Zinc acetate Side Effects

Some side effects of zinc acetate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to zinc acetate: oral capsule

Get emergency medical help if you have any of these signs of an allergic reaction while taking zinc acetate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects of zinc acetate may include:

• nausea; or

• upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to zinc acetate: compounding powder, oral capsule

General

In general, zinc acetate is relatively nontoxic if used at recommended dosages.

Hepatic

Although elevations in amylase, lipase and alkaline phosphatase have not been associated with any clinically significant events during clinical trials, it is suggested that liver and pancreatic function be closely monitored during zinc acetate therapy.

Hypocalcemia and decreased bone resorption have been demonstrated in animal models receiving high levels of dietary zinc.

Hepatic side effects have included increases in amylase and lipase.

Endocrine

Endocrine side effects have included the reduction of high density lipoprotein (HDL) in males.

Due to an accompanying decrease in low density lipoproteins (LDL), the LDL/HDL ratio remains relatively unchanged and little risk is assumed in terms of coronary heart disease. Triglyceride levels have not been shown to be affected.

Immunologic

In healthy subjects receiving zinc as a dietary supplement, lymphocyte stimulation, polymorphonuclear migration and phagocytosis were impaired. The clinical significance of this effect is unknown.

Immunologic side effects have included a decrease in the immunologic response.

Hematologic

Hematologic side effects have NOT included hematologic abnormalities due to iron deficiency anemia.

Because zinc competes with the absorption of iron, copper and other minerals, it may be necessary to monitor the patient's iron status for any possible deficiencies.

Gastrointestinal

Gastrointestinal side effects have been reported the most frequently. These have included gastrointestinal upset, which may occur in up to 10% of patients.

Gastrointestinal irritation appears to be dose-related.

To alleviated gastric upset and increase compliance, it has been suggested to administer the first morning dose between breakfast and lunch, rather than before breakfast.

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