Trelstar Side Effects

Generic name: triptorelin

Medically reviewed by Drugs.com. Last updated on Jan 1, 2024.

Note: This document contains side effect information about triptorelin. Some dosage forms listed on this page may not apply to the brand name Trelstar.

Applies to triptorelin: intramuscular powder for suspension, intramuscular powder for suspension 6 month.

Serious side effects of Trelstar

Along with its needed effects, triptorelin (the active ingredient contained in Trelstar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking triptorelin:

More common

For children

Diarrhea
loss of appetite
nausea
stomach pain
weakness

Less common

For children

Anxiety
body aches or pain
chest tightness
chills
cough
cough producing mucus
difficulty with breathing
ear congestion
fever
general feeling of discomfort or illness
headache
joint pain
loss of voice
mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
muscle aches and pains
nasal congestion
runny nose
shivering
sneezing
sore throat
sweating
trouble sleeping
unusual tiredness or weakness
vomiting

For adult men

Bladder pain
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody or cloudy urine
blurred vision
chest pain or tightness
cough producing mucus
decrease in urine volume or frequency of urination
difficult or labored breathing
difficult, burning, or painful urination
difficulty in passing urine
dizziness
dry mouth
flushed, dry skin
frequent urge to urinate
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
loss of consciousness
lower back or side pain
nausea
nervousness
pale skin
pounding in the ears
rapid weight gain
slow or fast heartbeat
stomach ache
sweating
tingling of the hands or feet
trouble breathing
unexplained weight loss
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
vomiting

Incidence not known

For children

Blurred or loss of vision
change in ability to see colors, especially blue or yellow
depression
difficulty with swallowing
disturbed color perception
dizziness
double vision
eye pain
halos around lights
hives, itching, skin rash
nervousness
night blindness
overbright appearance of lights
pounding in the ears
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
seizures
slow or fast heartbeat
thoughts of killing oneself

For adult men

Anxiety
changes in skin color
changes in vision
chest discomfort
cold, clammy, or pale skin
confusion
dizziness or lightheadedness
fainting
inability to speak
irregular heartbeat
numbness or tingling in the face, arms, or legs
pain
pain or discomfort in the arms, jaw, back, or neck
pain, redness, or swelling in the arm or leg
seizures
severe or sudden headache
slow heart rate
slurred speech
temporary blindness
tenderness
trouble speaking, thinking, or walking
weakness in the arm or leg on one side of the body, sudden and severe

Other side effects of Trelstar

Some side effects of triptorelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For children

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
stuffy or runny nose

For adult men

Bone pain
chills
decrease in testicle size
decreased interest in sexual intercourse
diarrhea
feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
fever
general feeling of discomfort or illness
inability to have or keep an erection
joint pain
leg pain
loss in sexual ability, desire, drive, or performance
loss of appetite
muscle aches and pains
redness of the face, neck, arms, and occasionally, upper chest
runny nose
shivering
sore throat
sudden sweating
trouble sleeping

Less common

For children

Change in hearing
dryness or soreness of the throat
ear drainage
earache
hoarseness
itching of the ears
pain or tenderness around the eyes and cheekbones
tender, swollen glands in the neck
voice changes

For adult men

Back pain
belching
body aches or pain
breast pain
burning, dry, or itching eyes
congestion
crying
depersonalization
difficulty having a bowel movement
difficulty with moving
discharge or excessive tearing
dysphoria
euphoria
eye pain
heartburn
hoarseness
indigestion
injection site pain
itching or rash
lack or loss of strength
leg cramps
loss of appetite
muscle aching or cramping
muscle pains or stiffness
paranoia
quick to react or overreact emotionally
rapidly changing moods
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
runny nose
stomach discomfort, upset, or pain
swelling of the breasts or breast soreness in both females and males
swollen joints
tender, swollen glands in the neck
trouble swallowing
voice changes
weight loss

For Healthcare Professionals

Applies to triptorelin: intramuscular powder for injection, intramuscular powder for injection extended release.

General

The most common adverse events were hot flushes, impotence, decreased libido, skeletal pain, and headache.^[Ref]

Cardiovascular

Very common (10% or more): Hot flush (73%), hypertension (14%)

Common (1% to 10%): Dependent edema

Uncommon (0.1% to 1%): Embolism

Rare (less than 0.1%): Hypotension

Postmarketing reports: Blood pressure increased, thromboembolic events including, but not limited to, pulmonary emboli, cerebrovascular accident, myocardial infarction, deep venous thrombosis, transient ischemic attack, and thrombophlebitis^[Ref]

Genitourinary

Very common (10% or more): Impotence (40%), urinary tract infection (12%), erectile dysfunction (10%), dysuria; women: dyspareunia, dysmenorrhea, ovarian hyperstimulation syndrome, ovarian hypertrophy, pelvic pain, vulvovaginal dryness, bleeding/spotting, genital hemorrhage (including menorrhagia and metrorrhagia)

Common (1% to 10%): Testicular atrophy, breast pain, gynecomastia, urinary retention, vaginal bleeding (children)

Uncommon (0.1% to 1%): Testicular pain, vaginal discharge (children)

Rare (less than 0.1%): Ejaculation failure

Frequency not reported: Testosterone levels increased, testosterone levels decreased, worsening of urethral or bladder outlet obstruction, worsening of symptoms of endometriosis

