TNKase Side Effects

Generic Name: tenecteplase

Note: This page contains side effects data for the generic drug tenecteplase. It is possible that some of the dosage forms included below may not apply to the brand name TNKase.

It is possible that some side effects of TNKase may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tenecteplase: intravenous kit, intravenous powder for solution

As well as its needed effects, tenecteplase (the active ingredient contained in TNKase) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tenecteplase, check with your doctor immediately:

More common
  • Bleeding or bruising of any kind, especially around the place of injection
  • collection of blood under skin
Less common or rare
  • Abdominal or stomach pain or swelling
  • back pain or backaches
  • blood in throat
  • blood in urine
  • bloody or black, tarry stools
  • constipation
  • cough
  • coughing up blood
  • difficulty swallowing
  • dizziness
  • fast, slow or irregular breathing
  • fast, slow or irregular heartbeat
  • headaches
  • hives
  • nosebleeds
  • shortness of breath and/or wheezing
  • skin rash, hives or itching
  • swelling of eyes, face, lips, or tongue
  • tightness in chest
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • wheezing

Some tenecteplase side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Bloody nose
  • unexplained nosebleeds

For Healthcare Professionals

Applies to tenecteplase: intravenous powder for injection

Hematologic

Major hematological side effects including hematoma (1.7%), gastrointestinal bleeding (>1%), urinary tract bleeding (<1%), puncture site bleeding (<1%), retroperitoneal bleeding (<1%), respiratory tract bleeding (<1%), and unspecified bleeding (<1%) have been reported. Intracranial hemorrhage (ICH) has also been reported. In one study, ICH occurred in 1%, 1.9%, and 3.8% of patients treated with 30, 40, and 50 mg of tenecteplase (the active ingredient contained in TNKase) respectively (patients were also receiving heparin).

Minor hematological side effects including hematoma (12.3%), urinary tract bleeding (3.7%), pharyngeal (3.1%), gastrointestinal tract bleeding (1.9%), epistaxis (1.5%), and unspecified bleeding (1.3%) have been reported.

Cardiovascular

Cardiovascular side effects including cardiogenic shock, arrhythmias, atrioventricular block, heart failure, cardiac arrest, recurrent myocardial ischemia, myocardial reinfarction, myocardial rupture, cardiac tamponade, pericarditis, pericardial effusion, mitral regurgitation, thrombosis, electromechanical dissociation, and hypotension have been reported.

Local

Local side effects including bleeding from the puncture side have been reported.

Respiratory

Respiratory side effects including pulmonary edema have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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