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CIPROBAY 500MG TABLETS

Active substance: CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE

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Ref: 1273/110713/1/F

Ciproxin®500 mg Tablets
(ciprofloxacin)
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours.
* If any of the side effects get serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.
Your medicine is called Ciproxin 500mg Tablets but will be referred as
ciproxin throughout this leaflet.
In this leaflet:
1 What Ciproxin is and what it is used for
2 Before you take Ciproxin
3 How to take Ciproxin
4 Possible side effects
5 How to store Ciproxin
6 Further information

1

What Ciproxin is and what is it used for

Ciproxin is an antibiotic belonging to the fluoroquinolone family. The active
substance is ciprofloxacin. Ciproxin works by killing bacteria that cause
infections. It only works with specific strains of bacteria.
Adults
Ciproxin is used in adults to treat the following bacterial infections:
* respiratory tract infections
* long lasting or recurring ear or sinus infections
* urinary tract infections
* genital tract infections in men and women
* gastro-intestinal tract infections and intra-abdominal infections
* skin and soft tissue infections
* bone and joint infections
* to prevent infections due to the bacterium Neisseria meningitidis
* anthrax inhalation exposure
Ciprofloxacin may be used in the management of patients with low white
blood cell counts (neutropenia) who have a fever that is suspected to be due
to a bacterial infection.
If you have a severe infection or one that is caused by more than one type
of bacterium, you may be given additional antibiotic treatment in addition to
Ciproxin.
Children and adolescents
Ciproxin is used in children and adolescents, under specialist medical
supervision, to treat the following bacterial infections:
* lung and bronchial infections in children and adolescents suffering from
cystic fibrosis
* complicated urinary tract infections, including infections that have reached
the kidneys (pyelonephritis)
* anthrax inhalation exposure
Ciproxin may also be used to treat other specific severe infections in
children and adolescents when your doctor considered this necessary.

2

Before you take Ciproxin

Do not take Ciproxin if you are:
* allergic (hypersensitive) to the active substance, to other quinolone drugs
or to any of the other ingredients of ciproxin (see section 6)
* taking tizanidine (see Section 2: Taking other medicines)
Take special care with Ciproxin
Before taking Ciproxin
Tell your doctor if you:
* have ever had kidney problems because your treatment may need to be
adjusted
* suffer from epilepsy or other neurological conditions
* have a history of tendon problems during previous treatment with
antibiotics such as ciproxin
* have myasthenia gravis (a type of muscle weakness)
* have heart problems. Caution should be taken when using Ciprofloxacin, if
you were born with or have family history of prolonged QT interval (seen
on ECG, electrical recording of the heart), have salt imbalance in the
blood (especially low level of potassium or magnesium in the blood), have
a very slow heart rhythm (called ‘bradycardia’), have a weak heart (heart
failure), have a history of heart attack (myocardial infarction), you
are female or elderly or you are taking other medicines that result in
abnormal ECG changes (see section: Taking other medicines).
For the treatment of some genital tract infections, your doctor can prescribe
another antibiotic in addition to ciprofloxacin. If there is no improvement in
symptoms after 3 days of treatment, please consult your doctor.
While taking Ciproxin
Tell your doctor immediately, if any of the following occurs while taking
Ciproxin. Your doctor will decide whether treatment with Ciproxin needs to
be stopped.
* Severe, sudden allergic reaction (an anaphylactic reaction/shock,
angio-oedema). Even with the first dose, there is a small chance that you
may experience a severe allergic reaction with the following symptoms:
tightness in the chest, feeling dizzy, sick or faint, or experiencing dizziness
when standing up. If this happens, stop taking Ciproxin and contact
your doctor immediately.
* Pain and swelling in the joints and tendinitis may occur occasionally,
particularly if you are elderly and are also being treated with
corticosteroids. Inflammation and ruptures of tendons may occur even
within the first 48 hours of treatment or up to several months after
discontinuation of Ciproxin therapy.

At the first sign of any pain or inflammation stop taking Ciproxin and rest
the painful area. Avoid any unnecessary exercise, as this might increase
the risk of a tendon rupture
* If you suffer from epilepsy or other neurological conditions such as
cerebral ischemia or stroke, you may experience side effects associated
with the central nervous system. If this happens, stop taking Ciproxin
and contact your doctor immediately.
* You may experience psychiatric reactions the first time you take
Ciproxin. If you suffer from depression or psychosis, your symptoms
may become worse under treatment with Ciproxin. In rare cases,
depression or psychosis can progress to thoughts of suicide, suicide
attempts, or completed suicide. If this happens, stop taking Ciproxin and
contact your doctor immediately.
* You may experience symptoms of neuropathy such as pain, burning,
tingling, numbness and/or weakness. If this happens, stop taking Ciproxin
and contact your doctor immediately.
* Diarrhoea may develop while you are taking antibiotics, including Ciproxin,
or even several weeks after you have stopped taking them. If it becomes
severe or persistent or you notice that your stool contains blood or
mucus, stop taking Ciproxin immediately, as this can be life-threatening.
Do not take medicines that stop or slow down bowel movements and
contact your doctor.
* Tell the doctor or laboratory staff that you are taking Ciproxin if you have to
provide a blood or urine sample.
* If you suffer from kidney problems, tell the doctor because your dose
may need to be adjusted.
* Ciproxin may cause liver damage. If you notice any symptoms such as
loss of appetite, jaundice (yellowing of the skin), dark urine, itching, or
tenderness of the stomach, stop taking Ciproxin and contact your doctor
immediately.
* Ciproxin may cause a reduction in the number of white blood cells and
your resistance to infection may be decreased. If you experience an
infection with symptoms such as fever and serious deterioration of
your general condition, or fever with local infection symptoms such as sore
throat/pharynx/mouth or urinary problems you should see your doctor
immediately. A blood test will be taken to check possible reduction of
white blood cells (agranulocytosis). It is important to inform your doctor
about your medicine.
* Tell your doctor if you or a member of your family is known to have a
deficiency in glucose-6-phosphate dehydrogenase (G6PD), since you may
experience a risk of anemia with ciprofloxacin.
* Your skin becomes more sensitive to sunlight or ultraviolet (UV) light
when taking Ciproxin. Avoid exposure to strong sunlight, or artificial UV
light such as sunbeds.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken
any other medicines, including any that you obtained without a prescription.
Do not take Ciproxin together with tizanidine, because this may cause
side effects such as low blood pressure and sleepiness (see Section 2: “Do
not take Ciproxin”).
The following medicines are known to interact with Ciproxin in your body.
Taking Ciproxin together with these medicines can influence the therapeutic
effect of those medicines. It can also increase the probability of experiencing
side effects.
Tell your doctor if you are taking:
* Vitamin K antagonists (e.g: warfarin) or other oral anti-coagulants (to thin
the blood)
* probenecid (for gout)
* methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis)
* theophylline (for breathing problems)
* tizanidine (for muscle spasticity in multiple sclerosis)
* olanzapine (an antipsychotic)
* clozapine (an antipsychotic)
* ropinirole (for Parkinson’s disease)
* phenytoin (for epilepsy)
* metoclopramide (for nausea and vomiting)
* cyclosporin (for skin conditions, rheumatoid arthritis and in organ
transplantation)
* glibenclamide (for diabetes)
* other medicines that can alter your heart rhythm: medicines that belong to
the group of anti-arrhythmics (e.g. quinidine, hydroquinidine, disopyramide,
amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, some
antimicrobials (that belong to the group of macrolides), some
antipsychotics.
Ciproxin may increase the levels of the following medicines in your blood:

