BENDROFLUMETHIAZIDE TABLETS 2.5MG

Active substance: BENDROFLUMETHIAZIDE

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BENDROFLUMETHIAZIDE
Tablets
2.5mg

Each tablet contains:
Bendroflumethiazide
2.5mg

KEEP OUT OF THE
REACH AND SIGHT
OF CHILDREN
Do not store above 25°C.

500 Tablets
Page 1

M0121TB
M0121
PL 20416/0027 POM

68 x 35

5 017123 268106

Contains lactose.
For oral administration,
as directed by the doctor.
For further information,
see Patient Information
Leaflet.

your doctor that you have an intolerance to some
sugars, contact your doctor before taking this medicine.
Tests
Your doctor may want to carry out regular blood tests
during your treatment with this medicine, to check
your kidney function and to monitor the levels of
potassium and other salts, as this medicine may lead
to an imbalance of salts/chemicals in your blood (see
Section 4 “Possible Side Effects”
for symptoms of this disorder).
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3. HOW TO TAKE BENDROFLUMETHIAZIDE
TABLETS
The tablets should be taken with a drink of water. The
usual doses are given below but your doctor will
decide the dose that is best for you. The pharmacist’s
label will tell you how many tablets to take and how
often. If you are not sure about anything, ask your
doctor or pharmacist.
Adults
For fluid retention: Initially 5 mg to 10 mg once a day
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in the morning or on alternate days. The maintenance
dose is 2.5 mg to 5 mg two or three times a week.
For high blood pressure: 2.5 mg once a day in the
morning.
Children
The dose will depend on the body weight of the child
and the condition being treated, and may be given
using a more appropriate formulation (i.e. a liquid).
Elderly
Your doctor may have prescribed you a lower dose
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than the usual adult dose, particularly if you have
problems with your kidney function.
If you have taken too many tablets:
If you think you have taken too many tablets,
contact your doctor straight away or go to the
nearest hospital casualty department. Take with you
any remaining tablets and the pack so that the
medicine can be identified.
If you forget to take a dose:
If you miss a dose of this medicine, take it as soon
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as possible. However, if it is almost time for your
next dose, skip the missed dose and continue with
the regular dosing schedule. DO NOT DOUBLE THE
DOSE.
4. POSSIBLE SIDE EFFECTS
Like all medicines, bendroflumethiazide can cause
side effects, although not everybody gets them.
If you suffer from any of the following at any time
during your treatment STOP TAKING the medicine
and contact your doctor IMMEDIATELY as these are
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serious effects:
• allergic reactions affecting the skin such as
rashes, severe itching, peeling or blistering,
sensitivity to light
• allergic reactions affecting the lungs causing
inflammation of the lung tissue or fluid on the
lungs; signs include cough, difficulty breathing,
tiredness, fever, sweating
• yellowing of your skin or whites of your eyes, pale
stools, dark urine, loss of appetite; these may be
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signs of liver problems caused by blocked bile
flow. Damage to the brain may also occur in
those who already have existing liver disease
such as cirrhosis (signs include changes in
personality or behaviour, abnormal movements
or shaking)
• you experience any unusual bruising, nose
bleeds, feel unusually tired, have a sore throat;
these may be signs of a blood disorder.
Tell your doctor or pharmacist if you suffer from
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any of the following other effects:
• changes to the salts/chemicals in your blood
especially of potassium, chloride, sodium and
magnesium. Symptoms include mild loss of
appetite, thirst, nausea, vomiting, constipation,
muscle weakness, twitching, cramps, dizziness,
abnormal heart rhythm, confusion, tiredness, fits
• inability to get an erection or lack of sex drive
• worsening of gout
• diarrhoea and occasionally indigestion
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• feeling faint on standing up
• increase in amount and frequency of urination
• inflammation of the pancreas (rarely).
If you notice any of these or any other side effects
not mentioned in this leaflet, or if any side effect
gets serious, then tell your doctor or pharmacist.
5. HOW TO STORE
BENDROFLUMETHIAZIDE TABLETS
Keep the tablets in the pack provided. Do not store
above 25°C.
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KEEP ALL MEDICINES OUT OF THE REACH AND
SIGHT OF CHILDREN
Do not take the tablets if the expiry date on the
pack has passed. If you have any medicines that
are out of date, return them to your pharmacist for
safe disposal.
6. FURTHER INFORMATION
Ingredients:
Each tablet contains 2.5mg of bendroflumethiazide
as the active ingredient. They also contain the
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following other ingredients: lactose, maize
starch, pregelatinised maize starch and
magnesium stearate.
What the medicine looks like:
Bendroflumethiazide Tablets 2.5mg are white,
round tablets engraved with the company logo
on one side and “A268” on the other. The tablets
are available in packs of 28, 30, 42, 56, 60, 84,
90, 112 or 500. (Not all pack sizes may be
marketed).
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Who makes this medicine and holds the
Product Licence:
Crescent Pharma Limited, Units 3 & 4,
Quidhampton Business Units, Polhampton Lane,
Overton, Hants, RG25 3ED
Date leaflet revised: October 2011
If you would like this leaflet in a different format
please contact the licence holder at the above
address.

