ADRENALINE INJECTION BP 1MG IN 1ML (1:1000)

Active substance: ADRENALINE ACID TARTRATE

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Package leaflet: information for the user

Adrenaline (Epinephrine) Injection BP 1:1000

D02484

It may not be possible for you to read this leaflet before
you are given Adrenaline (Epinephrine) Injection BP
1:1000.
• The leaflet will be kept for you as you may wish to read it
later.
• If you have further questions, please ask your doctor or
nurse.
• If any of the side effects become serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor or nurse.

In this leaflet:
1. What Adrenaline (Epinephrine) Injection BP 1:1000 is, and
what it is used for
2. Before Adrenaline (Epinephrine) Injection BP 1:1000 is
given
3. How Adrenaline (Epinephrine) Injection BP 1:1000 is given
4. Possible side effects
5. Storing Adrenaline (Epinephrine) Injection BP 1:1000
6. Further information

1. What Adrenaline (Epinephrine) Injection BP
1:1000 is, and what it is used for
• Adrenaline (Epinephrine) belongs to a group of medicines
used to restart your heart if it has stopped
• It can be used for the treatment of serious shock produced
by a severe allergic reaction or collapse
• It may also be used if you have severe asthma

2. Before Adrenaline (Epinephrine) Injection
BP 1:1000 is given
You should not be given Adrenaline (Epinephrine)
Injection BP 1:1000 if you are:
• allergic (hypersensitive) to any of the ingredients in this
injection
• suffering from any form of heart disease
• in shock (other than that caused by a sudden life
threatening reaction)
• suffering from brain damage or hardening of the arteries in
the brain
• suffering from glaucoma (increased pressure in the eye)
• having or are about to have an operation under general
anaesthetic
• in the second stage of labour
Take special care with Adrenaline (Epinephrine) Injection
BP 1:1000 if you are:
• suffering from high blood pressure
• pregnant or breastfeeding
• diabetic
If any of the above applies to you or your child, please tell the
doctor before this medicine is given.
Taking other medicines
Please tell your doctor or nurse if you are taking or have
recently taken any other medicines, including medicines
obtained without a prescription.
Medicines that may interact with Adrenaline (Epinephrine)
Injection BP 1:1000 include:
• antihistamines (drugs used to treat allergic reactions or
allergies)
• drugs used to treat high blood pressure, heart conditions,
depression or thyroid problems
• ergot alkaloids (drugs used to treat migraine)
• insulin or oral hypoglycaemics (drugs used to treat
diabetes)
• oxytocin (used in childbirth to stimulate contractions of the
uterus)
• doxapram (given as an injection in hospitals to help severe
breathing problems)
• antipsychotics (for the treatment of serious mental
disorders)
Pregnancy & breast-feeding
If you are pregnant or are breast-feeding, your doctor will
advise you whether you can have Adrenaline (Epinephrine)
Injection BP 1:1000 as an emergency treatment.
Important information about some of the ingredients in
this medication
The product also contains Sodium Metabisulphite which
may cause allergic (hypersensitive) type reactions in some
people, which can lead to breathing difficulties or collapse.
People with a history of asthma or allergies are most likely to
experience these problems.

3. How Adrenaline (Epinephrine) Injection BP
1:1000 is given
Depending on why you are being given adrenaline 1:1000
injection, the doctor, nurse or paramedic will give the
injection either into a vein (intravenous), into a bone
(intraosseous), into a muscle (intramuscular) or under the skin
(subcutaneous).
Your doctor will decide the correct dose and the best way to
give it to you.
Adrenaline must not be injected into the fingers, toes, ears,
nose or genital area. Intramuscular injection in the buttocks
should be avoided.
When there is either uncontrolled beating of the heart, or
if the heart has stopped working:
Adults and children over 12 years:
1mg adrenaline is given either into the vein or into a bone
every 3-5 minutes until the heart starts to work. Once the
heart is working, further doses may be given but this depends
on your blood pressure. Intravenous doses of 50 micrograms
are usually sufficient for most patients. To give this dose, your
doctor will need to use a different strength of adrenaline
injection.
Continued overleaf

