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Topicort Side Effects

Generic Name: desoximetasone topical

Note: This page contains side effects data for the generic drug desoximetasone topical. It is possible that some of the dosage forms included below may not apply to the brand name Topicort.

It is possible that some side effects of Topicort may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to desoximetasone topical: topical application cream, topical application gel/jelly, topical application ointment, topical application spray

As well as its needed effects, desoximetasone topical (the active ingredient contained in Topicort) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking desoximetasone topical, check with your doctor immediately:

  • Flushing or redness of the skin
  • redness, blistering, peeling, or loosening of the skin
  • unusually warm skin
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • redness and scaling around the mouth
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • thinning, weakness, or wasting away of the skin

Some desoximetasone topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

  • Burning, itching, and pain in hairy areas, or pus at the root of the hair
Incidence not known
  • Acne or pimples
  • burning and itching of the skin with pinhead-sized red blisters
  • increased hair growth on the forehead, back, arms, and legs
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • softening of the skin

For Healthcare Professionals

Applies to desoximetasone topical: compounding powder, topical cream, topical gel, topical ointment, topical spray


The most commonly reported side effects were application site dryness, application site irritation, and application site pruritus.[Ref]


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome[Ref]


Frequency not reported: Folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria[Ref]


Common (1% to 10%): Application site dryness, application site irritation, application site pruritus
Frequency not reported: Burning, itching[Ref]


Frequency not reported: Hyperglycemia, latent diabetes mellitus[Ref]


1. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.

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