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COMBIGAN 2 MG/ML + 5 MG/ML EYE DROPS SOLUTION

Active substance: TIMOLOL MALEATE

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The following additional side effects have been seen with brimonidine:
-- inflammation within eye, small pupils, difficulty sleeping cold-like symptoms shortness of breath,
symptoms involving the stomach and digestion, general allergic reactions, skin reactions including
redness, face swelling itching rash and widening of blood vessels.
Like other medicines applied into eyes, COMBIGAN (brimonidine/timolol) is absorbed into the blood. Absorption
of timolol, a beta blocker component of COMGIBAN, may cause similar side effects as seen with intravenous”
and /or “oral” beta-blocking agents. Incidence of side effects after topical ophthalmic administration is lower than
when medicines are for example, taken by mouth or injected. Listed side effects include reactions seen within the
class of beta-blockers when used for treating eye conditions:
-- Generalised allergic reactions, including swelling beneath the skin (that can occur in areas such as the
face and limbs, and can obstruct the airway which may cause difficulty swallowing or breathing), hives
(or itchy rash), localised and generalised rash, itchiness, severe sudden life threatening allergic reaction
-- Low-blood glucose levels
-- Difficulty in sleeping (insomnia), nightmares, memory loss
-- Stroke, reduced blood supply to the brain, increased signs and symptoms of myasthenia gravis (muscle
disorder), unusual sensations (like pins and needles).
-- Inflammation in the cornea, detachment of the layer below the retina that contains blood vessels following
filtration surgery which may cause visual disturbances, decreased corneal sensitivity, corneal erosion
(damage to the front layer of the eyeball), drooping of the upper eyelid (making the eye half closed),
double vision
-- Chest pain, oedema (fluid build up), changes in the rhythm or speed of the heartbeat, a type of heart
rhythm disorder, heart attack, heart failure,
-- Raynaud’s phenomenon, cold hands and feet
-- Constriction of the airways in the lung (predominantly in patients with pre-existing disease) difficulty
breathing, cough
-- Indigestion, abdominal pain, vomiting
-- Hair loss, skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of
psoriasis, skin rash
-- Muscle pain not caused by exercise
-- Sexual dysfunction, decreased libido
-- Muscle weakness/tiredness
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
5. HOW TO STORE COMBIGAN
Keep out of the reach and sight of children.
Keep the bottle in the outer carton to protect it from light.
You should only use one bottle at a time.
Do not use COMBIGAN after the expiry date which is stated on the label of the bottle and the carton after EXP:.
The expiry date refers to the last day of that month.
You must throw away the bottle four weeks after you first opened it, even if there are still some drops left. This will
help to prevent infections. To help you remember, write down the date that you opened it in the space on the carton.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose
of medicines no longer required. These measures will help to protect the environment.
6. FURTHER INFORMATION
What COMBIGAN contains
• The active substances are brimonidine tartrate and timolol.
• One millilitre of solution contains 2 milligrams of brimonidine tartrate and timolol maleate equivalent to
5 milligrams of timolol.
• The other ingredients are benzalkonium chloride (a preservative), sodium phosphate monobasic monohydrate,
sodium phosphate dibasic heptahydrate and purified water. Small amounts of hydrochloric acid or sodium
hydroxide may be added to bring the solution to the correct pH (a measure of the acidity or alkalinity of the solution).
What COMBIGAN looks like and contents of the pack
COMBIGAN is a clear, greenish-yellow eye drop solution in a plastic bottle with a screw-cap. Each bottle is about
half full and contains 5 ml of solution. Packs are available containing either 1 or 3 bottles. Not all pack sizes may
be marketed.
Marketing Authorisation Holder and Manufacturer
Allergan Pharmaceuticals Ireland, Castlebar Road, Westport, Co Mayo, Ireland
For any information about this medicinal product, please contact the local representative of the Marketing
Authorisation Holder:
Allergan Ltd, The Parkway, Marlow, Bucks, SL7 1YL United Kingdom
Tel: +44 (0)1628 494026 e-mail: uk_medinfo@allergan.com
This leaflet was last approved in 12/2011

