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Xalatan Side Effects

Generic Name: latanoprost ophthalmic

Note: This page contains side effects data for the generic drug latanoprost ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Xalatan.

It is possible that some side effects of Xalatan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to latanoprost ophthalmic: ophthalmic solution

As well as its needed effects, latanoprost ophthalmic (the active ingredient contained in Xalatan) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking latanoprost ophthalmic, check with your doctor immediately:

Less common
  • Eyelid crusting, redness, swelling, discomfort, or pain
  • Cough
  • difficulty breathing
  • noisy breathing
  • redness of eye or inside of eyelid
  • shortness of breath
  • swelling of the eye
  • tightness in chest
  • wheezing

If any of the following side effects occur while taking latanoprost ophthalmic, check with your doctor or nurse as soon as possible:

More common
  • Blurred vision, eye irritation, or tearing
  • darkening of eyelid skin color
  • increase in brown color in colored part of eye
  • longer, thicker, and darker eyelashes
Less common
  • Angina pectoris or other chest pain
  • cold or flu symptoms
  • eye pain
  • pain in muscles, joints, or back
  • skin rash
  • Discharge from the eye
  • double vision or other change in vision
  • fever
  • sensitivity of eye to light
  • sore throat

Some latanoprost ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Burning of eye
  • feeling of something in eye
  • itching of eye
  • stinging of eye
Less common
  • Dryness of eye

For Healthcare Professionals

Applies to latanoprost ophthalmic: ophthalmic solution


Very common (10% or more): Iris pigmentation (33%), foreign body sensation (13%), punctate epithelial keratopathy (10%), eye irritation
Common (1% to 10%): Stinging, conjunctival hyperemia, blurred vision, itching, burning, increased pigmentation of the iris, excessive tearing, lid discomfort/pain, dry eye, eye pain, lid crusting, lid erythema, photophobia, lid edema, blepharitis
Uncommon (0.1% to 1%): Keratitis
Rare(less than 0.1%): Distichiasis
Postmarketing reports: Eyelash/vellus hair changes (increased length, thickness, pigmentation, and number), corneal edema/erosions, intraocular inflammation (iritis/uveitis), macular edema (including cystoid macular edema), misdirected eyelashes, periorbital and lid changes resulting in deepening of the eyelid sulcus[Ref]


Common (1% to 10%): Upper respiratory tract infection/cold/flu, bronchitis
Very are (less than 0.01%): Asthma and exacerbation of asthma, dyspnea[Ref]


Common (1% to 10%): Muscle/joint/back pain
Postmarketing reports: Myalgia, arthralgia[Ref]


Very rare (less than 0.01%): Aggravation of angina in patients with pre-existing disease, chest pain
Postmarketing reports: Palpitations[Ref]


Common (1% to 10%): Rash, allergic skin reaction
Postmarketing reports: Toxic epidermal necrolysis, eyelid skin darkening[Ref]

Nervous system

Postmarketing reports: Dizziness, headache[Ref]


The most commonly reported side effect was increased iris pigmentation.[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Abnormal liver function[Ref]


Postmarketing reports: Herpes keratitis[Ref]


1. "Product Information. Xalatan (latanoprost ophthalmic)." Pharmacia and Upjohn, Kalamazoo, MI.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

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