Tranylcypromine Side Effects

Some side effects of tranylcypromine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to tranylcypromine: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking tranylcypromine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Stop using tranylcypromine and call your doctor at once if you have any of these serious side effects:

• frequent headaches, vision problems, sensitivity to light;

• fast or pounding heart beats, tight feeling in your chest or throat;

• swelling of your ankles or feet;

• pale skin, easy bruising or bleeding, unusual weakness;

• nausea, vomiting, dizziness, sweating, stiffness in your neck;

• confusion, lack of coordination, feeling light-headed, fainting; or

• tremors, muscle twitches you cannot control.

Less serious side effects of tranylcypromine may include:

• feeling restless, weak, or drowsy;

• nausea, diarrhea or constipation, loss of appetite, stomach pain;

• chills, numbness or tingly feeling;

• dry mouth, decreased urination;

• blurred vision, ringing in your ears; or

• impotence, difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to tranylcypromine: oral tablet

Cardiovascular

Hypertensive crisis (sometimes fatal) is the most important reaction associated with tranylcypromine therapy and is characterized by some or all of the following symptoms: occipital headache that may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating (sometimes with fever and sometimes with cold, clammy skin), pupil dilatation, photophobia, tachycardia or bradycardia, and constricting chest pain. Hypertensive crises may be precipitated by concomitant administration of sympathomimetic drugs or related compounds, other monoamine oxidase inhibitors, or dibenzazepine-related entities. Ingestion of foods with a high concentration of tyramine may also cause a hypertensive crisis. Blood pressure should be monitored closely in all patients to detect any pressor response. Patients should be observed frequently, as blood pressure readings should not be relied upon completely. Therapy should be discontinued immediately upon the occurrence of palpitation or frequent headaches, as these signs may be prodromal of a hypertensive crisis.

Cardiovascular side effects have included hypertensive crisis, postural hypotension, tachycardia, palpitations, and edema. Intracranial bleeding, which can be fatal, has been reported with the paradoxical increase in blood pressure.

Nervous system

Nervous system side effects have included weakness, drowsiness, tinnitus, numbness, paresthesia, headache without blood pressure elevation, insomnia, dizziness, orthostatic dysregulation, syncope, restlessness, and arterial hypertonia (possibly due to failure in low-tyramine diet). Lowering the dosage may relieve some of these effects. Ataxia, confusion, disorientation, memory loss, and akinesia have been reported during postmarketing experience.

Psychiatric

Psychiatric side effects have included anxiety, agitation, suicidality, and manic symptoms. Some of these effects may be due to overstimulation or excessive therapeutic action and may be relieved by lowering the dosage.

Gastrointestinal

Gastrointestinal side effects have included nausea, dry mouth, diarrhea, abdominal pain, anorexia, and constipation. Lowering the dosage may relieve some of these effects. Fissuring in corner of mouth has been reported during postmarketing experience.

Endocrine

Endocrine side effects have included hypoglycemic episodes and impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Genitourinary

Genitourinary side effects have included urinary retention, impotence, and retarded ejaculation. Urinary frequency and urinary incontinence have been reported during postmarketing experience.

Hematologic

Hematologic side effects have included anemia, leukopenia, agranulocytosis, and thrombocytopenia.

Hepatic

Hepatic side effects have rarely included hepatitis and abnormal liver enzymes.

Musculoskeletal

Musculoskeletal side effects have included muscle spasms, myoclonic jerks, and tremors.

Other

Other side effects have included chills.

Ocular

Ocular side effects have included blurred vision.

Dermatologic

Dermatologic side effects have rarely included skin rash and alopecia. Localized scleroderma, cystic acne flare-up, and urticaria have been reported during postmarketing experience.

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