* pentoxifylline (for circulatory disorders)
* caffeine
* duloxetine (for depression, diabetic nerve damage or incontinence)
* lidocaine (for heart conditions or anesthetic use)
* sildenafil (e.g. for erectile dysfunction)
Some medicines reduce the effect of Ciproxin. Tell your doctor if you take or
wish to take:
* antacids
* omeprazole
* mineral supplements
* sucralfate
* a polymeric phosphate binder (e.g. sevelamer)
* medicines or supplements containing calcium, magnesium, aluminium or
iron
If these preparations are essential, take Ciproxin about two hours before or
no sooner than four hours after them.
Taking Ciproxin with food and drink
Unless you take Ciproxin during meals, do not eat or drink any dairy
products (such as milk or yoghurt) or drinks with added calcium when you
take the tablets, as they may affect the absorption of the active substance.
Pregnancy and breast-feeding
It is preferable to avoid the use of Ciproxin during pregnancy. Tell your
doctor if you are planning to get pregnant.
Do not take Ciproxin during breast feeding because ciprofloxacin is excreted
in breast milk and can be harmful for your child.

Ref: 1273/110713/1/B

®

Ciproxin 500 mg Tablets
(ciprofloxacin)
Patient Information Leaflet (continued)
*
Driving and using machines
Ciproxin may make you feel less alert. Some neurological adverse events
can occur. Therefore, make sure you know how you react to Ciproxin before
driving a vehicle or operating machinery. If in doubt, talk to your doctor.

3

How to take Cirpoxin

Your doctor will explain to you exactly how much Ciproxin you will have to
take as well as how often and for how long. This will depend on the type of
infection you have and how bad it is.
Tell your doctor if you suffer from kidney problems because your dose may
need to be adjusted.
The treatment usually lasts from 5 to 21 days, but may take longer for
severe infections. Take the tablets exactly as your doctor has told you. Ask
your doctor or pharmacist if you are not sure how many tablets to take and
how to take Ciproxin.
a. Swallow the tablets with plenty of fluid. Do not chew the tablets because
they do not taste nice.
b. Do try to take the tablets at around the same time every day.
c. You can take the tablets at mealtimes or between meals. Any calcium you
take as part of a meal will not seriously affect uptake. However, do not
take Ciproxin tablets with dairy products such as milk or yoghurt or with
fortified fruit juices (e.g. calcium-fortified orange juice).
Remember to drink plenty of fluids while you are taking Ciproxin.
If you take more Ciproxin than you should
If you take more than the prescribed dose, get medical help immediately.
If possible, take your tablets or the box with you to show the doctor.

*

If you forget to take Ciproxin
* Take the normal dose as soon as possible and then continue as
prescribed. However, if it is almost time for your next dose, do not take
the missed dose and continue as usual. Do not take a double dose to
make up for a forgotten dose. Be sure to complete your course of
treatment.

*
*

Very rare side effects (less than 1 in every 10,000 people are likely to get
these):
* a special type of reduced red blood cell count (haemolytic anaemia); a
dangerous drop in a type of white blood cells (agranulocytosis ); a drop in
the number of red and white blood cells and platelets (pancytopenia),
which may be fatal; and bone marrow depression, which may also be fatal
(see Section 2: Take special care with Ciproxin)
* severe allergic reactions (anaphylactic reaction or anaphylactic shock,
which can be fatal - serum sickness) (see Section 2: Take special care
with Ciproxin)
* mental disturbances (psychotic reactions potentially leading to thoughts of
suicide, suicide attempts, or completed suicide) (see Section 2: Take
special care with Ciproxin)
* migraine, disturbed coordination, unsteady walk (gait disturbance),
disorder of sense of smell (olfactory disorders), pressure on the brain
(intracranial pressure)
* visual colour distortions
* inflammation of the wall of the blood vessels (vasculitis)
* pancreatitis
* death of liver cells (liver necrosis) very rarely leading to life-threatening
liver failure
* small, pin-point bleeding under the skin (petechiae); various skin eruptions
or rashes (for example, the potentially fatal Stevens-Johnson syndrome or
toxic epidermal necrolysis)
* muscle weakness, tendon inflammation, tendon rupture – especially of
the large tendon at the back of the ankle (Achilles tendon) (see Section 2:
Take special care with Ciproxin); worsening of the symptoms of
myasthenia gravis (see Section 2: Take special care with Ciproxin)
Frequency not known (cannot be estimated from the available data)
* troubles associated with the nervous system such as pain, burning,
tingling, numbness and/or weakness in extremities
* abnormal fast heart rhythm, life-threatening irregular heart rhythm,
alteration of the heart rhythm (called ‘prolongation of QT interval’, seen on
ECG, electrical activity of the heart)
* pustular rash
* influence on blood clotting (in patients treated with Vitamin K antagonists)

If you stop taking Ciproxin
* It is important that you finish the course of treatment even if you begin
to feel better after a few days. If you stop taking this medicine too soon
your infection may not be completely cured and the symptoms of the
infection may return or get worse. You might also develop resistance to
the antibiotic.

