Tigan Side Effects
Generic Name: trimethobenzamide
Note: This page contains side effects data for the generic drug trimethobenzamide. It is possible that some of the dosage forms included below may not apply to the brand name Tigan.
It is possible that some side effects of Tigan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to trimethobenzamide: intramuscular solution, oral capsule
As well as its needed effects, trimethobenzamide (the active ingredient contained in Tigan) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking trimethobenzamide, check with your doctor immediately:Rare
- Body spasm, with head and heels bent backward and body bowed forward
- convulsions (seizures)
- shakiness or tremors
- skin rash
- sore throat or fever
- unusual tiredness
- vomiting (severe or continuing)
- yellow eyes or skin
Some trimethobenzamide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Blurred vision
- muscle cramps
For Healthcare Professionals
Applies to trimethobenzamide: compounding powder, intramuscular solution, oral capsule, rectal suppository
Extrapyramidal reactions to trimethobenzamide (the active ingredient contained in Tigan) have been reported in some patients, the youngest of whom was 2 weeks old. This patient received approximately 300 mg rectally, although the drug is not recommended for newborn infants.[Ref]
Nervous system adverse effects have included dizziness, drowsiness, headache, disorientation, coma, convulsions, depression of mood, opisthotonus, Parkinson's-like symptoms, trismus, and extrapyramidal symptoms.[Ref]
Hypersensitivity reactions have included allergic-type skin reactions.[Ref]
Cardiovascular side effects have been reported rarely. Hypotension has been occasionally associated with intramuscular administration in surgical patients.[Ref]
Psychiatric side effects have included depression.[Ref]
Gastrointestinal adverse effects include diarrhea.[Ref]
Hepatic side effects have included reports of jaundice and hepatotoxicity.[Ref]
An isolated case report described a 50-year-old white female receiving trimethobenzamide capsules during a study protocol for use as a prophylactic antiemetic. After two days of administration, the patient had become jaundiced and her urine was dark. She felt tired, anorexic and nauseated with mild epigastric pain. A liver scan four days after the episode indicated hepatocellular dysfunction. She denied any other factors which may have contributed to the episode.[Ref]
Muscle cramps have occurred in some patients.[Ref]
Hematologic side effects have rarely included blood dyscrasias.[Ref]
Ocular side effects have included reports of blurring of vision.[Ref]
The manufacturer recommends giving trimethobenzamide (the active ingredient contained in Tigan) by deep injection into the upper outer quadrant of the gluteal region, and avoiding the escape of the injectable solution along the route, in order to reduce the incidence of side effects at the injection site.[Ref]
Dermatologic side effects reported following intramuscular injection have included pain, stinging, burning, redness and swelling at the site of injection.[Ref]
1. Holmes C, Flaherty RJ "Trimethobenzamide HCL (Tigan)-induced extrapyramidal dysfunction in a neonate." J Pediatr 89 (1976): 669-70
2. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
3. Borda I, Jick H "Hepatitis following the administration of trimethobenzamide hydrochloride." Arch Intern Med 120 (1967): 371-3
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