Ticarcillin and clavulanate potassium Side Effects

Please note - some side effects for Ticarcillin and clavulanate potassium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: intravenous powder for injection; intravenous solution

Gastrointestinal

Pseudomembranous colitis has been reported in patients treated with penicillins, and may occur during or after treatment. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.

Gastrointestinal side effects have included nausea, vomiting, diarrhea, taste and smell disturbances, stomatitis, flatulence, epigastric pain, and pseudomembranous colitis.

Hypersensitivity

Hypersensitivity side effects have included rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, and anaphylaxis.

Hematologic

Hematologic side effects have included thrombocytopenia, leukopenia, neutropenia, eosinophilia, decreased hemoglobin or hematocrit, and prolonged prothrombin time and bleeding time.

The risk of significant bleeding may be increased in patients over the age of 60 years, patients receiving cytotoxic chemotherapy, patients with preexisting thrombocytopenia, and azotemia, and patients undergoing surgical procedures.

Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics.

Metabolic

Metabolic side effects have included hypernatremia, decreased serum potassium, and decreased uric acid.

Some studies have shown a correlation between the degree of hypokalemia and the dose of ticarcillin in addition to the serum BUN/creatinine ratio. These findings suggest that dehydration and high doses may be risk factors for hypokalemia.

Local

Local side effects have included pain, burning, swelling, and induration at the injection site, and thrombophlebitis.

Hepatic

Hepatic side effects have included increased SGOT, SGPT, alkaline phosphatase, LDH, and bilirubin. Transient hepatitis and cholestatic jaundice have also been reported.

Nervous system

Nervous system side effects have included headache, giddiness, neuromuscular hyperirritability, and seizures.

Genitourinary

Genitourinary side effects have included hemorrhagic cystitis. An increased incidence of vaginal yeast infections has been associated with penicillins.

Renal

Renal side effects have included increased serum creatinine and/or BUN.

Dermatologic

Dermatologic side effects have included rash, pruritus, urticaria, erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome.

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