Travoprost ophthalmic Side Effects

Some side effects of travoprost ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to travoprost ophthalmic: ophthalmic solution

Along with its needed effects, travoprost ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking travoprost ophthalmic:

Less common
  • Acid or sour stomach (heartburn or indigestion)
  • blindness
  • blood in urine
  • blurred or decreased vision
  • burning, dry or itching eyes
  • cough producing mucus
  • eye color changes
  • chest pain
  • chest tightness
  • confusion
  • dull nervousness
  • faintness or lightheadedness when getting up from a lying or sitting position
  • fast or irregular heartbeat
  • fever or chills
  • headache
  • high cholesterol
  • lightheadedness, dizziness or fainting
  • loss of bladder control
  • lower back pain
  • mood or mental changes
  • muscle pain or stiffness
  • pain, swelling, or redness in joints
  • pain or burning while urinating
  • pelvic pain
  • pounding in the ears
  • runny nose
  • sore throat
  • shortness of breath
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • slow or irregular heartbeat (less than 50 beats per minute)
  • sudden sweating
  • tightness in chest or wheezing
  • unusual tiredness

Some side effects of travoprost ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased vision
  • eye discomfort
  • eye pain
  • feeling of having something in the eye
  • itching eye
  • redness of eye
Less common
  • Dry eyes
  • eye discharge or excessive tearing
  • increased sensitivity of eyes to sunlight

For Healthcare Professionals

Applies to travoprost ophthalmic: ophthalmic solution


Ocular side effects have most frequently included ocular hyperemia (35% to 50%). Decreased visual acuity, eye discomfort, foreign body sensation, pain and pruritus have been reported in 5% to 10% of patients. Abnormal vision, blepharitis, blurred vision, cataract, cells, conjunctivitis, dry eye, eye disorder, flare, iris discoloration, keratitis, lid margin crusting, photophobia, subconjunctival hemorrhage, and tearing have been reported in 1% to 4% of patients. Increased brown pigmentation of the iris and macular edema, including cystoid macular edema, have also been reported. In postmarketing use with prostaglandin analogs, periorbital and lid changes including deepening of the eyelid sulcus have been observed.

Travoprost can increase the amount of brown pigment in the eye by stimulating melanin production in melanocytes. The change in eye color occurs gradually over months to years and may be permanent. The entire or parts of the iris may be affected. Changes may be more prominent in patients with green-brown, blue/gray-brown or yellow-brown irides.

The manufacturer reports discontinuation of therapy due to conjunctival hyperemia in approximately 3% of patients.


A single case of poliosis was reported after 4 months of therapy. The affected lashes were interspersed with normally pigmented lashes. Hypertrichosis was also reported with this patient.

Dermatologic side effects have included increases in length, thickness, pigmentation, and/or number of eyelashes. Increased brown pigmentation of the eyelashes, periorbital, and/or eyelid tissue of the treated eye have also been reported. A single case of poliosis has been reported.


Cardiovascular side effects have included angina pectoris, bradycardia, chest pain, hypertension, and hypotension in less than 5% of patients.


A 34-year-old woman receiving travoprost ophthalmic solution for open-angle glaucoma experienced abdominal cramps approximately 30 minutes following administration and lasting for approximately 2 hours in duration. The patient continued to report a similar experience with 3 rechallenges of travoprost, and patient-blind challenges using disguised delivery containers. The patient failed to experience abdominal cramps when undergoing a blind challenge with latanoprost.

Gastrointestinal side effects have included dyspepsia and gastrointestinal disorder in less than 5% of patients. Abdominal cramps have rarely been reported (1 case report).


Genitourinary side effects have included prostate disorder, urinary incontinence, and urinary tract infection in less than 5% of patients.


Musculoskeletal side effects have included arthritis and back pain in less than 5% of patients.

Nervous system

Nervous system side effects have included anxiety and headache in less than 5% of patients.


Respiratory side effects have included bronchitis, cold syndrome and sinusitis in less than 5% of patients.


Metabolic side effects have included hypercholesterolemia (<5%).


Other side effects have included accidental injury and pain in less than 5% of patients.


Psychiatric side effects have included depression (<5%).


Immunologic side effects have included infection (<5%).

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