*
*

If you have any more questions about the use of this product, ask your
doctor or pharmacist.

*

5

*
4

Possible side effects

Like all medicines, Ciproxin can cause side effects, although not everybody
gets them.
If any of the side effects gets serious, or if you notice any side effects not
listed in this leaflet, tell your doctor or pharmacist.
Common side effects (between 1 and 10 in every 100 people are likely to
get these):
* nausea, diarrhoea
* joint pains in children

kidney failure, blood or crystals in the urine (see Section 2: Take special
care with Ciproxin), urinary tract inflammation
fluid retention or excessive sweating
increased levels of the enzyme amylase

How to store Ciproxin

Keep out of the sight and reach of children.
Do not use Ciproxin after the expiry date, which is stated on the blister or
carton after “EXP”: The expiry date refers to the last day of the month
concerned.
If your medicine becomes discoloured or shows any other signs of
deterioration consult your pharmacist who will tell you what to do.
Medicines should not be disposed of down the drain or with household
rubbish. Ask your pharmacist how to dispose of any medicines no longer
required. These measures will help to protect the environment.

6

Further information

What Ciproxin contains
Ciproxin 500 mg film-coated tablets contain the active ingredient,
Ciprofloxacin.
Also contain microcrystalline cellulose, maize starch, crospovidone, colloidal
silicon dioxide, magnesium stearate and purified water. The tablet film-coat
consists of a mixture of hypromellose, macrogol 4000, titanium dioxide and
purified water.

Uncommon side effects (between 1 and 10 in every 1,000 people are likely
to get these):
* fungal superinfections
* a high concentration of eosinophils, a type of white blood cell
* loss of appetite (anorexia)
* hyperactivity or agitation
* headache, dizziness, sleeping problems, or taste disorders
* vomiting, abdominal pain, digestive problems such as stomach upset
(indigestion/heartburn), or wind
* increased amounts of certain substances in the blood (transaminases
and/or bilirubin)
* rash, itching, or hives
* joint pain in adults
* poor kidney function
* pains in your muscles and bones, feeling unwell (asthenia), or fever
* increase in blood alkaline phosphatase (a certain substance in the blood)

What Ciproxin looks like and contents of the pack
Ciproxin are white, film-coated tablets. On one side it is marked with a break
line and CIP 500 and marked BAYER on the other. They are available in
blister packs containing 10 Tablets

Rare side effects (between 1 and 10 in every 10,000 people are likely to
get these):
* inflammation of the bowel (colitis) linked to antibiotic use (can be fatal in
very rare cases) (see Section 2: Take special care with Ciproxin)
* changes to the blood count (leukopenia, leukocytosis, neutropenia,
anaemia), increased or decreased amounts of a blood clotting factor
(thrombocytes)
* allergic reaction, swelling (oedema), or rapid swelling of the skin and
mucous membranes (angio-oedema)
* increased blood sugar (hyperglycaemia)
* confusion, disorientation, anxiety reactions, strange dreams, depression
(potentially leading to thoughts of suicide, suicide attempts, or completed
suicide), or hallucinations
* pins and needles, unusual sensitivity to stimuli of the senses, decreased
skin sensitivity, tremors, seizures (see Section 2: Take special care with
Ciproxin), or giddiness
* eyesight problems including double vision
* tinnitus, loss of hearing, impaired hearing
* rapid heartbeat (tachycardia)
* expansion of blood vessels (vasodilation), low blood pressure, or fainting
* shortness of breath, including asthmatic symptoms
* liver disorders, jaundice (cholestatic icterus), or hepatitis
* sensitivity to light (see Section 2: Take special care with Ciproxin)
* muscle pain, inflammation of the joints, increased muscle tone, or cramp

Ciproxin is a registered trademark of Bayer Aktiengesellschaft

Manufacturer and Licence Holder
This medicine is manufactured by Bayer Schering Pharma AG, D-51368,
Leverkusen, Germany and is procured from within the EU and repackaged
by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow
Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1273 Ciproxin 500mg Tablets

Revision date: 11/07/13

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited, Tel: 01527 505414 for
help.

®

Ref: 1273/110713/2/F

Ciprobay 500 mg Tablets
(ciprofloxacin)
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours.
* If any of the side effects get serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.
Your medicine is called Ciprobay 500mg Tablets but will be referred as
ciprobay throughout this leaflet.
In this leaflet:
1 What Ciprobay is and what it is used for
2 Before you take Ciprobay
3 How to take Ciprobay
4 Possible side effects
5 How to store Ciprobay
6 Further information

1

What Ciprobay is and what is it used for

Ciprobay is an antibiotic belonging to the fluoroquinolone family. The active
substance is ciprofloxacin. Ciprobay works by killing bacteria that cause
infections. It only works with specific strains of bacteria.
Adults
Ciprobay is used in adults to treat the following bacterial infections:
* respiratory tract infections
* long lasting or recurring ear or sinus infections
* urinary tract infections
* genital tract infections in men and women
* gastro-intestinal tract infections and intra-abdominal infections
* skin and soft tissue infections
* bone and joint infections
* to prevent infections due to the bacterium Neisseria meningitidis
* anthrax inhalation exposure
Ciprobay may be used in the management of patients with low white blood
cell counts (neutropenia) who have a fever that is suspected to be due to a
bacterial infection.
If you have a severe infection or one that is caused by more than one type
of bacterium, you may be given additional antibiotic treatment in addition to
Ciprobay.
Children and adolescents
Ciprobay is used in children and adolescents, under specialist medical
supervision, to treat the following bacterial infections:
* lung and bronchial infections in children and adolescents suffering from
cystic fibrosis
* complicated urinary tract infections, including infections that have reached
the kidneys (pyelonephritis)
* anthrax inhalation exposure
Ciprobay may also be used to treat other specific severe infections in
children and adolescents when your doctor considered this necessary.

