Topicort Side Effects
Please note - some side effects for Topicort may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects of Topicort - for the Consumer
Topicort Cream
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Topicort Cream:
Seek medical attention right away if any of these SEVERE side effects occur when using Topicort Cream:Mild, temporary stinging when first applied.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); itching, burning, redness, or swelling not present before using Topicort Cream.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Topicort LP Cream
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Topicort LP Cream:
Seek medical attention right away if any of these SEVERE side effects occur when using Topicort LP Cream:Mild, temporary stinging when first applied.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); itching, burning, redness, or swelling not present before using Topicort LP Cream.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Topicort Gel
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Topicort Gel:
Seek medical attention right away if any of these SEVERE side effects occur when using Topicort Gel:Mild, temporary stinging when first applied.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); itching, burning, redness, or swelling not present before using Topicort Gel.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
TopTopicort Side Effects - for the Professional
Topicort
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
| Burning | Hypertrichosis | Maceration of the skin |
| Itching | Acneiform eruptions | Secondary infection |
| Irritation | Hypopigmentation | Skin atrophy |
| Dryness | Perioral dermatitis | Striae |
| Folliculitis | Allergic contact dermatitis | Miliaria |
In controlled clinical studies the incidence of adverse reactions were low (0.8%) for Topicort® (desoximetasone) Cream 0.25%, and included burning, folliculitis, and folliculo-pustular lesions. The incidence of adverse reactions were also 0.8% for Topicort® LP (desoximetasone) Cream 0.05% and included pruritus, erythema, vesiculation, and burning sensation.
TopSide Effects by Body System - for Healthcare Professionals
Endocrine
Endocrine side effects have rarely included suppression of the hypothalamic-pituitary-adrenal axis. This suppression was more likely when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used.
Local
Local side effects have commonly included burning, itching, and irritation, especially if applied to denuded skin. Long-term use of topical corticosteroids has been associated with skin atrophy and thinning, striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Topical corticosteroid use may also inhibit local immune response, rendering the skin more susceptible to infections. Folliculitis and allergic contact dermatitis have been occasionally reported.
Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical desoximetasone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.
Perioral dermatitis or rosacea-like dermatitis has occurred in patients with seborrheic skin type treated with potent topical corticosteroids. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.
More Topicort resources
- Topicort Prescribing Information (FDA)
- Topicort Concise Consumer Information (Cerner Multum)
- Topicort Monograph (AHFS DI)
- Topicort Advanced Consumer (Micromedex) - Includes Dosage Information
- Topicort Cream MedFacts Consumer Leaflet (Wolters Kluwer)
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