® marks owned by Allergan, Inc.
© 2012 Allergan, Inc., Irvine CA 92612

71458GB15

Using other medicines
COMBIGAN can affect or be affected by other medicines
you are using, including other eye drops for the treatment
of glaucoma. Please tell your doctor or pharmacist if you are
taking or have recently taken any other medicines, including
medicines for any condition, even if unrelated to your eye
condition, including medicines obtained without a prescription.
There are a number of medicines which may interfere with
COMBIGAN, so it is particularly important to tell your doctor
if you are taking:
• pain killers
• medicines to help you sleep or for anxiety
• medicines to treat high blood pressure (hypertension)
• medicines for heart conditions (for example an abnormal
heartbeat) such as beta blockers,digoxin or quinidine (used to
treat heart conditions and some types of malaria)
• medicines to treat diabetes or high blood sugar
• medicines for depression such as fluxetine and paroxetine
• another eye drop used to lower high pressure in the eye (glaucoma)
• medicines to treat severe allergic reactions
• medicines that affect some of the hormones in your body, like adrenaline and dopamine
• medicines that affect the muscles in your blood vessels
• medicines to treat heartburn or stomach ulcers
If the dose of any of your current medicines is changed or if you are regularly consuming alcohol you should
tell your doctor.
If you are due to have an anaesthetic, you should tell the doctor or dentist that you are taking COMBIGAN.
Pregnancy and breast-feeding
Ask your doctor or pharmacist for advice before taking any medicine. Tell your doctor if you are pregnant
or planning to become pregnant.
Do not use COMBIGAN if you are pregnant unless your doctor considers it necessary.
Do not use COMBIGAN if you are breast-feeding. Timolol may get into your milk. Ask you doctor for advice before
taking any medicine during breast-feeding.
Driving and Using Machines
COMBIGAN may cause drowsiness, tiredness or blurred vision in some patients. Do not drive or use any tools
or machines until the symptoms have cleared. If you experience any problems, talk to your doctor.
Important information about some of the ingredients of COMBIGAN
Contact Lenses
• Do not use COMBIGAN while your contact lenses are in your eyes. Wait at least 15 minutes after using
COMBIGAN before putting your lenses back in.
• A preservative in COMBIGAN (benzalkonium chloride) may cause eye irritation and is also known to discolour
soft contact lenses.
3. HOW TO USE COMBIGAN
Always use COMBIGAN exactly as your doctor has told you. You should check with your doctor or pharmacist
if you are not sure. COMBIGAN must not be used in infants below 2 years of age. COMBIGAN should not usually
be used in children and adolescents (from 2 to 17 years).
The usual dose is one drop of COMBIGAN, twice a day about 12 hours apart. Do not change the dose or stop
taking it without speaking to your doctor.
If you have other eye drops as well as COMBIGAN, leave at least 5 minutes between using COMBIGAN and the
other eye drops.
Instructions for use
You must not use the bottle if the tamper-proof seal on the bottle neck is broken before you first begin to use it.
Wash your hands before opening the bottle. Tilt your head back and look at the ceiling.
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Gently pull down the lower eyelid until there is a small pocket.
Turn the bottle upside down and squeeze it to release one drop into each eye that needs treatment.
Let go of the lower lid, and close your eye.
Keep the eye closed and press your finger against the corner of your eye (the side where your eye meets your
nose) for two minute. This helps stop COMBIGAN getting into the rest of the body.
If a drop misses your eye, try again.
To avoid contamination, do not let the tip of the bottle touch your eye or anything else. Put the screw-cap back on
to close the bottle, straight after you have used it.
If you use more COMBIGAN than you should
Adults
If you use more COMBIGAN than you should, it is unlikely to cause you any harm. Put your next drop in at the
usual time. If you are worried, talk to your doctor or pharmacist.

