Z-Clinz 10 Side Effects

Generic Name: benzoyl peroxide / clindamycin topical

Note: This page contains side effects data for the generic drug benzoyl peroxide / clindamycin topical. It is possible that some of the dosage forms included below may not apply to the brand name Z-Clinz 10.

It is possible that some side effects of Z-Clinz 10 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to benzoyl peroxide / clindamycin topical: gel

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin.

Seek medical attention right away if any of these SEVERE side effects occur while taking benzoyl peroxide / clindamycin topical:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; peeling of the skin; severe or persistent diarrhea; stomach cramps or pain.

For Healthcare Professionals

Applies to benzoyl peroxide / clindamycin topical: topical gel, topical kit

Dermatologic

Dermatologic side effects have included dry skin (12%), pruritus (2%), peeling (2%), erythema (1%), and sunburn (1%) and reactions at the application site (3%).

Application site reactions including burning, stinging, and pruritus are frequently reported following topical application of the combination of 5% benzoyl peroxide and 1% clindamycin.

Gastrointestinal

Pseudomembranous colitis may be revealed upon endoscopic examination; stool cultures for Clostridium difficile, and stool assays for Clostridium difficile toxin may be helpful diagnostically.

Gastrointestinal side effects have been reported with the use of topical clindamycin. Diarrhea, bloody diarrhea, and colitis, including pseudomembranous colitis, have occurred. Colitis usually manifests as severe persistent diarrhea, severe abdominal cramps, and passage of blood and mucous. Some cases of colitis have been fatal. Due to the possible serious nature of pseudomembranous colitis, patients should be advised to discontinue clindamycin therapy and consult a physician if diarrhea occurs.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis and allergic reactions leading to hospitalization during postmarketing experience.

Other

A 14-year-old boy developed reproducible ringing in his right ear and hearing loss while using topical clindamycin and after discontinuing use. He underwent a complete physical exam and labs which failed to find a cause for his symptoms. The patient was restarted on benzoyl peroxide / clindamycin topical and the ringing in his ear increased. He was told to stop all medications and was started on methylprednisolone. The tinnitus decreased in 1 to 2 days with no improvement in the hearing deficit. After the third time he was restarted on benzoyl peroxide/clindamycin gel, the tinnitus returned at an increased level together with right-sided headaches within 1 to 2 days. The patient again stopped using the benzoyl peroxide and clindamycin gel and the tinnitus returned to a low level over 1 to 2 days. It is believed that the clindamycin component played a part in this patient's tinnitus and hearing loss.

Other side effects have included one case of ringing in the ear and partial hearing loss believed to be caused by clindamycin.

More about Z-Clinz 10 (benzoyl peroxide / clindamycin topical)

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