Postmarketing reports: Amenorrhea^[Ref]

At the beginning of treatment, endometriosis symptoms including pelvic pain and dysmenorrhea are commonly exacerbated due to an initial transient increase in plasma estradiol levels. These symptoms are transient and usually disappear in one to two weeks.^[Ref]

Psychiatric

Very common (10% or more): Decreased libido (40%), sleep disorders, mood changes

Common (1% to 10%): Insomnia, emotional lability, loss of libido, depression, depressed mood, irritability

Rare (less than 0.1%): Confusional state, decreased activity, euphoric mood

Postmarketing reports: Anxiety, affect lability, nervousness^[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin, decreased red blood count

Common (1% to 10%): Anemia

Frequency not reported: Increased lymphocyte count^[Ref]

Hepatic

Very common (10% or more): Increased AST, increased ALT, increased alkaline phosphatase, increased hepatic transaminases

Common (1% to 10%): Abnormal hepatic function

Uncommon (0.1% to 1%): Gama-glutamyl transferase increased

Rare (less than 0.1%): Blood alkaline phosphatase increased^[Ref]

Metabolic

Very common (10% or more): Increased glucose

Common (1% to 10%): Diabetes mellitus/hyperglycemia, anorexia

Uncommon (0.1% to 1%): Weight increased, gout, increased appetite, weight decreased^[Ref]

Renal

Very common (10% or more): Increased BUN

Uncommon (0.1% to 1%): Blood creatinine increased

Frequency not reported: Worsening hematuria, decreased kidney function^[Ref]

Respiratory

Very common (10% or more): Influenza (16%)

Common (1% to 10%): Bronchitis, coughing, dyspnea, pharyngitis

Uncommon (0.1% to 1%): Asthma aggravated

Rare (less than 0.1%): Orthopnea, epistaxis, nasopharyngitis^[Ref]

Musculoskeletal

Very common (10% or more): Skeletal pain (13%), back pain (11%)

Common (1% to 10%): Pain in extremity, arthralgia, edema in legs, leg cramps, myalgia, musculoskeletal pain, muscle spasms

Uncommon (0.1% to 1%): Muscle cramp, muscular weakness

Rare (less than 0.1%): Joint stiffness, joint swelling, musculoskeletal stiffness, osteoarthritis

Frequency not reported: Worsening of bone pain, increased bone loss, osteoporosis, bone fracture, bone disorder, epiphysiolysis, slipped capital femoral epiphysis

Postmarketing reports: Bone pain^[Ref]

Nervous system

Very common (10% or more): Paresthesia in lower limbs

Common (1% to 10%): Headache, dizziness, fatigue

Uncommon (0.1% to 1%): Tinnitus, somnolence, paresthesia

Rare (less than 0.1%): Vertigo, dysstasia, memory impairment

Frequency not reported: Worsening of neuropathy, spinal cord compression with weakness or paralysis of the lower extremities

Postmarketing reports: Convulsions^[Ref]

Other

Very common (10% or more): Asthenia

Common (1% to 10%): Leg pain, peripheral edema, leg pain, back pain, fatigue, chest pain, edema

Uncommon (0.1% to 1%): Lethargy, pain, rigors, blood lactate dehydrogenase increased, blood cholesterol increased

Rare (less than 0.1%): Pyrexia, influenza like illness, body temperature increased

Frequency not reported: Chills

Postmarketing reports: Malaise^[Ref]

Dermatologic

Very common (10% or more): Hyperhidrosis

Common (1% to 10%): Rash, pruritus

Uncommon (0.1% to 1%): Acne, alopecia, hypotrichosis

Rare (less than 0.1%): Purpura, blister

Postmarketing reports: Angioneurotic edema, urticaria^[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reaction

Uncommon (0.1% to 1%): Allergic reactions

Rare (less than 0.1%): Anaphylactic reaction, hypersensitivity

Frequency not reported: Anaphylactic shock, angioedema^[Ref]

Local

Common (1% to 10%): Injection site pain, injection site reactions, injection site erythema, injection site inflammation^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, constipation, dyspepsia, diarrhea, abdominal pain, abdominal discomfort

Uncommon (0.1% to 1%): Abdominal pain upper, dry mouth

Rare (less than 0.1%): Abdominal distension, dysgeusia, flatulence

Frequency not reported: Gastralgia^[Ref]

Ocular

Common (1% to 10%): Eye pain, conjunctivitis

Rare (less than 0.1%): Abnormal sensation in eye, visual disturbance

Postmarketing reports: Vision blurred^[Ref]

Oncologic

Frequency not reported: Tumor flare, exacerbation of disease symptoms

Postmarketing reports: Pituitary adenoma^[Ref]

Tumor flare occurred in 5% or less of patients, usually manifested by an increase in urinary symptoms and metastatic pain.^[Ref]

Endocrine

Postmarketing reports: Pituitary apoplexy^[Ref]

The majority of pituitary apoplexy cases occurred within 2 weeks of the first dose, some within the first hour. In these cases, pituitary apoplexy presented as sudden headache, vomiting, visual changes, ophthalmoplegia, altered mental status, and sometimes cardiovascular collapse. Immediate medical attention has been required.^[Ref]