Generic Name: docetaxel (doe se TAX el)
Brand Name: Docefrez, Taxotere
What is Taxotere?
Taxotere (docetaxel) is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Taxotere is used to treat breast cancer, lung cancer, prostate cancer, stomach cancer, and head/neck cancer.
Taxotere may also be used for purposes not listed in this medication guide.
Important information about Taxotere
Taxotere can cause life-threatening side effects, especially if you have liver disease or if you have ever had a severe allergic reaction to docetaxel.
Taxotere can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
Taxotere may cause fluid retention or severe skin reactions. Tell your doctor if you have swelling of your ankles or feet, rapid weight gain, or redness and peeling of the skin on your hands or feet.
Taxotere can also affect your nervous system. Tell your doctor if you have any numbness, burning pain, tingly feeling, or severe weakness.
Before receiving Taxotere
You should not use Taxotere if you are allergic to docetaxel, or to drugs made with polysorbate 80.
To make sure Taxotere is safe for you, tell your doctor if you have:
heart disease, congestive heart failure;
fluid retention or swelling problems; or
if you have ever had an allergic reaction to docetaxel.
FDA pregnancy category D. Do not use Taxotere if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
See also: Taxotere pregnancy and breastfeeding warnings (in more detail)
It is not known whether docetaxel passes into breast milk or if it could harm a nursing baby. You should not breast-feed while receiving Taxotere.
Older adults may be more likely to have side effects from this medicine.
How is Taxotere given?
Taxotere is injected into a vein through an IV. A healthcare provider will give you this injection. You may receive other cancer medicines at the same time.
You may need to take a steroid medicine for a few days before your Taxotere injection. This may help prevent certain side effects of Taxotere. Try not to miss any doses of your steroid medication.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Taxotere is injected.
Taxotere can be harmful if it gets on your skin during an IV infusion. If this happens, wash right away with soap and water.
Taxotere can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Taxotere injection, or if you miss a dose of your steroid medication.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving Taxotere?
Docetaxel can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Taxotere side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Taxotere: hives, red skin rash; difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe vomiting or diarrhea;
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
swelling of your ankles or feet, rapid weight gain;
urinating less than usual or not at all;
redness or peeling of the skin on your hands and feet;
numbness, burning pain, or tingly feeling; or
redness, swelling, burning, irritation, or skin changes where the injection was given.
Common Taxotere side effects may include:
feeling weak or tired;
nausea, vomiting, diarrhea, constipation;
altered sense of taste;
temporary hair loss; or
fingernail or toenail changes.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Taxotere side effects (in more detail)
What other drugs will affect Taxotere?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Taxotere, especially:
an antibiotic--clarithromycin, telithromycin;
antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
heart medication--nicardipine, quinidine;
hepatitis C medications--boceprevir, telaprevir; or
HIV or AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.
This list is not complete. Other drugs may interact with Taxotere, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More Taxotere resources
- Taxotere MedFacts Consumer Leaflet (Wolters Kluwer)
- Taxotere Prescribing Information (FDA)
- Taxotere Monograph (AHFS DI)
- Taxotere Advanced Consumer (Micromedex) - Includes Dosage Information
- Docefrez Prescribing Information (FDA)
- Docetaxel Professional Patient Advice (Wolters Kluwer)
- Docetaxel Prescribing Information (FDA)
Compare Taxotere with other medications
Where can I get more information?
- Your doctor or pharmacist can provide more information about Taxotere.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Taxotere only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2013 Cerner Multum, Inc. Version: 11.02. Revision Date: 2013-07-08, 11:14:23 AM.