Ziana Side Effects

Generic Name: clindamycin / tretinoin topical

Note: This page contains side effects data for the generic drug clindamycin / tretinoin topical. It is possible that some of the dosage forms included below may not apply to the brand name Ziana.

It is possible that some side effects of Ziana may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to clindamycin / tretinoin topical: topical application gel/jelly

As well as its needed effects, clindamycin / tretinoin topical may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking clindamycin / tretinoin topical, check with your doctor immediately:

More common
  • Dryness and peeling of the skin
  • flushing or redness of the skin
  • itching
  • unusually warm skin
Less common
  • Burning or stinging at the site of application
  • changes in the color of the skin
  • fever
  • stomach cramps, tenderness, or pain
  • watery or bloody diarrhea

Some clindamycin / tretinoin topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Cough
  • dry skin
  • headaches
  • muscle aches
  • pain and tenderness around the eyes and cheekbones
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest or wheezing
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clindamycin / tretinoin topical: topical gel

General

The most commonly reported side effects were erythema, dryness, and itching.

Dermatologic

Very common (10% or more): Erythema, dryness
Common (1% to 10%): Sunburn, scaling, burning, itching
Uncommon (0.1% to 1%): Acne, dry skin, seborrhea, photosensitivity reaction, pruritus, rash, exfoliative rash, skin exfoliation
Rare (less than 0.1%): Dermatitis, herpes simplex, rash macular, skin bleeding, skin depigmentation, skin irritation

Local

Common (1% to 10%): Application site dryness, application site irritation, application site exfoliation, application site erythema, application site pruritus, application site dermatitis
Uncommon (0.1% to 1%): Application site reaction, application site burning
Rare (less than 0.1%): Application site swelling, application site erosion, application site discoloration, application site desquamation

Other

Rare (less than 0.1%): Feeling hot, pain

Endocrine

Rare (less than 0.1%): Hypothyroidism

Gastrointestinal

Rare (less than 0.1%): Gastroenteritis, nausea

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity

Nervous system

Rare (less than 0.1%): Headache

Ocular

Rare (less than 0.1%): Eye irritation

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