2

Before you take Ciprobay

Do not take Ciprobay if you are:
* allergic (hypersensitive) to the active substance, to other quinolone drugs
or to any of the other ingredients of ciprobay (see section 6)
* taking tizanidine (see Section 2: Taking other medicines)
Take special care with Ciprobay
Before taking Ciprobay
Tell your doctor if you:
* have ever had kidney problems because your treatment may need to be
adjusted
* suffer from epilepsy or other neurological conditions
* have a history of tendon problems during previous treatment with
antibiotics such as ciprobay
* have myasthenia gravis (a type of muscle weakness)
* have heart problems. Caution should be taken when using Ciprobay, if
you were born with or have family history of prolonged QT interval (seen
on ECG, electrical recording of the heart), have salt imbalance in the
blood (especially low level of potassium or magnesium in the blood), have
a very slow heart rhythm (called ‘bradycardia’), have a weak heart (heart
failure), have a history of heart attack (myocardial infarction), you
are female or elderly or you are taking other medicines that result in
abnormal ECG changes (see section: Taking other medicines).
For the treatment of some genital tract infections, your doctor can prescribe
another antibiotic in addition to ciprofloxacin. If there is no improvement in
symptoms after 3 days of treatment, please consult your doctor.
While taking Ciprobay
Tell your doctor immediately, if any of the following occurs while taking
Ciprobay. Your doctor will decide whether treatment with Ciprobay needs to
be stopped.
* Severe, sudden allergic reaction (an anaphylactic reaction/shock,
angio-oedema). Even with the first dose, there is a small chance that you
may experience a severe allergic reaction with the following symptoms:
tightness in the chest, feeling dizzy, sick or faint, or experiencing dizziness
when standing up. If this happens, stop taking Ciprobay and contact
your doctor immediately.
* Pain and swelling in the joints and tendinitis may occur occasionally,
particularly if you are elderly and are also being treated with
corticosteroids. Inflammation and ruptures of tendons may occur even
within the first 48 hours of treatment or up to several months after
discontinuation of Ciprobay therapy.

At the first sign of any pain or inflammation stop taking Ciprobay and rest
the painful area. Avoid any unnecessary exercise, as this might increase
the risk of a tendon rupture
* If you suffer from epilepsy or other neurological conditions such as
cerebral ischemia or stroke, you may experience side effects associated
with the central nervous system. If this happens, stop taking Ciprobay
and contact your doctor immediately.
* You may experience psychiatric reactions the first time you take
Ciprobay. If you suffer from depression or psychosis, your symptoms
may become worse under treatment with Ciprobay. In rare cases,
depression or psychosis can progress to thoughts of suicide, suicide
attempts, or completed suicide. If this happens, stop taking Ciprobay and
contact your doctor immediately.
* You may experience symptoms of neuropathy such as pain, burning,
tingling, numbness and/or weakness. If this happens, stop taking Ciprobay
and contact your doctor immediately.
* Diarrhoea may develop while you are taking antibiotics, including
Ciprobay, or even several weeks after you have stopped taking them. If it
becomes severe or persistent or you notice that your stool contains blood
or mucus, stop taking Ciprobay immediately, as this can be
life-threatening. Do not take medicines that stop or slow down bowel
movements and contact your doctor.
* Tell the doctor or laboratory staff that you are taking Ciprobay if you have
to provide a blood or urine sample.
* If you suffer from kidney problems, tell the doctor because your dose
may need to be adjusted.
* Ciprobay may cause liver damage. If you notice any symptoms such as
loss of appetite, jaundice (yellowing of the skin), dark urine, itching, or
tenderness of the stomach, stop taking Ciprobay and contact your doctor
immediately.
* Ciprobay may cause a reduction in the number of white blood cells and
your resistance to infection may be decreased. If you experience an
infection with symptoms such as fever and serious deterioration of
your general condition, or fever with local infection symptoms such as sore
throat/pharynx/mouth or urinary problems you should see your doctor
immediately. A blood test will be taken to check possible reduction of
white blood cells (agranulocytosis). It is important to inform your doctor
about your medicine.
* Tell your doctor if you or a member of your family is known to have a
deficiency in glucose-6-phosphate dehydrogenase (G6PD), since you may
experience a risk of anemia with ciprofloxacin.
* Your skin becomes more sensitive to sunlight or ultraviolet (UV) light
when taking Ciprobay. Avoid exposure to strong sunlight, or artificial UV
light such as sunbeds.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken
any other medicines, including any that you obtained without a prescription.
Do not take Ciprobay together with tizanidine, because this may cause
side effects such as low blood pressure and sleepiness (see Section 2: “Do
not take Ciprobay”).
The following medicines are known to interact with Ciprobay in your body.
Taking Ciprobay together with these medicines can influence the therapeutic
effect of those medicines. It can also increase the probability of experiencing
side effects.
Tell your doctor if you are taking:
* Vitamin K antagonists (e.g: warfarin) or other oral anti-coagulants (to thin
the blood)
* probenecid (for gout)
* methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis)
* theophylline (for breathing problems)
* tizanidine (for muscle spasticity in multiple sclerosis)
* olanzapine (an antipsychotic)
* clozapine (an antipsychotic)
* ropinirole (for Parkinson’s disease)
* phenytoin (for epilepsy)
* metoclopramide (for nausea and vomiting)
* cyclosporin (for skin conditions, rheumatoid arthritis and in organ
transplantation)
* glibenclamide (for diabetes)
* other medicines that can alter your heart rhythm: medicines that belong to
the group of anti-arrhythmics (e.g. quinidine, hydroquinidine, disopyramide,
amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, some
antimicrobials (that belong to the group of macrolides), some
antipsychotics.
Ciprobay may increase the levels of the following medicines in your blood:

* pentoxifylline (for circulatory disorders)
* caffeine
* duloxetine (for depression, diabetic nerve damage or incontinence)
* lidocaine (for heart conditions or anesthetic use)
* sildenafil (e.g. for erectile dysfunction)
Some medicines reduce the effect of Ciproxin. Tell your doctor if you take or
wish to take:
* antacids
* omeprazole
* mineral supplements
* sucralfate
* a polymeric phosphate binder (e.g. sevelamer)
* medicines or supplements containing calcium, magnesium, aluminium or
iron
If these preparations are essential, take Ciprobay about two hours before or
no sooner than four hours after them
Taking Ciprobay with food and drink
Unless you take Ciprobay during meals, do not eat or drink any dairy
products (such as milk or yoghurt) or drinks with added calcium when you
take the tablets, as they may affect the absorption of the active substance.
Pregnancy and breast-feeding
It is preferable to avoid the use of Ciprobay during pregnancy. Tell your
doctor if you are planning to get pregnant.
Do not take Ciprobay during breast feeding because ciprofloxacin is
excreted in breast milk and can be harmful for your child.

