CAVERJECT DUAL CHAMBER 20 MICROGRAMS

Active substance: ALPROSTADIL

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Leaflet Details

Pfizer August 2010

UK Leaflet:

Black print on white paper

Colour:

Title = 16pt
Generic Name = 9pt
Main Section Headings = 9pt
Sub Headings = 8pt
Main Text = Font 8pt / Leading 9.5pt
Statement for Blind = 12pt

Font Size:

Arial

Font:

5mm (around edge & between columns)

Text Free Border:

97.5mm

Column width:

175mm x 420mm, Portrait double sided - 2 columns on each side

Leaflet size:

PLPI 15184/1115

Licence Number:

Lexon Revision date:

29/03/12

Ref: 1115/290312/1/F & Ref: 1115/290312/1/B =
Caverject Dual Chamber 20 micrograms (Front & Back)
Ref: 1115/290312/2/F & Ref: 1115/290312/2/B =
Alprostadil 20 micrograms powder and solvent for solution injection (Front & Back)

This is the final mock-up.
User Testing
This leaflet is being bridge to PLPI 15184/0131

Common conditions affect at least 100 in 10,000 patients taking
CAVERJECT DUAL CHAMBER (this means that for every 10,000 patients,
up to 9,900 are not expected to have these side effects).
These include:
• Swelling and skin discolouration at site of injection .You may find this
happening the first time you use Caverject Dual Chamber but should
occur less often with practice

• Prolonged and painful erections
• Tender lump in the penis
• Penis becoming scarred, bent or kinked
Other less common side effects have been seen in some patients taking
CAVERJECT or other medicines of this kind. Not all of these effects have
necessarily been linked to the use of these medicines.
Uncommon conditions affect fewer than 100 in 10,000 patients taking
CAVERJECT (this means that for every 10,000 patients taking CAVERJECT,
at least 9,900 are not expected to have these side effects).
These include:
• Excessive dilation of the pupil; nausea; dry mouth; skin irritation; sensation
of warmth in the penis; blood in urine; decreased blood pressure; increase
in heart rate; leg cramps, yeast infections; symptoms of common cold;
impaired urination; increased urinary frequency; urinary urgency; abnormal
ejaculation; pain in the testes; scrotum and pelvic area; oedema of the
testes and scrotum; skin rash; painful scrotal swelling; dizziness; back or
pelvic pain; general weakness; dry mouth; changes in blood pressure and
heart rhythm; faintness; shallow breathing and collapse; skin itching or
rash; increased sweating; eye sensitivity to bright light; impaired sense of
touch, cold hands and feet.
If you get any of these, or any other unusual effects, tell your doctor or
pharmacist at once.
5

How to store Caverject Dual Chamber

Do not use this medicine after the expiry date shown on the carton or plastic
tray or Dual Chamber label. If your doctor tells you to stop using this medicine,
return any unused medicine to your pharmacist for safe disposal. Only keep
this medicine, if your doctor tells you to. If your medicine becomes discoloured
or shows any other signs of deterioration, consult your pharmacist who will tell
you what to do.
6

Further information

What Caverject Dual Chamber looks like and contents of the pack
Caverject Dual Chamber is a Dual chamber glass cartridge, containg a white
lyophilised powder and diluent for reconstitution.
There are sufficient components in each box to enable two separate
injections of Caverject Dual Chamber. In the Caverject Dual Chamber box
you will find:
1. Two single use injection devices each containing a dual chamber
cartridge
2. Two 29 gauge needles - 0.5 inch long
3. Four alcohol cleaning swabs
What Caverject Dual Chamber Contains
Each 0.5ml cartridge delivers a maximum dose of 20 micrograms of
alprostadil as the active ingredient.
Caverject Dual Chamber also contains the following inactive ingredients:
lactose monohydrate, sodium citrate, alfadex, hydrochloric acid, sodium
hydroxide, benzyl alcohol and water for injections.
Manufacturer and Licence Holder
Your medicine is manufactured by Pfizer Manufacturing Belgium NV, Puurs,
Belgium and procured from within the EU and repackaged by the product
Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons
Moat, Redditch, Worcestershire, B98 ORE.

