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Zemplar Side Effects

Generic Name: paricalcitol

Note: This page contains side effects data for the generic drug paricalcitol. It is possible that some of the dosage forms included below may not apply to the brand name Zemplar.

It is possible that some side effects of Zemplar may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to paricalcitol: oral capsule liquid filled

Other dosage forms:

As well as its needed effects, paricalcitol (the active ingredient contained in Zemplar) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking paricalcitol, check with your doctor immediately:

More common
  • Blurred vision
  • cough or hoarseness
  • difficulty with swallowing
  • dizziness
  • fever or chills
  • headache
  • hives
  • itching
  • lower back or side pain
  • nervousness
  • pain
  • painful or difficult urination
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • slow or fast heartbeat
  • swelling
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Less common
  • Abdominal or stomach pain
  • abnormal growth filled with fluid or semisolid material
  • ammonia-like breath odor
  • anxiety
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • chest pain or discomfort
  • cold sweats
  • coma
  • confusion
  • convulsions
  • cool, pale skin
  • decreased urine
  • depression
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • increase in heart rate
  • increased hunger
  • increased thirst
  • irregular heartbeat
  • joint pain
  • lightheadedness
  • loss of appetite
  • muscle aches and pains
  • nausea or vomiting
  • nightmares
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • rapid breathing
  • rapid weight gain
  • runny nose
  • sensation of pins and needles
  • shakiness
  • shivering
  • slurred speech
  • sneezing
  • sore throat
  • stabbing pain
  • sunken eyes
  • sweating
  • thirst
  • trouble sleeping
  • troubled breathing
  • unusual weight gain or loss
  • weight loss
  • wrinkled skin
Incidence not known
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • slow or irregular breathing

If any of the following symptoms of overdose occur while taking paricalcitol, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach cramps
  • constipation
  • depression
  • high urine levels of calcium
  • incoherent speech
  • increased urination
  • metallic taste
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle weakness
  • tremor

Some paricalcitol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Acid or sour stomach
  • back pain
  • belching
  • bloody nose
  • bruising
  • change in vision
  • cough producing mucus
  • difficulty with moving
  • feeling of constant movement of self or surroundings
  • heartburn
  • impaired vision
  • indigestion
  • lack or loss of strength
  • large, flat, blue, or purplish patches in the skin
  • leg cramps
  • muscle pain or stiffness
  • pain or tenderness around the eyes and cheekbones
  • pain, swelling, or redness in the joints
  • sensation of spinning
  • sores on the skin
  • stomach discomfort, upset, or pain
  • stuffy nose

For Healthcare Professionals

Applies to paricalcitol: intravenous solution, oral capsule

General

The most common adverse events were nausea, diarrhea, and elevated calcium phosphate product.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (12.9%), diarrhea (11.5%)
Common (1% to 10%): Vomiting, constipation, gastrointestinal hemorrhage, abdominal discomfort, dry mouth, gastroenteritis, stomach discomfort, gastroesophageal reflux disease
Uncommon (0.1% to 1%): Rectal hemorrhage, colitis, gastritis, dyspepsia, dysphagia, abdominal pain, gastrointestinal disorder
Frequency not reported: Intestinal ischemia, gastrointestinal hemorrhage[Ref]

Metabolic

Very common (10% or more): Elevated calcium phosphate product (12%)
Common (1% to 10%): Fluid overload, hypoglycemia, dehydration, hypercalcemia, hypocalcemia, decreased appetite, hyperphosphatemia
Uncommon (0.1% to 1%): Hyperkalemia, anorexia, thirst[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, hypotension, palpitations
Uncommon (0.1% to 1%): Cardiac arrest, arrhythmia, atrial flutter
Frequency not reported: Irregular heart rate[Ref]

Nervous system

Common (1% to 10%): Vertigo, dizziness, headache, syncope, dysgeusia
Uncommon (0.1% to 1%): Coma, cerebrovascular accident, transient ischemic attack, myoclonus, hypoesthesia, paresthesia, gait disturbance
Frequency not reported: Unresponsive to stimuli[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, pneumonia, influenza, oropharyngeal pain, sinusitis, cough
Uncommon (0.1% to 1%): Pulmonary edema, asthma, dyspnea, epistaxis, pharyngitis
Frequency not reported: Upper respiratory tract infection, orthopnea, wheezing[Ref]

Other

Common (1% to 10%): Viral infection, edema, peritonitis, chills, pyrexia, pain, fatigue, peripheral edema, malaise, chest pain, fungal infection, infection
Uncommon (0.1% to 1%): Laboratory test abnormal, decreased weight, ear disorder, condition aggravated, asthenia
Frequency not reported: Phosphorous increased, ear discomfort, chest discomfort, feeling abnormal, swelling[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity
Postmarketing reports: Allergic reactions including rash, urticaria, and angioedema (including laryngeal edema)[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus, skin ulcer, acne
Uncommon (0.1% to 1%): Urticaria, bullous dermatitis, alopecia, hirsutism, hyperhidrosis
Frequency not reported: Blister, night sweats, rash pruritic, skin burning sensation[Ref]

Endocrine

Common (1% to 10%): Hypoparathyroidism
Uncommon (0.1% to 1%): Hyperparathyroidism[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, breast tenderness
Uncommon (0.1% to 1%): Vaginal infection, breast pain, erectile dysfunction[Ref]

Musculoskeletal

Common (1% to 10%): Chills, arthralgia, arthritis, back pain, muscle spasms
Uncommon (0.1% to 1%): Joint stiffness, muscle twitching, myalgia[Ref]

Renal

Common (1% to 10%): Renal failure chronic
Uncommon (0.1% to 1%): Blood creatinine increased[Ref]

Immunologic

Common (1% to 10%): Sepsis[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression
Uncommon (0.1% to 1%): Confusional state, delirium, depersonalization, agitation, nervousness
Frequency not reported: Restlessness[Ref]

Hematologic

Uncommon (0.1% to 1%): Bleeding time prolonged, anemia, leukopenia, lymphadenopathy[Ref]

Hepatic

Uncommon (0.1% to 1%): Hepatic enzyme abnormal, increased aspartate aminotransferase
Frequency not reported: Alkaline phosphatase decreased[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, glaucoma
Frequency not reported: Ocular hyperemia[Ref]

Oncologic

Uncommon (0.1% to 1%): Breast cancer[Ref]

Local

Uncommon (0.1% to 1%): Injection site pain
Frequency not reported: Injection site extravasation[Ref]

References

1. "Product Information. Zemplar (paricalcitol)." Abbott Pharmaceutical, Abbott Park, IL.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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