Tranylcypromine Side Effects

Brand Names: Parnate

Please note - some side effects for Tranylcypromine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Tranylcypromine - for the Consumer

Tranylcypromine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tranylcypromine:

Constipation; diarrhea; drowsiness; dry mouth; stomach pain; tremors; upset stomach; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; blurred vision; chest pain; difficulty sleeping; dilated pupils; dizziness; fainting; fast, slow, or irregular heartbeat; feelings of irritability and hostility; fever; headache; impulsive behavior or other unusual changes in behavior; nausea; new or worsening mental or mood changes (eg, agitation, anxiety, depression); panic attacks; pounding in the chest; sensitivity to light; severe nervousness; severe restlessness; sleeplessness; sore or stiff neck; suicidal thoughts or actions; sweating (sometimes with fever or cold, clammy skin); vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Tranylcypromine Side Effects - for the Professional

Tranylcypromine

Overstimulation which may include increased anxiety, agitation, and manic symptoms is usually evidence of excessive therapeutic action. Dosage should be reduced, or a phenothiazine tranquilizer should be administered concomitantly.

Patients may experience restlessness or insomnia; may notice some weakness, drowsiness, episodes of dizziness or dry mouth; or may report nausea, diarrhea, abdominal pain, or constipation. Most of these effects can be relieved by lowering the dosage or by giving suitable concomitant medication.

Tachycardia, significant anorexia, edema, palpitation, blurred vision, chills, and impotence have each been reported.

Headaches without blood pressure elevation have occurred.

Rare instances of hepatitis, skin rash, and alopecia have been reported.

Impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported.

Tinnitus, muscle spasm, tremors, myoclonic jerks, numbness, paresthesia, urinary retention, and retarded ejaculation have been reported.

Hematologic disorders including anemia, leukopenia, agranulocytosis, and thrombocytopenia have been reported.

Post-Introduction Reports

The following are spontaneously reported adverse events temporally associated with use of Tranylcypromine sulfate. No clear relationship between Tranylcypromine sulfate and these events has been established. Localized scleroderma, flare-up of cystic acne, ataxia, confusion, disorientation, memory loss, urinary frequency, urinary incontinence, urticaria, fissuring in corner of mouth, akinesia.

Side Effects by Body System - for Healthcare Professionals

Cardiovascular

Hypertensive crisis (sometimes fatal) is the most important reaction associated with tranylcypromine therapy and is characterized by some or all of the following symptoms: occipital headache that may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating (sometimes with fever and sometimes with cold, clammy skin), pupil dilatation, photophobia, tachycardia or bradycardia, and constricting chest pain. Hypertensive crises may be precipitated by concomitant administration of sympathomimetic drugs or related compounds, other monoamine oxidase inhibitors, or dibenzazepine-related entities. Ingestion of foods with a high concentration of tyramine may also cause a hypertensive crisis. Blood pressure should be monitored closely in all patients to detect any pressor response. Patients should be observed frequently, as blood pressure readings should not be relied upon completely. Therapy should be discontinued immediately upon the occurrence of palpitation or frequent headaches, as these signs may be prodromal of a hypertensive crisis.

Cardiovascular side effects have included hypertensive crisis, postural hypotension, tachycardia, palpitations, and edema. Intracranial bleeding, which can be fatal, has been reported with the paradoxical increase in blood pressure.

Nervous system

Nervous system side effects have included weakness, drowsiness, tinnitus, numbness, paresthesia, headache without blood pressure elevation, insomnia, dizziness, orthostatic dysregulation, syncope, restlessness, and arterial hypertonia (possibly due to failure in low-tyramine diet). Lowering the dosage may relieve some of these effects. Ataxia, confusion, disorientation, memory loss, and akinesia have been reported during postmarketing experience.

Psychiatric

Psychiatric side effects have included anxiety, agitation, suicidality, and manic symptoms. Some of these effects may be due to overstimulation or excessive therapeutic action and may be relieved by lowering the dosage.

Gastrointestinal

Gastrointestinal side effects have included nausea, dry mouth, diarrhea, abdominal pain, anorexia, and constipation. Lowering the dosage may relieve some of these effects. Fissuring in corner of mouth has been reported during postmarketing experience.

Endocrine

Endocrine side effects have included hypoglycemic episodes and impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Genitourinary

Genitourinary side effects have included urinary retention, impotence, and retarded ejaculation. Urinary frequency and urinary incontinence have been reported during postmarketing experience.

Hematologic

Hematologic side effects have included anemia, leukopenia, agranulocytosis, and thrombocytopenia.

Hepatic

Hepatic side effects have rarely included hepatitis and abnormal liver enzymes.

Musculoskeletal

Musculoskeletal side effects have included muscle spasms, myoclonic jerks, and tremors.

Other

Other side effects have included chills.

Ocular

Ocular side effects have included blurred vision.

Dermatologic

Dermatologic side effects have rarely included skin rash and alopecia. Localized scleroderma, cystic acne flare-up, and urticaria have been reported during postmarketing experience.

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