Ref: 1273/110713/2/B

®

Ciprobay 500 mg Tablets
(ciprofloxacin)
Patient Information Leaflet (continued)
*
Driving and using machines
Ciprobay may make you feel less alert. Some neurological adverse events
can occur. Therefore, make sure you know how you react to Ciprobay before
driving a vehicle or operating machinery. If in doubt, talk to your doctor.

3

How to take Ciprobay

Your doctor will explain to you exactly how much Ciprobay you will have to
take as well as how often and for how long. This will depend on the type of
infection you have and how bad it is.
Tell your doctor if you suffer from kidney problems because your dose may
need to be adjusted.
The treatment usually lasts from 5 to 21 days, but may take longer for
severe infections. Take the tablets exactly as your doctor has told you. Ask
your doctor or pharmacist if you are not sure how many tablets to take and
how to take Ciprobay.
a. Swallow the tablets with plenty of fluid. Do not chew the tablets because
they do not taste nice.
b. Do try to take the tablets at around the same time every day.
c. You can take the tablets at mealtimes or between meals. Any calcium you
take as part of a meal will not seriously affect uptake. However, do not
take Ciprobay tablets with dairy products such as milk or yoghurt or with
fortified fruit juices (e.g. calcium-fortified orange juice).
Remember to drink plenty of fluids while you are taking Ciprobay.
If you take more Ciprobay than you should
If you take more than the prescribed dose, get medical help immediately.
If possible, take your tablets or the box with you to show the doctor.

*

If you forget to take Ciprobay
* Take the normal dose as soon as possible and then continue as
prescribed. However, if it is almost time for your next dose, do not take
the missed dose and continue as usual. Do not take a double dose to
make up for a forgotten dose. Be sure to complete your course of
treatment.

*
*

Very rare side effects (less than 1 in every 10,000 people are likely to get
these):
* a special type of reduced red blood cell count (haemolytic anaemia); a
dangerous drop in a type of white blood cells (agranulocytosis ); a drop in
the number of red and white blood cells and platelets (pancytopenia),
which may be fatal; and bone marrow depression, which may also be fatal
(see Section 2: Take special care with Ciprobay)
* severe allergic reactions (anaphylactic reaction or anaphylactic shock,
which can be fatal - serum sickness) (see Section 2: Take special care
with Ciprobay)
* mental disturbances (psychotic reactions potentially leading to thoughts of
suicide, suicide attempts, or completed suicide) (see Section 2: Take
special care with Ciprobay)
* migraine, disturbed coordination, unsteady walk (gait disturbance),
disorder of sense of smell (olfactory disorders), pressure on the brain
(intracranial pressure)
* visual colour distortions
* inflammation of the wall of the blood vessels (vasculitis)
* pancreatitis
* death of liver cells (liver necrosis) very rarely leading to life-threatening
liver failure
* small, pin-point bleeding under the skin (petechiae); various skin eruptions
or rashes (for example, the potentially fatal Stevens-Johnson syndrome or
toxic epidermal necrolysis)
* muscle weakness, tendon inflammation, tendon rupture – especially of
the large tendon at the back of the ankle (Achilles tendon) (see Section 2:
Take special care with Ciprobay); worsening of the symptoms of
myasthenia gravis (see Section 2: Take special care with Ciprobay)
Frequency not known (cannot be estimated from the available data)
* troubles associated with the nervous system such as pain, burning,
tingling, numbness and/or weakness in extremities
* abnormal fast heart rhythm, life-threatening irregular heart rhythm,
alteration of the heart rhythm (called ‘prolongation of QT interval’, seen on
ECG, electrical activity of the heart)
* pustular rash
* influence on blood clotting (in patients treated with Vitamin K antagonists)

If you stop taking Ciprobay
* It is important that you finish the course of treatment even if you begin
to feel better after a few days. If you stop taking this medicine too soon
your infection may not be completely cured and the symptoms of the
infection may return or get worse. You might also develop resistance to
the antibiotic.

*
*

If you have any more questions about the use of this product, ask your
doctor or pharmacist.

*

5

*
4

Possible side effects

Like all medicines, Ciprobay can cause side effects, although not everybody
gets them.
If any of the side effects gets serious, or if you notice any side effects not
listed in this leaflet, tell your doctor or pharmacist.
Common side effects (between 1 and 10 in every 100 people are likely to
get these):
* nausea, diarrhoea
* joint pains in children

kidney failure, blood or crystals in the urine (see Section 2: Take special
care with Ciprobay), urinary tract inflammation
fluid retention or excessive sweating
increased levels of the enzyme amylase

How to store Ciprobay

Keep out of the sight and reach of children.
Do not use Ciprobay after the expiry date, which is stated on the blister or
carton after “EXP”: The expiry date refers to the last day of the month
concerned.
If your medicine becomes discoloured or shows any other signs of
deterioration consult your pharmacist who will tell you what to do.
Medicines should not be disposed of down the drain or with household
rubbish. Ask your pharmacist how to dispose of any medicines no longer
required. These measures will help to protect the environment.

6

Further information

What Ciprobay contains
Ciprobay 500 mg film-coated tablets contain the active ingredient,
Ciprofloxacin.
Also contain microcrystalline cellulose, maize starch, crospovidone, colloidal
silicon dioxide, magnesium stearate and purified water. The tablet film-coat
consists of a mixture of hypromellose, macrogol 4000, titanium dioxide and
purified water.

