Tiagabine Side Effects

It is possible that some side effects of tiagabine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tiagabine: oral capsule, oral tablet

As well as its needed effects, tiagabine may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tiagabine, check with your doctor or nurse as soon as possible:

More common
  • Blue or purple spots on skin
  • difficulty in concentrating or paying attention
Less common
  • Burning, numbness, or tingling sensations
  • clumsiness or unsteadiness
  • confusion
  • itching
  • mental depression
  • speech or language problems
Rare
  • Agitation
  • bloody or cloudy urine
  • burning, pain, or difficulty in urinating
  • frequent urge to urinate
  • generalized weakness
  • hostility
  • memory problems
  • quick to react or overreact emotionally
  • rash
  • uncontrolled back-and-forth and/or rolling eye movements
  • walking in unusual manner
Symptoms of overdose
  • Agitation (severe)
  • clumsiness or unsteadiness (severe)
  • coma
  • confusion (severe)
  • drowsiness (severe)
  • increase in seizures
  • mental depression
  • severe muscle twitching or jerking
  • sluggishness
  • speech problems (severe)
  • weakness

Some tiagabine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Chills
  • diarrhea
  • dizziness
  • drowsiness
  • fever
  • headache
  • muscle aches or pain
  • nervousness
  • sore throat
  • tremor
  • unusual tiredness or weakness
  • vomiting
Less common
  • Abdominal pain
  • flushing
  • impaired vision
  • increased appetite
  • increased cough
  • mouth ulcers
  • muscle weakness
  • nausea
  • pain
  • trouble in sleeping

For Healthcare Professionals

Applies to tiagabine: oral tablet

Nervous system

Nervous system side effects including dizziness (28% to 31%), asthenia (18% to 23%), tremor (14% to 21%), somnolence (19% to 21%), nervousness (11% to 14%), difficulty with concentration/attention (7% to 14%), ataxia (6% to 9%), depression (1% to 7%), insomnia (5% to 6%), abnormal gait (5%), and hostility (5%) have been reported. From the launch of tiagabine in 1997 through the end of 2004, fifty-nine postmarketing reports of seizures in patients without a history of epilepsy have been reported. A case of transient athetosis induced by tiagabine has also been reported.

General

In patients experiencing incapacitating generalized weakness, the weakness resolved in all cases after either discontinuation or a reduction in tiagabine dosage.

General side effects including accidental injury (15% to 21%), infection (10% to 19%), flu syndrome (6% to 9%), pain (2% to 7%), and abdominal pain (5% to 7%) have been reported. Moderately severe to incapacitating generalized weakness (1%) has also been reported.

Gastrointestinal

Gastrointestinal side effects including diarrhea (2% to 10%), nausea, vomiting, and mouth ulceration have been reported.

Ocular

Studies have reported that when dogs received a single dose of radiolabeled tiagabine, residual binding in the retina and uvea was present after 3 weeks. While no specific recommendations for periodic ophthalmic monitoring are recommended, prescribers should be aware of the possibility of long term ophthalmic effects.

Ocular side effects including amblyopia (4% to 9% ) have been reported.

Respiratory

Respiratory side effects including pharyngitis (7% to 8%) have been reported.

Hematologic

Hematologic side effects including ecchymosis have been reported in up to 6% of patients receiving tiagabine therapy. A case of thrombocytopenia suspected of being secondary to tiagabine has also been reported.

Musculoskeletal

Musculoskeletal side effects including myalgia (2% to 5%) have been reported. Three cases of transient dystonias have also been reported.

Genitourinary

Genitourinary side effects including urinary tract infection have been reported in up to 5% of patients on tiagabine therapy.

Dermatologic

A definite correlation between tiagabine and any of the rashes was not made.

Dermatologic side effects including four cases of serious rashes have been reported. Two of the rashes were maculopapular, one case was vesiculobullous, and the last was diagnosed as Stevens-Johnson Syndrome.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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