Package Leaflet:
Information For The User

2 mg/ml + 5 mg/ml eye drops, solution
Brimonidine tartrate and timolol

Read all of this leaflet carefully before you start using this medicine.
• Keep this leaflet. You may need to read it again.
• If you have further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
In this leaflet:
1. What COMBIGAN is and what it is used for
2. Before you use COMBIGAN
3. How to use COMBIGAN
4. Possible side effects
5. How to store COMBIGAN
6. Further information
1. WHAT COMBIGAN IS AND WHAT IT IS USED FOR
COMBIGAN is an eye drop that is used to control glaucoma. It contains two different medicines (brimonidine and
timolol) that both reduce high pressure in the eye. Brimonidine belongs to a group of medicines called alpha‑2
adrenergic receptor agonists. Timolol belongs to a group of medicines called beta‑blockers. COMBIGAN is
prescribed to reduce high pressure in the eye when beta-blocker eye drops used alone are not enough.
Your eye contains a clear, watery liquid that feeds the inside of the eye. Liquid is constantly being drained out of
the eye and new liquid is made to replace this. If the liquid cannot drain out quickly enough, the pressure inside
the eye builds up and could eventually damage your sight. COMBIGAN works by reducing the production of liquid
and increasing the amount of liquid that is drained. This reduces the pressure inside the eye whilst still continuing
to feed the eye.
2. BEFORE YOU USE COMBIGAN
Do not use COMBIGAN eye drops solution
• if you are allergic (hypersensitive) to brimonidine tartrate, timolol, beta-blockers or any of the other
ingredients of COMBIGAN. Symptoms of an allergic reaction may include swelling of the face, lips and
throat, wheeziness, feeling faint, shortness of breath, itching or redness around the eye.
• if you have now or have had in the past respiratory problems such as asthma, severe chronic
obstructive bronchitis (severe lung disease which may cause wheeziness, difficulty in breathing and/or
long‑standing cough).
• if you have heart problems such as low heart rate, heart failure, heart beat disorders (unless controlled
by a pacemaker).
• if you are taking monoamine oxidase (MAO) inhibitors or certain other antidepressant drugs.
COMBIGAN should not be used in children less than 2 years old and should not usually be used in children aged 2 to 17.
If you think any of these points apply to you, do not use COMBIGAN until you have talked again to your doctor.
Take special care with COMBIGAN
Before you take this medicine, tell your doctor
• if you have now or have had in the past
-- coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart
failure, low blood pressure
-- disturbances of heart rate such as slow heart beat
-- breathing problems, asthma or chronic obstructive pulmonary disease
-- poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome)
-- diabetes as timolol may mask signs and symptoms of low blood sugar levels
-- over activity of the thyroid gland as timolol may mask signs and symptoms
-- kidney or liver problems
-- tumour of the adrenal gland
-- eye surgery to lower the pressure in your eye
• if you suffer or have suffered from any allergy (e.g. hayfever, eczema) or a severe allergic reaction be aware
that the usual dose of adrenaline used to control a severe reaction may need to be increased.
• Tell the doctor before you have an operation that you are using COMBIGAN, as the timolol may change effects
of some medicines during anaesthesia.

Babies and Children
Several cases of overdose have been reported in babies and children receiving brimonidine (one of the
ingredients of COMBIGAN) as part of medical treatment for glaucoma. Signs include sleepiness, floppiness, low
body temperature, paleness and breathing difficulties. Should this happen, contact your doctor immediately.
Adults and Children
If COMBIGAN has been accidentally swallowed then you should contact your doctor immediately.
If you forget to use COMBIGAN
If you forget to use COMBIGAN, use a single drop in each eye that needs treatment as soon as you remember,
and then go back to your regular routine. Do not take a double dose to make up for a forgotten dose.
If you stop using COMBIGAN
COMBIGAN should be used every day to work properly.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, COMBIGAN can cause side effects, although not everybody gets them.
If you experience any of the following side effects, please contact your doctor immediately:
• Heart failure (eg. chest pain) or irregular heart rate
• Increased or decreased heart rate or low blood pressure
The chance of having a side effect is described by the following categories:
Not known
Frequency cannot be estimated from the available data
Very common Occurs in more than 1 out of 10 patients
Common
Occurs in fewer than 1 out of 10 patients
Uncommon
Occurs in fewer than 1 out of 100 patients
The following side effects may be seen with COMBIGAN.
Affecting the eye

Very common: Eye redness or burning.
Common:
• Stinging or pain in the eye
• Allergic reaction in the eye or on the skin around the eye,
• Small breaks in the surface of the eye (with or without inflammation)
• Swelling, redness or inflammation of the eyelid
• Irritation, or a feeling of something in the eye
• Itching of the eye and eyelid
• Follicles or white spots on the see through layer which covers the surface of the eye
• Vision disturbance
• Tearing
• Eye dryness
• Sticky eyes
Uncommon:
• Difficulty in seeing clearly
• Swelling or inflammation of the see-through layer which covers the surface of the eye
• Tired eyes
• Sensitivity to light
• Eyelid pain
• Whitening of the see-through layer which covers the surface of the eyes
• Swelling or areas of inflammation under the surface of the eye
• Floaters in front of the eyes
Not known
• Blurred vision
Affecting the body:
Common:
• High blood pressure
• Depression
• Sleepiness
• Headache
• Dry mouth
• General weakness
Uncommon:
• Heart failure
• Irregular heart rate
• Light-headedness
• Fainting
• Dry nose
• Taste disturbance
• Nausea
• Diarrhoea
Not known:
• Increased or decreased heart rate
• Low blood pressure
• Face redness
Some of these effects may be due to an allergy to any of the ingredients. Additional side effects have been seen
with brimonidine or timolol and therefore may potentially occur with COMBIGAN.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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