Active substance: IBUPROFEN

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Read all of this leaflet carefully because it contains important information for you.
This medicine is available without a prescription, for you to treat a mild illness without a
doctor’s help. Nevertheless, you still need to use your medicine carefully to get the best
results. Keep this leaflet. You may need to read it again.
Ask your pharmacist if you need more information or advice. You must see a doctor if your
symptoms worsen or do not improve.
If any of the side effects get serious, or if you notice any side effect not listed in this
leaflet, please tell your doctor or pharmacist.
1. What your medicine is and what it is used for
2. Before you take your medicine
3. How to take your medicine
4. Possible side effects
5. How to store your medicine
6. Further information
1. What your medicine is and what it is used for
Each liquid filled soft capsule contains: 400mg of ibuprofen Ph Eur.
Ibuprofen belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs
(NSAIDs) that work by relieving pain, reducing inflammation, swelling and fever. Your
medicine is for effective relief from: Headache, dental pain, muscular pain, symptoms of
colds and flu, backache, period pain, feverishness, migraine, neuralgia, rheumatic pain, and
the pain of non-serious arthritic conditions.
2. Before you take your medicine
Please read the following information. Do not give to children under 12 years.
Do not take if you:
• have or have ever had a stomach ulcer, perforation or bleeding
• are allergic to ibuprofen or any other ingredient of the product, aspirin or other related
• suffer from severe liver, kidney or heart failure
• are in the last 3 months of pregnancy
Take special care and talk to a pharmacist or your doctor before taking this medicine if
you are:
• asthmatic or suffer from kidney or liver problems, or from hayfever
• suffering from Systemic Lupus Erythematosus (SLE) – a condition of the immune system
affecting connective tissue resulting in joint pain, skin change and disorders of other organs
• trying to become pregnant (ibuprofen belongs to a group of medicines (NSAIDs) which
may impair fertility in women. This effect is reversible upon stopping the medicine. It is
unlikely that ibuprofen, used occasionally will affect your chances of becoming pregnant,
however, tell your doctor before taking this medicine, if you have problems becoming
• you are in the first 6 months of pregnancy

• suffering from heart problems, have had a previous stroke or think that you may be at risk
of these conditions (for example if you have high blood pressure, diabetes or high cholesterol
or are a smoker). Medicines such as ibuprofen may be associated with a small increased risk
of heart attack (“myocardial infarction”) or stroke. Any risk is more likely with high doses
and prolonged treatment. Do not exceed the recommended dose or duration of treatment (10
Taking other medicines
Do not use this medicine if you are:
• taking other NSAID painkillers, or aspirin with a daily dose above 75mg
Talk to your doctor or pharmacist if you are:
• taking medicines that are anti-coagulants (i.e. thin blood/prevent clotting e.g.
aspirin/acetylsalicylic acid, warfarin, ticlopidine), some medicines that reduce high blood
pressure (ACE-inhibitors such as captopril, beta-blockers such as atenolol, or angiotensin-II
receptor antagonists such as losartan), and other medicines, as these may affect or be affected
by treatment with ibuprofen
• taking other medicines such as corticosteroids, anti platelet agents, cardiac glycosides,
selective serotonin reuptake inhibitors, lithium, methotrexate, ciclosporin, mifepristone,
tacrolimus, zidovudine, or quinolone antibiotics
You should always seek the advice of your doctor or pharmacist before you take ibuprofen
with other medicines.
Important information about some of the ingredients of your medicine
• Each capsule contains 40mg potassium, which should be taken into consideration by
patients with kidney problems or patients on a low potassium diet
• Each capsule also contains mannitol (E421), which may have a mild laxative effect
• If you have been told by your doctor that you have an intolerance to some sugars, contact
your doctor before taking this medicinal product as it also contains sorbitol (E420)
3. How to take your medicine
For oral administration and short term use only.
Dosage: Adults, the elderly and young persons over 12 years:
The minimum effective dose should be used for the shortest time necessary to relieve
1 capsule up to 3 times a day, as required. The capsule should be taken with water. Do not
Take only as much as you need to relieve your symptoms and leave at least 4 hours between
each dose.
Do not take more than 3 capsules in any 24 hour period.
You should not take this product for longer than 10 days unless your doctor tells you to. If
symptoms persist or worsen consult your doctor.
If you take more capsules than you should:
If you take too many capsules, contact your doctor or hospital immediately. Bring the
remaining capsules with you to show the doctor.
4. Possible side effects:
Like all medicines, your medicine can cause side effects, although not everybody gets them.
The following effects are very rare (less than 1 in 10,000 people) but if you experience any of
the following serious effects then STOP taking this medicine immediately and contact your
doctor or pharmacist:

• Peptic ulceration or perforation. Symptoms could include severe abdominal pain, vomiting
blood (or liquid with what looks like coffee grounds), blood in the faeces (stools/motions) or
passing black tarry stools
• Inflammation of the brain lining. Symptoms could include stiff neck, headache, feeling or
being sick, fever or feeling disorientated
• Severe allergic reactions. Symptoms could include fainting, faster heart rate, swelling of the
face, tongue and throat
• Worsening of asthma and wheezing or difficulty breathing
Other possible side effects
If any of the following side effects get serious, or if you notice any side effect not listed in
this leaflet, please tell your doctor or pharmacist.
Less than 1 in 100 people may experience the following uncommon side effects:
• Allergic reactions such as hives, skin rashes and itching (or SLE)
• Abdominal pain, indigestion, heartburn and feeling sick
• Headache
Less than 1 in 1000 people may experience the following rare side effects:
• Diarrhoea, wind, constipation or being sick
Less than 1 in 10,000 people may experience the following very rare side effects:
• Reduction in blood cells, which can make the skin pale or yellow, cause fever, sore throat,
mild mouth ulcers, flu-like symptoms, exhaustion or weakness, easy bruising, or bleeding
from the skin or nose
• High blood pressure, heart failure or chest pain
• Nervousness, visual disturbance, ringing in the ears and dizziness
• Liver problems. Symptoms could include yellowing of the skin or the whites of the eyes
• Kidney problems. Symptoms could include swelling of the ankles
• Severe skin reactions. Symptoms could include blistering
Medicines such as Anadin Ultra Double Strength 400mg Capsules may be associated with a
small increased risk of heart attack ("myocardial infarction") or stroke.
5. How to store your medicine
• Do not use this medicine after the expiry date shown on the end of the carton
• Do not store above 25˚C
• Keep out of sight and reach of children
6. Further Information
What does this medicine contain?
The active substance is ibuprofen. Your medicine contains 400mg of ibuprofen Ph Eur. in
liquid filled soft capsules.
Each liquid filled soft capsule also contains; macrogol 600, potassium hydroxide, sorbitol
liquid, partially dehydrated (containing sorbitan, mannitol), gelatin, lecithin, triglycerides
(medium chain), glycerol stearate, oleic acid, ascorbyl palmitate, purified water, Opacode
black ink (propylene glycol, iron oxide black (E172), polyvinyl acetate phthalate
(PVAP) and polyethylene glycol 400).
Your medicine is a liquid filled soft capsule, with ‘400’ printed on one side in black ink,
available in packs containing 10 and 20 capsules. These packs are available only from your
Who makes this medicine?

Your medicine is manufactured by: Wyeth Lederle SpA,Via Nettunense, 90 - 04011 Aprilia
(LT), Italy.
The Marketing Authorisation Holder is: Pfizer Consumer Healthcare Ltd, Ramsgate Road,
Sandwich, Kent, CT13 9NJ, UK.
This leaflet was approved in: May 2011.
If you have any queries or comments about your medicine or any other Pfizer Consumer
Healthcare Ltd products, ring our customer Careline or write in confidence to:
Careline, Pfizer Consumer Healthcare Ltd, Vanwall Road, Maidenhead, Berkshire, SL6 4UB,
UK or

PL 00165/0148

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.