Uncommon side effects (between 1 and 10 in every 1,000 people are likely
to get these):
* fungal superinfections
* a high concentration of eosinophils, a type of white blood cell
* loss of appetite (anorexia)
* hyperactivity or agitation
* headache, dizziness, sleeping problems, or taste disorders
* vomiting, abdominal pain, digestive problems such as stomach upset
(indigestion/heartburn), or wind
* increased amounts of certain substances in the blood (transaminases
and/or bilirubin)
* rash, itching, or hives
* joint pain in adults
* poor kidney function
* pains in your muscles and bones, feeling unwell (asthenia), or fever
* increase in blood alkaline phosphatase (a certain substance in the blood)

What Ciprobay looks like and contents of the pack
Ciprobay are white, film-coated tablets. On one side it is marked with a
break line and CIP 500 and marked BAYER on the other. They are available
in blister packs containing 10 Tablets

Rare side effects (between 1 and 10 in every 10,000 people are likely to
get these):
* inflammation of the bowel (colitis) linked to antibiotic use (can be fatal in
very rare cases) (see Section 2: Take special care with Ciprobay)
* changes to the blood count (leukopenia, leukocytosis, neutropenia,
anaemia), increased or decreased amounts of a blood clotting factor
(thrombocytes)
* allergic reaction, swelling (oedema), or rapid swelling of the skin and
mucous membranes (angio-oedema)
* increased blood sugar (hyperglycaemia)
* confusion, disorientation, anxiety reactions, strange dreams, depression
(potentially leading to thoughts of suicide, suicide attempts, or completed
suicide), or hallucinations
* pins and needles, unusual sensitivity to stimuli of the senses, decreased
skin sensitivity, tremors, seizures (see Section 2: Take special care with
Ciprobay), or giddiness
* eyesight problems including double vision
* tinnitus, loss of hearing, impaired hearing
* rapid heartbeat (tachycardia)
* expansion of blood vessels (vasodilation), low blood pressure, or fainting
* shortness of breath, including asthmatic symptoms
* liver disorders, jaundice (cholestatic icterus), or hepatitis
* sensitivity to light (see Section 2: Take special care with Ciprobay)
* muscle pain, inflammation of the joints, increased muscle tone, or cramp

Ciprobay is a registered trademark of Bayer Aktiengesellschaft

Manufacturer and Licence Holder
This medicine is manufactured by Bayer Schering Pharma AG, D-51368,
Leverkusen, Germany and is procured from within the EU and repackaged
by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow
Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1273 Ciprobay 500mg Tablets

Revision date: 11/07/13

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited, Tel: 01527 505414 for
help.

Ref: 1273/110713/3/F

Ciprofloxacin 500 mg Tablets
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours.
* If any of the side effects get serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.
Your medicine is called Ciprofloxacin 500mg Tablets but will be referred as
ciprofloxacin throughout this leaflet.
In this leaflet:
1 What Ciprofloxacin is and what it is used for
2 Before you take Ciprofloxacin
3 How to take Ciprofloxacin
4 Possible side effects
5 How to store Ciprofloxacin
6 Further information

1

What Ciprofloxacin is and what is it used for

Ciprofloxacin is an antibiotic belonging to the fluoroquinolone family. The
active substance is ciprofloxacin. Ciprofloxacin works by killing bacteria that
cause infections. It only works with specific strains of bacteria.
Adults
Ciprofloxacin is used in adults to treat the following bacterial infections:
* respiratory tract infections
* long lasting or recurring ear or sinus infections
* urinary tract infections
* genital tract infections in men and women
* gastro-intestinal tract infections and intra-abdominal infections
* skin and soft tissue infections
* bone and joint infections
* to prevent infections due to the bacterium Neisseria meningitidis
* anthrax inhalation exposure
Ciprofloxacin may be used in the management of patients with low white
blood cell counts (neutropenia) who have a fever that is suspected to be due
to a bacterial infection.
If you have a severe infection or one that is caused by more than one type
of bacterium, you may be given additional antibiotic treatment in addition to
Ciprofloxacin.
Children and adolescents
Ciprofloxacin is used in children and adolescents, under specialist medical
supervision, to treat the following bacterial infections:
* lung and bronchial infections in children and adolescents suffering from
cystic fibrosis
* complicated urinary tract infections, including infections that have reached
the kidneys (pyelonephritis)
* anthrax inhalation exposure
Ciprofloxacin may also be used to treat other specific severe infections in
children and adolescents when your doctor considered this necessary.

2

Before you take Ciprofloxacin

Do not take Ciprofloxacin if you are:
* allergic (hypersensitive) to the active substance, to other quinolone drugs
or to any of the other ingredients of ciprofloxacin (see section 6)
* taking tizanidine (see Section 2: Taking other medicines)
Take special care with Ciprofloxacin
Before taking Ciprofloxacin
Tell your doctor if you:
* have ever had kidney problems because your treatment may need to be
adjusted
* suffer from epilepsy or other neurological conditions
* have a history of tendon problems during previous treatment with
antibiotics such as ciprofloxacin
* have myasthenia gravis (a type of muscle weakness)
* have heart problems. Caution should be taken when using Ciprofloxacin, if
you were born with or have family history of prolonged QT interval (seen
on ECG, electrical recording of the heart), have salt imbalance in the
blood (especially low level of potassium or magnesium in the blood), have
a very slow heart rhythm (called ‘bradycardia’), have a weak heart (heart
failure), have a history of heart attack (myocardial infarction), you
are female or elderly or you are taking other medicines that result in
abnormal ECG changes (see section: Taking other medicines).
For the treatment of some genital tract infections, your doctor can prescribe
another antibiotic in addition to ciprofloxacin. If there is no improvement in
symptoms after 3 days of treatment, please consult your doctor.
While taking Ciprofloxacin
Tell your doctor immediately, if any of the following occurs while taking
Ciprofloxacin. Your doctor will decide whether treatment with Ciprofloxacin
needs to be stopped.
* Severe, sudden allergic reaction (an anaphylactic reaction/shock,
angio-oedema). Even with the first dose, there is a small chance that you
may experience a severe allergic reaction with the following symptoms:
tightness in the chest, feeling dizzy, sick or faint, or experiencing dizziness
when standing up. If this happens, stop taking Ciprofloxacin and
contact your doctor immediately.
* Pain and swelling in the joints and tendinitis may occur occasionally,
particularly if you are elderly and are also being treated with
corticosteroids. Inflammation and ruptures of tendons may occur even
within the first 48 hours of treatment or up to several months after
discontinuation of Ciprofloxacin therapy.