POM

PL -15184/1115 Caverject Dual Chamber 20 micrograms

Caverject ® Dual Chamber 20 micrograms

Ref:1115/290312/1/F

(alprostadil)

Patient Information Leaflet
Read all of this leaflet carefully before you start using this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.
Your medicine is called Caverject Dual Chamber 20 micrograms and will be
referred to as Caverject Dual Chamber throughout this leaflet.

In this leaflet:
1 What Caverject Dual Chamber is and what it is used for
2 Before you use Caverject Dual Chamber
3 How to use Caverject Dual Chamber
4 Possible side effects
How to store Caverject Dual Chamber
Further information

• have a condition (such as severe heart disease) in which sexual activity
should be avoided.

• have a penis which is scarred or not straight.
• have a tight foreskin.
Take special care with Caverject Dual Chamber
Tell you doctor before using Caverject Dual Chamber if you:

• have a lung, chest or heart disorder
• have a history of mental illness or addiction
• have had a mini- stroke (transient ischaemic attack)
Sexually transmitted diseases
Caverject Dual Chamber will not protect you or your partner from sexually
transmitted diseases like AIDS, herpes or gonorrhoea. The injection of
Caverject Dual Chamber can start a small amount of bleeding where the
needle enters. This could increase the risk of transmission of such diseases.
Condoms can protect against sexually transmitted diseases. If you need
advice about contraception or “safe sex” speak to your doctor or contact your
local Family Planning Clinic.

5

6

1

Taking other medicines
Tell you doctor if you are taking any of the following medicines before you
start using Caverject Dual Chamber:

What Caverject Dual Chamber is and what it is used for

Caverject Dual Chamber contains alprostadil which is similar to the natural
substance in your body called prostaglandin E1. It widens blood vessels,
increasing blood flow to your penis making it easier for you to have an
erection. Caverject Dual Chamber is used for “erectile dysfunction” including
weak erections or impotence. Your doctor may also use it to help find the
exact cause of your erectile dysfunction along with other tests.

Caverject is a registered trademark of Pharmacia & Upjohn Company LLC.

Do not use Caverject Dual Chamber if you:
• are allergic (hypersensitive) to Caverject Dual Chamber, any other
medicines containing alprostadil or any of the other ingredients of Caverject
Dual Chamber.
• have sickle cell (a blood disease), leukaemia (cancer of the blood), multiple
myeloma (bone cancer) or any other problem which increases risk of
getting “priapism”. This is when your erection lasts for a long time.

• Antihypertensives (used for treating high blood pressure)
• Sympathomimetrics (used for respiratory and heart disease)
• Vasodilative agents (drugs that widen blood vessels)
• Anticoagulants (blood-thinning agents)
• Other treatments for erectile dysfunction (e.g. sildenafil or papaverine)
Please tell your doctor or pharmacist if you are taking or have recently taken
any other medicines, including medicines obtained without a prescription.

• have an implant in your penis.

Page 4

- KEEP THIS MEDICINE OUT OF THE REACH AND SIGHT OF CHILDREN.
- For single use only. Any unused contents of the syringe should be
discarded
- Do not use Caverject Dual Chamber if the injection is cloudy or contains
particles
- After reconstitution it is recommended to be used immediately, if it is not
possible it should be used within 24 hours provided it is not stored above
25°C.
Medicines should not be disposed of via wastewater or household waste. Ask
your pharmacist how to dispose of medicines no longer required. These
measures will help to protect the environment.

