Topicort Side Effects

Please note - some side effects for Topicort may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Topicort - for the Consumer

Topicort Cream

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Topicort Cream:

Mild, temporary stinging when first applied.

Seek medical attention right away if any of these SEVERE side effects occur when using Topicort Cream:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); itching, burning, redness, or swelling not present before using Topicort Cream.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Topicort LP Cream

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Topicort LP Cream:

Mild, temporary stinging when first applied.

Seek medical attention right away if any of these SEVERE side effects occur when using Topicort LP Cream:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); itching, burning, redness, or swelling not present before using Topicort LP Cream.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Topicort Gel

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Topicort Gel:

Mild, temporary stinging when first applied.

Seek medical attention right away if any of these SEVERE side effects occur when using Topicort Gel:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); itching, burning, redness, or swelling not present before using Topicort Gel.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

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Topicort Side Effects - for the Professional

Topicort

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:

Burning	Hypertrichosis	Maceration of the skin
Itching	Acneiform eruptions	Secondary infection
Irritation	Hypopigmentation	Skin atrophy
Dryness	Perioral dermatitis	Striae
Folliculitis	Allergic contact dermatitis	Miliaria

In controlled clinical studies the incidence of adverse reactions were low (0.8%) for Topicort® (desoximetasone) Cream 0.25%, and included burning, folliculitis, and folliculo-pustular lesions. The incidence of adverse reactions were also 0.8% for Topicort® LP (desoximetasone) Cream 0.05% and included pruritus, erythema, vesiculation, and burning sensation.

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Side Effects by Body System - for Healthcare Professionals

Endocrine

Endocrine side effects have rarely included suppression of the hypothalamic-pituitary-adrenal axis. This suppression was more likely when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used.

Local

Local side effects have commonly included burning, itching, and irritation, especially if applied to denuded skin. Long-term use of topical corticosteroids has been associated with skin atrophy and thinning, striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Topical corticosteroid use may also inhibit local immune response, rendering the skin more susceptible to infections. Folliculitis and allergic contact dermatitis have been occasionally reported.

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical desoximetasone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients with seborrheic skin type treated with potent topical corticosteroids. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.

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