Tiotropium Side Effects

Some side effects of tiotropium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to tiotropium: inhalation capsule

Along with its needed effects, tiotropium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tiotropium:

More common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • fast or irregular heartbeat
  • nausea
  • shortness of breath
  • sweating
Less common
  • Cough
  • difficulty with swallowing
  • dizziness
  • hives
  • itching
  • painful blisters on the trunk of body
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Rare
  • Fainting
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • palpitations
  • pounding, or irregular heartbeat or pulse

Some side effects of tiotropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • bladder pain
  • bloody or cloudy urine
  • body aches or pain
  • chest pain
  • chills
  • congestion
  • cough
  • difficult, burning, or painful urination
  • difficulty with breathing
  • dry mouth
  • dryness of the throat
  • ear congestion
  • fever
  • frequent urge to urinate
  • headache
  • heartburn
  • hoarseness
  • indigestion
  • loss of voice
  • lower back or side pain
  • pain or tenderness around the eyes and cheekbones
  • runny or stuffy nose
  • sneezing
  • sore throat
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • trouble with swallowing
  • troubled breathing
  • unusual tiredness or weakness
  • voice changes
Less common
  • Abdominal or stomach pain
  • bloody nose
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • canker sores
  • difficulty having a bowel movement (stool)
  • discouragement
  • feeling sad or empty
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • irritability
  • lack of appetite
  • large amount of cholesterol in the blood
  • leg pain
  • loss of interest or pleasure
  • muscle pain
  • nausea
  • painful or difficult urination
  • skeletal pain
  • sore mouth or tongue
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • sweating
  • swelling
  • swelling or inflammation of the mouth
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • troubled breathing
  • unexplained weight loss
  • vomiting
  • white patches in the mouth and/or on the tongue
Incidence not known
  • Bloating
  • change in vision
  • constipation
  • diarrhea
  • itching or red skin

For Healthcare Professionals

Applies to tiotropium: inhalation capsule

Respiratory

Respiratory side effects have included upper respiratory tract infection (up to 43%), pharyngitis (up to 12.5%), sinusitis (up to 11%), rhinitis (up to 6%), epistaxis (up to 4%), laryngitis (up to 3%), coughing (3% or greater), and paradoxical bronchospasm. Hoarseness and throat irritation have been reported during postmarketing experience.

Gastrointestinal

Gastrointestinal side effects have included dry mouth (up to 16%), abdominal pain (up to 6%), dyspepsia (up to 6%), constipation (up to 5.1%), vomiting (up to 4%), gastrointestinal disorder not otherwise specified (up to 3%), gastroesophageal reflux (up to 3%), stomatitis (including ulcerative stomatitis; up to 3%), gingivitis, and oropharyngeal candidiasis. Dysphagia, oral candidiasis, and intestinal obstruction including paralytic ileus have been reported during postmarketing experience.

Cardiovascular

Cardiovascular side effects have included angina pectoris (including aggravated angina pectoris; up to 3%), atrial fibrillation (less than 1%), supraventricular tachycardia (less than 1%), and tachycardia. Tachycardia and palpitations have been reported during postmarketing experience.

Nervous system

Nervous system side effects have included headache (5.7%), dysphonia (up to 3%), and paresthesia (up to 3%). Dizziness has been reported during postmarketing experience.

Other

Other side effects have included nonspecific chest pain (up to 7%), dependent edema (up to 5%), infection (up to 4%), moniliasis (up to 4%), influenza-like symptoms (3% or greater), and herpes zoster (up to 3%). Application site irritation (glossitis, mouth ulceration, and pharyngolaryngeal pain) has been reported during postmarketing experience.

Dermatologic

Dermatologic side effects have included rash (up to 4%), skin ulcer, dry skin, and skin infection. Urticaria and pruritus have been reported during postmarketing experience.

Metabolic

Metabolic side effects have included hypercholesterolemia (up to 3%), hyperglycemia (up to 3%), and dehydration.

Genitourinary

Genitourinary side effects have included urinary tract infection (up to 7%), urinary retention (less than 1%), worsening of urinary retention, urinary difficulty, and dysuria.

Hypersensitivity

Hypersensitivity side effects have included allergic reaction (up to 3%) and angioedema (less than 1%). Immediate hypersensitivity reactions, including urticaria, angioedema (including swelling of the lips, tongue, or throat), rash, bronchospasm, anaphylaxis, or itching, have been reported.

Psychiatric

Psychiatric side effects have included depression (up to 4.4%) and insomnia (4.4%).

Ocular

Ocular side effects have included cataracts (up to 3%), glaucoma (new onset or worsening), worsening of narrow-angle glaucoma, and blurred vision. Increased intraocular pressure has been reported during postmarketing experience.

Musculoskeletal

Musculoskeletal side effects have included arthritis (up to 4.2%), myalgia (4%), skeletal pain (up to 3%), leg pain (up to 3%), and joint swelling.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web5)