Leaflet revision date: 29/03/12

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

2

Before you use Caverject Dual Chamber

Pregnancy and breast feeding
Caverject Dual Chamber can be used by couples wishing to conceive and
with a partner who is pregnant or breastfeeding. It will not protect your
partner from pregnancy, so you should use a reliable contraceptive if
appropriate
Driving and using machines
Caverject Dual Chamber should not affect your ability to drive or use
machines
Page 1

Important information about some of the ingredients of Caverject Dual
Chamber
Caverject Dual Chamber contains benzyl alcohol which may cause allergic
reactions.
This medicine contains less than 1 mmol sodium (23 mg) per dose and is
essentially ‘sodium-free’.

3

How to use Caverject Dual Chamber

A doctor or nurse will show you how to do the injection for at least the first
time. Do not try to do it yourself until you have learnt the correct way or if you
can’t remember what to do, see your doctor again. These instructions are a
reminder only.

The Caverject Dual Chamber device

Outer
Protective
cap

Inner
Protective
cap

Superfine
needle

Clear plastic tip
(glass cartridge
inside)

Dose window

Plunger rod

Preparing the injection
Wash your hands. Dry them with a clean towel. If your partner wishes to be
involved in preparing or giving the injection, they should wash their hands
too.
1. Remove one of the injection devices and needles
from the box. Peel the foil cover from the needle.

How much Caverject Dual Chamber should you inject?
Different people need different amounts of Caverject Dual Chamber to treat
erectile dysfunction. Your doctor will advise on the right dose for you and
monitor you regularly to check how it is working.

6. To remove any large bubbles from the solution, flick the
cartridge with your finger until the bubbles disappear.
Then, keeping the device upright, ,make sure that the
plunger rod is fully turned to the stop by screwing it to
the right (clockwise) then immediately press the plunger
rod as far as it will go. A few drops will appear at the
needle point. It is normal for there to be small bubbles
at the side of the glass cartridge.
7. Turn the end of the plunger rod slowly clockwise to
select your dose. There are four dosage options. Each
option is one of four quarterly parts of a full dose
delivered by the device. Your doctor will have told you
what this should be. The number appearing in the
window indicates the dose of the injection. If you make
a mistake, continue to turn the plunger rod clockwise
until you reach the correct dose.
You can prepare your injection up to 24 hours before using it, providing it is
kept at room temperature.

3. Hold the device with the needle pointing upwards.
The white plunger rod is in the extended position.

If Caverject Dual Chamber is being used to find the reason for your erectile
dysfunction, the dose will be 5-20 micrograms.

2. Attach the needle to the device by pushing the
needle on to the tip of the device. Turn clockwise
until it is firmly in place. Pull off the outer protective
cap of the needle.

The starting dose in the clinic is 1.25-2.5 micrograms, although doses lower
than 2.5 micrograms cannot be delivered with Caverject Dual Chamber. In
this case, Caverject Powder for Injection will be used. Most men find that a
dose of 5-20 micrograms works for them, however, some men may require a
higher dose. You should never use more than 40 micrograms.

How do you do the injection?
•Get undressed and make yourself comfortable. Take some time to relax
yourself and your partner. If your doctor has recommended you use an
alcohol cleansing pad, open one now.

•Make sure that the needle is not bent. If it is, do not use it and throw it
away. Do not attempt to straighten it out.
Injection site (shaded areas)

If the dose that has been prescribed for you does not work well enough, tell
your doctor. Do not change your dose unless your doctor tells you to. If you
forget how much to use, read the label on the pack or speak to your doctor.
4. Turn the plunger rod clockwise until it stops. This
mixes the powder and diluent. Gently shake to
make sure that the solution is evenly mixed and the
powder has dissolved. Do not use if it remains
cloudy or contains particles.

How do you use Caverject Dual Chamber?
These instructions are intended as a reminder only; you should follow your
doctor’s advice where it differs from this leaflet. If you are using Caverject
Dual Chamber for the first time and you have previously used Caverject
Powder for Injection, your doctor should have given you advice about using
Caverject Dual Chamber.

