Travoprost Side Effects

Please note - some side effects for Travoprost may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Travoprost - for the Consumer

Travoprost Drops

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Travoprost Drops:

Bloodshot eyes; blurred vision; changes in eyelash growth; eye dryness, itching, or discomfort; feeling of having something in your eye; headache; increased tear production.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; darkening of the eyelid or eye color; eye or eyelid crusting, discharge, inflammation, irritation, pain, or swelling; severe headache or dizziness; slow heartbeat; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: ophthalmic solution

Ocular

Ocular side effects have most frequently included ocular hyperemia (35% to 50%). Decreased visual acuity, eye discomfort, foreign body sensation, pain and pruritus have been reported in 5% to 10% of patients. Abnormal vision, blepharitis, blurred vision, cataract, cells, conjunctivitis, dry eye, eye disorder, flare, iris discoloration, keratitis, lid margin crusting, photophobia, subconjunctival hemorrhage, and tearing have been reported in 1% to 4% of patients. Increased brown pigmentation of the iris and macular edema, including cystoid macular edema, have also been reported. In postmarketing use with prostaglandin analogs, periorbital and lid changes including deepening of the eyelid sulcus have been observed.

Travoprost can increase the amount of brown pigment in the eye by stimulating melanin production in melanocytes. The change in eye color occurs gradually over months to years and may be permanent. The entire or parts of the iris may be affected. Changes may be more prominent in patients with green-brown, blue/gray-brown or yellow-brown irides.

The manufacturer reports discontinuation of therapy due to conjunctival hyperemia in approximately 3% of patients.

Dermatologic

A single case of poliosis was reported after 4 months of therapy. The affected lashes were interspersed with normally pigmented lashes. Hypertrichosis was also reported with this patient.

Dermatologic side effects have included increases in length, thickness, pigmentation, and/or number of eyelashes. Increased brown pigmentation of the eyelashes, periorbital, and/or eyelid tissue of the treated eye have also been reported. A single case of poliosis has been reported.

Cardiovascular

Cardiovascular side effects have included angina pectoris, bradycardia, chest pain, hypertension, and hypotension in less than 5% of patients.

Gastrointestinal

A 34-year-old woman receiving travoprost ophthalmic solution for open-angle glaucoma experienced abdominal cramps approximately 30 minutes following administration and lasting for approximately 2 hours in duration. The patient continued to report a similar experience with 3 rechallenges of travoprost, and patient-blind challenges using disguised delivery containers. The patient failed to experience abdominal cramps when undergoing a blind challenge with latanoprost.

Gastrointestinal side effects have included dyspepsia and gastrointestinal disorder in less than 5% of patients. Abdominal cramps have rarely been reported (1 case report).

Genitourinary

Genitourinary side effects have included prostate disorder, urinary incontinence, and urinary tract infection in less than 5% of patients.

Musculoskeletal

Musculoskeletal side effects have included arthritis and back pain in less than 5% of patients.

Nervous system

Nervous system side effects have included anxiety and headache in less than 5% of patients.

Respiratory

Respiratory side effects have included bronchitis, cold syndrome and sinusitis in less than 5% of patients.

Metabolic

Metabolic side effects have included hypercholesterolemia (<5%).

Other

Other side effects have included accidental injury and pain in less than 5% of patients.

Psychiatric

Psychiatric side effects have included depression (<5%).

Immunologic

Immunologic side effects have included infection (<5%).

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