Topicort Side Effects

Generic Name: desoximetasone topical

Note: This page contains side effects data for the generic drug desoximetasone topical. It is possible that some of the dosage forms included below may not apply to the brand name Topicort.

It is possible that some side effects of Topicort may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to desoximetasone topical: topical application cream, topical application gel/jelly, topical application ointment, topical application spray

As well as its needed effects, desoximetasone topical (the active ingredient contained in Topicort) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking desoximetasone topical, check with your doctor immediately:

Rare
  • Flushing or redness of the skin
  • redness, blistering, peeling, or loosening of the skin
  • unusually warm skin
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • redness and scaling around the mouth
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • thinning, weakness, or wasting away of the skin

Some desoximetasone topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Rare
  • Burning, itching, and pain in hairy areas, or pus at the root of the hair
Incidence not known
  • Acne or pimples
  • burning and itching of the skin with pinhead-sized red blisters
  • increased hair growth on the forehead, back, arms, and legs
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • softening of the skin

For Healthcare Professionals

Applies to desoximetasone topical: compounding powder, topical cream, topical gel, topical ointment, topical spray

Endocrine

Endocrine side effects have rarely included suppression of the hypothalamic-pituitary-adrenal axis. This suppression was more likely when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used.[Ref]

Local

Local side effects have commonly included burning, itching, and irritation, especially if applied to denuded skin. Adverse reactions associated with the topical spray include application site dryness, irritation, and pruritus. Long-term use of topical corticosteroids has been associated with skin atrophy and thinning, striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Topical corticosteroid use may also inhibit local immune response, rendering the skin more susceptible to infections. Folliculitis and allergic contact dermatitis have been occasionally reported.[Ref]

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical desoximetasone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients with seborrheic skin type treated with potent topical corticosteroids. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.[Ref]

References

1. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.

2. Willis I, Cornell RC, Penneys NS, Zaias N "Multicenter study comparing 0.05% gel formulations of desoximetasone and fluocinonide in patients with scalp psoriasis." Clin Ther 8 (1986): 275-82

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