•Take hold of the penis from the front, with the
first two fingers underneath close to the testicles
and the thumb on top. Gently squeeze the penis
between your thumb and finger so that the
injection site bulges out. If there is a foreskin on
the penis, make sure it is stretched. The
injection will go into the part of the penis shown
as the shaded area in diagram A.

Top side

Avoid
Injecting
these
areas

5. Hold the device with the needle upwards. Carefully
remove the inner protective cap from the needle.
Make sure that the needle is not bent. If it is, do not
use it and throw it away. Do not attempt to
straighten it out.

You and your partner
You may like your partner to be involved in preparing and/or giving the
injection. If so, you should speak to your doctor about training for your
partner.

90°

Underside

•Using the alcohol swab, wipe over the area and
let it dry. Check or if necessary adjust so that
the right dose is in the dose window.

•Keeping a firm grip on the penis and taking the
syringe in your free hand, push the needle
straight through the skin all the way into the
bulgy part avoiding veins or other obvious blood
vessels. The angle is shown in diagrams B and
C. Push the plunger firmly and if the solution
does not come out fairly easily, move the needle
slightly and try again. Do not force the Caverject
Dual Chamber liquid from the syringe.
•Pull the needle out. On the needlemark, press gently with the alcohol swab.
Massage the penis to help the alprostadil spread through it.
•Do not keep any mixture in the cartridge to use for a second injection.
When you have finished with the needle, throw it away carefully as
recommended by your doctor, so no-one will see it, use it, or prick
themselves on it.
How often can you use Caverject Dual Chamber?
Do not use Caverject Dual Chamber more than once in 24 hours or more
than three times in a week. Change the exact place and side of the penis
that you inject Caverject Dual Chamber each time you use it.
Your erection after injecting Caverject Dual Chamber
It will take a little while for your erection to come on after the injection. With
the right dose of Caverject Dual Chamber, your erection should be strong
enough for you and your partner to enjoy lovemaking. Usually, your erection
should not last longer than an hour. If you would like it to last longer, talk to
your doctor. If your erection lasts longer than four hours, you should
seek medical advice immediately (see section on side effects below).
If you use too much Caverject Dual Chamber
Tell your doctor straight away as you may need treatment; particularly if you
experience an erection that lasts for longer than four hours.
If you have any further questions on how to use this product, ask your
doctor.

4

Possible side effects

As with all medicines, Caverject can sometimes cause side effects in some
individuals. If any of the following side effects bother you or you notice any
other unpleasant effects, tell your doctor or pharmacist before you use
Caverject Dual Chamber again:

Corpora
Cavernosa

Very common conditions affect at least 1 in 10 patients. Pain in penis
is a very common reaction and should -be discussed with your doctor.
Ref:1115/290312/1/B

Page 2

Page 3

Common conditions affect at least 100 in 10,000 patients taking
ALPROSTADIL (this means that for every 10,000 patients, up to 9,900 are
not expected to have these side effects).
These include:
• Swelling and skin discolouration at site of injection .You may find this
happening the first time you use Alprostadil but should occur less often with
practice

• Prolonged and painful erections
• Tender lump in the penis
• Penis becoming scarred, bent or kinked
Other less common side effects have been seen in some patients taking
ALPROSTADIL or other medicines of this kind. Not all of these effects have
necessarily been linked to the use of these medicines.
Uncommon conditions affect fewer than 100 in 10,000 patients taking
ALPROSTADIL (this means that for every 10,000 patients taking
ALPROSTADIL, at least 9,900 are not expected to have these side effects).
These include:
• Excessive dilation of the pupil; nausea; dry mouth; skin irritation; sensation
of warmth in the penis; blood in urine; decreased blood pressure; increase
in heart rate; leg cramps, yeast infections; symptoms of common cold;
impaired urination; increased urinary frequency; urinary urgency; abnormal
ejaculation; pain in the testes; scrotum and pelvic area; oedema of the
testes and scrotum; skin rash; painful scrotal swelling; dizziness; back or
pelvic pain; general weakness; dry mouth; changes in blood pressure and
heart rhythm; faintness; shallow breathing and collapse; skin itching or
rash; increased sweating; eye sensitivity to bright light; impaired sense of
touch, cold hands and feet.
If you get any of these, or any other unusual effects, tell your doctor or
pharmacist at once.

