Trecator-SC Side Effects

Generic name: ethionamide

Note: This document contains side effect information about ethionamide. Some of the dosage forms listed on this page may not apply to the brand name Trecator-SC.

Some side effects of Trecator-SC may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to ethionamide: oral tablet

If you experience any of the following serious side effects, stop taking ethionamide (the active ingredient contained in Trecator-SC) and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• yellow skin or eyes;

• dark urine;

• numbness or tingling in your hands or feet;

• seizures;

• blurred or double vision; or

• confusion or abnormal behavior.

Other, less serious side effects may be more likely to occur. Continue to take ethionamide and talk to your doctor if you experience

• nausea, vomiting, or loss of appetite;

• a metallic taste in your mouth;

• excessive salivation;

• diarrhea;

• unusual fatigue or weakness;

• headache;

• mild dizziness;

• tremors (shaking); or

• a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to ethionamide: oral tablet

Gastrointestinal

Gastrointestinal side effects are the most common side effects of ethionamide (the active ingredient contained in Trecator-SC) and may be dose-related. They have included nausea, vomiting, diarrhea, abdominal pain excessive salivation, metallic taste, stomatitis, anorexia, and weight loss. Approximately one-half of patients cannot tolerate 1 gram as a single dose.

Nervous system

Nervous system side effects have included psychotic disturbances, mental depression, drowsiness, dizziness, restlessness, headache, peripheral neuritis, and a pellagra-like syndrome. Concomitant pyridoxine has been recommended to prevent or relieve neurotoxic effects.

Ocular

Ocular side effects have rarely included optic neuritis, diplopia, and blurred vision.

Hepatic

Hepatic side effects have included transient increases in serum bilirubin, SGOT, SGPT, and hepatitis with or without jaundice.

Hypersensitivity

Hypersensitivity reactions have rarely included rash, photosensitivity, thrombocytopenia, and purpura.

Metabolic

Metabolic side effects have included hypoglycemia and hypothyroidism.

Genitourinary

Genitourinary side effects have included gynecomastia and impotence.

Dermatologic

Dermatologic side effects have included rash and acne.

Hematologic

Hematologic side effects have included thrombocytopenia and purpura.

Cardiovascular

Cardiovascular side effects have included postural hypotension.

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