Generic Name: diltiazem (dil TYE a zem)
Brand Names: Cardizem, Cardizem CD, Cardizem LA, Cartia XT, Dilacor XR, Dilt-CD, Dilt-XR, Diltia XT, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Diltzac, Taztia XT, Tiazac, Cardizem SR, Cardizem Monovial, Matzim LA

What is Tiazac?

Tiazac (diltiazem) belongs to a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.

Tiazac is used to treat hypertension (high blood pressure) It may be used alone or in combination with other high blood pressure medications. Tiazac is also used to treat angina (chest pain).

Tiazac may also be used for purposes not listed in this medication guide.

Important information

Do not use Tiazac if you have certain heart conditions such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), low blood pressure, or if you have recently had a heart attack.

Before taking Tiazac, tell your doctor if you have kidney disease, liver disease, or congestive heart failure.

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Tiazac may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Do not stop taking this medication without first talking to your doctor. If you stop taking Tiazac suddenly, your condition may become worse.

Tiazac may be only part of a complete program of treatment that also includes diet, exercise, and other medications. Follow your diet, medication, and exercise routines very closely.

If you are being treated for high blood pressure, keep using Tiazac even if you feel well. High blood pressure often has no symptoms.

Before taking this medicine

You should not use Tiazac if you are allergic to diltiazem, or if you have:

  • certain heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);

  • low blood pressure; or

  • if you have recently had a heart attack.

To make sure you can safely take Tiazac, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease;
  • congestive heart failure; or

  • if you are also taking clonidine (Catapres).

FDA pregnancy category C. It is not known whether Tiazac will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Diltiazem can pass into breast milk and may harm a nursing baby. Do not use Tiazac without telling your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I take Tiazac?

Take Tiazac exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take Tiazac with a full glass of water. Do not crush or chew an extended-release capsule. If you have trouble swallowing a Tiazac capsule whole it may also be taken by carefully opening the capsule and sprinkling the capsule contents on a spoonful of applesauce. The applesauce should be swallowed immediately without chewing and followed with a glass of cool water to ensure complete swallowing of the capsule contents. The applesauce should not be hot, and it should be soft enough to be swallowed without chewing. Any capsule contents/applesauce mixture should be used immediately and not stored for future use. Discard the empty Tiazac capsule.

Use Tiazac regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop taking this medication without first talking to your doctor. If you stop taking Tiazac suddenly, your condition may become worse.

If you are being treated for high blood pressure, keep using Tiazac even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Tiazac may be only part of a complete program of treatment that also includes diet, exercise, and other medications. Follow your diet, medication, and exercise routines very closely.

To be sure this medicine is helping your condition and is not causing harmful effects, your blood pressure will need to be checked often. Your liver and kidney function may also need to be tested. Visit your doctor regularly.

Store Tiazac at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Tiazac can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, feeling light-headed, or fainting.

What should I avoid?

Tiazac may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol while taking Tiazac.

Grapefruit and grapefruit juice may interact with Tiazac and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Avoid exposure to sunlight or tanning beds. Tiazac can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Tiazac side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Tiazac: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • a red, blistering skin rash;

  • swelling in your hands or feet;

  • trouble breathing;

  • slow heartbeats;

  • dizziness, fainting, fast or pounding heartbeat;

  • upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious Tiazac side effects may include:

  • headache;

  • dizziness, weakness, tired feeling;

  • upset stomach, nausea;

  • sore throat, cough, stuffy nose; or

  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Tiazac?

Tell your doctor about all other medicines you use, especially:

  • amiodarone (Cordarone, Pacerone);

  • buspirone (BuSpar);

  • carbamazepine (Carbatrol, Tegretol);

  • cimetidine (Tagamet);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • digoxin (digitalis, Lanoxin, Lanoxicaps);

  • quinidine (Quin-G);

  • rifampin (Rifadin, Rimactane, Rifater);

  • an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend);

  • a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

  • cholesterol medications such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);

  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), or ritonavir (Norvir, Kaletra); or

  • a sedative such as midazolam (Versed) or triazolam (Halcion).

This list is not complete and other drugs may interact with Tiazac. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Tiazac.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 11.01. Revision Date: 3/9/2011 3:47:55 PM.

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