Do not use this medicine after the expiry date shown on the carton or plastic
tray or Dual Chamber label. If your doctor tells you to stop using this medicine,
return any unused medicine to your pharmacist for safe disposal. Only keep
this medicine, if your doctor tells you to. If your medicine becomes discoloured
or shows any other signs of deterioration, consult your pharmacist who will tell
you what to do.
6

Further information

What Alprostadil looks like and contents of the pack
Alprostadil is a Dual chamber glass cartridge, containg a white lyophilised
powder and diluent for reconstitution.
There are sufficient components in each box to enable two separate
injections of Alprostadil. In the Alprostadil box you will find:
1. Two single use injection devices each containing a dual chamber
cartridge
2. Two 29 gauge needles - 0.5 inch long
3. Four alcohol cleaning swabs
What Alprostadil Contains
Each 0.5ml cartridge delivers a maximum dose of 20 micrograms of
alprostadil as the active ingredient.
Alprostadil also contains the following inactive ingredients:
lactose monohydrate, sodium citrate, alfadex, hydrochloric acid, sodium
hydroxide, benzyl alcohol and water for injections.
Manufacturer and Licence Holder
Your medicine is manufactured by Pfizer Manufacturing Belgium NV, Puurs,
Belgium and procured from within the EU and repackaged by the product
Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons
Moat, Redditch, Worcestershire, B98 ORE.

POM
5

How to store Alprostadil

- KEEP THIS MEDICINE OUT OF THE REACH AND SIGHT OF CHILDREN.
- For single use only. Any unused contents of the syringe should be
discarded
- Do not use Alprostadil if the injection is cloudy or contains
particles
- After reconstitution it is recommended to be used immediately, if it is not
possible it should be used within 24 hours provided it is not stored above
25°C.
Medicines should not be disposed of via wastewater or household waste. Ask
your pharmacist how to dispose of medicines no longer required. These
measures will help to protect the environment.

PL -15184/1115 Alprostadil 20 micrograms powder and solvent
for solution for injection

Alprostadil is a registered trademark of Pharmacia & Upjohn Company LLC.

Alprostadil ® 20 Micrograms Powder and Solvent for Solution Injection
(alprostadil)

2 Before you use Alprostadil
3 How to use Alprostadil
4 Possible side effects

2

Ref:1115/290312/1/F

Patient Information Leaflet
Read all of this leaflet carefully before you start using this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.
Your medicine is called Alprostadil 20 micrograms powder and solvent for
solution for injection and will be referred to as Alprostadil throughout this
leaflet.

In this leaflet:
1 What Alprostadil is and what it is used for

• have a condition (such as severe heart disease) in which sexual activity
should be avoided.

• have a penis which is scarred or not straight.
• have a tight foreskin.
Take special care with Alprostadil
Tell you doctor before using Alprostadil if you:

• have a lung, chest or heart disorder
• have a history of mental illness or addiction
• have had a mini- stroke (transient ischaemic attack)
Sexually transmitted diseases
Alprostadil will not protect you or your partner from sexually transmitted
diseases like AIDS, herpes or gonorrhoea. The injection of Alprostadil can
start a small amount of bleeding where the needle enters. This could
increase the risk of transmission of such diseases. Condoms can protect
against sexually transmitted diseases. If you need advice about
contraception or “safe sex” speak to your doctor or contact your local Family
Planning Clinic.

