contains 8.1 mmol (187 mg) of sodium per sachet. This
should be taken into consideration if you are on a controlled sodium diet.
3. How to take CosmoCol Plain
Treatment of chronic constipation in adults, children (aged 12 years and
above) and the elderly:
The recommended dose for constipation is one sachet taken one to three
times daily.
Duration of treatment
This course of treatment for constipation should not normally last longer than
2 weeks.
Treatment of faecal impaction in adults, children (aged 12 years and
above) and the elderly:
Before you take CosmoCol Plain for faecal impaction, your doctor must check
to confirm that you have this condition. The recommended dose is 8 sachets
daily, all of which should be consumed within 6 hours.
To prevent further problems from faecal impaction, your doctor may advise
that you continue taking this medicine. You should use the dose for treating
chronic constipation.
Duration of treatment
The course of treatment for faecal impaction should be stopped when a large
volume of stools is passed and does not normally last longer than 3 days.
How to mix
Open the sachet and pour the contents into a glass. Add about 125 ml or a
quarter pint of water to the glass. Stir well until the powder has dissolved and
then drink it.
If you take more CosmoCol Plain than you should
This can cause severe pain and swelling in your abdomen (stomach), or
vomiting (sickness) or diarrhoea. If this happens, contact your doctor or
If you forget to take CosmoCol Plain
If you forget to take a dose, take it as soon as you remember and then
continue on as before. Do not take a double dose to make up for a forgotten
If you stop taking CosmoCol Plain
To get the most benefit from CosmoCol Plain, always finish the course of
treatment according to the directions in this package leaflet. This will make
sure that your constipation is cleared, otherwise the symptoms you are
suffering from may persist.
You must contact a doctor if your symptoms worsen or do not improve after
14 days.
If you have any further questions on the use of this product, ask your doctor or

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4. Possible side effects
Like all medicines, CosmoCol Plain can cause side effects, although not
everybody gets them.
If you experience any of the following side effects, stop taking CosmoCol
Plain and see your doctor immediately:
- signs of an allergy, such as a rash, itching, shortness of breath or difficulty
in breathing.
- signs of a change in your body’s fluid or electrolyte levels (salts levels),
such as swelling (mainly in the ankles), feeling weak, increasingly tired or
increased thirst with headache
The following side effects are also possible:
- abdominal (stomach) pain
- mild diarrhoea (when starting to take CosmoCol Plain, this usually stops if
you reduce the number of sachets you take)
- nausea (feeling sick)
- vomiting
- swelling of your abdomen (feeling bloated)
- stomach rumbling
- flatulence (wind)
- soreness of the anus (bottom)
If you get any side effects, talk to your doctor or pharmacist. This includes any
possible side effects not listed in this leaflet.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also report
side effects directly via the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the safety
of this medicine.
5. How to store CosmoCol Plain
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton
and sachet. The expiry date refers to the last day of that month.
Do not store above 25 °C.
Do not use this medicine if you notice that any of the sachets is damaged.
Reconstituted CosmoCol Plain solution can be covered and stored in the
refrigerator (2°C to 8°C), and should be used within 24 hours. After 24 hours,
any unused solution should be discarded.
Do not throw away any medicines via wastewater or household waste. Ask
your pharmacist how to throw away medicines you no longer use. These
measures will help protect the environment.
6. Contents of the pack and other information
The active substances are:
Each sachet contains:
macrogol 3350
sodium chloride
sodium hydrogen carbonate
potassium chloride

13.125  g
0.3507 g
0.1785 g
0.0466 g

The other ingredients are colloidal anhydrous silica.
What CosmoCol Plain looks like and contents of the pack
CosmoCol Plain is a white powder.
Each sachet contains 13.8 g of powder and is packed in cartons containing
2, 6, 8, 10, 20, 30, 50, 60 (2x30) and 100 (2x50) sachets.
Not all of these pack sizes are marketed.
Marketing Authorisation Holder
Stirling Anglian Pharmaceuticals Ltd
Hillington Park Innovation Centre
1 Ainslie Road
Hillington Park
G52 4RU
United Kingdom

Klocke Pharma-Service GmbH
Strassburger Strasse 77
77767 Appenweier
Hermes Pharma Ges.m.b.H.
Allgäu 36
9400 Wolfsberg

This leaflet was last revised in February 2015

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.