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Vaseretic 5-12.5 Side Effects

Generic Name: enalapril / hydrochlorothiazide

Note: This page contains side effects data for the generic drug enalapril / hydrochlorothiazide. It is possible that some of the dosage forms included below may not apply to the brand name Vaseretic 5-12.5.

It is possible that some side effects of Vaseretic 5-12.5 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to enalapril / hydrochlorothiazide: oral tablet

As well as its needed effects, enalapril / hydrochlorothiazide may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking enalapril / hydrochlorothiazide, check with your doctor immediately:

Less common
  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • increased thirst
  • irritability
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • rapid breathing
  • seizures
  • shortness of breath
  • sunken eyes
  • sweating
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness
  • weak pulse
  • wrinkled skin

Some enalapril / hydrochlorothiazide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Cough
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance

For Healthcare Professionals

Applies to enalapril / hydrochlorothiazide: oral tablet


The most common adverse reactions were dizziness, headache, fatigue, and cough.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, syncope
Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus

Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia[Ref]


Common (1% to 10%): Fatigue, asthenia, orthostatic effects
Frequency not reported: Chest pain

Postmarketing reports: Gynecomastia

Frequency not reported: Weakness, fever[Ref]


Common (1% to 10%): Cough
Frequency not reported: Dyspnea

Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Common (1% to 10%): Muscle cramps
Frequency not reported: Back pain, arthralgia

Postmarketing reports: Flank pain

Frequency not reported: Muscle spasm[Ref]


Common (1% to 10%): Nausea, diarrhea
Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth

Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth

Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation[Ref]


Common (1% to 10%): Impotence
Frequency not reported: Urinary tract infection

Postmarketing reports: Oliguria[Ref]


Common (1% to 10%): Orthostatic hypotension
Uncommon (0.1% to 1%): Hypotension
Frequency not reported: Palpitation, tachycardia

Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing

Frequency not reported: Vasculitis[Ref]


Uncommon (0.1% to 1%): BUN increased, serum creatinine increased

Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection

Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis[Ref]


Frequency not reported: Pruritus, rash, diaphoresis, angioedema

Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity

Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia[Ref]


Frequency not reported: Insomnia, nervousness, libido decreased

Postmarketing reports: Depression, confusion, dream abnormality

Frequency not reported: Restlessness[Ref]


Frequency not reported: Hemoglobin decreased, hematocrit decreased

Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref]


Frequency not reported: Liver enzymes increased, serum bilirubin increased

Postmarketing reports: Hepatic failure, hepatitis

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Frequency not reported: Gout
Postmarketing reports: Anorexia

Frequency not reported: Anorexia[Ref]


Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing

Frequency not reported: Transient blurred vision, xanthopsia[Ref]


Postmarketing reports: Anaphylactoid reactions

Frequency not reported: Anaphylactic reactions[Ref]


1. "Product Information. Vaseretic (enalapril-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

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