5 How to store Alprostadil
6 Further information

1

Taking other medicines
Tell you doctor if you are taking any of the following medicines before you
start using Alprostadil :

What Alprostadil is and what it is used for

Alprostadil contains alprostadil which is similar to the natural substance in
your body called prostaglandin E1. It widens blood vessels, increasing blood
flow to your penis making it easier for you to have an erection. Alprostadil is
used for “erectile dysfunction” including weak erections or impotence. Your
doctor may also use it to help find the exact cause of your erectile dysfunction along with other tests.

Leaflet revision date: 29/03/12

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

Before you use Alprostadil

Do not use Alprostadil if you:
• are allergic (hypersensitive) to Alprostadi, any other
medicines containing alprostadil or any of the other ingredients of
Alprostadi.
• have sickle cell (a blood disease), leukaemia (cancer of the blood), multiple
myeloma (bone cancer) or any other problem which increases risk of
getting “priapism”. This is when your erection lasts for a long time.

• Antihypertensives (used for treating high blood pressure)
• Sympathomimetrics (used for respiratory and heart disease)
• Vasodilative agents (drugs that widen blood vessels)
• Anticoagulants (blood-thinning agents)
• Other treatments for erectile dysfunction (e.g. sildenafil or papaverine)
Please tell your doctor or pharmacist if you are taking or have recently taken
any other medicines, including medicines obtained without a prescription.
Pregnancy and breast feeding
Alprostadil can be used by couples wishing to conceive and with a partner
who is pregnant or breastfeeding. It will not protect your partner from
pregnancy, so you should use a reliable contraceptive if appropriate
Driving and using machines
Alprostadil should not affect your ability to drive or use machines

• have an implant in your penis.

Page 4

Page 1

Important information about some of the ingredients of Alprostadil
Alprostadil contains benzyl alcohol which may cause allergic reactions.
This medicine contains less than 1 mmol sodium (23 mg) per dose and is
essentially ‘sodium-free’.

3

How to use Alprostadil

A doctor or nurse will show you how to do the injection for at least the first
time. Do not try to do it yourself until you have learnt the correct way or if you
can’t remember what to do, see your doctor again. These instructions are a
reminder only.

The Alprostadil device

Outer
Protective
cap

Inner
Protective
cap

Superfine
needle

Clear plastic tip
(glass cartridge
inside)

Dose window

Plunger rod

Preparing the injection
Wash your hands. Dry them with a clean towel. If your partner wishes to be
involved in preparing or giving the injection, they should wash their hands
too.

How much Alprostadil should you inject?
Different people need different amounts of Alprostadil to treat erectile
dysfunction. Your doctor will advise on the right dose for you and monitor you
regularly to check how it is working.

1. Remove one of the injection devices and needles
from the box. Peel the foil cover from the needle.

6. To remove any large bubbles from the solution, flick the
cartridge with your finger until the bubbles disappear.
Then, keeping the device upright, ,make sure that the
plunger rod is fully turned to the stop by screwing it to
the right (clockwise) then immediately press the plunger
rod as far as it will go. A few drops will appear at the
needle point. It is normal for there to be small bubbles
at the side of the glass cartridge.
7. Turn the end of the plunger rod slowly clockwise to
select your dose. There are four dosage options. Each
option is one of four quarterly parts of a full dose
delivered by the device. Your doctor will have told you
what this should be. The number appearing in the
window indicates the dose of the injection. If you make
a mistake, continue to turn the plunger rod clockwise
until you reach the correct dose.
You can prepare your injection up to 24 hours before using it, providing it is
kept at room temperature.

The starting dose in the clinic is 1.25-2.5 micrograms, although doses lower
than 2.5 micrograms cannot be delivered with Alprostadil. In this case,
Caverject Powder for Injection will be used. Most men find that a dose of
5-20 micrograms works for them, however, some men may require a higher
dose. You should never use more than 40 micrograms.

