Unipen Side Effects

Generic Name: nafcillin

Please note - some side effects for Unipen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, gastrointestinal irritation, and pseudomembranous colitis.

Local

Local side effects have included pain, swelling, phlebitis, thrombophlebitis, and skin sloughing after intravenous administration. Intramuscular injections may cause pain at the injection site. Extravasation may result in severe chemical irritation. Subcutaneous extravasation has been associated with severe tissue necrosis.

Hypersensitivity

Hypersensitivity reactions have included urticaria, pruritus, angioneurotic edema, laryngeal edema, laryngospasm, bronchospasm, hypotension, vascular collapse, anaphylaxis, serum sickness-like reactions, fever, and death.

Hematologic

Hematologic side effects have included agranulocytosis, neutropenia, bone marrow depression, and platelet dysfunction. These reactions are usually reversible upon discontinuation of nafcillin.

At least three cases of platelet dysfunction with prolonged bleeding times have been reported with nafcillin therapy. All cases resolved following discontinuation of nafcillin.

Renal

Renal side effects have included renal tubular damage and interstitial nephritis. Symptoms may include rash, fever, eosinophilia, hematuria, proteinuria, and renal insufficiency.

Hepatic

Hepatic adverse effects are rare, but cases of hepatotoxicity associated with nafcillin therapy have been reported.

Nervous system

Nervous system side effects have included neurotoxicity with high intravenous or intraventricular doses, especially in patients with both hepatic and renal impairment.

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