TNKase Side Effects
Generic Name: tenecteplase
Note: This page contains side effects data for the generic drug tenecteplase. It is possible that some of the dosage forms included below may not apply to the brand name TNKase.
It is possible that some side effects of TNKase may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to tenecteplase: intravenous kit, intravenous powder for solution
As well as its needed effects, tenecteplase (the active ingredient contained in TNKase) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking tenecteplase, check with your doctor immediately:More common
- Bleeding or bruising of any kind, especially around the place of injection
- collection of blood under skin
- Abdominal or stomach pain or swelling
- back pain or backaches
- blood in throat
- blood in urine
- bloody or black, tarry stools
- coughing up blood
- difficulty swallowing
- fast, slow or irregular breathing
- fast, slow or irregular heartbeat
- shortness of breath and/or wheezing
- skin rash, hives or itching
- swelling of eyes, face, lips, or tongue
- tightness in chest
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Some tenecteplase side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Less common
- Bloody nose
- unexplained nosebleeds
For Healthcare Professionals
Applies to tenecteplase: intravenous powder for injection
Major hematological side effects including hematoma (1.7%), gastrointestinal bleeding (>1%), urinary tract bleeding (<1%), puncture site bleeding (<1%), retroperitoneal bleeding (<1%), respiratory tract bleeding (<1%), and unspecified bleeding (<1%) have been reported. Intracranial hemorrhage (ICH) has also been reported. In one study, ICH occurred in 1%, 1.9%, and 3.8% of patients treated with 30, 40, and 50 mg of tenecteplase (the active ingredient contained in TNKase) respectively (patients were also receiving heparin).
Minor hematological side effects including hematoma (12.3%), urinary tract bleeding (3.7%), pharyngeal (3.1%), gastrointestinal tract bleeding (1.9%), epistaxis (1.5%), and unspecified bleeding (1.3%) have been reported.
Cardiovascular side effects including cardiogenic shock, arrhythmias, atrioventricular block, heart failure, cardiac arrest, recurrent myocardial ischemia, myocardial reinfarction, myocardial rupture, cardiac tamponade, pericarditis, pericardial effusion, mitral regurgitation, thrombosis, electromechanical dissociation, and hypotension have been reported.
Local side effects including bleeding from the puncture side have been reported.
Respiratory side effects including pulmonary edema have been reported.
More about TNKase (tenecteplase)
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