2. Attach the needle to the device by pushing the
needle on to the tip of the device. Turn clockwise
until it is firmly in place. Pull off the outer protective
cap of the needle.

If Alprostadil is being used to find the reason for your erectile dysfunction, the
dose will be 5-20 micrograms.

How do you do the injection?
•Get undressed and make yourself comfortable. Take some time to relax
yourself and your partner. If your doctor has recommended you use an
alcohol cleansing pad, open one now.

•Make sure that the needle is not bent. If it is, do not use it and throw it
away. Do not attempt to straighten it out.

3. Hold the device with the needle pointing upwards.
The white plunger rod is in the extended position.

If the dose that has been prescribed for you does not work well enough, tell
your doctor. Do not change your dose unless your doctor tells you to. If you
forget how much to use, read the label on the pack or speak to your doctor.
How do you use Alprostadil?
These instructions are intended as a reminder only; you should follow your
doctor’s advice where it differs from this leaflet. If you are using Alprpstadil
for the first time and you have previously used Caverject Powder for
Injection, your doctor should have given you advice about using Alprostadil.

4. Turn the plunger rod clockwise until it stops. This
mixes the powder and diluent. Gently shake to
make sure that the solution is evenly mixed and the
powder has dissolved. Do not use if it remains
cloudy or contains particles.

You and your partner
You may like your partner to be involved in preparing and/or giving the
injection. If so, you should speak to your doctor about training for your
partner.

Injection site (shaded areas)

•Take hold of the penis from the front, with the
first two fingers underneath close to the testicles
and the thumb on top. Gently squeeze the penis
between your thumb and finger so that the
injection site bulges out. If there is a foreskin on
the penis, make sure it is stretched. The
injection will go into the part of the penis shown
as the shaded area in diagram A.

Top side

Avoid
Injecting
these
areas

5. Hold the device with the needle upwards. Carefully
remove the inner protective cap from the needle.
Make sure that the needle is not bent. If it is, do not
use it and throw it away. Do not attempt to
straighten it out.

90°

Underside

•Using the alcohol swab, wipe over the area and
let it dry. Check or if necessary adjust so that
the right dose is in the dose window.

•Keeping a firm grip on the penis and taking the
syringe in your free hand, push the needle
straight through the skin all the way into the
bulgy part avoiding veins or other obvious blood
vessels. The angle is shown in diagrams B and
C. Push the plunger firmly and if the solution
does not come out fairly easily, move the needle
slightly and try again. Do not force the
Alprostadil liquid from the syringe.
•Pull the needle out. On the needlemark, press gently with the alcohol swab.
Massage the penis to help the alprostadil spread through it.
•Do not keep any mixture in the cartridge to use for a second injection.
When you have finished with the needle, throw it away carefully as
recommended by your doctor, so no-one will see it, use it, or prick
themselves on it.
How often can you use Alprostadil?
Do not use Alprostadil more than once in 24 hours or more than three times
in a week. Change the exact place and side of the penis that you inject
Alprostadil each time you use it.
Your erection after injecting Alprostadil
It will take a little while for your erection to come on after the injection. With
the right dose of Alprostadil, your erection should be strong enough for you
and your partner to enjoy lovemaking. Usually, your erection should not last
longer than an hour. If you would like it to last longer, talk to your doctor. If
your erection lasts longer than four hours, you should seek medical
advice immediately (see section on side effects below).
If you use too much Alprostadil
Tell your doctor straight away as you may need treatment; particularly if you
experience an erection that lasts for longer than four hours.
If you have any further questions on how to use this product, ask your
doctor.

4

Possible side effects

As with all medicines, Alprostadil can sometimes cause side effects in some
individuals. If any of the following side effects bother you or you notice any
other unpleasant effects, tell your doctor or pharmacist before you use
Alprostadil again:

Corpora
Cavernosa

Very common conditions affect at least 1 in 10 patients. Pain in penis
is a very common reaction and should -be discussed with your doctor.
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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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