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Tetrahydrozoline nasal Side Effects

It is possible that some side effects of tetrahydrozoline nasal may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tetrahydrozoline nasal: nasal solution, nasal spray

Get emergency medical help if you have any of these signs of an allergic reaction while taking tetrahydrozoline nasal: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using tetrahydrozoline nasal and call your doctor at once if you have:

  • ongoing or worsening symptoms;

  • severe burning or stinging in your nose after using the nasal spray;

  • pounding heartbeats or fluttering in your chest;

  • slow heartbeats; or

  • severe headache, buzzing in your ears, anxiety, confusion, or feeling short of breath.

Common side effects may include:

  • mild burning or stinging of the nose;

  • sneezing; or

  • dryness of your nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to tetrahydrozoline nasal: nasal solution, nasal spray


Rhinitis medicamentosa (RM) is attributed to chronic swelling of the nasal mucosa resulting in redness, swelling, and rhinitis. RM has been reported after too frequent, prolonged, or excessive doses. Treatment consists of gradual or abrupt withdrawal of therapy and substituting an orally administered decongestant in the interim (if indicated and appropriate).[Ref]

Respiratory side effects have included rhinitis medicamentosa (rebound nasal congestion), transient burning, stinging, or dryness of the mucosa, and sneezing.[Ref]

Nervous system

Nervous system side effects have included headache, weakness, drowsiness, tremors, light-headedness, insomnia, and sweating. Overdosage has resulted in drowsiness in adults.[Ref]


Cardiovascular side effects have included palpitations. Overdosage has resulted in hypertension, bradycardia, rebound hypotension, and a shock-like syndrome.[Ref]


Local side effects have included transient burning, stinging, or dryness of the mucosa, and sneezing.[Ref]


1. "Product Information. Tyzine (tetrahydrozoline)." Kenwood Laboratories, Fairfield, NJ.

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