Totect Side Effects
Generic name: dexrazoxane
Note: This document contains side effect information about dexrazoxane. Some of the dosage forms listed on this page may not apply to the brand name Totect.
Some side effects of Totect may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to dexrazoxane: intravenous powder for solution
Along with its needed effects, dexrazoxane (the active ingredient contained in Totect) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dexrazoxane:More common
- Bluish color
- changes in skin color
- chest pain
- cold hands and feet
- cough or hoarseness
- difficult or labored breathing
- fever or chills
- lower back or side pain
- pain, redness, or swelling in arm or leg
- painful or difficult urination
- pale skin
- shortness of breath
- sore throat
- swelling of hands, ankles, feet, or lower legs
- tightness in chest
- troubled breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- Black, tarry stools
- chest discomfort
- fast, irregular, or pounding heartbeat
- pain at place of injection
- ulcers, sores, or white spots in mouth
Some side effects of dexrazoxane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- difficulty having a bowel movement (stool)
- feeling sad or empty
- hair loss, thinning of hair
- lack or loss of appetite
- loss of interest or pleasure
- muscle pain, spasms, cramps, or stiffness
- stomach pain
- trouble concentrating
- trouble sleeping
- weight loss
For Healthcare Professionals
Applies to dexrazoxane: intravenous powder for injection
Gastrointestinal side effects including nausea (43%), vomiting (19%), diarrhea (11%), abdominal pain (6%), and constipation (6%) have been reported.
General side effects including pyrexia (21%), postoperative infection (16%), fatigue (13%), peripheral edema (10%), chest pain, chest discomfort, decreased drug effect, hyperpyrexia, and decreased therapeutic response have been reported.
Local side effects including injection site pain (16%) and injection site phlebitis (6%) have been reported.
Cardiovascular side effects including vascular disorders (15%) and cardiac disorders (5%) have been reported.
Dermatologic side effects including alopecia (14%) have been reported.
Musculoskeletal side effects including "musculoskeletal and connective tissue disorders" (13%) have been reported.
Nervous system side effects including dizziness (11%) and headache (6%) have been reported.
Respiratory side effects including dyspnea (8%), pneumonia (6%), and cough (5%) have been reported.
Psychiatric side effects including depression (8%), anorexia (5%), and insomnia (5%) have been reported.
Hematologic side effects including anemia (6%), decreased WBC, decreased neutrophils, and decreased platelets have been reported.
Hepatic side effects including increased bilirubin, increased AST, increased ALT, increased alkaline phosphatase, and increased LDH have been reported
Metabolic side effects including increased creatinine, decreased sodium, and increased total calcium have been reported.
More Totect resources
- Totect Consumer Overview
- Totect Prescribing Information (FDA)
- Totect Advanced Consumer (Micromedex) - Includes Dosage Information
- Dexrazoxane Prescribing Information (FDA)
- Dexrazoxane Professional Patient Advice (Wolters Kluwer)
- dexrazoxane MedFacts Consumer Leaflet (Wolters Kluwer)
- Dexrazoxane Hydrochloride Monograph (AHFS DI)
- Zinecard Prescribing Information (FDA)
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