When treating life threatening allergic reactions (acute
anaphylaxis):
Adrenaline (Epinephrine) 1:1000 injection will be given into
your muscle to treat an allergic reaction.
Adults and children over 12 years:
500 micrograms (0.5ml of Adrenaline 1:1000 injection) into
the muscle
Children 6 – 12 years:
300 micrograms (0.3ml of Adrenaline 1:1000 injection) into
the muscle
Children 6 months to 6 years:
150 micrograms (0.15ml of Adrenaline 1:1000 injection) into
the muscle
Children less than 6 months:
150 micrograms (0.15ml of Adrenaline 1:1000 injection) into
the muscle
To treat severe asthma:
300 micrograms (0.3ml of Adrenaline 1:1000 injection) given
under the skin. This may be repeated up to a total of 3 doses
at 20 minute intervals.
If you are given more Adrenaline (Epinephrine) Injection
BP 1:1000 than you should
As this medicine will be given to you whilst you are in hospital,
it is unlikely that you will be given too little or too much;
however, tell your doctor or nurse if you have any concerns.

4. Possible side effects
Like all medicines Adrenaline (Epinephrine) Injection BP
1:1000 can cause side effects, although not everybody gets
them.
Adrenaline (Epinephrine) solutions may be associated with
some unwanted effects although these are normally related
to higher strengths of the drug. The unwanted effects include:
• anxiety
• difficulty in breathing
• high blood sugar levels
• high blood pressure
• restlessness
• palpitations (irregular or faster heart beat)
• tremors (shaking)
• weakness
• dizziness
• headache
• coldness of the fingers and toes
• feeling sick (nausea)
• being sick (vomiting)
• sweating
• cerebral haemorrhage (bleeding in the brain which can
cause very severe headaches, stiff neck, fits and loss of
consciousness)
• hemiplegia (paralysis of one side of the body)
• ECG changes
In patients with Parkinson’s disease, Adrenaline (Epinephrine)
may increase rigidity (stiffness) and tremors (shaking).
After being given this product, you may experience slight
pain, minor bruising/bleeding or some left over liquid in the
place where you have been injected.
Repeated injection may cause tissue damage in the place
where you have been injected. Tissue damage may also occur
in the extremities (fingers and toes), kidneys and liver.
If any of the side effects become serious or you notice any
other effects not mentioned in this leaflet, please tell your
doctor or nurse.

5. Storing Adrenaline (Epinephrine) Injection
BP 1:1000
Keep out of the sight and reach of children.
Your doctor, nurse or paramedic will check that the expiry
date on the label has not passed before giving Adrenaline
(Epinephrine) Injection BP 1:1000 to you. The expiry date
refers to the last day of that month.
Adrenaline (Epinephrine) is sensitive to light, therefore
Adrenaline (Epinephrine) Injection BP 1:1000 must always be
kept in the original outer carton.
Do not store above 25ºC and do not freeze.
You should not be given Adrenaline (Epinephrine) Injection
BP 1:1000 if it has been used or shows signs of visible damage.

6. Further Information
What Adrenaline (Epinephrine) Injection BP 1:1000
contains
The active ingredient is Adrenaline (Epinephrine) as acid
tartrate.
Each 1ml solution for injection contains 1mg of adrenaline
(epinephrine) as the acid tartrate.
The other ingredients are Sodium Chloride, Sodium
Metabisulphite and Water for Injections. Dilute Hydrochloric
acid may be added to adjust the acidity.
What Adrenaline (Epinephrine) Injection BP 1:1000 looks
like and contents of the pack
Adrenaline (Epinephrine) Injection BP 1:1000 is a clear
colourless solution supplied in a pre-filled syringe. Each prefilled syringe contains 1ml of the solution.
Marketing Authorisation
Manufacturer:
Holder:
Aurum Pharmaceuticals Ltd. Martindale Pharmaceuticals
Bampton Road, Romford,
Bampton Road, Romford
RM3 8UG
RM3 8UG
United Kingdom
United Kingdom
This leaflet was last revised in: April 2013
Product License Number: PL 12064/0024

D02484

100mm Measurement Verification Bar

2484-B

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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