At the first sign of any pain or inflammation stop taking Ciprofloxacin and
rest the painful area. Avoid any unnecessary exercise, as this might
increase the risk of a tendon rupture
* If you suffer from epilepsy or other neurological conditions such as
cerebral ischemia or stroke, you may experience side effects associated
with the central nervous system. If this happens, stop taking Ciprofloxacin
and contact your doctor immediately.
* You may experience psychiatric reactions the first time you take
Ciprofloxacin. If you suffer from depression or psychosis, your symptoms
may become worse under treatment with Ciprofloxacin. In rare cases,
depression or psychosis can progress to thoughts of suicide, suicide
attempts, or completed suicide. If this happens, stop taking Ciprofloxacin
and contact your doctor immediately.
* You may experience symptoms of neuropathy such as pain, burning,
tingling, numbness and/or weakness. If this happens, stop taking
Ciprofloxacin and contact your doctor immediately.
* Diarrhoea may develop while you are taking antibiotics, including
Ciprofloxacin, or even several weeks after you have stopped taking them.
If it becomes severe or persistent or you notice that your stool contains
blood or mucus, stop taking Ciprofloxacin immediately, as this can be
life-threatening. Do not take medicines that stop or slow down bowel
movements and contact your doctor.
* Tell the doctor or laboratory staff that you are taking Ciprofloxacin if you
have to provide a blood or urine sample.
* If you suffer from kidney problems, tell the doctor because your dose
may need to be adjusted.
* Ciprofloxacin may cause liver damage. If you notice any symptoms such
as loss of appetite, jaundice (yellowing of the skin), dark urine, itching, or
tenderness of the stomach, stop taking Ciprofloxacin and contact your
doctor immediately.
* Ciprofloxacin may cause a reduction in the number of white blood cells
and your resistance to infection may be decreased. If you experience
an infection with symptoms such as fever and serious deterioration of
your general condition, or fever with local infection symptoms such as sore
throat/pharynx/mouth or urinary problems you should see your doctor
immediately. A blood test will be taken to check possible reduction of
white blood cells (agranulocytosis). It is important to inform your doctor
about your medicine.
* Tell your doctor if you or a member of your family is known to have a
deficiency in glucose-6-phosphate dehydrogenase (G6PD), since you may
experience a risk of anemia with ciprofloxacin.
* Your skin becomes more sensitive to sunlight or ultraviolet (UV) light
when taking Ciprofloxacin. Avoid exposure to strong sunlight, or artificial
UV light such as sunbeds.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken
any other medicines, including any that you obtained without a prescription.
Do not take Ciprofloxacin together with tizanidine, because this may
cause side effects such as low blood pressure and sleepiness (see Section
2: “Do not take Ciprofloxacin”).
The following medicines are known to interact with Ciprofloxacin in your
body. Taking Ciprofloxacin together with these medicines can influence the
therapeutic effect of those medicines. It can also increase the probability of
experiencing side effects.
Tell your doctor if you are taking:
* Vitamin K antagonists (e.g: warfarin) or other oral anti-coagulants (to thin
the blood)
* probenecid (for gout)
* methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis)
* theophylline (for breathing problems)
* tizanidine (for muscle spasticity in multiple sclerosis)
* olanzapine (an antipsychotic)
* clozapine (an antipsychotic)
* ropinirole (for Parkinson’s disease)
* phenytoin (for epilepsy)
* metoclopramide (for nausea and vomiting)
* cyclosporin (for skin conditions, rheumatoid arthritis and in organ
transplantation)
* glibenclamide (for diabetes)
* other medicines that can alter your heart rhythm: medicines that belong to
the group of anti-arrhythmics (e.g. quinidine, hydroquinidine, disopyramide,
amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, some
antimicrobials (that belong to the group of macrolides), some
antipsychotics.
Ciprofloxacin may increase the levels of the following medicines in your
blood:
* pentoxifylline (for circulatory disorders)
* caffeine
* duloxetine (for depression, diabetic nerve damage or incontinence)
* lidocaine (for heart conditions or anesthetic use)
* sildenafil (e.g. for erectile dysfunction)
Some medicines reduce the effect of Ciproxin. Tell your doctor if you take or
wish to take:
* antacids
* omeprazole
* mineral supplements
* sucralfate
* a polymeric phosphate binder (e.g. sevelamer)
* medicines or supplements containing calcium, magnesium, aluminium or
iron
If these preparations are essential, take Ciprofloxacin about two hours
before or no sooner than four hours after them
Taking Ciprofloxacin with food and drink
Unless you take Ciprofloxacin during meals, do not eat or drink any dairy
products (such as milk or yoghurt) or drinks with added calcium when you
take the tablets, as they may affect the absorption of the active substance.
Pregnancy and breast-feeding
It is preferable to avoid the use of Ciprofloxacin during pregnancy. Tell your
doctor if you are planning to get pregnant.
Do not take Ciprofloxacin during breast feeding because ciprofloxacin is
excreted in breast milk and can be harmful for your child.

Ref: 1273/110713/3/B

Ciprofloxacin 500 mg Tablets
Patient Information Leaflet (continued)
*
Driving and using machines
Ciprofloxacin may make you feel less alert. Some neurological adverse
events can occur. Therefore, make sure you know how you react to
Ciprofloxacin before driving a vehicle or operating machinery. If in doubt, talk
to your doctor.

3

How to take Ciprofloxacin

Your doctor will explain to you exactly how much Ciprofloxacin you will have
to take as well as how often and for how long. This will depend on the type
of infection you have and how bad it is.
Tell your doctor if you suffer from kidney problems because your dose may
need to be adjusted.
The treatment usually lasts from 5 to 21 days, but may take longer for
severe infections. Take the tablets exactly as your doctor has told you. Ask
your doctor or pharmacist if you are not sure how many tablets to take and
how to take Ciprofloxacin.
a. Swallow the tablets with plenty of fluid. Do not chew the tablets because
they do not taste nice.
b. Do try to take the tablets at around the same time every day.
c. You can take the tablets at mealtimes or between meals. Any calcium you
take as part of a meal will not seriously affect uptake. However, do not
take Ciprofloxacin tablets with dairy products such as milk or yoghurt or
with fortified fruit juices (e.g. calcium-fortified orange juice).
Remember to drink plenty of fluids while you are taking Ciprofloxacin.
If you take more Ciprofloxacin than you should
If you take more than the prescribed dose, get medical help immediately.
If possible, take your tablets or the box with you to show the doctor.

