Xalkori Side Effects
Generic Name: crizotinib
Note: This page contains side effects data for the generic drug crizotinib. It is possible that some of the dosage forms included below may not apply to the brand name Xalkori.
It is possible that some side effects of Xalkori may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to crizotinib: oral capsule
As well as its needed effects, crizotinib (the active ingredient contained in Xalkori) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking crizotinib, check with your doctor immediately:More common
- Black, tarry stools
- bloating or swelling of the face, arms, hands, lower legs, or feet
- body aches or pain
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- cough or hoarseness
- difficult or labored breathing
- ear congestion
- fever or chills
- increased sensitivity to pain or touch
- lightheadedness, dizziness, or fainting
- loss of voice
- lower back or side pain
- nerve pain
- painful or difficult urination
- pale skin
- rapid weight gain
- runny or stuffy nose
- slow or irregular heartbeat
- sore throat
- tightness in the chest
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- weakness in the arms, hands, legs, or feet
- Bleeding gums
- blood in the urine or stools
- pinpoint red spots on the skin
Some crizotinib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Abdominal or stomach discomfort, pain, or tenderness
- acid or sour stomach
- back pain
- change in taste
- decrease or change in vision
- decreased appetite
- difficulty having a bowel movement (stool)
- difficulty with moving
- difficulty with swallowing
- increased sensitivity of the eyes to sunlight
- muscle pain or stiffness
- pain in the joints
- pain or burning in the throat
- pain or discomfort in the chest, upper stomach, or throat
- problems with balance
- redness, swelling, or soreness of the tongue
- scaling, redness, burning, pain, chapping, swelling, or other signs of inflammation of the lips
- seeing flashes or sparks of light
- swelling or inflammation of the mouth
- trouble sleeping
For Healthcare Professionals
Applies to crizotinib: oral capsule
Dermatologic side effects have included rash (10%).
Gastrointestinal side effects have included nausea (53%), diarrhea (43%), vomiting (40%), constipation (27%), esophageal disorder (11%), abdominal pain (8%), and stomatitis (6%).
General side effects have included edema (28%), fatigue (20%), chest pain/discomfort (1%), and fever (less than 1%).
Hepatic side effects have included alanine aminotransferase (ALT) increased (13%), and aspartate aminotransferase (AST) increased (9%).
Metabolic side effects have included decreased appetite (19%).
Laboratory abnormalities have included Grade 3 or 4 lymphopenia (11.4%), Grade 3 or 4 neutropenia (5.2%), and Grade 3 or 4 thrombocytopenia (0.4%).
Musculoskeletal side effects have included arthralgia (2%), and back pain (less than 1%).
Nervous system side effects have included dizziness (16%), neuropathy (13%), dysgeusia (12%), and headache (4%).
Ocular side effects have included vision disorder (62%).
Psychiatric side effects have included insomnia (3%).
Respiratory side effects have included cough (4%), dyspnea (2%), and upper respiratory infection (2%).
Genitourinary side effects have included hypogonadism.
Cardiovascular side effects have included bradycardia (10.5%).
More about Xalkori (crizotinib)
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