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Vaseretic 5-12.5 Side Effects

Generic Name: enalapril / hydrochlorothiazide

Note: This page contains side effects data for the generic drug enalapril / hydrochlorothiazide. It is possible that some of the dosage forms included below may not apply to the brand name Vaseretic 5-12.5.

For the Consumer

Applies to enalapril / hydrochlorothiazide: oral tablet

As well as its needed effects, enalapril / hydrochlorothiazide may cause unwanted side effects that require medical attention.

Severity: Major

If any of the following side effects occur while taking enalapril / hydrochlorothiazide, check with your doctor immediately:

Less common
  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • increased thirst
  • irritability
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • rapid breathing
  • seizures
  • shortness of breath
  • sunken eyes
  • sweating
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness
  • weak pulse
  • wrinkled skin

Severity: Minor

Some enalapril / hydrochlorothiazide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Cough
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance

For Healthcare Professionals

Applies to enalapril / hydrochlorothiazide: oral tablet

General

The most common adverse reactions were dizziness, headache, fatigue, and cough.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, syncope
Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus

Enalapril:
Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia[Ref]

Other

Common (1% to 10%): Fatigue, asthenia, orthostatic effects
Frequency not reported: Chest pain

Enalapril:
Postmarketing reports: Gynecomastia

Hydrochlorothiazide:
Frequency not reported: Weakness, fever[Ref]

Respiratory

Common (1% to 10%): Cough
Frequency not reported: Dyspnea

Enalapril:
Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema

Hydrochlorothiazide:
Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramps
Frequency not reported: Back pain, arthralgia

Enalapril:
Postmarketing reports: Flank pain

Hydrochlorothiazide:
Frequency not reported: Muscle spasm[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea
Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth

Enalapril:
Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth

Hydrochlorothiazide:
Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation[Ref]

Genitourinary

Common (1% to 10%): Impotence
Frequency not reported: Urinary tract infection

Enalapril:
Postmarketing reports: Oliguria[Ref]

Cardiovascular

Common (1% to 10%): Orthostatic hypotension
Uncommon (0.1% to 1%): Hypotension
Frequency not reported: Palpitation, tachycardia

Enalapril:
Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing

Hydrochlorothiazide:
Frequency not reported: Vasculitis[Ref]

Renal

Uncommon (0.1% to 1%): BUN increased, serum creatinine increased

Enalapril:
Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection

Hydrochlorothiazide:
Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis[Ref]

Dermatologic

Frequency not reported: Pruritus, rash, diaphoresis, angioedema

Enalapril:
Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity

Hydrochlorothiazide:
Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia[Ref]

Psychiatric

Frequency not reported: Insomnia, nervousness, libido decreased

Enalapril:
Postmarketing reports: Depression, confusion, dream abnormality

Hydrochlorothiazide:
Frequency not reported: Restlessness[Ref]

Hematologic

Frequency not reported: Hemoglobin decreased, hematocrit decreased

Enalapril:
Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia

Hydrochlorothiazide:
Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref]

Hepatic

Frequency not reported: Liver enzymes increased, serum bilirubin increased

Enalapril:
Postmarketing reports: Hepatic failure, hepatitis

Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice[Ref]

Metabolic

Frequency not reported: Gout
Postmarketing reports: Anorexia

Hydrochlorothiazide:
Frequency not reported: Anorexia[Ref]

Ocular

Enalapril:
Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing

Hydrochlorothiazide:
Frequency not reported: Transient blurred vision, xanthopsia[Ref]

Immunologic

Enalapril:
Postmarketing reports: Anaphylactoid reactions

Hydrochlorothiazide:
Frequency not reported: Anaphylactic reactions[Ref]

References

1. "Product Information. Vaseretic (enalapril-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Vaseretic 5-12.5 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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