Tazarotene topical Side Effects

It is possible that some side effects of tazarotene topical may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to tazarotene topical: topical cream, topical foam, topical gel/jelly

As well as its needed effects, tazarotene topical may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tazarotene topical, check with your doctor immediately:

More common
  • Burning or stinging of the skin (severe)
  • changes in color of the treated skin
  • deep grooves or lines in the skin
  • dryness, itching, peeling, or redness of the skin (severe)
  • pain or swelling of the treated skin
  • skin rash (in patients with psoriasis only)

Some tazarotene topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Burning or stinging after application
  • dryness, itching, peeling, or redness of the skin (mild)

For Healthcare Professionals

Applies to tazarotene topical: topical cream, topical foam, topical gel

Dermatologic

Dermatologic side effects associated with Avage(R) topical cream have included desquamation (40%), erythema (34%), burning sensation (26%), dry skin (16%), skin irritation (10%), pruritus (10%), irritant contact dermatitis (8%), stinging (3%), acne (3%), rash (3%), and cheilitis (1%). Pruritus, erythema, and burning have been reported (in descending order) with Tazorac(R) topical cream in 10% to 23% of psoriasis patients. Desquamation, dry skin, erythema, and burning sensation have been reported (in descending order) with Tazorac(R) topical cream in 10% to 30% of acne patients. Irritation, desquamation, stinging, contact dermatitis, dermatitis, eczema, worsening of psoriasis, skin pain, rash, dry skin, and skin inflammation have been reported (in descending order) with Tazorac(R) topical cream in greater than 1% to less than 10% of psoriasis patients. Pruritus, irritation, face pain, and stinging have been reported with Tazorac(R) topical cream in 1% to 5% of acne patients. Dermatitis (less than 1%), impetigo (less than 1%), pruritus (less than 1%), local skin reactions, dryness, erythema, peeling, burning/stinging, and itching have been reported with tazarotene topical foam. Pruritus, burning/stinging, erythema, worsening of psoriasis, irritation, and skin pain have been reported (in descending order) with tazarotene topical gel in 10% to 30% of psoriasis patients. Desquamation, burning/stinging, dry skin, erythema, and pruritus have been reported (in descending order) with tazarotene topical gel in 10% to 30% of acne patients. Rash, desquamation, irritant contact dermatitis, skin inflammation, fissuring, bleeding, and dry skin have been reported with tazarotene topical gel in 1% to 10% of psoriasis patients. Irritation, skin pain, fissuring, and skin discoloration have been reported with tazarotene topical gel in 1% to 10% of acne patients. Psoriasis worsening and sun-induced erythema have also been reported with tazarotene topical gel in psoriasis patients. Blister, rash, skin discoloration (including skin hyperpigmentation or skin hypopigmentation), and pain have been reported during postmarketing experience with tazarotene topical gel.[Ref]

Local

Local side effects associated with tazarotene topical foam have included application site irritation (14%), application site dryness (7%), application site erythema (6%), application site exfoliation (6%), application site pain (1%), application site photosensitivity (including sunburn; 1%), application site pruritus (1%), application site dermatitis (1%), and application site reactions (including discoloration, discomfort, edema, rash, and swelling; less than 1%). Localized edema has been reported with tazarotene topical gel in 1% to 10% of acne patients.[Ref]

Metabolic

Metabolic side effects associated with Tazorac(R) topical cream have included hypertriglyceridemia (greater than 1% to less than 10%).[Ref]

Other

Other side effects associated with Tazorac(R) topical cream have included peripheral edema (greater than 1% to less than 10%).[Ref]

Ocular

Ocular side effects associated with Avage(R) topical cream have included edema, irritation, and inflammation directly related to the eye or eyelid.

References

1. Marks R "Clinical safety of tazarotene in the treatment of plaque psoriasis." J Am Acad Dermatol 37 (1997): s25-32

2. Weinstein GD, Krueger GG, Lowe NJ, Duvic M, Friedman DJ, Jegasothy BV, Jorizzo JL, Shmunes E, Tschen EH, Lew-Kaya DA, Lue JC, Sefton J, Gibson JR "Tazarotene gel, a new retinoid, for topical therapy of psoriasis: vehicle-controlled study of safety, efficacy, and duration o therapeutic effect." J Am Acad Dermatol 37 (1997): 85-92

3. "Product Information. Tazorac (tazarotene topical)." Allergan Inc, Irvine, CA.

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