Trelstar Depot Side Effects
Generic name: triptorelin
Note: This document contains side effect information about triptorelin. Some of the dosage forms listed on this page may not apply to the brand name Trelstar Depot.
Some side effects of Trelstar Depot may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to triptorelin: intramuscular powder for suspension
Along with its needed effects, triptorelin (the active ingredient contained in Trelstar Depot) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking triptorelin:Less common
- Bladder pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or cloudy urine
- blurred vision
- burning while urinating
- chest pain
- cough producing mucus
- decrease in urine volume or frequency of urination
- difficult or labored breathing
- difficult, burning, or painful urination
- difficulty in passing urine
- dry mouth
- flushed, dry skin
- frequent urge to urinate
- fruit-like breath odor
- high blood pressure
- increased hunger
- increased thirst
- increased urination
- loss of consciousness
- lower back or side pain
- pale skin
- pounding in the ears
- rapid weight gain
- shortness of breath
- slow or fast heartbeat
- tightness in the chest
- tingling of the hands or feet
- troubled breathing
- troubled breathing with exertion
- unexplained weight loss
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- changes in skin color
- changes in vision
- chest discomfort
- cold, clammy, or pale skin
- dizziness or lightheadedness
- inability to speak
- irregular heartbeats
- numbness or tingling in the face, arms, or legs
- pain or discomfort in the arms, jaw, back, or neck
- pain, redness, or swelling in the arm or leg
- severe or sudden headache
- slow heart rate
- slurred speech
- sudden shortness of breath or troubled breathing
- temporary blindness
- trouble speaking, thinking, or walking
- weakness in the arm or leg on one side of the body, sudden and severe
Some side effects of triptorelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Bone pain
- decrease in testicle size
- decreased interest in sexual intercourse
- feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
- general feeling of discomfort or illness
- inability to have or keep an erection
- joint pain
- leg pain
- loss in sexual ability, desire, drive, or performance
- loss of appetite
- muscle aches and pains
- redness of the face, neck, arms, and occasionally, upper chest
- runny nose
- sore throat
- sudden sweating
- trouble sleeping
- Acid or sour stomach
- back pain
- body aches or pain
- breast pain
- burning, dry, or itching eyes
- difficulty having a bowel movement (stool)
- difficulty with moving
- discharge or excessive tearing
- eye pain
- injection site pain
- lack or loss of strength
- leg cramps
- loss of appetite
- mental depression
- muscle aching or cramping
- muscle pains or stiffness
- quick to react or overreact emotionally
- rapidly changing moods
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- runny nose
- stomach discomfort, upset, or pain
- swelling of the breasts or breast soreness in both females and males
- swollen joints
- tender, swollen glands in the neck
- trouble with swallowing
- voice changes
- weight loss
For Healthcare Professionals
Applies to triptorelin: intramuscular powder for injection
General effects including hot flushes (58%), pain (2.1%), leg pain (2.1%), and fatigue (2.1%) have been reported.
Musculoskeletal effects including skeletal pain (12.1%) have been reported.
Psychiatric effects including impotence (7.1%), insomnia (2.1%), and emotional lability (1.4%) have been reported.
Nervous system effects including headache (5.0%) and dizziness (1.4%) have been reported. Postmarketing reports have included convulsions.
Local effects including injection site pain (3.6%) have been reported.
Cardiovascular effects including hypertension (3.6%) have been reported. Seven cases of angioedema have also been reported. Myocardial infarction, sudden cardiac death, and stroke have been reported in patients treated with GnRH agonists.
Gastrointestinal effects including vomiting (2.1%) and diarrhea (1.4%) have been reported.
Hematologic effects including anemia (1.4%) have been reported.
Dermatologic effects including pruritus (1.4%) have been reported.
Genitourinary effects including urinary retention (1.4%) and urinary tract infection (1.4%) have been reported.
Because administration of triptorelin (the active ingredient contained in Trelstar Depot) in therapeutic dosages results in suppression of the pituitary-gonadal axis, diagnostic tests of pituitary-gonadal function may be misleading.
Endocrine side effects including pituitary apoplexy and diabetes mellitus have been reported.
Metabolic side effects have included hyperglycemia.
More Trelstar Depot resources
- Trelstar Depot Prescribing Information (FDA)
- Trelstar Depot Concise Consumer Information (Cerner Multum)
- Trelstar Depot MedFacts Consumer Leaflet (Wolters Kluwer)
- Trelstar Depot Advanced Consumer (Micromedex) - Includes Dosage Information
- Trelstar LA Prescribing Information (FDA)
- Triptorelin Pamoate Monograph (AHFS DI)
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