Zemplar Side Effects

Generic Name: paricalcitol

Note: This page contains side effects data for the generic drug paricalcitol. It is possible that some of the dosage forms included below may not apply to the brand name Zemplar.

It is possible that some side effects of Zemplar may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to paricalcitol: oral capsule liquid filled

Other dosage forms:

As well as its needed effects, paricalcitol (the active ingredient contained in Zemplar) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking paricalcitol, check with your doctor immediately:

More common
  • Blurred vision
  • cough or hoarseness
  • difficulty with swallowing
  • dizziness
  • fever or chills
  • headache
  • hives
  • itching
  • lower back or side pain
  • nervousness
  • pain
  • painful or difficult urination
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • slow or fast heartbeat
  • swelling
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Less common
  • Abdominal or stomach pain
  • abnormal growth filled with fluid or semisolid material
  • ammonia-like breath odor
  • anxiety
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • chest pain or discomfort
  • cold sweats
  • coma
  • confusion
  • convulsions
  • cool, pale skin
  • decreased urine
  • depression
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • increase in heart rate
  • increased hunger
  • increased thirst
  • irregular heartbeat
  • joint pain
  • lightheadedness
  • loss of appetite
  • muscle aches and pains
  • nausea or vomiting
  • nightmares
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • rapid breathing
  • rapid weight gain
  • runny nose
  • sensation of pins and needles
  • shakiness
  • shivering
  • slurred speech
  • sneezing
  • sore throat
  • stabbing pain
  • sunken eyes
  • sweating
  • thirst
  • trouble sleeping
  • troubled breathing
  • unusual weight gain or loss
  • weight loss
  • wrinkled skin
Incidence not known
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • slow or irregular breathing

If any of the following symptoms of overdose occur while taking paricalcitol, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach cramps
  • constipation
  • depression
  • high urine levels of calcium
  • incoherent speech
  • increased urination
  • metallic taste
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle weakness
  • tremor

Some paricalcitol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Acid or sour stomach
  • back pain
  • belching
  • bloody nose
  • bruising
  • change in vision
  • cough producing mucus
  • difficulty with moving
  • feeling of constant movement of self or surroundings
  • heartburn
  • impaired vision
  • indigestion
  • lack or loss of strength
  • large, flat, blue, or purplish patches in the skin
  • leg cramps
  • muscle pain or stiffness
  • pain or tenderness around the eyes and cheekbones
  • pain, swelling, or redness in the joints
  • sensation of spinning
  • sores on the skin
  • stomach discomfort, upset, or pain
  • stuffy nose

For Healthcare Professionals

Applies to paricalcitol: intravenous solution, oral capsule

Gastrointestinal

Gastrointestinal side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included nausea (13%), vomiting (8%), gastrointestinal bleeding (5%), and dry mouth (3%). Taste perversion has been reported rarely.

Gastrointestinal side effects associated with paricalcitol oral have included diarrhea (7%), nausea (6%), vomiting (6%), constipation (4%), abdominal pain (4%), gastroenteritis (3%), dyspepsia (2%), gastritis (2%), and rectal disorder (2%).

Cardiovascular

Cardiovascular side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included edema (7%), palpitations (3%), and angioedema (including laryngeal edema).

Cardiovascular side effects associated with paricalcitol oral have included hypertension (7%), hypotension (5%), syncope (3%), cardiomyopathy (2%), congestive heart failure (2%), myocardial infarct (2%), and postural hypotension (2%).

Nervous system

Nervous system side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included lightheadedness (5%).

Nervous system side effects associated with paricalcitol oral have included dizziness (5%), vertigo (5%), depression (3%), insomnia (2%), and neuropathy (2%).

Respiratory

Respiratory side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included pneumonia (5%).

Respiratory side effects associated with paricalcitol oral have included pharyngitis (10%), rhinitis (5%), bronchitis (3%), increased cough (3%), sinusitis (3%), epistaxis (2%), and pneumonia (2%).

Other

Other side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included fever (5%), chills (5%), flu (5%), sepsis (5%), and feeling unwell (3%). In addition, side effects associated with paricalcitol injection may resemble those seen with excessive vitamin D intake.

Other side effects associated with paricalcitol oral have included accidental injury (9%), pain (7%), edema (7%), viral infection (7%), headache (5%), back pain (4%), infection (4%), fungal infection (3%), asthenia (3%), chest pain (3%), fever (3%), bacterial infection (2%), cyst (2%), flu syndrome (2%), and hypervolemia (2%).

Other side effects associated with paricalcitol oral and injection have included hypercalcemia, elevated Ca x P product, and metastatic calcification. Vitamin D intoxication may be associated with hypercalcemia.

Early signs and symptoms of vitamin D intoxication have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, and metallic taste.

Late signs and symptoms of vitamin D intoxication have included anorexia, weight loss, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, hypercholesterolemia, elevated AST and ALT, ectopic calcification, hypertension, cardiac arrhythmias, somnolence, and death. Overt psychosis occurs rarely.

Hypersensitivity

Hypersensitivity side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have rarely included pruritus, rash, urticaria, and facial and oral edema.

Hypersensitivity side effects associated with paricalcitol oral have included allergic reaction in 6% of patients.

Dermatologic

Dermatologic side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included rash and urticaria.

Dermatologic side effects associated with paricalcitol oral have included rash (6%), pruritus (3%), skin ulcer (3%), skin hypertrophy (2%), and vesiculobullous rash (2%).

Endocrine

Endocrine side effects associated with paricalcitol (the active ingredient contained in Zemplar) oral have included hypoglycemia in 2% of patients.

Genitourinary

Genitourinary side effects associated with paricalcitol (the active ingredient contained in Zemplar) oral have included urinary tract infection in 3% of patients.

Metabolic

Metabolic side effects associated with paricalcitol (the active ingredient contained in Zemplar) oral have included uremia (7%), gout (4%), dehydration (3%), acidosis (2%), hyperkalemia (2%), hyperphosphatemia (2%), and hypokalemia (2%).

Musculoskeletal

Musculoskeletal side effects associated with paricalcitol (the active ingredient contained in Zemplar) injection have included arthralgia (5%).

Musculoskeletal side effects associated with paricalcitol oral have included arthritis (5%), leg cramps (3%), and myalgia (2%).

Ocular

Ocular side effects associated with paricalcitol (the active ingredient contained in Zemplar) oral have included amblyopia and retinal disorder in 2% of patients.

Renal

Renal side effects associated with paricalcitol (the active ingredient contained in Zemplar) oral have included abnormal kidney function in 2% of patients.

Hematologic

Hematologic side effects associated with paricalcitol (the active ingredient contained in Zemplar) oral have included ecchymosis in 2% of patients.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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