Tranylcypromine Side Effects

Brand Names: Parnate

Please note - some side effects for Tranylcypromine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Tranylcypromine - for the Consumer

Tranylcypromine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tranylcypromine:

Blurred vision; constipation; diarrhea; drowsiness; dry mouth; stomach pain; tremors; upset stomach; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation or anxiety; bizarre behavior; blurred vision; chest pain; difficulty sleeping; dilated pupils; dizziness; fainting; fast, slow, or irregular heartbeat; feelings of irritability and hostility; fever; headache; impulsive behavior or other unusual changes in behavior; nausea; panic attacks; pounding in the chest; sensitivity to light; severe nervousness or anxiety; severe restlessness; sleeplessness; sore or stiff neck; sweating (sometimes with fever or cold, clammy skin); thoughts of suicide; vomiting; worsening feelings of depression.

Tranylcypromine Side Effects - for the Professional

Tranylcypromine

Overstimulation which may include increased anxiety, agitation, and manic symptoms is usually evidence of excessive therapeutic action. Dosage should be reduced, or a phenothiazine tranquilizer should be administered concomitantly.

Patients may experience restlessness or insomnia; may notice some weakness, drowsiness, episodes of dizziness or dry mouth; or may report nausea, diarrhea, abdominal pain, or constipation. Most of these effects can be relieved by lowering the dosage or by giving suitable concomitant medication.

Tachycardia, significant anorexia, edema, palpitation, blurred vision, chills, and impotence have each been reported.

Headaches without blood pressure elevation have occurred.

Rare instances of hepatitis, skin rash, and alopecia have been reported.

Impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported.

Tinnitus, muscle spasm, tremors, myoclonic jerks, numbness, paresthesia, urinary retention, and retarded ejaculation have been reported.

Hematologic disorders including anemia, leukopenia, agranulocytosis, and thrombocytopenia have been reported.

Post-Introduction Reports

The following are spontaneously reported adverse events temporally associated with use of Tranylcypromine sulfate. No clear relationship between Tranylcypromine sulfate and these events has been established. Localized scleroderma, flare-up of cystic acne, ataxia, confusion, disorientation, memory loss, urinary frequency, urinary incontinence, urticaria, fissuring in corner of mouth, akinesia.

Side Effects by Body System

Cardiovascular

Hypertensive crisis can occur during tranylcypromine therapy and is characterized by some or all of the following symptoms: occipital headache that may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating that is sometimes accompanied by fever or cold, clammy skin, pupil dilatation, photophobia, tachycardia or bradycardia, and constricting chest pain. Hypertensive crises may be precipitated by concomitant administration of sympathomimetic drugs or related compounds or other MAO inhibitors. Ingestion of foods with a high concentration of tyramine or dopamine and excessive amounts of caffeine and chocolate may also cause a hypertensive crisis. Blood pressure should be monitored frequently in all patients and therapy discontinued immediately upon the occurrence of palpitation or frequent headaches, as these signs may be prodromal of a hypertensive crisis.

Cardiovascular side effects have included hypertensive crisis, postural hypotension, tachycardia, palpitations, and edema. Intracranial bleeding, which can be fatal, has been reported with the paradoxical increase in blood pressure.

Nervous system

Nervous system side effects have included weakness, drowsiness, tinnitus, numbness, paresthesia, headache without blood pressure elevation, insomnia, dizziness, orthostatic dysregulation, syncope, restlessness, and arterial hypertonia (possibly due to failure in low-tyramine diet). Lowering the dosage may relieve some of these effects. Ataxia, confusion, disorientation, memory loss, and akinesia have been reported during postmarketing experience.

Psychiatric

Psychiatric side effects have included anxiety, agitation, suicidality, and manic symptoms. Some of these effects may be due to overstimulation or excessive therapeutic action and may be relieved by lowering the dosage.

Gastrointestinal

Gastrointestinal side effects have included nausea, dry mouth, diarrhea, abdominal pain, anorexia, and constipation. Lowering the dosage may relieve some of these effects. Fissuring in corner of mouth has been reported during postmarketing experience.

Endocrine

Endocrine side effects have included hypoglycemic episodes and impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Genitourinary

Genitourinary side effects have included urinary retention, impotence, and retarded ejaculation. Urinary frequency and urinary incontinence have been reported during postmarketing experience.

Hematologic

Hematologic disorders have included anemia, leukopenia, agranulocytosis, and thrombocytopenia.

Hepatic

Hepatic side effects have rarely included hepatitis and abnormal liver enzymes.

Musculoskeletal

Musculoskeletal side effects have included muscle spasms, myoclonic jerks, and tremors.

Ocular

Ocular side effects have included blurred vision.

Dermatologic

Dermatologic side effects have rarely included skin rash and alopecia. Localized scleroderma, cystic acne flare-up, and urticaria have been reported during postmarketing experience.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.