Xalkori Side Effects

Generic Name: crizotinib

Note: This page contains side effects data for the generic drug crizotinib. It is possible that some of the dosage forms included below may not apply to the brand name Xalkori.

It is possible that some side effects of Xalkori may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to crizotinib: oral capsule

As well as its needed effects, crizotinib (the active ingredient contained in Xalkori) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking crizotinib, check with your doctor immediately:

More common
  • Black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • cough or hoarseness
  • difficult or labored breathing
  • ear congestion
  • fever or chills
  • headache
  • increased sensitivity to pain or touch
  • lightheadedness, dizziness, or fainting
  • loss of voice
  • lower back or side pain
  • nerve pain
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • runny or stuffy nose
  • slow or irregular heartbeat
  • sneezing
  • sore throat
  • tightness in the chest
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet
Rare
  • Bleeding gums
  • blood in the urine or stools
  • pinpoint red spots on the skin

Some crizotinib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Abdominal or stomach discomfort, pain, or tenderness
  • acid or sour stomach
  • back pain
  • belching
  • change in taste
  • decrease or change in vision
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • difficulty with swallowing
  • heartburn
  • increased sensitivity of the eyes to sunlight
  • indigestion
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • pain or burning in the throat
  • pain or discomfort in the chest, upper stomach, or throat
  • problems with balance
  • rash
  • redness, swelling, or soreness of the tongue
  • scaling, redness, burning, pain, chapping, swelling, or other signs of inflammation of the lips
  • seeing flashes or sparks of light
  • swelling or inflammation of the mouth
  • trouble sleeping

For Healthcare Professionals

Applies to crizotinib: oral capsule

Cardiovascular

Common (1% to 10%): Electrocardiogram QT prolonged, bradycardia

Hepatic

Very common (10% or more): ALT elevation (up to 76%), AST elevation (up to 61%)
Common (1% to 10%): Increased alkaline phosphatase, hepatic failure

Hematologic

Very common (10% or more): Lymphopenia (up to 51%), neutropenia (up to 49%), anemia (up to 17%)
Common (1% to 10%): Leukopenia

Respiratory

Very common (10% or more): Upper respiratory infection (up to 26%)
Common (1% to 10%): Pulmonary embolism, interstitial lung disease

Gastrointestinal

Very common (10% or more): Diarrhea (up to 60%), nausea (up to 55%), vomiting (up to 47%), constipation (up to 42%)
Common (1% to 10%): Dyspepsia, gastrointestinal perforation

Ocular

Very common (10% or more): Vision disorders (up to 60%)

Vision disorders included diplopia, photophobia, photopsia, blurred vision, reduced vision acuity, visual impairment, and vitreous floaters.

Dermatologic

Common (1% to 10%): Rash

General

The most common adverse reactions (25% or more) are vision disorder, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, and fatigue.

Metabolic

Very common (10% or more): Hypophosphatemia (up to 28%), decreased appetite (up to 27%), hypokalemia (up to 18%), decreased weight (up to 10%)

Nervous system

Neuropathy included dysesthesia, gait disturbance, hypoesthesia, muscular weakness, neuralgia, peripheral neuropathy, paresthesia, peripheral sensory neuropathy, polyneuropathy, and skin burning sensation.

Very common (10% or more): Dysgeusia (up to 26%), dizziness (up to 22%), neuropathy (up to 19%)
Common (1% to 10%): Syncope

Other

Edema included face edema, generalized edema, local swelling, localized edema, peripheral edema, and periorbital edema.

Very common (10% or more): Edema (up to 39%), fatigue (up to 27%)

Renal

Common (1% to 10%): Renal cyst

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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