Tenex Side Effects

Generic Name: guanfacine

Please note - some side effects for Tenex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Tenex - for the Consumer

Tenex

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Tenex:

Constipation; dizziness; drowsiness; dry mouth; tiredness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in heartbeat; inability to have sex; pounding in the chest.

Side Effects by Body System

General

Guanfacine is generally well-tolerated. In a study of 580 hypertensive patients, only 7% withdrew due to adverse side effects. In addition, most side effects were mild, dose-related, and resolved over time.

Nervous system

Nervous system side effects include fatigue or a sedative effect and dizziness in 33% and 15% of patients, respectively. After one year of therapy, the incidence of these side effects falls to 6% and 1%, respectively. Headaches occur in less than 5% of patients.

Gastrointestinal

Gastrointestinal problems include dry mouth in up to 60% of patients. Constipation has been associated with the use of this drug in 14% of patients. After one year of therapy the incidence of dry mouth and constipation averages 15% and 3%, respectively.

Cardiovascular

Cardiovascular side effects include orthostatic hypotension and palpitations, each of which is rare. There is limited, indirect (ECG) evidence of left ventricular hypertrophy resolution after guanfacine therapy.

Genitourinary

Genitourinary complaints in male patients are limited to impotence, which is associated with higher doses (daily doses of 3 mg or more).

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