*

If you forget to take Ciprofloxacin
* Take the normal dose as soon as possible and then continue as
prescribed. However, if it is almost time for your next dose, do not take
the missed dose and continue as usual. Do not take a double dose to
make up for a forgotten dose. Be sure to complete your course of
treatment.
If you stop taking Ciprofloxacin
* It is important that you finish the course of treatment even if you begin
to feel better after a few days. If you stop taking this medicine too soon
your infection may not be completely cured and the symptoms of the
infection may return or get worse. You might also develop resistance to
the antibiotic.
If you have any more questions about the use of this product, ask your
doctor or pharmacist.

4

Possible side effects

Like all medicines, Ciprofloxacin can cause side effects, although not
everybody gets them.
If any of the side effects gets serious, or if you notice any side effects not
listed in this leaflet, tell your doctor or pharmacist.
Common side effects (between 1 and 10 in every 100 people are likely to
get these):
* nausea, diarrhoea
* joint pains in children
Uncommon side effects (between 1 and 10 in every 1,000 people are likely
to get these):
* fungal superinfections
* a high concentration of eosinophils, a type of white blood cell
* loss of appetite (anorexia)
* hyperactivity or agitation
* headache, dizziness, sleeping problems, or taste disorders
* vomiting, abdominal pain, digestive problems such as stomach upset
(indigestion/heartburn), or wind
* increased amounts of certain substances in the blood (transaminases
and/or bilirubin)
* rash, itching, or hives
* joint pain in adults
* poor kidney function
* pains in your muscles and bones, feeling unwell (asthenia), or fever
* increase in blood alkaline phosphatase (a certain substance in the blood)
Rare side effects (between 1 and 10 in every 10,000 people are likely to
get these):
* inflammation of the bowel (colitis) linked to antibiotic use (can be fatal in
very rare cases) (see Section 2: Take special care with Ciprofloxacin)
* changes to the blood count (leukopenia, leukocytosis, neutropenia,
anaemia), increased or decreased amounts of a blood clotting factor
(thrombocytes)
* allergic reaction, swelling (oedema), or rapid swelling of the skin and
mucous membranes (angio-oedema)
* increased blood sugar (hyperglycaemia)
* confusion, disorientation, anxiety reactions, strange dreams, depression
(potentially leading to thoughts of suicide, suicide attempts, or completed
suicide), or hallucinations
* pins and needles, unusual sensitivity to stimuli of the senses, decreased
skin sensitivity, tremors, seizures (see Section 2: Take special care with
Ciprofloxacin), or giddiness
* eyesight problems including double vision
* tinnitus, loss of hearing, impaired hearing
* rapid heartbeat (tachycardia)
* expansion of blood vessels (vasodilation), low blood pressure, or fainting
* shortness of breath, including asthmatic symptoms
* liver disorders, jaundice (cholestatic icterus), or hepatitis
* sensitivity to light (see Section 2: Take special care with Ciprofloxacin)
* muscle pain, inflammation of the joints, increased muscle tone, or cramp

*
*

kidney failure, blood or crystals in the urine (see Section 2: Take special
care with Ciprofloxacin), urinary tract inflammation
fluid retention or excessive sweating
increased levels of the enzyme amylase

Very rare side effects (less than 1 in every 10,000 people are likely to get
these):
* a special type of reduced red blood cell count (haemolytic anaemia); a
dangerous drop in a type of white blood cells (agranulocytosis ); a drop in
the number of red and white blood cells and platelets (pancytopenia),
which may be fatal; and bone marrow depression, which may also be fatal
(see Section 2: Take special care with Ciprofloxacin)
* severe allergic reactions (anaphylactic reaction or anaphylactic shock,
which can be fatal - serum sickness) (see Section 2: Take special care
with Ciprofloxacin)
* mental disturbances (psychotic reactions potentially leading to thoughts of
suicide, suicide attempts, or completed suicide) (see Section 2: Take
special care with Ciprofloxacin)
* migraine, disturbed coordination, unsteady walk (gait disturbance),
disorder of sense of smell (olfactory disorders), pressure on the brain
(intracranial pressure)
* visual colour distortions
* inflammation of the wall of the blood vessels (vasculitis)
* pancreatitis
* death of liver cells (liver necrosis) very rarely leading to life-threatening
liver failure
* small, pin-point bleeding under the skin (petechiae); various skin eruptions
or rashes (for example, the potentially fatal Stevens-Johnson syndrome or
toxic epidermal necrolysis)
* muscle weakness, tendon inflammation, tendon rupture – especially of
the large tendon at the back of the ankle (Achilles tendon) (see Section 2:
Take special care with Ciprofloxacin); worsening of the symptoms of
myasthenia gravis (see Section 2: Take special care with Ciprofloxacin)
Frequency not known (cannot be estimated from the available data)
* troubles associated with the nervous system such as pain, burning,
tingling, numbness and/or weakness in extremities
* abnormal fast heart rhythm, life-threatening irregular heart rhythm,
alteration of the heart rhythm (called ‘prolongation of QT interval’, seen on
ECG, electrical activity of the heart)
* pustular rash
* influence on blood clotting (in patients treated with Vitamin K antagonists)
5

*
*
*
*

How to store Ciprofloxacin

Keep out of the sight and reach of children.
Do not use Ciprofloxacin after the expiry date, which is stated on the
blister or carton after “EXP”: The expiry date refers to the last day of the
month concerned.
If your medicine becomes discoloured or shows any other signs of
deterioration consult your pharmacist who will tell you what to do.
Medicines should not be disposed of down the drain or with household
rubbish. Ask your pharmacist how to dispose of any medicines no longer
required. These measures will help to protect the environment.

6

Further information

What Ciprofloxacin contains
Ciprofloxacin 500 mg film-coated tablets contain the active ingredient,
Ciprofloxacin.
Also contain microcrystalline cellulose, maize starch, crospovidone, colloidal
silicon dioxide, magnesium stearate and purified water. The tablet film-coat
consists of a mixture of hypromellose, macrogol 4000, titanium dioxide and
purified water.
What Ciprofloxacin looks like and contents of the pack
Ciprofloxacin are white, film-coated tablets. On one side it is marked with a
break line and CIP 500 and marked BAYER on the other. They are available
in blister packs containing 10 Tablets
Manufacturer and Licence Holder
This medicine is manufactured by Bayer Schering Pharma AG, D-51368,
Leverkusen, Germany and is procured from within the EU and repackaged
by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow
Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1273 Ciprofloxacin 500mg Tablets

Revision date: 11/07/13

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited, Tel: 01527 505414 for
help.

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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