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PATIENT INFORMATION LEAFLET

BENDROFLUMETHIAZIDE
Tablets 2.5mg
Please read all of this leaflet carefully before you
start taking this medicine.
Keep the leaflet; you may need to read it again.
If you have any questions or are not sure about
anything, ask your doctor or pharmacist.

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This medicine has been prescribed for you. Do
not pass it on to others; it may harm them, even
if their symptoms are the same as yours.
If any of the side effects gets serious, or if you
notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
In this leaflet:
1. What Bendroflumethiazide Tablets are and
what they are used for
2. Before you take Bendroflumethiazide Tablets
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3. How to take Bendroflumethiazide Tablets
4. Possible side effects
5. How to store Bendroflumethiazide Tablets
6. Further information
1. WHAT BENDROFLUMETHIAZIDE TABLETS
ARE AND WHAT THEY ARE USED FOR
This medicine belongs to a group of drugs known
as diuretics (water tablets). This medicine is used
to reduce fluid retention (oedema) caused by
heart, liver or kidney conditions by increasing the
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flow of urine. It is also used to treat high blood
pressure, either alone or in combination with other
drugs which lower blood pressure.
2. BEFORE YOU TAKE
BENDROFLUMETHIAZIDE TABLETS
Do not take these tablets if you have:
• an allergy to bendroflumethiazide or to any of the
other ingredients (see section 6)
• Addison's disease (a disorder where the adrenal
glands do not produce enough steroid hormones)
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• low blood levels of sodium (hyponatraemia) or of
potassium (hypokalaemia)
• high levels of calcium in the blood
(hypercalcaemia)
• high levels of uric acid in the blood
(hyperuricaemia) causing symptoms of gout ie.
pain in the joints
• acute porphyria
• severe kidney or liver function problems.

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Check with your doctor before taking these
tablets if you have:
• diabetes
• porphyria
• gout
• systemic lupus erythematosus (SLE) which is a
destructive skin condition
• liver disease (cirrhosis), including that caused by
alcohol
• kidney or liver function problems
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• inflammation of the pancreas (pancreatitis)
• prostate problems
• severe asthma and you are taking beta agonist
(sympathomimetic) medicines (see below)
• high blood lipid levels.
Taking other medicines:
Check with your doctor or pharmacist before taking
these tablets if you are taking other medicines,
including any that you can buy without a prescription.
This is especially important if you taking:
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• any medicines for treatment of asthma including
sympathomimetics (bambuterol, fenoterol,
formoterol, reproterol, ritodrine, salbutamol,
salmeterol, terbutaline, tulobuterol) or
theophylline
• non-steroidal anti-inflammatory drugs (NSAIDs)
for pain and inflammation eg. ibuprofen,
indometacin or ketorolac
• medicines containing opiates, used for the relief of
pain eg. codeine, morphine
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• any other medicines used to treat high blood
pressure, including ACE inhibitors eg. enalapril,
angiotensin II antagonists eg. losartan, alpha
blockers eg. prazosin, and calcium channel
blockers eg. amlodipine, diltiazem
• medicines for heart problems including beta
blockers (especially sotalol) and cardiac
glycosides eg. digoxin
• medicines to control irregular heart beat
especially amiodarone, disopyramide, flecainide,
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lidocaine, mexiletine and quinidine
• medicines to treat depression such as lithium,
tricyclic antidepressants or reboxetine
• any other diuretic medicines especially
acetazolamide
• medicines taken by mouth for diabetes especially
chlorpropamide
• corticosteroids eg. prednisolone
• oestrogens or progesterones (as present in oral
contraceptives or HRT)
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• allopurinol (used to treat gout)
• alprostadil (for impotence)
• aminoglutethimide (used in some cancers and
Cushing’s syndrome)
• amphotericin (used to treat fungal infections)
• calcium salts or Vitamin D
• carbamazepine or barbiturates (used in epilepsy)
• carbenoxolone (used for stomach ulcers)
• cisplatin (used to treat cancer) or toremifene (for
breast cancer)
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• colestyramine and colestipol (used to lower blood
cholesterol)
• pimozide (used to treat mental illness)
• moxisylyte (for Raynaud’s syndrome)
• terfenadine (used in allergies)
• baclofen or tizanidine (muscle relaxants).
Pregnancy and breast-feeding
Bendroflumethiazide is not recommended for use in
pregnant or breast-feeding women. Check with your
doctor or pharmacist before taking this medicine.
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Taking bendroflumethiazide with alcohol
Alcohol consumption should be kept to a minimum as
this medicine increases the likelihood of dehydration
after drinking alcohol.
Effects on driving or operating machiner y
This medicine may cause dizziness. Do not drive or
operate machinery if it has this effect on you.
Important information about an ingredient of this
medicine
This medicine contains lactose. If you have been told by
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BENDROFLUMETHIAZIDE
Tablets
2.5mg

Each tablet contains:
Bendroflumethiazide 2.5mg

500 Tablets
68

M0121TB
M0121

PL Holder: Crescent Pharma Limited
Overton, Hants, RG25 3ED

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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