Tikosyn Side Effects
Generic Name: dofetilide
Note: This document contains side effect information about dofetilide. Some of the dosage forms listed on this page may not apply to the brand name Tikosyn.
Some side effects of Tikosyn may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to dofetilide: oral capsule
Along with its needed effects, dofetilide (the active ingredient contained in Tikosyn) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking dofetilide:More common
- fast or irregular heartbeat
- Chest pain
- facial or flaccid paralysis
- numbness or tingling of the hands, feet or face
- pounding, slow heartbeat
- slurred speech
- swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, and/or throat
- troubled breathing
- unexplained shortness of breath
- unusual tiredness or weakness
- weight gain
- yellow eyes or skin
Some side effects of dofetilide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Abdominal or stomach pain
- accidental injury
- back pain
- flu-like symptoms
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- muscle aches and pains
- runny nose
- sore throat
- trouble sleeping
For Healthcare Professionals
Applies to dofetilide: oral capsule
Torsade de pointes is the only arrhythmia reported by the manufacturer that showed a dose-response relationship.
Cardiovascular effects have included ventricular arrhythmias, AV block, bundle branch block, heart block, chest pain, angioedema, bradycardia, cerebral ischemia, cerebrovascular accident, edema, heart arrest and myocardial infarct.
General side effects including headache (11%), dizziness (8%), flu syndrome ( 4%), insomnia (4%), accidental injury (3%), back pain (3%) and rash (3%) and sudden death have been reported.
Gastrointestinal effects have included nausea (5%), diarrhea (3%) and abdominal pain (3%).
Respiratory effects have included respiratory tract infection (7%), dyspnea (6%) and cough.
Nervous system effects have included paresthesias, facial paralysis, paralysis, flaccid paralysis, migraine and syncope.
Hepatic side effects including liver damage has been reported with a frequency of less than 2%.
More about Tikosyn (dofetilide)
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