Xtandi Side Effects

Generic Name: enzalutamide

Note: This page contains side effects data for the generic drug enzalutamide. It is possible that some of the dosage forms included below may not apply to the brand name Xtandi.

It is possible that some side effects of Xtandi may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to enzalutamide: oral capsule liquid filled

As well as its needed effects, enzalutamide (the active ingredient contained in Xtandi) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking enzalutamide, check with your doctor immediately:

More common
  • Back pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in urine
  • blurred vision
  • chest pain
  • cough
  • cough with mucus
  • difficulty breathing
  • dizziness
  • fever or chills
  • headache
  • loss of bladder control
  • loss of bowel control
  • nervousness
  • no sensation in the legs
  • painful or difficult urination
  • pounding in the ears
  • rapid weight gain
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • tightness in the chest
  • tingling of the hands or feet
  • unable to move legs
  • unusual weight gain or loss
  • wheezing
Less common
  • Confusion or excitement
  • fainting
  • falling
  • lightheadedness
  • loss of memory
  • mental depression or anxiety
  • nightmares or unusually vivid dreams
  • problems with memory or attention span
  • rapid, shallow breathing
  • trouble performing routine tasks
Rare
  • Seizures

Some enzalutamide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Body aches or pain
  • bone pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty in moving
  • dry throat
  • ear congestion
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • hoarseness
  • joint pain
  • lack or loss of strength
  • loss of voice
  • muscle pain, stiffness, or weakness
  • nervousness
  • pain or tenderness around the eyes and cheekbones
  • redness of the face, neck, arms and occasionally, upper chest
  • sensation of spinning
  • stuffy or runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • trouble sleeping
  • unusual tiredness or weakness
  • voice changes
Less common
  • Bloody nose
  • dry skin
  • frequent urination
  • itching skin
  • pale-colored urine

For Healthcare Professionals

Applies to enzalutamide: oral capsule

Cardiovascular

Very common (10% or more): Hot flush (20.3%), peripheral edema (15.4%)
Common (1% to 10%): Hypertension (6.4%)

Dermatologic

Common (1% to 10%): Pruritus (3.8%), dry skin (3.5%)

Gastrointestinal

Very common (10% or more): Diarrhea (21.8%)

Genitourinary

Common (1% to 10%): Hematuria (6.9%), pollakiuria (4.8%)

Hematologic

Very common (10% or more): Neutropenia (15%)
Uncommon (0.1% to 1%): Thrombocytopenia (0.5%)
Frequency not reported: Small increases in mean QTc interval

Hepatic

Very common (10% or more): Elevations in ALT (10%)
Common (1% to 10%): Elevations in bilirubin (3%)

Musculoskeletal

Very common (10% or more): Back pain (26.4%), arthralgia (20.5%), musculoskeletal pain (15%)
Common (1% to 10%): Muscular weakness (9.8%), musculoskeletal stiffness (2.6%)

Nervous system

Very common (10% or more): Headache (12.1%)
Common (1% to 10%): Dizziness, includes vertigo (9.5%), spinal cord compression and cauda equina syndrome (7.4%), paresthesia (6.6%), mental impairment, includes amnesia, memory impairment, cognitive disorder, and disturbance in attention (4.3%), hypoesthesia (4%)

Other

Very common (10% or more): Asthenic conditions, including asthenia and fatigue (50.6%)
Common (1% to 10%): Falls (4.6%), non-pathologic fractures (4%)

Psychiatric

Common (1% to 10%): Insomnia (8.8%), anxiety (6.5%), hallucinations (1.6%)

Respiratory

Very common (10% or more): Upper respiratory tract infection, includes nasopharyngitis, sinusitis, rhinitis, pharyngitis, and laryngitis (10.9%)
Common (1% to 10%): Lower respiratory tract and lung infection, includes pneumonia, and bronchitis (8.5%), epistaxis (3.3%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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