Torecan Side Effects

Please note - some side effects for Torecan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Torecan Side Effects - for the Professional

Torecan

Central Nervous System

Serious: Convulsions have been reported. Extrapyramidal symptoms (E.P.S.) may occur, such as dystonia, torticollis, oculogyric crises, akathisia and gait disturbances. Others: Occasional cases of dizziness, headache, fever and restlessness have been reported.

Drowsiness may occur on occasion, following an initial injection. Generally this effect tends to subside with continued therapy or is usually alleviated by a reduction in dosage.

Autonomic Nervous System

Dryness of the mouth and nose, blurred vision, tinnitus. An occasional case of sialorrhea together with altered gustatory sensation has been observed.

Endocrine System

Peripheral edema of the arms, hands and face.

Hepatotoxicity

An occasional case of cholestatic jaundice has been observed.

Other

An occasional case of cerebral vascular spasm and trigeminal neuralgia has been reported.

Phenothiazine Derivatives

The physician should be aware that the following have occurred with one or more phenothiazines and should be considered whenever one of these drugs is used:

Blood Dyscrasias Serious–Agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, pancytopenia. Other: Eosinophilia, leukocytosis.

Autonomic Reactions–Miosis, obstipation, anorexia, paralytic ileus.

Cutaneous Reactions Serious–Erythema, exfoliative dermatitis, contact dermatitis.

Hepatotoxicity Serious–Jaundice, biliary stasis.

Cardiovascular Effects Serious–Hypotension, rarely leading to cardiac arrest; electrocardiographic (ECG) changes.

Extrapyramidal Symptoms Serious–Akathisia, agitation, motor restlessness, dystonic reactions, trismus, torticollis, opisthotonos, oculogyric crises, tremor, muscular rigidity, akinesia–some of which have persisted for several months or years especially in patients of advanced age with brain damage.

Endocrine Disturbances–Menstrual irregularities, altered libido, gynecomastia, weight gain. False positive pregnancy tests have been reported.

Urinary Disturbances–Retention, incontinence.

Allergic Reactions Serious–Fever, laryngeal edema, angioneurotic edema, asthma.

Others: Hyperpyrexia. Behavioral effects suggestive of a paradoxical reaction have been reported. These include excitement, bizarre dreams, aggravation of psychoses and toxic confusional states. While there is no evidence at present that ECG changes observed in patients receiving phenothiazines are in any way precursors of any significant disturbance of cardiac rhythm, it should be noted that sudden and unexpected deaths apparently due to cardiac arrest have been reported in a few instances in hospitalized psychotic patients previously showing characteristic ECG changes. A peculiar skin-eye syndrome has also been recognized as a side effect following long-term treatment with certain phenothiazines. This reaction is marked by progressive pigmentation of areas of the skin or conjunctiva and/or accompanied by discoloration of the exposed sclera and cornea. Opacities of the anterior lens and cornea described as irregular or stellate in shape have also been reported.

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Side Effects by Body System - for Healthcare Professionals

Nervous system

Nervous system side effects have included sedation, dizziness, or headache. Extrapyramidal reactions have been reported in less than 1% of patients and included dystonia, torticollis, oculogyric crises, akathisia, and gait disturbances. Pseudo-parkinsonian reactions including mask-like facies, drooling, cogwheel rigidity, and shuffling gait have been reported. Convulsions have also been reported rarely. Neuroleptic malignant syndrome has been reported with other phenothiazines, and the potential to occur with thiethylperazine should be considered.

Gastrointestinal

Gastrointestinal side effects have included dryness of the mouth and nose, sialorrhea, and altered taste sensation.

Hepatic

Hepatic side effects have rarely included the development of cholestatic jaundice.

Hematologic

Hematologic side effects associated with phenothiazine derivatives have rarely included leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, pancytopenia, eosinophilia, and leukocytosis.

Cardiovascular

Cardiovascular side effects have included hypotension during intravenous administration.

Dermatologic

Dermatologic side effects have rarely included erythema, exfoliative dermatitis, and contact dermatitis.

Ocular

Ocular side effects have included blurred vision.

Hypersensitivity

Hypersensitivity side effects including at least one case of anaphylactic reaction have been reported.

A 15-year-old female was admitted for angioedema and respiratory distress coincident with thiethylperazine therapy. She had been prescribed thiethylperazine (total of three doses) for abdominal pain and heavy nausea lasting for 2 days. Three hours after the last dose, she began to complain of face and tongue edema, speech difficulties, and dysphagia. On physical examination, she was in good general condition and showed an angioedema and erythema of the face, the upper thorax, and the tongue. An anaphylactic reaction was suspected and treatment was initiated. Her symptoms improved after treatment with intravenous biperiden, two aerosols of albuterol and budesonide, and intravenous methylprednisolone.

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